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1. 发明申请

US20030109473A1 One dose vaccination with mycoplasma hyopneumoniae 有权
标题翻译：一次剂量接种支原体猪肺炎支原体
公开(公告)号：US20030109473A1
公开(公告)日：2003-06-12
申请号：US10174701
申请日：2002-06-19
申请人： Pfizer Inc.
发明人： Robin Lee Keich , Lisa Grace Sabbadini
IPC分类号： A61K048/00 , A61K039/295
CPC分类号： A61K39/0241 , A61K2039/521 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , Y10S435/87
摘要： The present invention relates to methods for treating or preventing a disease or disorder in an animal caused by infection by Mycoplasma hyopneumoniae (M. hyo) by administering to the animal at approximately three (3) to ten (10) days of age, a single dose of an effective amount of a M. hyo vaccine. The M. hyo vaccine can be a whole or partial cell inactivated or modified live preparation, a subunit vaccine, or a nucleic acid or DNA vaccine. The M. hyo vaccine administered in accordance with the present invention can be synthesized or recombinantly produced.
摘要翻译：本发明涉及通过在大约三（3）至十（10）天龄时给动物施用由猪肺炎支原体（M.hoo）感染引起的动物引起的疾病或病症的方法，剂量的有效量的猪尾杆菌疫苗。 M.hoo疫苗可以是全部或部分细胞灭活或修饰的活体制剂，亚单位疫苗或核酸或DNA疫苗。可以合成或重组生产根据本发明施用的猪尾杆菌疫苗。

2. 发明授权

US5968525A Inactivated Mycolplasma hyopneumoniae and uses therefor 失效
标题翻译：灭活的猪肺炎支原体并用于其
公开(公告)号：US5968525A
公开(公告)日：1999-10-19
申请号：US2477
申请日：1998-01-02
申请人： Gerald R. Fitzgerald , C. Joseph Welter
发明人： Gerald R. Fitzgerald , C. Joseph Welter
IPC分类号： G01N33/569 , A01K67/027 , A61K39/00 , A61K39/02 , A61K39/102 , A61K39/116 , A61K39/39 , A61K39/395 , A61P31/00 , A61P31/04 , C07K14/30 , C12N7/00
CPC分类号： C07K14/30 , A01K67/027 , A61K39/0241 , A61K2039/521 , A61K2039/552 , A61K2039/55505 , A61K2039/55583 , Y10S424/825 , Y10S435/87
摘要： The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of aluminum hydroxide and DEAE dextran and injected into pigs. The resulting bacterin and adjuvant mixture can also be mixed with other bacteria such as Bordetella and Pasteurella, for further adjuvant effect. Protective immunity against mycoplasmal pneumonia is elicited in swine using these vaccines.
摘要翻译：本发明涉及通过用硫柳汞灭活细菌来制造猪肺炎支原体灭活疫苗的方法。将所得菌苗与氢氧化铝和DEAE葡聚糖的佐剂混合并注入猪中。所得到的菌苗和佐剂混合物也可以与其他细菌如博德特氏菌和巴氏杆菌混合，用于进一步的佐剂效应。使用这些疫苗在猪中引起支原体肺炎的保护性免疫。

3. 发明授权

US5529904A Diagnostic kit and diagnostic method for mycoplasma utilizing carbohydrate receptors 失效
标题翻译：使用碳水化合物受体的支原体的诊断试剂盒和诊断方法
公开(公告)号：US5529904A
公开(公告)日：1996-06-25
申请号：US79387
申请日：1993-06-21
申请人： Victor Ginsburg , Howard C. Krivan , David D. Roberts
发明人： Victor Ginsburg , Howard C. Krivan , David D. Roberts
IPC分类号： C12Q1/04 , A61K31/70 , C07H15/00 , C12N11/00 , C12Q1/24 , C12R1/01 , C12R1/19 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/569 , G01N33/554
CPC分类号： G01N33/56933 , A61K31/70 , A61K31/7004 , C12Q1/24 , G01N33/54313 , G01N33/54366 , G01N33/566 , G01N33/569 , G01N33/56911 , G01N2333/30 , G01N2400/00 , Y10S435/87 , Y10S435/975
摘要： A diagnostic kit for detecting the presence of microorganisms, comprising an insoluble substrate; and a carbohydrate receptor immobilized on the insoluble substrate, the carbohydrate receptor being capable of adsorbing microorganisms; and a labelled reagent useful for detecting the presence of microorganisms bound to the carbohydrate receptors and a method for detecting the presence of specified microorganisms in a sample, which comprises contacting a sample to be tested with carbohydrate receptors immobilized on an insoluble substrate; and determining the extent of binding of microorganisms in the sample to the carbohydrate receptors by use of a labelled reagent.
摘要翻译：一种用于检测微生物存在的诊断试剂盒，其包含不溶性底物; 和固定在不溶性底物上的碳水化合物受体，能够吸附微生物的碳水化合物受体; 和用于检测与碳水化合物受体结合的微生物的存在的标记试剂和检测样品中特定微生物的存在的方法，其包括将被检样品与固定在不溶性底物上的碳水化合物受体接触; 并通过使用标记的试剂测定样品中的微生物与碳水化合物受体的结合程度。

4. 发明授权

US5338543A Thimerosal inactivated mycoplasma hyopneumoniae vaccine 失效
标题翻译：硫柳汞灭活支原体猪肺炎支原体疫苗
公开(公告)号：US5338543A
公开(公告)日：1994-08-16
申请号：US889911
申请日：1992-05-29
申请人： Gerald R. Fitzgerald , C. Joseph Welter
发明人： Gerald R. Fitzgerald , C. Joseph Welter
IPC分类号： G01N33/569 , A01K67/027 , A61K39/00 , A61K39/02 , A61K39/102 , A61K39/116 , A61K39/39 , A61K39/395 , A61P31/00 , A61P31/04 , C07K14/30 , C12N7/00
CPC分类号： C07K14/30 , A01K67/027 , A61K39/0241 , A61K2039/521 , A61K2039/552 , A61K2039/55505 , A61K2039/55583 , Y10S424/825 , Y10S435/87
摘要： The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of aluminum hydroxide and DEAE dextran and injected into pigs. The resulting bacterin and adjuvant mixture can also be mixed with other bacteria such as Borderella and Pasteurella, for further adjuvant effect. Protective immunity against mycoplasmal pneumonia is elicited in swine using these vaccines.
摘要翻译：本发明涉及通过用硫柳汞灭活细菌来制造猪肺炎支原体灭活疫苗的方法。将所得菌苗与氢氧化铝和DEAE葡聚糖的佐剂混合并注入猪中。所得到的菌苗和佐剂混合物也可以与其他细菌如Borderella和Pasteurella混合，用于进一步的佐剂效应。使用这些疫苗在猪中引起支原体肺炎的保护性免疫。

5. 发明授权

US4985243A Composition and method for protecting against diseases caused by microorganisms 失效
标题翻译：防止微生物引起的疾病的组合物和方法
公开(公告)号：US4985243A
公开(公告)日：1991-01-15
申请号：US146256
申请日：1988-01-20
申请人： Daryl H. Faulds , Mimi Vishoot
发明人： Daryl H. Faulds , Mimi Vishoot
IPC分类号： C12N9/16 , A61K38/46 , A61K39/00 , A61K39/395 , A61K48/00 , A61P31/00 , C12N9/22
CPC分类号： C12Y301/21001 , A61K38/465 , A61K39/0241 , A61K39/39533 , A61K2039/552 , Y10S435/87
摘要： A vaccine for protecting against a disease caused by a microorganism which does not synthesize nucleic acid precursors such as a Micoplasma organism, which contains nuclease and/or a nuclease fragment or derivative which produces antibodies which recognize nuclease secreted or available on the surface of the microorganism against which protection is to be afforded. A vaccine may also be prepared from an antibody or fragment or derivative thereof which recognizes such nuclease of such microorganism.

6. 发明授权

US3668075A Growth inhibitions of selective mycoplasmas 失效
标题翻译：选择性MYCOPLASMAS的增长抑制
公开(公告)号：US3668075A
公开(公告)日：1972-06-06
申请号：US3668075D
申请日：1968-10-04
申请人： HOFFMANN LA ROCHE
发明人： CEKORIC THOMAS JR , EVANS GEORGE , SEARCY RONALD
IPC分类号： C12N1/38 , C12K1/06
CPC分类号： C12N1/38 , Y10S435/80 , Y10S435/805 , Y10S435/87
摘要： The use of certain heparinoid compounds to selectively inhibit the growth of mycoplasmas is described. The invention provides a practical means for facilitating the selective identification of mycoplasmas. The identification of mycoplasmas isolated from man is especially useful as a diagnostic aid in prescribing treatment for diseases caused by these microorganisms. Additionally, the invention provides a means of preventing the growth of mycoplasmas in culture media especially media used for tissue cultures in which mycoplasmas frequently occur as undesirable contaminants.
摘要翻译：描述了某些类肝素化合物选择性抑制支原体生长的用途。

7. 发明授权

US07074894B2 Antigen composition against mycoplasma 失效
标题翻译：针对支原体的抗原组成
公开(公告)号：US07074894B2
公开(公告)日：2006-07-11
申请号：US08913430
申请日：1996-03-15
申请人： John Walker , Rogan Lee , Stephen William Doughty
发明人： John Walker , Rogan Lee , Stephen William Doughty
IPC分类号： C07H1/00 , C07H14/00 , C07H17/00
CPC分类号： C07K14/30 , A61K39/00 , C07K16/1253 , Y10S435/87 , Y10S530/806 , Y10S530/82 , Y10S530/821
摘要： An isolated antigen against a Mycoplasma, prepared by a method including providing a sample of a Mycoplasma and an antibody probe, probing the Mycoplasma sample with the antibody probe to detect at least one antigen, and isolating the antigen detected. The antibody probe includes at least one antibody against the Mycoplasma that is produced by a method including (a) providing a biological sample taken a short time after an immune animal has been challenged with a Mycoplasma or Mycoplasma extract taken from the infection site or an area of a lesion or an area close to the infection site or lesion; (b) isolating cells from the biological sample; (c) culturing the cells in vitro in a suitable culture medium; and (d) harvesting antibodies produced from the cell.
摘要翻译：通过包括提供支原体样品和抗体探针的方法制备的针对支原体的分离抗原，用抗体探针探测支原体样品以检测至少一种抗原，并分离所检测的抗原。抗体探针包括至少一种针对支原体的抗体，其通过以下方法制备，所述方法包括：（a）在免疫动物用来自感染部位或区域的支原体或支原体提取物进行攻击后提供短时间内的生物样品的病变或接近感染部位或病变的区域; （b）从生物样品中分离细胞; （c）在合适的培养基中体外培养细胞; 和（d）收获从细胞产生的抗体。

8. 发明授权

US07056492B2 Mycoplasma hyopneumoniae vaccine and methods for reducing Mycoplasma bovis pneumonia in cattle 失效
标题翻译：猪肺炎支原体疫苗以及牛中支原体肺炎支原体的方法
公开(公告)号：US07056492B2
公开(公告)日：2006-06-06
申请号：US10177860
申请日：2002-06-20
申请人： Alexander C. Goudie , Andrew Raymond Peters , Robin Lee Keich
发明人： Alexander C. Goudie , Andrew Raymond Peters , Robin Lee Keich
IPC分类号： A61K49/00 , A61K39/00 , A01N63/00
CPC分类号： A61K39/0241 , A61K2039/521 , A61K2039/552 , A61K2039/55566 , Y10S435/87
摘要： The present invention relates to methods for treating or preventing a disease or disorder in an animal caused by infection by Mycoplasma bovis (M. bovis) by administering to the animal an effective amount of a Mycoplasma hyopneumoniae (M. hyo) vaccine. The M. hyo vaccine can be a whole or partial cell inactivated or modified live preparation, a subunit vaccine, or a nucleic acid or DNA vaccine. The M. hyo vaccine administered in accordance with the present invention can be synthesized or recombinantly produced.
摘要翻译：本发明涉及通过向动物施用有效量的猪肺炎支原体（M.hoo）疫苗来治疗或预防由牛支原体感染引起的动物疾病或病症的方法。 M.hoo疫苗可以是全部或部分细胞灭活或修饰的活体制剂，亚单位疫苗或核酸或DNA疫苗。可以合成或重组生产根据本发明施用的猪尾杆菌疫苗。

9. 发明申请

US20030219714A1 Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound 审中-公开
标题翻译：利用哺乳动物应激启动子来确定化合物的毒性的方法和诊断试剂盒
公开(公告)号：US20030219714A1
公开(公告)日：2003-11-27
申请号：US10298695
申请日：2002-11-19
申请人： President and Fellows of Harvard College and Xenometrix, Inc.
发明人： Spencer B. Farr , Marque D. Todd
IPC分类号： C12Q001/00 , C12Q001/68
CPC分类号： C12Q1/6897 , Y10S435/87
摘要： This invention provides methods and diagnostic kits for identifying and characterizing toxic compounds. These methods and diagnostic kits measure transcription or translation levels from genes linked to native eukaryotic stress promoters, especially those of mammals. The kits and methods of this invention utilize at least one stress promoter from each of the following groups: redox stress, DNA stress, protein stress and energy/ionic stress. The invention also provides methods and diagnostic kits for identifying and characterizing compounds that are toxic to specific organs, such as skin and the eye, as well as for each of the individual stresses indicated above. The methods and diagnostic kits of this invention yield information concerning the action of a compound on a subcellular level. This information may be utilized to design antitoxins to compounds found to be toxic and in active drug design.
摘要翻译：本发明提供用于鉴定和表征有毒化合物的方法和诊断试剂盒。这些方法和诊断试剂盒测量与天然真核应激启动子，特别是哺乳动物相关的基因的转录或翻译水平。本发明的试剂盒和方法利用来自以下各组中的至少一种应激启动子：氧化还原应激，DNA胁迫，蛋白质应激和能量/离子应力。本发明还提供用于鉴定和表征对特定器官如皮肤和眼睛有毒的化合物的方法和诊断试剂盒，以及针对上述各个应力的每一个。本发明的方法和诊断试剂盒产生关于化合物在亚细胞水平上的作用的信息。该信息可用于设计发现有毒性和活性药物设计的化合物的抗毒素。

10. 发明授权

US5215914A Adherent and invasive mycoplasma 失效
标题翻译：附着和侵袭性支原体
公开(公告)号：US5215914A
公开(公告)日：1993-06-01
申请号：US800370
申请日：1991-12-02
申请人： Shyh-Ching Lo , Richard Y. Wang , Michael M. Hayes
发明人： Shyh-Ching Lo , Richard Y. Wang , Michael M. Hayes
IPC分类号： A61K39/00 , A61K39/02 , A61K39/12 , C07K14/30 , C12N7/00 , G01N33/569
CPC分类号： C12N7/00 , A61K39/0241 , C07K14/30 , C12R1/35 , G01N33/56933 , G01N33/56988 , A61K39/00 , C12N2740/16011 , Y10S435/87 , Y10S435/974 , Y10S435/975
摘要： The present invention relates to a novel mycoplasma isolated from the urine of patients with AIDS. The mycoplasma has unique morphological and pathobiological properties. The invention also relates to the antigens and antibodies of the novel mycoplasma, and methods of detection utilizing these antigens and antibodies. Antigenically and genetically, the mycoplasma is distinct from all other known mycoplasmas. The invention further relates to the DNA sequence of the novel mycoplasma and vaccines against the mycoplasma infection.
摘要翻译：本发明涉及从艾滋病患者的尿中分离的新型支原体。支原体具有独特的形态和病理特性。本发明还涉及新型支原体的抗原和抗体，以及利用这些抗原和抗体的检测方法。抗原和遗传上的支原体与所有其他已知的支原体不同。本发明还涉及新型支原体的DNA序列和针对支原体感染的疫苗。

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