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1. 发明申请

US20170306315A1 METHOD FOR RECOMBINANT PRODUCTION OF HORSESHOE CRAB FACTOR C PROTEIN IN PROTOZOA 审中-公开
公开(公告)号：US20170306315A1
公开(公告)日：2017-10-26
申请号：US15635301
申请日：2017-06-28
申请人： HYGLOS INVEST GMBH
发明人： Bernd BUCHBERGER , Holger GRALLERT , Sonja MOLINARO
IPC分类号： C12N9/64 , G01N33/579
CPC分类号： C12N9/6424 , C12N9/6408 , C12N2800/10 , C12N2800/22 , C12Y304/21084 , G01N33/579
摘要： The present invention provides a novel method for the recombinant production of Factor C protein from horseshoe crab using a parasitic protozoan expressing the Factor C protein. In particular, the present invention provides a parasitic protozoan host cell harbouring a polynucleotide encoding horseshoe crab Factor C protein, and a method for producing Factor C protein comprising culturing said parasitic protozoan host cell under conditions such that the cells express the horseshoe crab Factor C protein. Furthermore, the present invention provides recombinant Factor C protein produced by the novel method and its use in the detection and/or removal of endotoxin.

2. 发明申请

US20150238577A1 Chimeric Polypeptides and Their Use in Bacterial Decolonization 有权
标题翻译：嵌合多肽及其在细菌非殖民化中的应用
公开(公告)号：US20150238577A1
公开(公告)日：2015-08-27
申请号：US14709118
申请日：2015-05-11
申请人： HYGLOS INVEST GMBH
发明人： Holger Grallert , Sonja Molinaro
IPC分类号： A61K38/48 , C07K14/195 , C12N9/50
CPC分类号： A61K38/4886 , C07K14/195 , C07K2319/33 , C12N9/2462 , C12N9/503 , C12N9/52 , C12Y304/24075
摘要： The present invention relates to chimeric polypeptides comprising a first portion, which comprises a bacteriocin cell wall-binding domain (CBD) and a second portion, which comprises an enzymatic active domain (EAD) selected from the lytic domain of a bacteriophage lysin, a bacteriocin and a bacterial autolysin. Provided are such chimeric polypeptides and variants and fragments thereof, nucleic acids encoding the same, vectors carrying such nucleic acids and host cells transformed or transfected with such vectors. The chimeric polypeptides of the present invention are useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial infections. For example, chimeric polypeptides of the present invention have been shown to effectively kill various bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), as well as other human pathogens. Thus, provided are compositions comprising chimeric polypeptides according to the present invention, variants or fragments thereof, and the use of such compositions in prophylaxis or therapy of bacterial diseases, bacterial infections or bacterial colonisations.
摘要翻译：本发明涉及包含第一部分的嵌合多肽，第一部分包含细菌细胞壁结合结构域（CBD）和第二部分，其包含选自噬菌体溶素裂解结构域的酶活性结构域（EAD），细菌素和细菌自溶素。提供这样的嵌合多肽及其变体和片段，编码它们的核酸，携带这种核酸的载体和用这些载体转化或转染的宿主细胞。本发明的嵌合多肽可用于减少某些细菌群体，包括用于治疗各种细菌感染的方法和组合物。例如，本发明的嵌合多肽已显示有效地杀死包括耐甲氧西林金黄色葡萄球菌（MRSA）在内的各种细菌，以及其它人类病原体。因此，提供了包含根据本发明的嵌合多肽，其变体或片段，以及这些组合物在预防或治疗细菌性疾病，细菌感染或细菌结肠中的用途的组合物。

3. 发明授权

US10697958B2 Unmasking endotoxins in solution 有权
公开(公告)号：US10697958B2
公开(公告)日：2020-06-30
申请号：US15318086
申请日：2015-06-12
申请人： HYGLOS INVEST GMBH
发明人： Johannes Reich , Holger Grallert
IPC分类号： G01N33/53 , G01N33/92 , G01N33/50
摘要： The invention relates to unmasking endotoxins in compositions so that previously present, but undetectable endotoxins are rendered detectable.

4. 发明授权

US09018155B2 Proteins for use in human and animal staphylococcus infections 有权
标题翻译：用于人和动物葡萄球菌感染的蛋白质
公开(公告)号：US09018155B2
公开(公告)日：2015-04-28
申请号：US14022152
申请日：2013-09-09
申请人： Hyglos Invest GmbH
发明人： Michael Forchheim , Holger Grallert , Anja Philipp , Manfred Biebl
IPC分类号： C07K14/00 , C12N9/24 , C12N9/50 , C12N9/80
CPC分类号： C12N9/2402 , C07K2319/035 , C07K2319/20 , C12N9/50 , C12N9/80
摘要： The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.
摘要翻译：本发明涉及包含如SEQ ID NO：1所示的序列以及该多肽的变体的称为ply_pitti26的多肽。此外，本发明涉及编码所述多肽及其变体的核酸和载体以及包含这些核酸和/或载体的宿主细胞。最后，本发明涉及所述多肽，其变体，核酸序列，载体和宿主细胞的用途，特别是用于治疗或预防感染或暴露于葡萄球菌的受试者。

5. 发明申请

US20140377775A1 METHOD FOR DETECTING AND REMOVING ENDOTOXIN 审中-公开
标题翻译：检测和去除内毒素的方法
公开(公告)号：US20140377775A1
公开(公告)日：2014-12-25
申请号：US14445327
申请日：2014-07-29
申请人： Hyglos Invest GmbH
发明人： Stefan MILLER , Roman MEYER , Renate GRASSL , Manfred BIEBL , Holger GRALLERT
IPC分类号： G01N33/566 , C12N7/00 , C07K14/005
CPC分类号： G01N33/566 , B01D15/08 , C07K1/13 , C07K1/22 , C07K14/005 , C12N7/00 , C12N2795/00022 , C12N2795/00031 , G01N30/00 , G01N33/56911 , G01N33/92 , G01N2333/005 , G01N2400/50
摘要： The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
摘要翻译：本发明涉及在没有二价阳离子，特别是Ca 2+或Mg 2+的情况下能够结合内毒素的噬菌体尾蛋白及其衍生物和片段。此外，本发明涉及使用根据本发明的噬菌体尾蛋白从溶液和样品中消耗内毒素的方法以及内毒素的检测方法。

6. 发明申请

US20210018495A1 UNMASKING ENDOTOXINS IN SOLUTION 有权
公开(公告)号：US20210018495A1
公开(公告)日：2021-01-21
申请号：US16948687
申请日：2020-09-29
申请人： HYGLOS INVEST GMBH
发明人： Johannes REICH , Holger GRALLERT
IPC分类号： G01N33/53 , G01N33/50 , G01N33/92
摘要： The invention relates to unmasking endotoxins in compositions so that previously present, but undetectable endotoxins are rendered detectable.

7. 发明授权

US10585086B2 Unmasking endotoxins in solution 有权
公开(公告)号：US10585086B2
公开(公告)日：2020-03-10
申请号：US15316884
申请日：2015-06-12
申请人： HYGLOS INVEST GMBH
发明人： Bernd Buchberger
IPC分类号： G01N33/52 , G01N33/15 , G01N33/569
摘要： The invention relates to unmasking endotoxins in compositions so that previously present, but undetectable endotoxins are rendered detectable.

8. 发明授权

US10323238B2 Method for recombinant production of horseshoe crab factor C protein in protozoa 有权
公开(公告)号：US10323238B2
公开(公告)日：2019-06-18
申请号：US15635301
申请日：2017-06-28
申请人： HYGLOS INVEST GMBH
发明人： Bernd Buchberger , Holger Grallert , Sonja Molinaro
IPC分类号： C12N9/64 , G01N33/579
摘要： The present invention provides a novel method for the recombinant production of Factor C protein from horseshoe crab using a parasitic protozoan expressing the Factor C protein. In particular, the present invention provides a parasitic protozoan host cell harbouring a polynucleotide encoding horseshoe crab Factor C protein, and a method for producing Factor C protein comprising culturing said parasitic protozoan host cell under conditions such that the cells express the horseshoe crab Factor C protein. Furthermore, the present invention provides recombinant Factor C protein produced by the novel method and its use in the detection and/or removal of endotoxin.

9. 发明申请

US20140065104A1 PROTEINS FOR USE IN HUMAN AND ANIMAL STAPHYLOCOCCUS INFECTIONS 审中-公开
标题翻译：用于人类和动物斑马鱼感染的蛋白质
公开(公告)号：US20140065104A1
公开(公告)日：2014-03-06
申请号：US14022152
申请日：2013-09-09
申请人： Hyglos Invest GmbH
发明人： Michael FORCHHEIM , Holger GRALLERT , Anja PHILIPP , Manfred BIEBL
IPC分类号： C12N9/24
CPC分类号： C12N9/2402 , C07K2319/035 , C07K2319/20 , C12N9/50 , C12N9/80
摘要： The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.
摘要翻译：本发明涉及包含如SEQ ID NO：1所示的序列以及该多肽的变体的称为ply_pitti26的多肽。此外，本发明涉及编码所述多肽及其变体的核酸和载体以及包含这些核酸和/或载体的宿主细胞。最后，本发明涉及所述多肽，其变体，核酸序列，载体和宿主细胞的用途，特别是用于治疗或预防感染或暴露于葡萄球菌的受试者。

10. 发明申请

US20130183689A1 METHOD FOR DETECTING AND REMOVING ENDOTOXIN 有权
标题翻译：检测和去除内毒素的方法
公开(公告)号：US20130183689A1
公开(公告)日：2013-07-18
申请号：US13683999
申请日：2012-11-21
申请人： HYGLOS INVEST GMBH
发明人： Stefan MILLER , Roman MEYER , Renate GRASSL , Manfred BIEBL , Holger GRALLERT
IPC分类号： G01N33/92 , C07K14/005
CPC分类号： G01N33/566 , B01D15/08 , C07K1/13 , C07K1/22 , C07K14/005 , C12N7/00 , C12N2795/00022 , C12N2795/00031 , G01N30/00 , G01N33/56911 , G01N33/92 , G01N2333/005 , G01N2400/50
摘要： The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
摘要翻译：本发明涉及在没有二价阳离子，特别是Ca 2+或Mg 2+的情况下能够结合内毒素的噬菌体尾蛋白及其衍生物和片段。此外，本发明涉及使用根据本发明的噬菌体尾蛋白从溶液和样品中消耗内毒素的方法以及内毒素的检测方法。

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