专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

US20240329169A1 USE OF FUNCTION-SPECIFIC GASES IN AN MAS MICRO-GAS TURBINE FOR SOLID STATE NMR 审中-公开
公开(公告)号：US20240329169A1
公开(公告)日：2024-10-03
申请号：US18619464
申请日：2024-03-28
申请人： Bruker BioSpin GmbH & Co. KG
发明人： Rico SIMMLER , David OSEN , Daniel PODADERA SANCHEZ , Lukas BECKER
IPC分类号： G01R33/30 , G01N24/08 , G01R33/31
CPC分类号： G01R33/307 , G01R33/31 , G01N24/08
摘要： An NMR method and apparatus uses a magic angle spinning (MAS) system with a MAS turbine having a MAS stator and a MAS rotor. At least two different gases or gas mixtures are fed to the stator through separate gas feeds, a first for the driving of the rotor and another, which is different from the first, for the bearing of the rotor. Respective pressures of the at least two different gases or gas mixtures are regulated separately, and the different gases or gas mixtures are prevented from mixing in the stator by means of a flushing seal through which they at least partially flow out of the stator. Conventional outflow nozzles do not need to be adapted, and the rotor can be operated at a high rotational frequency even at low pressures. The pressures remain stable so that no rotational oscillations occur during the NMR measurement.

2. 发明授权

US12106897B2 Superconducting magnet coil system 有权
公开(公告)号：US12106897B2
公开(公告)日：2024-10-01
申请号：US17259407
申请日：2019-07-03
申请人： Bruker BioSpin GmbH & Co. KG
发明人： Wolfgang Frantz , Rafael Caminada , Gerald Neuberth
IPC分类号： H01F6/02 , G01R33/3815 , H01B12/00 , H01F6/06
CPC分类号： H01F6/02 , G01R33/3815 , H01B12/00 , H01F6/06
摘要： The invention relates to a superconducting magnet coil system comprising a first electrical mesh (M1) and a second electrical mesh (M2), which are interconnected in series with one another, wherein the first electrical mesh (M1) comprises in a first path an HTS (high temperature superconductor) coil section (A0) and, in series therewith, a first main coil section (A1) and in a second path a quench protection element (Q1), which bridges the series connection of HTS coil section (A0) and first main coil section (A1). The first main coil section (A1) comprises a conductor comprising superconducting filaments in a matrix. The second electrical mesh (M2) comprises a neighbouring main coil section (A3) comprising a conductor comprising superconducting filaments in a matrix. The neighbouring main coil section (A3) is that main coil section of an electrical mesh different from the first electrical mesh which, in a radial direction outwards, lies closest to the first main coil section (A1) of the first electrical mesh. The magnet coil system is characterized in that, in the case of a quench, the conductors of the main coil sections (A1, A3, A4) each generate a specific power input (LT/2π)2*1/ρM, wherein the specific power input of the conductor of the first main coil section (A1) of the first electrical mesh (M1) is higher than the specific power input of the conductor of the neighbouring main coil section (A3) of the second electrical mesh (M2). Consequently, using HTS superconductor material, it is possible to provide a magnet coil system with which particularly high field strengths can be generated and/or which has a small structural size.

3. 发明公开

US20240230812A1 CIRCUIT ASSEMBLY FOR CORRECTION OF AN INPUT SIGNAL, USE OF THE CIRCUIT ASSEMBLY FOR DETECTION OF A PHYSIOLOGICAL SIGNAL IN A MAGNETIC RESONANCE (MR) SYSTEM 审中-公开
公开(公告)号：US20240230812A1
公开(公告)日：2024-07-11
申请号：US18432246
申请日：2024-02-05
申请人： Bruker BioSpin GmbH & Co. KG
发明人： Michael MAIXNER
IPC分类号： G01R33/565 , H03K5/1252
CPC分类号： G01R33/56509 , G01R33/56572 , H03K5/1252
摘要： A circuit assembly for correction of an input signal including a useful signal and a disturbance signal comprises: a voltage-controlled circuit having at least one voltage-controlled circuit element, an input interface and an output interface, a resistor connected upstream of the voltage-controlled circuit in series with the voltage-controlled circuit, an operational amplifier having a first amplifier input, a second amplifier input and an amplifier output, and a low-pass filter connected between the input interface of the at least one voltage-controlled circuit element and the first amplifier input of the operational amplifier, wherein the output voltage from the operational amplifier is fed back to the low-resistance terminal of the circuit element in that the low-resistance terminal of the at least one voltage-controlled circuit element is electrically connected to the amplifier output of the operational amplifier and to the second amplifier input of the operational amplifier.

4. 发明授权

US12140652B2 Systems and methods for provisioning training data to enable neural networks to analyze signals in NMR measurements 有权
公开(公告)号：US12140652B2
公开(公告)日：2024-11-12
申请号：US18542259
申请日：2023-12-15
申请人： Bruker BioSpin GmbH Co. KG
发明人： Silvère Lux
IPC分类号： G01R33/46 , G01N24/08 , G01N35/00 , G06N3/0455 , G06N3/0464 , G06N3/09
CPC分类号： G01R33/4625 , G01N24/087 , G01N35/00693 , G06N3/0455 , G06N3/0464 , G06N3/09 , G01N2035/00702
摘要： A system, method and computer program product for generating a data record of a training dataset set configured to train a neural network for determination of the concentration of a particular target molecule in an NMR sample. An NMR spectrum associated with a known concentration of the target molecule is obtained. The obtained NMR spectrum is adjusted by applying a random shift to generate an adjusted NMR spectrum. A background generator adds a background spectrum which reflects contributions of impurities in the NMR sample. The resulting NMR spectrum together with the information about the concentration of the target molecule is then stored as a new data record of the training dataset.

5. 发明公开

US20240352542A1 MEANS AND METHODS FOR DIAGNOSING A VIRAL INFECTION OR A DISEASE ASSOCIATED THEREWITH 审中-公开
公开(公告)号：US20240352542A1
公开(公告)日：2024-10-24
申请号：US18628273
申请日：2024-04-05
申请人： Bruker Biospin GmbH & Co. KG , Murdoch University
发明人： Julien Wist , Samuele Sala , Philipp Nitschke , Jeremy K. Nicholson , Elaine Holmes , Christoph Trautwein , Claire Cannet
IPC分类号： C12Q1/70 , C12Q1/6872 , C12Q1/6876
CPC分类号： C12Q1/70 , C12Q1/6872 , C12Q1/6876
摘要： The invention relates to the field of viral diagnosis. In particular, it is directed to a method for diagnosing a viral infection or a disease associated therewith in a subject comprising the steps of: (a) determining in a sample of said subject the amount of at least one biomarker selected from the group of 3′(,5′-di)deoxy-3′,4′-didehydro furanose derivatives of formula (I) with the exception of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC); and (b) comparing the amount(s) of the at least one biomarkers determined in (a) with a reference, thereby diagnosing a viral infection.
Further, the invention is directed to a method for diagnosing a viral infection or a disease associated therewith in a subject comprising the steps of: (A) determining in a sample of said subject the amount of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC); and (B) comparing the amount of the ddhC determined in (A) with a reference, thereby diagnosing a viral infection; wherein the determination in (a) is done by NMR spectroscopy and the sample of the subject is a urine sample of said subject.
The invention is also related to a diagnostic means for use in diagnosing a viral infection or a disease associated therewith, said diagnostic means comprising at least one biomarker selected from the group of 3′(,5′-di)deoxy-3′,4′-didehydro furanose derivatives of formula (I) with the exception of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC), but also to a diagnostic means comprising 3′-deoxy-3′,4′-didehydro-cytidine (ddhC) for use in diagnosing a viral infection or a disease associated therewith, wherein the amount of the biomarker is determined done by NMR spectroscopy in a urine sample of a subject.
Furthermore, the invention is directed to a device for diagnosing a viral infection or a disease associated therewith in a sample of a subject and to a kit for identifying a subject suffering from a viral infection or a disease associated therewith.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式