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1. 发明申请

US20170360829A1 TREATMENT OF VASCULAR ANOMALIES 审中-公开
公开(公告)号：US20170360829A1
公开(公告)日：2017-12-21
申请号：US15444033
申请日：2017-02-27
申请人： GILLIES MCINDOE RESEARCH INSTITUTE
发明人： Swee Thong Tan , Paul Frank Davis , Tinte Itinteang
IPC分类号： A61K33/06 , A61K45/00 , A61K31/59
CPC分类号： A61K33/06 , A61K31/59 , A61K45/00 , G01N33/6893 , G01N2410/02 , G01N2800/328
摘要： The present invention provides a novel approach to the diagnosis, treatment and management of vascular anomalies by providing compositions and methods for the identification and specific targeting of the embryonic stem cell populations associated with vascular anomalies, by modulation of the Renin-Angiotensin System expressed by the stem cells.

2. 发明授权

US09719141B2 Prognostic marker for cryoglobulinemic vasculitis and B cell malignancies in HCV infected patients 有权
公开(公告)号：US09719141B2
公开(公告)日：2017-08-01
申请号：US13581759
申请日：2011-02-28
申请人： Vincent Agnello
发明人： Vincent Agnello
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , G01N33/576 , G01N33/574 , G01N33/68 , C07K16/28
CPC分类号： C12Q1/6886 , C07K16/28 , G01N33/57426 , G01N33/5767 , G01N33/686 , G01N2800/328 , G01N2800/52
摘要： The invention provides methods and compositions for early diagnosis and treatment of a disease associated with a specific antibody by employing the detection of a cross-idiotypic epitope on the specific antibody to detect the cells that produce the antibody before the development of clinical symptoms of the disease.

3. 发明申请

US20160083801A1 Prognostic Marker For Cryoglobulinemic Vasculitis And B Cell Malignancies In HCV Infected Patients 审中-公开
公开(公告)号：US20160083801A1
公开(公告)日：2016-03-24
申请号：US14863220
申请日：2015-09-23
申请人： Vincent Agnello
发明人： Vincent Agnello
IPC分类号： C12Q1/68 , C07K16/28
CPC分类号： C12Q1/6886 , C07K16/28 , G01N33/57426 , G01N33/5767 , G01N33/686 , G01N2800/328 , G01N2800/52
摘要： The invention provides methods and compositions for early diagnosis and treatment of a disease associated with a specific antibody by employing the detection of a cross-idiotypic epitope on the specific antibody to detect the cells that produce the antibody before the development of clinical symptoms of the disease.

4. 发明授权

US08741584B2 Follistatin-like protein-1 as a biomarker for inflammatory disorders 有权
标题翻译：氟赖斯汀样蛋白-1作为炎症性疾病的生物标志物
公开(公告)号：US08741584B2
公开(公告)日：2014-06-03
申请号：US13758405
申请日：2013-02-04
申请人： University of Pittsburgh—of the Commonwealth System of Higher Education
发明人： Raphael Hirsch , David C. Wilson
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/564 , G01N2800/102 , G01N2800/328 , G01N2800/56
摘要： The present invention relates to methods and compositions for diagnosis of inflammatory disorders, and in non-limiting embodiments, of inflammatory disorders associated with elevated interleukin-1β (“IL-1β”), based on increased levels of follistatin-like protein 1 (“FSTL-1”). In particular non-limiting embodiments, the invention further provides for methods of identifying subjects with systemic onset juvenile idiopathic arthritis (“SOJIA”) who are at increased risk for developing macrophage activation syndrome (“MAS”) comprising detecting, in said subjects, hyper-increased levels of FSTL-1. In additional non-limiting embodiments, the invention provides for methods of identifying subjects with Kawasaki disease who are at increased risk of developing aortic aneurysms comprising detecting, in said subjects, hyper-increased levels of FSTL-1.
摘要翻译：本发明涉及用于诊断炎症性疾病的方法和组合物，并且在非限制性实施方案中涉及与白细胞介素-1升高相关的炎症性疾病。（“FSTL-1”）的增加水平（“IL-1＆bgr”）。特别是非限制性实施方案，本发明进一步提供了鉴定具有增加发生巨噬细胞活化综合征（“MAS”）风险的全身性发作青少年特发性关节炎（“SOJIA”）的受试者的方法，包括在所述受试者中检测超 - 增加FSTL-1的水平。在另外的非限制性实施方案中，本发明提供了鉴定具有发展主动脉瘤的风险增加的川崎病患者的方法，包括在所述受试者中检测FSTL-1的高增加水平。

5. 发明申请

US20110117573A1 CELL DIVISION MARKER 有权
标题翻译：细胞分类标记
公开(公告)号：US20110117573A1
公开(公告)日：2011-05-19
申请号：US12728627
申请日：2010-03-22
申请人： Stephen J. Doxsey , Chun-Ting Chen
发明人： Stephen J. Doxsey , Chun-Ting Chen
IPC分类号： G01N33/566 , C12Q1/04 , C12Q1/06 , C12N9/12
CPC分类号： G01N33/57492 , C07K14/705 , G01N33/564 , G01N33/56966 , G01N33/57484 , G01N2800/085 , G01N2800/12 , G01N2800/20 , G01N2800/323 , G01N2800/328 , G01N2800/342 , G01N2800/347 , G01N2800/36 , G01N2800/364
摘要： This application relates to a newly identified animal cell structure, the midbody scar. This structure is a remnant of the midbody that is retained by one daughter cell following cytokinesis and persists through multiple subsequent cell cycles. The midbody scar can be useful as a marker of dividing cells or of a cell's replicative age.
摘要翻译：本申请涉及一种新鉴定的动物细胞结构，即中部瘢痕。这种结构是中间体的遗留物，其由一个子细胞在细胞分裂之后保留，并通过多个随后的细胞周期持续存在。中间体瘢痕可用作分裂细胞或细胞复制年龄的标记物。

6. 发明申请

US20100304424A1 DIAGNOSTIC AND THERAPEUTIC TOOLS FOR DISEASES ALTERING VASCULAR FUNCTION 有权
标题翻译：用于改变血管功能的疾病的诊断和治疗工具
公开(公告)号：US20100304424A1
公开(公告)日：2010-12-02
申请号：US12734876
申请日：2008-12-01
申请人： Hans Vink , Erik Sjoerd Gerard Stroes
发明人： Hans Vink , Erik Sjoerd Gerard Stroes
IPC分类号： C12Q1/02
CPC分类号： G01N33/6893 , G01N2333/525 , G01N2400/50 , G01N2800/32 , G01N2800/323 , G01N2800/328
摘要： The invention relates to diagnostic and therapeutic tools and applications, particularly useful in diseases that affect vascular health and in inflammatory diseases. In particular, said diagnostic and therapeutic tools employ suitable detection or modulation of endothelial glycocalyx.
摘要翻译：本发明涉及诊断和治疗工具和应用，特别适用于影响血管健康和炎性疾病的疾病。特别地，所述诊断和治疗工具使用合适的内皮糖萼的检测或调节。

7. 发明申请

US20100267615A1 METHODS FOR TREATMENT AND/OR PREVENTION OF A DISEASE ASSOCIATED WITH VASCULAR LEAK 审中-公开
标题翻译：治疗和/或预防与血管通透相关的疾病的方法
公开(公告)号：US20100267615A1
公开(公告)日：2010-10-21
申请号：US12793388
申请日：2010-06-03
申请人： Peter Petzelbauer , Rainer Henning , Sonja Reingruber , Waltraud Pasteiner , Marion Gröger
发明人： Peter Petzelbauer , Rainer Henning , Sonja Reingruber , Waltraud Pasteiner , Marion Gröger
IPC分类号： A61K38/16 , A61P5/00 , A61P11/06 , A61P35/00 , A61P27/06 , A61P27/02 , A61P3/10
CPC分类号： G01N33/5064 , G01N33/5088 , G01N2400/50 , G01N2800/328
摘要： The present invention is directed to methods for treatment and/or prevention of a disease associated with vascular leak in a patient comprising administering to the patient an effective amount of SEQ ID NO: 1.
摘要翻译：本发明涉及用于治疗和/或预防与患者血管渗漏相关的疾病的方法，其包括向患者施用有效量的SEQ ID NO：1。

8. 发明授权

US07070939B2 Methods for detecting vasculopathies and tumors 失效
公开(公告)号：US07070939B2
公开(公告)日：2006-07-04
申请号：US10130085
申请日：2001-09-26
申请人： Anthony Montgomery , Paul Demarco , Fang Mei
发明人： Anthony Montgomery , Paul Demarco , Fang Mei
IPC分类号： G01N33/53 , C12Q1/68 , C07K14/00 , C07K16/00
CPC分类号： G01N33/6893 , A61K49/0004 , C07B2200/07 , C07C29/03 , C07C29/48 , C07K14/70503 , C12Q1/6883 , G01N33/57423 , G01N33/5743 , G01N2333/70503 , G01N2800/328 , C07C33/26
摘要： This invention relates generally to the field of prognosis and diagnosis of vasculopathy and certain tumors. In particular, the invention provides a method for prognosing or diagnosing vasculopathy, neuroectodermal tumor, epithelial tumor, myelomonocytic tumor or lymphoid tumor in a mammal, which method comprises: a) assessing a NCAM L1 protein or a derivative or fragment thereof, or a mRNA encoding said NCAM L1 protein or a derivative or fragment thereof, in a mammal having or suspected of having vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor; b) assessing a NCAM L1 protein or a derivative or fragment thereof, or a mRNA encoding said NCAM L1 protein or a derivative or fragment thereof, in a mammal not having said vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor; c) comparing the presence or quantity of said NCAM L1 protein or mRNA assessed in steps a) and b), whereby said NCAM L1 protein or mRNA assessed in step a) is more than that assessed in step b) indicates the presence of said vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor in said mammal. The method can also be used for monitoring the effectiveness of the treatment of the vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor.

9. 发明申请

US20170052200A1 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF KAWASAKI DISEASE 审中-公开
标题翻译：川崎病诊断和治疗方法及组合
公开(公告)号：US20170052200A1
公开(公告)日：2017-02-23
申请号：US15308114
申请日：2015-05-01
申请人： Momenta Pharmaceuticals, Inc.
发明人： Dorota A. BULIK , Jay DUFFNER , Leona E. LING , Hetal SARVAIYA , Carlos J. BOSQUES
IPC分类号： G01N33/68 , A61K39/395 , A61K31/727
CPC分类号： G01N33/6893 , A61K31/727 , A61K38/1774 , A61K39/395 , G01N2800/328 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to the determination of levels or expression of particular biomarkers in biological samples which can be utilized to diagnose, prognose, and treat Kawasaki disease in subjects, and further to select subjects who would benefit from a Kawasaki disease therapy other than, or in addition to, IVIG treatment. Accordingly, the present invention encompasses methods and compositions that utilize these biomarkers for the diagnosis, prognosis, and treatment of Kawasaki disease.
摘要翻译：本发明涉及可用于诊断，预测和治疗受试者中川崎病的生物样品中特定生物标志物的水平或表达的确定，并进一步选择将受益于川崎病治疗以外的受试者，或除了IVIG治疗。因此，本发明包括利用这些生物标志物来诊断，预后和治疗川崎病的方法和组合物。

10. 发明申请

US20130310273A1 Methods and Means for Diagnosing Vasculitis 有权
标题翻译：诊断血管炎的方法和手段
公开(公告)号：US20130310273A1
公开(公告)日：2013-11-21
申请号：US13981956
申请日：2012-01-27
申请人： Torsten Witte , Niklas Thomas Baerlecken
发明人： Torsten Witte , Niklas Thomas Baerlecken
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61K39/0008 , C07K16/44 , G01N33/564 , G01N2800/101 , G01N2800/328 , G01N2800/50 , G01N2800/52
摘要： The present inventions relates generally to methods for diagnosing the presence or the risk of development or the therapy control of vasculitis, in particular, of large vessel vasculitis, like giant-cell arteritis (GCA), polymyalgia rheumatica (PMR) and Takayasu's arteritis in a subject, in particular, in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject analyzing for the presence of antibodies against ferritin, in particular heavy chain ferritin or immunoreactive peptides thereof or ferritin analog protein, preferably bacterial ferritin analog protein, or immunoreactive peptides thereof, in a subject. The presence of antibodies against ferritin or immunoreactive peptides thereof is indicative for the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis. In particular, detection of the presence of antibodies against ferritin or immunoreactive peptides thereof, allows early diagnosis of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis.
摘要翻译：本发明一般涉及用于诊断血管炎的存在或风险或治疗控制的方法，特别是大血管血管炎，如巨细胞动脉炎（GCA），风湿综合征（PMR）和Takayasu的动脉炎主题，特别是哺乳动物。此外，本发明涉及用于诊断存在或发展风险的检测试剂盒，或用于在受试者中诊断血管炎，特别是大血管血管炎（如GCA，PMR和Takayasu的动脉炎）的治疗控制。特别地，本发明涉及用于诊断存在或风险的方法，或用于治疗血管炎，特别是大血管血管炎，如GCA，PMR和Takayasu的动脉炎的治疗控制方法，抗体，特别是重链铁蛋白或其免疫反应性肽或铁蛋白类似蛋白，优选细菌铁蛋白类似物蛋白或其免疫反应性肽。针对铁蛋白或其免疫反应性肽的抗体的存在指示存在或发展的风险，或用于治疗血管炎，特别是大血管血管炎如GCA，PMR和Takayasu的动脉炎的治疗控制。特别地，检测抗铁蛋白或其免疫反应性肽的抗体的存在允许血管炎，特别是大血管血管炎如GCA，PMR和Takayasu的动脉炎的早期诊断。

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