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    • 6. 发明授权
    • Compositions and methods for the production of L-homoalanine
    • 用于生产L-高丙氨酸的组合物和方法
    • US09187774B2
    • 2015-11-17
    • US13581287
    • 2011-02-25
    • James C. LiaoKechun ZhangKwang Myung Cho
    • James C. LiaoKechun ZhangKwang Myung Cho
    • C12P13/04C12N9/06
    • C12N9/0016C12P13/04C12P13/06C12Y104/01002Y02P20/52
    • Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral drug intermediates, an environmentally friendly solution that can be used to generate pharmaceuticals at much lower costs than conventional techniques. In this context, embodiments of the invention comprise methods and materials designed to allow microorganisms to biosynthesize the nonnatural amino acid L-homoalanine. As is known in the art, L-homoalanine is a chiral precursor of a variety of pharmaceutically valuable compounds including the anticonvulsant medications levetiracetam (sold under the trade name Keppra®) and brivaracetam, as well as ethambutol, a bacteriostatic antimycobacterial drug used to treat tuberculosis. Consequently, embodiments of the invention can be used in low cost, environmentally friendly processes to generate these and other valuable compounds.
    • 保健费用在世界范围内是重要的,许多患者由于价格高昂而被拒绝服用药物。 解决这一问题的一种方法涉及手性药物中间体的生物合成,这是一种环境友好的解决方案,可以以比传统技术低得多的成本生产药物。 在本文中,本发明的实施方案包括设计用于允许微生物生物合成非天然氨基酸L-高丙氨酸的方法和材料。 如本领域已知的,L-高丙氨酸是各种药学上有价值的化合物的手性前体,包括抗惊厥药物左乙拉西坦(商品名为Keppra)和布立西坦(brivaracetam)),以及乙胺丁醇,用于治疗的抑菌抗分支杆菌药物 结核。 因此,本发明的实施方案可以用于低成本,环境友好的方法以产生这些和其它有价值的化合物。