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1. 发明授权

US06443898B1 Therapeutic delivery systems 失效
标题翻译：治疗递送系统
公开(公告)号：US06443898B1
公开(公告)日：2002-09-03
申请号：US08485998
申请日：1995-06-07
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B800
CPC分类号： A61K41/0028 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0052 , A61K47/6911 , A61K47/6925 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K49/227 , A61M5/3145 , Y10S977/904 , Y10S977/907
摘要： Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having encapsulated therein a contrast agent or drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
摘要翻译：描述包含含有治疗剂的气态前体填充微球的治疗递送系统。还提供了在治疗性递送应用中使用这种微球的方法。优选包含气体前体填充脂质体的包封造影剂或药物的治疗递送系统。还公开了制备这种脂质体的方法和装置以及在治疗性递送应用中使用这种脂质体的方法。

2. 发明授权

US06231834B1 Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same 失效
标题翻译：涉及使用造影剂和多幅图像的超声成像方法及其处理方法
公开(公告)号：US06231834B1
公开(公告)日：2001-05-15
申请号：US08982829
申请日：1997-12-02
申请人： Evan C. Unger , Thomas A. Fritz , Edward W. Gertz
发明人： Evan C. Unger , Thomas A. Fritz , Edward W. Gertz
IPC分类号： A61B813
CPC分类号： B82Y5/00 , A61K49/223 , A61K49/227 , A61K49/228
摘要： Improved methods for providing an image of an internal region of a patient. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises, in an aqueous carrier, a lipid, protein, polymer or surfactant, and a gas. The patient is scanned using ultrasound imaging to obtain a visible image of the region. In embodiments of the invention, the scanning step may comprise applying a first quantity of ultrasound energy to the patient to provide a first image, followed by the application substantially immediately thereafter of a second quantity of ultrasound energy to provide a second image. The first and second images are then processed. The methods are particularly useful for obtaining on-line images of the cardiovascular region which may be employed, for example, to diagnose the presence of diseased tissue in the cardiovascular region of a patient.
摘要翻译：用于提供患者内部区域的图像的改进方法。本发明的实施方案涉及向患者施用造影剂，其在水性载体中包含脂质，蛋白质，聚合物或表面活性剂和气体。使用超声成像扫描患者以获得该区域的可见图像。在本发明的实施例中，扫描步骤可以包括向患者施加第一数量的超声能量以提供第一图像，随后基本上立即应用第二数量的超声能量以提供第二图像。然后处理第一和第二图像。该方法对于获得可用于例如诊断患者的心血管区域中患病组织的存在的心血管区域的在线图像特别有用。

3. 发明授权

US6033646A Method of preparing fluorinated gas microspheres 失效
标题翻译：新型可分散脂质混合物及其用途
公开(公告)号：US6033646A
公开(公告)日：2000-03-07
申请号：US26326
申请日：1998-02-19
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/08 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01J13/02 , G01R33/28
CPC分类号： A61K9/1277 , A61K41/0028 , A61K41/0052 , A61K49/22 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1271 , A61K9/1278 , G01R33/5601 , A61M5/3145
摘要： Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
摘要翻译：冻干脂质组合物及其制备方法由本发明体现。使用冻干的脂质组合物制备的充气微球在例如超声成像应用和治疗药物递送系统中是特别有用的。

4. 发明授权

US5853752A Methods of preparing gas and gaseous precursor-filled microspheres 失效
标题翻译：制备气体和气态前体填充微球的方法
公开(公告)号：US5853752A
公开(公告)日：1998-12-29
申请号：US487230
申请日：1995-06-06
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00
CPC分类号： A61K49/227 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S424/812 , Y10S436/829 , Y10S977/907 , Y10S977/915 , Y10S977/927 , Y10S977/929
摘要： Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
摘要翻译：描述了制备温度活化气态前体填充脂质体的方法和装置。通过这些方法制备的气态前体填充脂质体在例如超声成像应用和治疗药物递送系统中是特别有用的。

5. 发明授权

US5585112A Method of preparing gas and gaseous precursor-filled microspheres 失效
公开(公告)号：US5585112A
公开(公告)日：1996-12-17
申请号：US159687
申请日：1993-11-30
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00
CPC分类号： A61K49/227 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S424/812 , Y10S436/829 , Y10S977/907 , Y10S977/915 , Y10S977/927 , Y10S977/929
摘要： Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

6. 发明授权

US5770222A Therapeutic drug delivery systems 失效
公开(公告)号：US5770222A
公开(公告)日：1998-06-23
申请号：US472305
申请日：1995-06-07
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K31/70 , A61K39/395 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00
CPC分类号： A61K49/22 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S436/829 , Y10S977/801 , Y10S977/907 , Y10S977/915
摘要： Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.

7. 发明授权

US5469854A Methods of preparing gas-filled liposomes 失效
标题翻译：制备充气脂质体的方法
公开(公告)号：US5469854A
公开(公告)日：1995-11-28
申请号：US76239
申请日：1993-06-11
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01J13/02 , A61K9/66
CPC分类号： A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61M5/3145 , Y10S977/795 , Y10S977/801 , Y10S977/905 , Y10S977/906 , Y10S977/907 , Y10S977/927 , Y10S977/929 , Y10S977/962
摘要： Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
摘要翻译：描述了制备充气脂质体的方法和装置。通过这些方法制备的充气脂质体在例如超声成像应用和治疗药物递送系统中是特别有用的。

8. 发明授权

US6071495A Targeted gas and gaseous precursor-filled liposomes 失效
标题翻译：靶向气体和气体前体填充脂质体
公开(公告)号：US6071495A
公开(公告)日：2000-06-06
申请号：US942862
申请日：1997-10-02
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , A61K49/04
CPC分类号： A61K49/227 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S424/812 , Y10S436/829 , Y10S977/907 , Y10S977/915 , Y10S977/927 , Y10S977/929
摘要： Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
摘要翻译：描述了制备温度活化气态前体填充脂质体的方法和装置。通过这些方法制备的气态前体填充脂质体在例如超声成像应用和治疗药物递送系统中是特别有用的。

9. 发明授权

US6033645A Methods for diagnostic imaging by regulating the administration rate of a contrast agent 失效
标题翻译：通过调节造影剂的给药速率进行诊断成像的方法
公开(公告)号：US6033645A
公开(公告)日：2000-03-07
申请号：US666129
申请日：1996-06-19
申请人： Evan C. Unger , Terry Matsunaga , Thomas A. Fritz , Varadarajan Ramaswami
发明人： Evan C. Unger , Terry Matsunaga , Thomas A. Fritz , Varadarajan Ramaswami
IPC分类号： A61M5/00 , A61B8/00 , A61K49/00 , A61K49/22 , A61K51/02
CPC分类号： A61K49/223 , Y10S977/801 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.
摘要翻译：提供患者内部区域的图像的方法。该方法的实施方案涉及向患者施用造影剂，其包含囊泡组合物，所述囊泡组合物在水性载体中包含气体或气体前体和包含脂质，蛋白质或聚合物的囊泡。使用诸如超声波之类的诊断成像扫描患者，以获得该区域的可见图像。将造影剂以基本上消除图像中的诊断伪像的速率施用于患者。该方法对于诊断患者中任何患病组织的存在特别有用。

10. 发明授权

US5580575A Therapeutic drug delivery systems 失效
标题翻译：治疗药物输送系统
公开(公告)号：US5580575A
公开(公告)日：1996-12-03
申请号：US76250
申请日：1993-06-11
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K31/70 , A61K39/395 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00
CPC分类号： A61K49/22 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S436/829 , Y10S977/801 , Y10S977/907 , Y10S977/915
摘要： Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
摘要翻译：描述包含含有治疗剂的充气微球的治疗药物递送系统。还提供了在治疗药物递送应用中使用这种微球的方法。药物递送系统包括其中封装有药物的充气脂质体。还公开了制备这种脂质体的方法和装置以及在药物递送应用中使用这种脂质体的方法。

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