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1. 发明授权

US07070939B2 Methods for detecting vasculopathies and tumors 失效
公开(公告)号：US07070939B2
公开(公告)日：2006-07-04
申请号：US10130085
申请日：2001-09-26
申请人： Anthony Montgomery , Paul Demarco , Fang Mei
发明人： Anthony Montgomery , Paul Demarco , Fang Mei
IPC分类号： G01N33/53 , C12Q1/68 , C07K14/00 , C07K16/00
CPC分类号： G01N33/6893 , A61K49/0004 , C07B2200/07 , C07C29/03 , C07C29/48 , C07K14/70503 , C12Q1/6883 , G01N33/57423 , G01N33/5743 , G01N2333/70503 , G01N2800/328 , C07C33/26
摘要： This invention relates generally to the field of prognosis and diagnosis of vasculopathy and certain tumors. In particular, the invention provides a method for prognosing or diagnosing vasculopathy, neuroectodermal tumor, epithelial tumor, myelomonocytic tumor or lymphoid tumor in a mammal, which method comprises: a) assessing a NCAM L1 protein or a derivative or fragment thereof, or a mRNA encoding said NCAM L1 protein or a derivative or fragment thereof, in a mammal having or suspected of having vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor; b) assessing a NCAM L1 protein or a derivative or fragment thereof, or a mRNA encoding said NCAM L1 protein or a derivative or fragment thereof, in a mammal not having said vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor; c) comparing the presence or quantity of said NCAM L1 protein or mRNA assessed in steps a) and b), whereby said NCAM L1 protein or mRNA assessed in step a) is more than that assessed in step b) indicates the presence of said vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor in said mammal. The method can also be used for monitoring the effectiveness of the treatment of the vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor.

2. 发明申请

US20060211038A1 Methods for detecting vasculopathies and tumors 审中-公开
标题翻译：检测血管病变和肿瘤的方法
公开(公告)号：US20060211038A1
公开(公告)日：2006-09-21
申请号：US11438821
申请日：2006-05-23
申请人： Anthony Montgomery , Paul Demarco , Fang Mei
发明人： Anthony Montgomery , Paul Demarco , Fang Mei
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/6893 , A61K49/0004 , C07B2200/07 , C07C29/03 , C07C29/48 , C07K14/70503 , C12Q1/6883 , G01N33/57423 , G01N33/5743 , G01N2333/70503 , G01N2800/328 , C07C33/26
摘要： This invention relates generally to the field of prognosis and diagnosis of vasculopathy and certain tumors. In particular, the invention provides a method for prognosing or diagnosing vasculopathy, neuroectodermal tumor, epithelial tumor, myelomonocytic tumor or lymphoid tumor in a mammal. The invention can also be used for monitoring the effectiveness of the treatment of the vasculopathy, neuroectodermal tumor, epithelial tumor, lymphoid tumor or myelomonocytic tumor.
摘要翻译：本发明一般涉及血管病变和某些肿瘤的预后和诊断领域。特别地，本发明提供了哺乳动物中预测或诊断血管病变，神经外胚层肿瘤，上皮肿瘤，骨髓单核细胞肿瘤或淋巴样肿瘤的方法。本发明还可用于监测血管病变，神经外胚层肿瘤，上皮肿瘤，淋巴样肿瘤或骨髓单核细胞肿瘤的治疗效果。

3. 发明申请

US20070266315A1 System and method for creating and presenting mathematical documents 有权
标题翻译：用于创建和呈现数学文件的系统和方法
公开(公告)号：US20070266315A1
公开(公告)日：2007-11-15
申请号：US11434609
申请日：2006-05-15
申请人： Laurent Bernardin , Paul Demarco , Kevin Ellis , David Hare
发明人： Laurent Bernardin , Paul Demarco , Kevin Ellis , David Hare
IPC分类号： G06F15/00
CPC分类号： G06F17/215
摘要： A system and method of creating and presenting mathematical documents are provided. The system comprises an input/output component for receiving user input and for displaying a mathematical document on a display device, a document repository 104 for storing the mathematical document and a mathematical engine for performing computations. The document includes markup that specifies display options. The method comprises the steps of receiving input data that represent characters, symbols and mathematical operations as well as manipulations and presentation control of the mathematical document, displaying mathematical expressions or a combination of mathematical expressions and text in an electronic document, performing computations on the mathematical expressions contained in the document, and controlling the formatting and display of the document.
摘要翻译：提供了一种创建和呈现数学文件的系统和方法。该系统包括用于接收用户输入并用于在显示设备上显示数学文档的输入/输出组件，用于存储数学文档的文档库104和用于执行计算的数学引擎。文档包括指定显示选项的标记。该方法包括以下步骤：接收表示字符，符号和数学运算的输入数据，以及数学文件的操作和呈现控制，在电子文档中显示数学表达式或数学表达式和文本的组合，对数学运算进行计算文档中包含的表达式，以及控制文档的格式和显示。

4. 发明授权

US07865826B2 System and method for creating and presenting mathematical documents 有权
标题翻译：用于创建和呈现数学文件的系统和方法
公开(公告)号：US07865826B2
公开(公告)日：2011-01-04
申请号：US11434609
申请日：2006-05-15
申请人： Laurent Bernardin , Paul Demarco , Kevin Ellis , David E. G. Hare
发明人： Laurent Bernardin , Paul Demarco , Kevin Ellis , David E. G. Hare
IPC分类号： G06F17/00
CPC分类号： G06F17/215
摘要： A system and method of creating and presenting mathematical documents are provided. The system comprises an input/output component for receiving user input and for displaying a mathematical document on a display device, a document repository 104 for storing the mathematical document and a mathematical engine for performing computations. The document includes markup that specifies display options. The method comprises the steps of receiving input data that represent characters, symbols and mathematical operations as well as manipulations and presentation control of the mathematical document, displaying mathematical expressions or a combination of mathematical expressions and text in an electronic document, performing computations on the mathematical expressions contained in the document, and controlling the formatting and display of the document.
摘要翻译：提供了一种创建和呈现数学文件的系统和方法。该系统包括用于接收用户输入并用于在显示设备上显示数学文档的输入/输出组件，用于存储数学文档的文档库104和用于执行计算的数学引擎。文档包括指定显示选项的标记。该方法包括以下步骤：接收表示字符，符号和数学运算的输入数据，以及数学文件的操作和呈现控制，在电子文档中显示数学表达或数学表达式和文本的组合，对数学运算进行计算文档中包含的表达式，以及控制文档的格式和显示。

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