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1. 发明申请

US20180038871A1 DIAGNOSTIC BIOMARKER TO IDENTIFY WOMEN AT RISK FOR PRETERM DELIVERY 审中-公开
公开(公告)号：US20180038871A1
公开(公告)日：2018-02-08
申请号：US15683487
申请日：2017-08-22
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： Ozlem EQUILS , Charles F. SIMMONS, JR.
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N33/6869 , G01N2333/54 , G01N2333/5428 , G01N2333/5437 , G01N2333/545 , G01N2800/368
摘要： The invention relates to biomarkers associated with preterm delivery. More specifically, the invention provides methods of measuring biomarkers found in women that are at risk for preterm delivery.

2. 发明申请

US20180031570A1 Method for Assessing Protein Identity and Stability 审中-公开
公开(公告)号：US20180031570A1
公开(公告)日：2018-02-01
申请号：US15783883
申请日：2017-10-13
申请人： ARMO BioSciences, Inc.
发明人： John Brian Mumm , Peter Van Vlasselaer
IPC分类号： G01N33/68 , G01N30/88 , G01N27/447
CPC分类号： G01N33/6869 , G01N27/447 , G01N33/6848 , G01N33/6851 , G01N2030/8831 , G01N2333/5428 , G01N2496/00 , G01N2560/00
摘要： The present invention relates to methods and other technologies that may be used to determine whether compositions (e.g., pharmaceutical compositions) comprising interleukin-10 molecules (e.g., pegylated interleukin-10) meet particular product-related specifications prior to being administered to a subject for the treatment and/or prevention of the diseases, disorders and conditions, and/or the symptoms thereof, described herein.

3. 发明申请

US20170131291A1 METHODS AND DEVICES FOR DIAGNOSING OCULAR SURFACE INFLAMMATION AND DRY EYE DISEASE 审中-公开
公开(公告)号：US20170131291A1
公开(公告)日：2017-05-11
申请号：US15285842
申请日：2016-10-05
申请人： Seinda Biomedical Corporation
发明人： Jing-Feng HUANG
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N33/6863 , G01N33/6893 , G01N2333/535 , G01N2333/5403 , G01N2333/5406 , G01N2333/5428 , G01N2800/16 , G01N2800/24 , G01N2800/245 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to the diagnosis, monitoring, and/or treatment of medical conditions and/or a predisposition thereto. The condition preferably is dry eye disease. Described herein are methods, kits, and devices for diagnosing and monitoring dry eye disease in a subject.

4. 发明授权

US09606117B2 Bioassay for the early detection of autoimmune diseases 有权
公开(公告)号：US09606117B2
公开(公告)日：2017-03-28
申请号：US13324963
申请日：2011-12-13
申请人： Sarah Hamm-Alvarez
发明人： Sarah Hamm-Alvarez
IPC分类号： G01N33/53 , G01N33/564 , A61K38/13 , A61K31/4178 , A61K31/46 , A61K31/56
CPC分类号： G01N33/564 , A61K31/4178 , A61K31/46 , A61K31/56 , A61K38/13 , G01N2333/525 , G01N2333/5428 , G01N2333/5443 , G01N2800/24
摘要： Provided are methods for aiding in diagnosing autoimmune diseases in a mammal, comprising contacting a biological sample that is not a tear sample from the mammal with an antibody that specifically binds to a first polypeptide selected from the group Ctss, Ctsh, Ctsr, Ctsw, Ctsz, Ifng, IL-6ra, IL-10, IL-10ra, IL-15, Tnfa, Apo-F, or Lcn-2 or a second polypeptide selected from the group lactoperoxidase, lactoferrin or lysozyme under conditions favoring the formation of an antibody-polypeptide complex, and determining the amount of complex formed, wherein an increased formation of antibody-first-polypeptide complex or a decreased formation of antibody-second-polypeptide complex as compared to a suitable control, indicates a likely positive diagnosis of an autoimmune disease for the mammal, thereby aiding in the diagnosis. Methods of treating the autoimmune diseases are also provided.

5. 发明申请

US20160375101A1 Methods of Using Interleukin-10 for Treating Diseases and Disorders 审中-公开
标题翻译：使用白细胞介素-10治疗疾病和疾病的方法
公开(公告)号：US20160375101A1
公开(公告)日：2016-12-29
申请号：US15110925
申请日：2015-01-09
申请人： ARMO BIOSCIENCES, INC.
发明人： Martin Oft
IPC分类号： A61K38/20 , G01N33/50 , A61K47/48 , G01N33/92 , A61K9/00 , A61K45/06
CPC分类号： A61K38/2066 , A61K9/0019 , A61K45/06 , A61K47/60 , G01N33/5088 , G01N33/92 , G01N2333/5428 , G01N2800/32 , G01N2800/323 , G01N2800/325 , G01N2800/328 , G01N2800/52
摘要： Methods for determining dosing parameters associated with subcutaneous administration of IL-10 useful for the treatment and/or prevention of a cholesterol-related disease, disorder or condition, and pharmaceutical compositions associated therewith, are provided herein. Certain embodiments are directed to means for establishing a therapeutic range of an IL-10 agent in a subject. In some embodiments, particular parameters (e.g., hematological parameters) are monitored to provide an indication of the upper limit of the therapeutic range such that any untoward adverse effects are avoided.
摘要翻译：本文提供了用于确定与用于治疗和/或预防胆固醇相关疾病，病症或病症的IL-10相关的给药参数以及与其相关的药物组合物的方法。某些实施方案涉及在受试者中建立IL-10试剂的治疗范围的手段。在一些实施方案中，监测特定参数（例如血液学参数）以提供治疗范围的上限的指示，从而避免任何不利的副作用。

6. 发明申请

US20160231333A1 Biomarkers for Tuberculosis 审中-公开
公开(公告)号：US20160231333A1
公开(公告)日：2016-08-11
申请号：US15022041
申请日：2014-09-17
申请人： MEDICAL RESEARCH COUNCIL
发明人： Jayne Sutherland
IPC分类号： G01N33/68 , A61K45/06
CPC分类号： G01N33/6893 , A61K45/06 , C12Q1/6883 , G01N33/5695 , G01N33/6863 , G01N2333/485 , G01N2333/50 , G01N2333/5428 , G01N2333/5437 , G01N2333/5443 , G01N2333/545 , G01N2333/57 , G01N2800/26
摘要： In one aspect, provided herein is a method for detecting tuberculosis in a subject, comprising (a) determining a level of one or more host immune system biomarkers in a sputum sample obtained from the subject; and (b) comparing the levels of the biomarkers in the sputum sample to one or more reference values; wherein the levels of the biomarkers in the sputum sample compared to the reference values are indicative of the presence or absence of tuberculosis in the subject.

7. 发明申请

US20160143940A1 VEHICLE FOR DELIVERING A COMPOUND TO A MUCOUS MEMBRANE AND RELATED COMPOSITIONS, METHODS AND SYSTEMS 审中-公开
标题翻译：用于将化合物递送至疏密膜的车辆及相关组合物，方法和系统
公开(公告)号：US20160143940A1
公开(公告)日：2016-05-26
申请号：US14803598
申请日：2015-07-20
申请人： California Institute of Technology
发明人： Yue Shen , Sarkis K. Mazmanian
IPC分类号： A61K31/715 , C12N5/0783 , G01N33/50 , A61K9/10
CPC分类号： A61K31/715 , A23L33/10 , A61K9/0065 , A61K9/10 , A61K39/0216 , A61K47/6901 , A61K2039/542 , A61K2039/55555 , A61K2039/55583 , A61K2039/57 , A61K2039/58 , C08B37/006 , C12N5/0637 , G01N33/505 , G01N2333/5428
摘要： PSA is delivered to the host by outer membrane vesicles (OMVs), secretion structures that target bacterial molecules to host cells. Purified OMVs direct the in vitro differentiation of functional Tregs with potent suppressive activity in a PSA dependent manner. Treatment of animals with OMVs containing PSA prevents experimental colitis and suppresses pro-inflammatory cytokine responses in the gut, and indicate that compositions, medicaments, and methods useful for the treatment of inflammation, and more particularly, inflammatory bowel diseases.
摘要翻译： PSA通过外膜囊泡（OMV）被递送到宿主，靶细菌分子到宿主细胞的分泌结构。纯化的OMV以PSA依赖的方式指导具有强效抑制活性的功能性Treg的体外分化。用含有OMV的PSA治疗动物可防止实验性结肠炎并抑制肠道中的促炎细胞因子反应，并表明可用于治疗炎症的组合物，药物和方法，特别是炎性肠病。

8. 发明申请

US20160002726A1 METHODS OF MEASURING IL-6 EXPRESSION TO DETERMINE RISK OF CHRONIC ALLOGRAFT LUNG DYSFUNCTION 有权
标题翻译：测量IL-6表达以测定慢性肺损伤肺功能损害的方法
公开(公告)号：US20160002726A1
公开(公告)日：2016-01-07
申请号：US14769425
申请日：2014-02-20
申请人： UNIVERSITY HEALTH NETWORK
发明人： Shaf KESHAVJEE , Mingyao LIU , Marcelo CYPEL
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N33/6869 , G01N2333/4727 , G01N2333/5412 , G01N2333/5428 , G01N2800/245 , G01N2800/50
摘要： Methods for assaying a donor lung for chronic allograft lung dysfunction (CLAD) optionally bronchiolitis obliterans syndrome (BOS) subtype or restrictive allograft syndrome (RAS) subtype of CLAD or risk of developing BOS subtype or RAS subtype CLAD post-transplant, the method comprising: a. measuring a normalized expression level of an RNA transcript of IL-6 or an expression product thereof in a sample of the donor lung pre-transplant or a normalized expression level of one or more S100 protein, optionally S100A8 and/or S100A9, polypeptide expression product in a sample from the donor lung post-transplant; b. assessing the likelihood of the donor lung developing BOS subtype CLAD or RAS subtype CLAD post-transplant based on said IL-6, S100, optionally S100A8 and/or S100A9, expression level wherein IL-6 expression level is positively correlated with an increased likelihood of developing BOS post-transplant, S100A8 expression level is positively correlated with having or having an increased likelihood of developing RAS and/or BOS subtype CLAD, and S100A9 is positively correlated with having and having an increased likelihood of developing RAS subtype CLAD.
摘要翻译：用于测定供体肺用于慢性同种异体移植肺功能障碍（CLAD）的方法，任选的细支气管闭塞症综合征（BOS）亚型或CLAD的限制性同种异体移植综合征（RAS）亚型或发生移植后BOS亚型或RAS亚型CLAD的风险，所述方法包括：一个。测量供体肺移植前样品中IL-6或其表达产物的RNA转录物的标准化表达水平或一种或多种S100蛋白（任选S100A8和/或S100A9）多肽表达产物的标准化表达水平在供体肺移植后的样品中; b。基于所述IL-6，S100，任选的S100A8和/或S100A9，评估供体肺发展BOS亚型CLAD或RAS亚型CLAD的可能性，其中IL-6表达水平与增加的可能性呈正相关开发BOS移植后，S100A8表达水平与发展RAS和/或BOS亚型CLAD的可能性增加呈正相关，S100A9与具有增加的RAS亚型CLAD的可能性增加呈正相关。

9. 发明申请

US20150140581A1 MICROFLUIDIC DEVICE FOR GENERATING NEURAL CELLS TO SIMULATE POST-STROKE CONDITIONS 有权
标题翻译：用于产生神经细胞以模拟后冲击条件的微流体装置
公开(公告)号：US20150140581A1
公开(公告)日：2015-05-21
申请号：US14539544
申请日：2014-11-12
申请人： The Charles Stark Draper Laboratory, Inc. , The University of South Florida
发明人： Anilkumar Harapanahalli Achyuta , Javier Cuevas , Shivshankar Sundaram , Chris Katnik
IPC分类号： G01N33/50 , C12M1/34 , C12M1/42 , C12M3/06
CPC分类号： G01N33/5058 , C12M23/16 , C12M35/02 , C12M35/08 , C12M41/34 , G01N21/6486 , G01N33/5005 , G01N33/5023 , G01N33/5026 , G01N2333/525 , G01N2333/5428 , G01N2333/545 , G01N2500/10 , G01N2510/00
摘要： This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.
摘要翻译：该应用程序提供了用于建模缺血性卒中病症的装置。该装置可用于培养神经元，并将神经元的第一群体置于低氧条件下，将第二群神经元置于常氧条件下。神经元在多孔屏障上培养，并且在屏障的另一侧运行一个或多个流体填充的通道。通过流过具有不同氧水平的流体通过通道，可以将所需的氧浓度递送到最靠近这些通道的细胞。

10. 发明授权

US08748118B2 Urinary biomarkers for cancer diagnosis 失效
标题翻译：泌尿生物标志物用于癌症诊断
公开(公告)号：US08748118B2
公开(公告)日：2014-06-10
申请号：US13388613
申请日：2010-08-03
申请人： Irun R. Cohen , Meirav Pevsner-Fischer , David Margel , Jack Baniel , Ofer Yossepowitch
发明人： Irun R. Cohen , Meirav Pevsner-Fischer , David Margel , Jack Baniel , Ofer Yossepowitch
IPC分类号： G01N33/574 , G01N33/48
CPC分类号： G01N33/57407 , G01N33/57434 , G01N33/57488 , G01N2333/5428 , G01N2333/5437 , G01N2333/545
摘要： The present invention is directed to the field of cancer diagnosis, specifically to the diagnosis of bladder cancer (BC) and prostate cancer (CaP). More specifically, the invention provides simple, non-invasive urinary tests characterized by high sensitivity and specificity, wherein urinary levels of heat shock proteins and anti-inflammatory cytokines are used as biomarkers.
摘要翻译：本发明涉及癌症诊断领域，特别涉及膀胱癌（BC）和前列腺癌（CaP）的诊断。更具体地，本发明提供了以高灵敏度和特异性为特征的简单的非侵入性尿检，其中使用热休克蛋白和抗炎细胞因子的尿酸水平作为生物标志物。

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