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1. 发明申请

US20150037326A1 Pharmaceutical composition comprising a polymeric carrier cargo complex and an antigen 审中-公开
标题翻译：药物组合物，其包含聚合物载体载体复合物和抗原
公开(公告)号：US20150037326A1
公开(公告)日：2015-02-05
申请号：US14375392
申请日：2013-01-30
申请人： BAYER INNOVATION GMBH , CUREVAC GMBH , ICON GENETICS GMBH
发明人： John-Edward Butler-Ransohoff , Karl-Josef Kallen , Thomas Kramps , Victor Klimyuk , Franziska Jarczowski
IPC分类号： A61K47/36 , C07K16/18 , A61K39/395 , A61K39/39 , A61K39/00
CPC分类号： A61K47/36 , A61K39/0011 , A61K39/39 , A61K39/39558 , A61K47/643 , A61K47/645 , A61K47/646 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/572 , A61K2039/585 , A61K2039/6081 , C07K16/18 , C07K16/3061 , C07K16/4208 , C07K2317/13 , C07K2317/55 , C07K2317/76 , C12N15/8258 , C12N15/87 , C12N2770/00043 , C12N2770/40043
摘要： The present invention is directed to a pharmaceutical composition including (eg for use as an adjuvant) a polymeric carrier cargo complex, comprising as a carrier a polymeric carrier formed by disulfide-crosslinked cationic components and as a cargo at least one nucleic acid (molecule) and at least one antigen associated with a tumour or cancer disease selected from; an idiotype immunoglobulin (e.g. an idiotype antibody or an idiotype B cell receptor); or at least one idiotype T cell receptor, or in each case a fragment, variant and/or derivative thereof. The inventive pharmaceutical composition allows for efficient induction of an adaptive immune response directed against the idiotype immunoglobulin or T cell receptor, particularly of a Th1-shiftet immune response. The present invention furthermore provides kits or kits of parts comprising the components of the inventive pharmaceutical composition, as well as the use of the inventive pharmaceutical composition or the inventive kit as a vaccine, particularly in the therapy of a tumour or cancer disease such as lymphoma, particularly B cell or T cell lymphoma.
摘要翻译：本发明涉及包含（例如用作佐剂）聚合物载体货物复合物的药物组合物，其包含作为载体的由二硫键交联的阳离子组分形成的聚合物载体和作为货物的至少一种核酸（分子）和与选自以下的肿瘤或癌症疾病相关的至少一种抗原; 独特型免疫球蛋白（例如独特型抗体或独特型B细胞受体）; 或至少一种独特型T细胞受体，或在每种情况下为其片段，变体和/或衍生物。本发明的药物组合物允许有效诱导针对独特型免疫球蛋白或T细胞受体，特别是Th1移位免疫应答的适应性免疫应答。本发明还提供了包含本发明药物组合物组分的试剂盒或试剂盒，以及本发明的药物组合物或本发明试剂盒作为疫苗的用途，特别是用于治疗肿瘤或癌症疾病例如淋巴瘤，特别是B细胞或T细胞淋巴瘤。

2. 发明申请

US20160145635A1 KITS COMPRISING PLUS-SENSE SINGLE STRANDED RNA VIRAL VECTORS AND METHODS FOR PRODUCING POLYPEPTIDES USING THE KITS 审中-公开
标题翻译：包含增强感测单链RNA病毒载体的框架和使用该工具生产多肽的方法
公开(公告)号：US20160145635A1
公开(公告)日：2016-05-26
申请号：US14764112
申请日：2014-03-21
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. , RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE AACHEN
发明人： Ulrich COMMANDEUR , Christina DICKMEIS , Rainer FISCHER
IPC分类号： C12N15/82
CPC分类号： C12N15/8242 , C12N2770/00043 , C12N2770/40043
摘要： The present invention relates to kits comprising plus-sense single stranded RNA viral vectors, as well as mixtures of these vectors and uses thereof, and methods for producing in a plant, or plant tissue, or plant cell simultaneously two or more polypeptides using the kits and vectors.
摘要翻译：本发明涉及包含正义单链RNA病毒载体的试剂盒，以及这些载体及其用途的混合物，以及在植物或植物组织或植物细胞中同时使用试剂盒生产两种或多种多肽的方法和向量。

3. 发明申请

US20110247088A1 TETRACYCLINE INDUCIBLE TRANSCRIPTION CONTROL SEQUENCE 有权
标题翻译：四环素诱导转录控制序列
公开(公告)号：US20110247088A1
公开(公告)日：2011-10-06
申请号：US13121673
申请日：2009-08-19
申请人： Hermann Bujard , Rainer Loew
发明人： Hermann Bujard , Rainer Loew
IPC分类号： A01K67/00 , C12N15/63 , C12N5/10 , C12N1/00 , C07H21/04 , A01H5/00 , C12N15/82
CPC分类号： C12N15/635 , C12N2770/40043 , C12N2830/003
摘要： The present invention relates to inducible transcription control sequences for the regulation of gene expression. Specifically, it relates to an transcription control sequence comprising at least two tet operator sequence motifs allowing the binding of tetracycline-dependent transcriptional regulators, wherein each of the said tetracycline-dependent transcriptional regulators binds with respect to its neighbour to an opposite face of the DNA helix, and a minimal promoter comprising a TATA box which is linked at its 5′ end to a general transcription factor binding site. Further, the present invention relates to a vector, a host cell, a plant or a non-human transgenic animal comprising the said transcription control sequence. Also contemplated is a method for regulating the expression of a nucleic acid sequence being operatively linked to the transcription control sequence of the present invention in a host cell, a plant or a non-human transgenic animal.
摘要翻译：本发明涉及用于调节基因表达的诱导型转录调控序列。具体地说，本发明涉及包含至少两个允许四环素依赖性转录调节子结合的tet操纵子序列基序的转录控制序列，其中所述四环素依赖性转录调节子中的每一个相对于DNA的相对面与DNA的相邻结合螺旋和包含在其5'末端与一般转录因子结合位点连接的TATA盒的最小启动子。此外，本发明涉及包含所述转录调控序列的载体，宿主细胞，植物或非人转基因动物。还考虑了在宿主细胞，植物或非人转基因动物中调节与本发明的转录调控序列有效连接的核酸序列的表达的方法。

4. 发明申请

US20170211081A1 FOXTAIL MOSAIC VIRUS-BASED VECTORS FOR GENE SILENCING AND GENE EXPRESSION 审中-公开
公开(公告)号：US20170211081A1
公开(公告)日：2017-07-27
申请号：US15411045
申请日：2017-01-20
申请人： Iowa State University Research Foundation, Inc.
发明人： John Hemmingson Hill , Chunquan Zhang , Steven Alan Whitham , Yu Mei
IPC分类号： C12N15/82 , C07K14/005 , C12N7/00
CPC分类号： C12N15/8218 , C07K14/005 , C12N7/00 , C12N15/8203 , C12N15/825 , C12N15/8263 , C12N15/8277 , C12N15/86 , C12N15/90 , C12N2770/00021 , C12N2770/00031 , C12N2770/00043 , C12N2770/40031 , C12N2770/40043
摘要： The present invention provides plant virus vectors developed from the Foxtail mosaic virus (FoMV). The vectors include a nucleic acid sequence encoding an infectious Foxtail mosaic virus (FoMV) with a functional movement encoding sequence operably linked to one or more regulatory elements functional in a plant. The plant virus vectors may be used to infect monocot plants, such as maize and can be used for VIGS, gene editing, gene expression or other transgenic protocols.

5. 发明授权

US09181556B2 Tetracycline inducible transcription control sequence 有权
标题翻译：四环素诱导型转录调控序列
公开(公告)号：US09181556B2
公开(公告)日：2015-11-10
申请号：US13121673
申请日：2009-08-19
申请人： Hermann Bujard , Rainer Loew
发明人： Hermann Bujard , Rainer Loew
IPC分类号： C07H21/04 , C12N15/63 , A61K31/70
CPC分类号： C12N15/635 , C12N2770/40043 , C12N2830/003
摘要： The present invention relates to inducible transcription control sequences for the regulation of gene expression. Specifically, it relates to an transcription control sequence comprising at least two tet operator sequence motifs allowing the binding of tetracycline-dependent transcriptional regulators, wherein each of the tetracycline-dependent transcriptional regulators binds with respect to its neighbor to an opposite face of the DNA helix, and a minimal promoter comprising a TATA box which is linked at its 5′ end to a general transcription factor binding site. Further, the present invention relates to a vector, a host cell, a plant or a non-human transgenic animal comprising the transcription control sequence. Also contemplated is a method for regulating the expression of a nucleic acid sequence being operatively linked to the transcription control sequence of the present invention in a host cell, a plant or a non-human transgenic animal.
摘要翻译：本发明涉及用于调节基因表达的诱导型转录调控序列。具体地说，本发明涉及包含至少两个允许四环素依赖性转录调节因子结合的tet操纵子序列基序的转录控制序列，其中四环素依赖性转录调节因子中的每一个相对于其邻近的DNA螺旋结构，以及包含在其5'末端与一般转录因子结合位点连接的TATA盒的最小启动子。此外，本发明涉及包含转录调控序列的载体，宿主细胞，植物或非人转基因动物。还考虑了在宿主细胞，植物或非人转基因动物中调节与本发明的转录调控序列有效连接的核酸序列的表达的方法。

6. 发明授权

US08637653B2 Infectious plant viral vector and an artificial bipartite plant viral vector an infectious plant viral vector and an artificial bipartite plant viral vector 失效
标题翻译：传染性植物病毒载体和人造二分子植物病毒载体，感染性植物病毒载体和人造二分子植物病毒载体
公开(公告)号：US08637653B2
公开(公告)日：2014-01-28
申请号：US12645027
申请日：2009-12-22
申请人： John Hammond , Hyoun Sub Lim , Leslie L. Domier
发明人： John Hammond , Hyoun Sub Lim , Leslie L. Domier
IPC分类号： C12N7/01 , C12N15/33 , C12N15/82 , C12N15/87 , C12N5/10 , C12N15/113 , A01H5/00
CPC分类号： C12N15/8203 , C12N15/8218 , C12N2770/40043
摘要： We have developed a versatile plant viral vector system based on Alternanthera mosaic virus (AltMV), suitable for infection by agroinfiltration or in vivo T7 transcripts from the same clone; agroinfection is enhanced by coinfiltration of a T7 RNA polymerase construct. Variants adapted for efficient protein expression, or for virus-induced gene silencing (VIGS), are based on a specific amino acid substitution (L88P) in the triple gene block 1 (TGB1) protein affecting RNA silencing suppression. A bipartite delivery system developed for AltMV delivers replicase (RdRp) functions separately from movement and encapsidation (TGB and coat protein, CP) functions by agroinfiltration, resulting in precise recombination of RdRp and TGB-CP constructs in planta. The bipartite delivery system has potential for high throughput protein expression or VIGS with the appropriate TGB1 variant, for hosts including Nicotiana benthamiana and Arabidopsis thaliana. Equivalent TGB1 substitutions in other potexviruses also reduced RNA silencing suppression, demonstrated with Potato virus X.
摘要翻译：我们开发了一种基于Alternanthera花叶病毒（AltMV）的多功能植物病毒载体系统，适用于通过农杆菌滤过或来自相同克隆的体内T7转录物的感染; 通过T7 RNA聚合酶构建体的组合过滤增强了农业感染。适用于有效蛋白表达或病毒诱导的基因沉默（VIGS）的变体基于影响RNA沉默抑制的三重基因阻断1（TGB1）蛋白中的特异性氨基酸取代（L88P）。为AltMV开发的一个双向递送系统通过农杆菌滤过与运动和壳化（TGB和外壳蛋白，CP）功能分开提供复制酶（RdRp）功能，导致植物中RdRp和TGB-CP构建体的精确重组。二分体递送系统具有高通量蛋白质表达的潜力或具有合适的TGB1变体的VIGS用于包括烟草和拟南芥的宿主。其他水痘病毒中相当于TGB1的取代也减少了RNA沉默抑制，用马铃薯病毒X证明。

7. 发明申请

US20110154538A1 Infectious Plant Viral Vector and An Artificial Bipartite Plant Viral Vector An Infectious Plant Viral Vector and An Artificial Bipartite Plant Viral Vector 失效
标题翻译：感染植物病毒载体和人造双分枝病毒病毒载体传染性病毒载体和人造二分子植物病毒载体
公开(公告)号：US20110154538A1
公开(公告)日：2011-06-23
申请号：US12645027
申请日：2009-12-22
申请人： John Hammond , Hyoun Sub Lim , Leslie L. Domier
发明人： John Hammond , Hyoun Sub Lim , Leslie L. Domier
IPC分类号： A01H5/00 , C12N15/82 , C12N15/83 , C12N7/01 , C12N5/10
CPC分类号： C12N15/8203 , C12N15/8218 , C12N2770/40043
摘要： We have developed a versatile plant viral vector system based on Alternanthera mosaic virus (AltMV), suitable for infection by agroinfiltration or in vivo T7 transcripts from the same clone; agroinfection is enhanced by coinfiltration of a T7 RNA polymerase construct. Variants adapted for efficient protein expression, or for virus-induced gene silencing (VIGS), are based on a specific amino acid substitution (L88P) in the triple gene block 1 (TGB1) protein affecting RNA silencing suppression. A bipartite delivery system developed for AltMV delivers replicase (RdRp) functions separately from movement and encapsidation (TGB and coat protein, CP) functions by agroinfiltration, resulting in precise recombination of RdRp and TGB-CP constructs in planta. The bipartite delivery system has potential for high throughput protein expression or VIGS with the appropriate TGB1 variant, for hosts including Nicotiana benthamiana and Arabidopsis thaliana. Equivalent TGB1 substitutions in other potexviruses also reduced RNA silencing suppression, demonstrated with Potato virus X.
摘要翻译：我们开发了一种基于Alternanthera花叶病毒（AltMV）的多功能植物病毒载体系统，适用于通过农杆菌滤过或来自相同克隆的体内T7转录物的感染; 通过T7 RNA聚合酶构建体的组合过滤增强了农业感染。适用于有效蛋白表达或病毒诱导的基因沉默（VIGS）的变体基于影响RNA沉默抑制的三重基因阻断1（TGB1）蛋白中的特异性氨基酸取代（L88P）。为AltMV开发的一个双向递送系统通过农杆菌滤过与运动和壳化（TGB和外壳蛋白，CP）功能分开提供复制酶（RdRp）功能，导致植物中RdRp和TGB-CP构建体的精确重组。二分体递送系统具有高通量蛋白质表达的潜力或具有合适的TGB1变体的VIGS用于包括烟草和拟南芥的宿主。其他水痘病毒中相当于TGB1的取代也减少了RNA沉默抑制，用马铃薯病毒X证明。

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