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1. 发明授权

US5215914A Adherent and invasive mycoplasma 失效
标题翻译：附着和侵袭性支原体
公开(公告)号：US5215914A
公开(公告)日：1993-06-01
申请号：US800370
申请日：1991-12-02
申请人： Shyh-Ching Lo , Richard Y. Wang , Michael M. Hayes
发明人： Shyh-Ching Lo , Richard Y. Wang , Michael M. Hayes
IPC分类号： A61K39/00 , A61K39/02 , A61K39/12 , C07K14/30 , C12N7/00 , G01N33/569
CPC分类号： C12N7/00 , A61K39/0241 , C07K14/30 , C12R1/35 , G01N33/56933 , G01N33/56988 , A61K39/00 , C12N2740/16011 , Y10S435/87 , Y10S435/974 , Y10S435/975
摘要： The present invention relates to a novel mycoplasma isolated from the urine of patients with AIDS. The mycoplasma has unique morphological and pathobiological properties. The invention also relates to the antigens and antibodies of the novel mycoplasma, and methods of detection utilizing these antigens and antibodies. Antigenically and genetically, the mycoplasma is distinct from all other known mycoplasmas. The invention further relates to the DNA sequence of the novel mycoplasma and vaccines against the mycoplasma infection.
摘要翻译：本发明涉及从艾滋病患者的尿中分离的新型支原体。支原体具有独特的形态和病理特性。本发明还涉及新型支原体的抗原和抗体，以及利用这些抗原和抗体的检测方法。抗原和遗传上的支原体与所有其他已知的支原体不同。本发明还涉及新型支原体的DNA序列和针对支原体感染的疫苗。

2. 发明授权

US5534413A Adherent and invasive mycoplasma 失效
标题翻译：附着和侵袭性支原体
公开(公告)号：US5534413A
公开(公告)日：1996-07-09
申请号：US57168
申请日：1993-05-04
申请人： Shyh-Ching Lo , Richard Y. Wang , Michael M. Hayes
发明人： Shyh-Ching Lo , Richard Y. Wang , Michael M. Hayes
IPC分类号： A61K39/00 , A61K39/02 , A61K39/12 , C07K14/30 , C12N7/00 , G01N33/569 , C12Q1/04 , C07K16/12
CPC分类号： C12N7/00 , A61K39/0241 , C07K14/30 , C12R1/35 , G01N33/56933 , G01N33/56988 , A61K39/00 , C12N2740/16011 , Y10S435/87 , Y10S435/974 , Y10S435/975
摘要： The present invention relates to a novel mycoplasma isolated from the urine of patients with AIDS. The mycoplasma has unique morphological and pathobiological properties. The invention also relates to the antigens and antibodies of the novel mycoplasma, and methods of detection utilizing these antigens and antibodies. Antigenically and genetically, the mycoplasma is distinct from all other known mycoplasmas.
摘要翻译：本发明涉及从艾滋病患者的尿中分离的新型支原体。支原体具有独特的形态和病理特性。本发明还涉及新型支原体的抗原和抗体，以及利用这些抗原和抗体的检测方法。抗原和遗传上的支原体与所有其他已知的支原体不同。

3. 发明授权

US5532134A Mycoplasma diagnostic assay 失效
标题翻译：支原体诊断测定
公开(公告)号：US5532134A
公开(公告)日：1996-07-02
申请号：US981341
申请日：1992-11-25
申请人： Shyh-Ching Lo , James W. K. Shih , Richard Y.-H. Wang
发明人： Shyh-Ching Lo , James W. K. Shih , Richard Y.-H. Wang
IPC分类号： A61K39/00 , A61K39/02 , A61K39/12 , C07K14/30 , C12N7/00 , G01N33/569 , G01N33/53
CPC分类号： C07K14/30 , A61K39/0241 , C12N7/00 , C12R1/35 , G01N33/56933 , G01N33/56988 , A61K39/00 , C12N2740/16011 , Y10S435/87 , Y10S435/973
摘要： The present invention relates to a diagnostic assay utilizing the lipid associated membrane proteins of mycoplasmas to detect the presence of species-specific mycoplasma antibodies. The sensitive assay is useful for the detection and differentiation of mycoplasma antibodies specific for individual species in biological samples from humans and animals, and exhibits virtually no cross-reactivity between different mycoplasma species.
摘要翻译：本发明涉及利用支原体的脂质相关膜蛋白检测物种特异性支原体抗体的存在的诊断测定法。敏感测定法可用于检测和分化来自人和动物的生物样品中个体物种特异性的支原体抗体，并且在不同的支原体物种之间几乎不显示交叉反应性。

4. 发明授权

US5242820A Pathogenic mycoplasma 失效
标题翻译：致病性支原体
公开(公告)号：US5242820A
公开(公告)日：1993-09-07
申请号：US710361
申请日：1991-06-06
申请人： Shyh-Ching Lo
发明人： Shyh-Ching Lo
IPC分类号： A61K39/02 , A61K39/12 , C12N7/00 , G01N33/569
CPC分类号： G01N33/56988 , A61K39/0241 , C12N7/00 , C12N2710/16411 , C12N2740/16011 , Y10S435/872
摘要： The invention relates to a novel pathogenic mycoplasma isolated from patients with Acquired Immune Deficiency Syndrome (AIDS) and its use in detecting antibodies in sera of AIDS patients, patients with AIDS-related complex (ARC) or patients dying of diseases and symptoms resembling AIDS diseases. The invention further relates to specific DNA sequences, antibodies against the pathogenic mycoplasma, and their use in detecting DNA or antigens of the pathogenic mycoplasma or other genetically and serologically closely related mycoplasmas in infected tissue of patients with AIDS or ARC or patients dying of symptoms resembling AIDS diseases. The invention still further relates to a variety of different forms of vaccine against mycoplasma infection in humans and/or animals.
摘要翻译：本发明涉及从获得性免疫缺陷综合征（AIDS）患者中分离的新型致病性支原体及其用于检测艾滋病患者血清中的抗体，AIDS相关复合物（ARC）患者或患有类似于AIDS疾病的疾病和症状的患者。本发明还涉及特异性DNA序列，针对病原性支原体的抗体及其在检测AIDS或ARC患者的感染组织中病原性支原体或其他遗传和血清学密切相关的支原体的DNA或抗原的病毒或类似于艾滋病。本发明还涉及针对人和/或动物中针对支原体感染的多种不同形式的疫苗。

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