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1. 发明公开

US20230167466A1 METHOD FOR PRODUCING ETHYLENE FROM CARBON DIOXIDE 审中-公开
公开(公告)号：US20230167466A1
公开(公告)日：2023-06-01
申请号：US17912903
申请日：2021-03-19
申请人： Oxy Low Carbon Ventures, LLC
发明人： Donald H. POWERS , Tahereh KARIMI , Robert L ZELLER, III , John PACE , Michael A. GARMON , Truong Huu NGUYEN
IPC分类号： C12P5/02 , C12M1/107 , C12M1/00 , C12N9/04 , C12N9/06 , C12N9/10
CPC分类号： C12P5/026 , C12M21/04 , C12M23/58 , C12M47/18 , C12N9/0006 , C12Y101/01042 , C12N9/0016 , C12Y104/01002 , C12N9/1066
摘要： A process comprising (i) providing a gaseous stream including greater than 1% by volume carbon dioxide; (ii) providing water; (iii) converting the carbon dioxide and the water to an organic intermediate and oxygen gas in the presence of light; (iv) separating the oxygen gas from the organic intermediate; and (v) converting the organic intermediate to ethylene and carbon dioxide after said step of separating the oxygen gas from the organic intermediate.

2. 发明申请

US20160017377A1 METHODS FOR REGULATING NITROGEN METABOLISM DURING THE PRODUCTION OF ETHANOL FROM CORN BY METABOLICALLY ENGINEERED YEAST STRAINS 审中-公开
标题翻译：通过代谢工程的YEAST菌株从玉米生产乙醇中调节氮代谢的方法
公开(公告)号：US20160017377A1
公开(公告)日：2016-01-21
申请号：US14771831
申请日：2014-03-13
申请人： LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC
发明人： Aaron Argyros , Trisha Barrett
IPC分类号： C12P7/06 , C12N9/00 , C12N9/50 , C12N9/02 , C12N9/04 , C12N9/34 , C12N9/06 , C12N9/10
CPC分类号： C12P7/06 , C12N9/0004 , C12N9/0006 , C12N9/0008 , C12N9/0016 , C12N9/1029 , C12N9/2428 , C12N9/50 , C12N9/93 , C12N15/52 , C12P7/10 , C12Y101/01001 , C12Y101/01002 , C12Y102/0101 , C12Y104/01002 , C12Y104/01004 , C12Y104/01014 , C12Y197/01004 , C12Y203/01054 , C12Y302/01003 , C12Y304/23041 , C12Y603/01002 , C12Y603/04006 , Y02E50/17
摘要： The present invention provides for a mechanism to reduce glycerol production and increase nitrogen utilization and ethanol production of recombinant microorganisms. One aspect of this invention relates to strains of S. cerevisiae with reduced glycerol productivity that get a kinetic benefit from higher nitrogen concentration without sacrificing ethanol yield. A second aspect of the invention relates to metabolic modifications resulting in altered transport and/or intracellular metabolism of nitrogen sources present in com mash.
摘要翻译：本发明提供减少甘油产生并增加重组微生物的氮利用和乙醇生产的机制。本发明的一个方面涉及具有降低的甘油生产力的酿酒酵母菌株，其从更高的氮浓度获得动力学益处而不牺牲乙醇产量。本发明的第二方面涉及导致存在于粉碎中的氮源的运输和/或细胞内代谢改变的代谢修饰。

3. 发明申请

US20070130643A1 METHOD OF PRODUCING TRANSGENIC PLANTS HAVING IMPROVED AMINO ACID COMPOSITION AND IMPROVED YIELDING 审中-公开
标题翻译：生产具有改进的氨基酸组成的转基因植物的方法和改进的接种
公开(公告)号：US20070130643A1
公开(公告)日：2007-06-07
申请号：US11626131
申请日：2007-01-23
申请人： Hiroaki KISAKA , Takao Kida
发明人： Hiroaki KISAKA , Takao Kida
IPC分类号： A01H5/00 , A01H1/00
CPC分类号： C12N9/0004 , C12N9/0016 , C12N9/93 , C12N15/8241 , C12N15/8251 , C12N15/8261 , C12Y104/01002 , C12Y104/01004 , Y02A40/146
摘要： The object of the present invention is to provide transgenic plants which accumulate free amino acids, particularly at least one amino acid selected from among glutamic acid, asparagine, aspartic acid, serine, threonine, alanine and histidine accumulated in a large amount, in the edible parts thereof, and a method of producing them are provided. The other object of the present invention is to provide a method of increasing the yielding of potato and to provide a transgenic potato of which yielding can be increased. In the present invention, a sequence encoding glutamate dehydrogenase (GDH) gene is introduced into a plant together with a suitable regulatory sequence to express it in a plant cell, and thereby the GDH gene is excessively expressed.
摘要翻译：本发明的目的是提供一种转基因植物，其在食用中积累游离氨基酸，特别是至少一种选自谷氨酸，天冬酰胺，天冬氨酸，丝氨酸，苏氨酸，丙氨酸和组氨酸中的至少一种氨基酸部分，以及它们的制造方法。本发明的另一个目的是提供一种增加马铃薯产量的方法，并且提供可以提高产量的转基因马铃薯。在本发明中，将编码谷氨酸脱氢酶（GDH）基因的序列与合适的调节序列一起导入植物，以在植物细胞中表达，从而过度表达GDH基因。

4. 发明公开

US20240376442A1 CHIMERIC ANTIGEN RECEPTOR POLYPEPTIDES IN COMBINATION WITH TRANS METABOLISM MOLECULES MODULATING KREBS CYCLE AND THERAPEUTIC USES THEREOF 审中-公开
公开(公告)号：US20240376442A1
公开(公告)日：2024-11-14
申请号：US18784028
申请日：2024-07-25
申请人： SOTIO BIOTECH INC.
发明人： Kathleen McGinness , Seth Ettenberg , Luke Barron , Michael Fray , Charles Wilson , Gregory Motz
IPC分类号： C12N9/04 , A61K35/17 , A61K48/00 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/30 , C12N9/06 , C12N9/10 , C12N9/80 , C12N9/88
CPC分类号： C12N9/0006 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/303 , C12N9/0016 , C12N9/1096 , C12N9/80 , C12N9/88 , C12Y101/01037 , C12Y101/01042 , C12Y104/01002 , C12Y206/01001 , C12Y206/01002 , C12Y206/01052 , C12Y305/01002 , C12Y401/01032 , A61K48/00 , C07K2319/02 , C07K2319/03
摘要： Disclosed herein are genetically engineered hematopoietic cells, which express one or more Krebs cycle modulating polypeptides, and optionally a chimeric receptor polypeptide (e.g., an antibody-coupled T cell receptor (ACTR) polypeptide or a chimeric antigen receptor (CAR) polypeptide) capable of binding to a target antigen of interest. Also disclosed herein are uses of the engineered hematopoietic cells for inhibiting cells expressing a target antigen in a subject in need thereof.

5. 发明授权

US10865391B2 Glutamate dehydrogenase mutants and their application in preparation of L-phosphinothricin 有权
公开(公告)号：US10865391B2
公开(公告)日：2020-12-15
申请号：US16476302
申请日：2018-09-12
申请人： ZHEJIANG UNIVERSITY
发明人： Lirong Yang , Xinjian Yin , Jianping Wu , Gang Xu
IPC分类号： C12N9/06 , C12P13/04
CPC分类号： C12N9/0016 , C12P13/04 , C12Y104/01002 , C12Y104/01003 , C12Y104/01004
摘要： The present invention relates to glutamate dehydrogenase mutants and their application in preparation of L-phosphinothricin. The amino acid sequences of the glutamate dehydrogenase mutants are as shown in SEQ ID NO. 1-9, 11, 13, 15, 17-19 and 22. By means of molecular engineering, mutating the specific alanine in glutamate dehydrogenase substrate-binding pocket into glycine and/or mutating the specific valine in glutamate dehydrogenase substrate-binding pocket into alanine, the present invention has obtained NADPH-specific glutamate dehydrogenase mutants with high enzyme activity in catalyzing the substrate 2-oxo-4-[(hydroxy)(methyl)phosphinoyl]butyric acid or its salt for L-phosphinothricin preparation or NADH-specific glutamate dehydrogenase mutants with catalytic activity toward PPO; this has significantly improved substrate conversion, and increased the product concentration of the L-phosphinothricin preparation process.

6. 发明申请

US20160299140A1 STABILIZATION OF GLUTAMATE DEHYDROGENASE IN AN AQUEOUS SOLUTION 审中-公开
标题翻译：谷氨酸脱氢酶在水溶液中的稳定性
公开(公告)号：US20160299140A1
公开(公告)日：2016-10-13
申请号：US15038554
申请日：2014-12-08
申请人： BIOMÉRIEUX
发明人： Florence BETTSWORTH , Jérôme MARTINEZ
IPC分类号： G01N33/573 , C12N9/96 , C12N9/06
CPC分类号： G01N33/573 , C12N9/0016 , C12N9/96 , C12Q1/04 , C12Q1/32 , C12Y104/01002 , G01N2333/33 , G01N2333/90616
摘要： A process for stabilizing glutamate dehydrogenase (GDH) from a bacterium of the Clostridium genus, in an aqueous solution, in order to maintain the antigenic properties thereof, includes the step of mixing the glutamate dehydrogenase and a stabilizing composition which is a carboxylic acid having a carbon-based chain of at least 3 carbon atoms and comprising at least 2 —COOH groups, or a salt thereof. GDH compositions thus stabilized and a method of detecting the presence of bacteria of the Clostridium genus are also disclosed.
摘要翻译：为了维持其抗原性质，在水溶液中稳定来自梭菌属细菌的谷氨酸脱氢酶（GDH）的方法包括混合谷氨酸脱氢酶和稳定组合物的步骤，该稳定组合物是具有至少3个碳原子的碳基链，并且包含至少2个-COOH基团，或其盐。还公开了如此稳定的GDH组合物和检测梭菌属细菌存在的方法。

7. 发明授权

US09187774B2 Compositions and methods for the production of L-homoalanine 有权
标题翻译：用于生产L-高丙氨酸的组合物和方法
公开(公告)号：US09187774B2
公开(公告)日：2015-11-17
申请号：US13581287
申请日：2011-02-25
申请人： James C. Liao , Kechun Zhang , Kwang Myung Cho
发明人： James C. Liao , Kechun Zhang , Kwang Myung Cho
IPC分类号： C12P13/04 , C12N9/06
CPC分类号： C12N9/0016 , C12P13/04 , C12P13/06 , C12Y104/01002 , Y02P20/52
摘要： Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral drug intermediates, an environmentally friendly solution that can be used to generate pharmaceuticals at much lower costs than conventional techniques. In this context, embodiments of the invention comprise methods and materials designed to allow microorganisms to biosynthesize the nonnatural amino acid L-homoalanine. As is known in the art, L-homoalanine is a chiral precursor of a variety of pharmaceutically valuable compounds including the anticonvulsant medications levetiracetam (sold under the trade name Keppra®) and brivaracetam, as well as ethambutol, a bacteriostatic antimycobacterial drug used to treat tuberculosis. Consequently, embodiments of the invention can be used in low cost, environmentally friendly processes to generate these and other valuable compounds.
摘要翻译：保健费用在世界范围内是重要的，许多患者由于价格高昂而被拒绝服用药物。解决这一问题的一种方法涉及手性药物中间体的生物合成，这是一种环境友好的解决方案，可以以比传统技术低得多的成本生产药物。在本文中，本发明的实施方案包括设计用于允许微生物生物合成非天然氨基酸L-高丙氨酸的方法和材料。如本领域已知的，L-高丙氨酸是各种药学上有价值的化合物的手性前体，包括抗惊厥药物左乙拉西坦（商品名为Keppra）和布立西坦（brivaracetam）），以及乙胺丁醇，用于治疗的抑菌抗分支杆菌药物结核。因此，本发明的实施方案可以用于低成本，环境友好的方法以产生这些和其它有价值的化合物。

8. 发明授权

US06558921B1 Promoters of the genes glutamate deshydrogenase, &bgr;-N-acetylhexosaminidase and &ggr;-actin and their use in filamentous fungi expression, secretion and antisense systems 失效
标题翻译：基因谷氨酸脱氢酶，β-N-乙酰氨基己糖苷酶和γ-肌动蛋白的启动子及其在丝状真菌表达，分泌和反义系统中的应用
公开(公告)号：US06558921B1
公开(公告)日：2003-05-06
申请号：US09631022
申请日：2000-08-02
申请人： Jose Luis Barredo Fuente , Marta Rodriguez Saiz , Alfonso J. Collados de la Vieja , Migeul Angel Moreno Valle , Francisco Salto Maldonado , Bruno Diez Garcia
发明人： Jose Luis Barredo Fuente , Marta Rodriguez Saiz , Alfonso J. Collados de la Vieja , Migeul Angel Moreno Valle , Francisco Salto Maldonado , Bruno Diez Garcia
IPC分类号： C12P102
CPC分类号： C12N15/1137 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C12N9/0016 , C12N9/2402 , C12N15/625 , C12N15/70 , C12N15/80 , C12Y104/01002 , C12Y302/01052
摘要： An isolated DNA having the promoter sequence of the hex gene of P. chrysogenum or a DNA fragment that is hybridizable to the complement of the promoter sequence under stringent conditions and is capable of directing expression of DNA downstream of the fragment in P. chrysogenum. Also a process for promoting expression of a coding sequence of interest in a microorganism using the isolated DNA and a process to block expression of a gene of interest in a microorganism using the isolated DNA are disclosed.
摘要翻译：一种分离的DNA，其具有产黄青霉六方基因的启动子序列或在严格条件下可与启动子序列的互补体杂交的DNA片段，并且能够引导产生产黄青霉的片段下游的DNA的表达。还公开了使用分离的DNA促进微生物中感兴趣的编码序列的表达的方法和使用分离的DNA阻断微生物中目的基因表达的过程。

9. 发明授权

US06300095B1 Promoters of the genes glutamate dehydrogenase &bgr;-N-acetylhexosaminidase and &ggr;-actin and their use in filamentous fungi expression, secretion and antisense systems 失效
标题翻译：基因谷氨酸脱氢酶β-N-乙酰氨基己糖苷酶和γ-肌动蛋白的启动子及其在丝状真菌表达，分泌和反义系统中的应用
公开(公告)号：US06300095B1
公开(公告)日：2001-10-09
申请号：US09171337
申请日：1999-05-14
申请人： Jose Luis Barredo Fuente , Marta Rodriguez Saiz , Alfonso J. Collados De La Vieja , Migeul Angel Moreno Valle , Francisco Salto Maldonado , Bruno Diez Garcia
发明人： Jose Luis Barredo Fuente , Marta Rodriguez Saiz , Alfonso J. Collados De La Vieja , Migeul Angel Moreno Valle , Francisco Salto Maldonado , Bruno Diez Garcia
IPC分类号： C07K14385
CPC分类号： C12N15/1137 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C12N9/0016 , C12N9/2402 , C12N15/625 , C12N15/70 , C12N15/80 , C12Y104/01002 , C12Y302/01052
摘要： The invention relates to promoters of the genes glutamate dehydrogenase, &bgr;-acetylhexosaminidase and &ggr;-actin and their use in systems of expression, secretion and anti-sense of filamentary fungi. The invention also relates to the use of the promoters of the genes which code: (I) glutamate dehydrogenase NADP depending (EC.1.4.1.4) of Penicillium chrysogenum, (II) &ggr;-N-actylhexosaminidase (EC.3.2.1.52) of Penicillium chrysogenum and (III) &ggr;-actin of Penicillium chrysogenum and Acrimonium chrysogenum, which can be used for the construction of potent vectors of expression and secretion useful both for P. chrysogenum and for A. chrysogenum and related species. These promoters can also be used for blocking the genic expression through anti-sense construction. Under the control of the above mentioned promoters, it is possible to conduct the expression of other genes in filamentary fungi, thereby increasing the production of antibiotics and/or proteins inherent to the same.
摘要翻译：本发明涉及谷氨酸脱氢酶，β-乙酰氨基己糖苷酶和γ-肌动蛋白基因的启动子及其在丝状真菌表达，分泌和反义系统中的用途。本发明还涉及编码：（I）谷氨酸脱氢酶NADP依赖于产生产青青霉（EC.1.4.1.4），（II）γ-N-酰基六氨基甲酰氨基（EC.3.2.1.52）的基因的启动子的使用，产黄青霉和（III）产黄青霉菌和产黄青霉素的γ-肌动蛋白，可用于构建有效的表达和分泌载体，可用于产黄青素和产黄青霉及相关物种。这些启动子也可用于通过反义结构阻断基因表达。在上述启动子的控制下，可以在丝状真菌中进行其他基因的表达，从而增加其固有的抗生素和/或蛋白质的产生。

10. 发明授权

US12104191B2 Cofactor self-sufficient 有权
公开(公告)号：US12104191B2
公开(公告)日：2024-10-01
申请号：US17823853
申请日：2022-08-31
申请人： ZHEJIANG UNIVERSITY OF TECHNOLOGY
发明人： Yaping Xue , Shuping Zou , Zhentao Jiang , Jianmiao Xu , Feng Cheng , Yuguo Zheng
IPC分类号： C12P13/00 , C07K14/245 , C12N1/21 , C12N9/00 , C12N9/04 , C12N9/06 , C12N9/10 , C12N9/12 , C12N15/10 , C12N15/52 , C12N15/70
CPC分类号： C12P13/001 , C07K14/245 , C12N9/0006 , C12N9/0016 , C12N9/1077 , C12N9/1205 , C12N9/1241 , C12N9/93 , C12N15/1082 , C12N15/52 , C12N15/70 , C12Y101/01119 , C12Y104/01002 , C12Y204/02011 , C12Y207/01086 , C12Y207/07018 , C12Y603/01005 , C12N2800/101
摘要： A cofactor self-sufficient Escherichia coli and its construction method and application in the synthesis of L-glufosinate are provided. The present invention expresses a NADH kinase and key enzymes of the cofactor synthesis pathway in E. coli, and knocks out the genes of enzymes that catabolizes cofactor, and with the addition of co-metabolic intermediates during cell incubation, the intracellular NADP(H) concentration is increased by at least 50% and the catalytic activity of glufosinate dehydrogenase by 2-fold, resulting in a significant increase in the spatiotemporal yield of the glufosinate synthesis reaction.

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