会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 6. 发明申请
    • Large scale preparation method for functionalizing the surface of magnetic microparticles with an inorganic phosphorous dendrimer
    • 用无机磷树枝状聚合物对磁性微粒表面进行官能化的大规模制备方法
    • US20140275628A1
    • 2014-09-18
    • US14208265
    • 2014-03-13
    • Marie J. ArcherBaochuan Lin
    • Marie J. ArcherBaochuan Lin
    • C07F9/6593
    • C07F9/65815
    • A method of attaching a phosphorous dendrimer onto magnetic microparticles by taking magnetic microparticles in a water-based solution, then performing a solvent exchange, then suspending the microparticles in a phosphorous dendrimer solution and shaking, then washing the microparticles with an organic solvent, and then washing the microparticles with a transition solvent. The solvent exchange is done by washing the microparticles with a first concentration of a transition solvent, then washing the microparticles with a second concentration of the transition solvent where the second concentration is greater than the first concentration, then washing the microparticles with an organic solvent, then washing the microparticles with the transition solvent, then washing the microparticles with the organic solvent, and then suspending the microparticles in the transition solvent. Also disclosed is the related phosphorous dendrimer made by this method.
    • 通过将水性溶液中的磁性微粒附着到磁性微粒上,然后进行溶剂交换,然后将微粒悬浮在磷树枝状聚合物溶液中并振荡,然后用有机溶剂洗涤微粒,然后再将该磷树枝状聚合物 用过渡溶剂洗涤微粒。 通过用第一浓度的过渡溶剂洗涤微粒,然后用第二浓度的第二浓度的过渡溶剂洗涤微粒,其中第二浓度大于第一浓度,然后用有机溶剂洗涤微粒来进行溶剂交换, 然后用过渡溶剂洗涤微粒,然后用有机溶剂洗涤微粒,然后将微粒悬浮在过渡溶剂中。 还公开了通过该方法制备的相关的磷树枝状聚合物。
    • 9. 发明授权
    • Dendritic oligopeptide-grafteded cyclotriphosphazene, a process for the preparation thereof and a drug delivery system containing the same
    • 树突状寡肽接枝的环三磷腈,其制备方法和含有它们的药物递送系统
    • US08344173B2
    • 2013-01-01
    • US12990089
    • 2009-04-28
    • Youn Soo SohnYong Joo JunSung Mo Choi
    • Youn Soo SohnYong Joo JunSung Mo Choi
    • C07C271/12C07K5/00
    • A61K47/24A61K9/0024C07F9/65815
    • A cyclotriphosphazene represented by Formula 1 prepared by introducing a dendritic tetrapeptide and a hydrophilic polyethylene glycol into a cyclotriphosphazene ring, a method of preparing the same, and a drug carrier including the cyclotriphosphazene of Formula 1.The compound according to the present invention may form a strong molecular hydrogel in a very low concentration of 2 w/w % or less. Furthermore, the hydrogel prepared using the compound of Formula 1 exhibits biodegradability, thermosensitivity at around body temperature, biocompatibility with protein drugs, and an easy way to prepare along with a sustained release property without any burst effect in the early stage of release. Therefore, the present cyclotriphosphazene molecular hydrogel may be efficiently used as a drug carrier for a sustained release of a drug, particularly, a protein drug.
    • 通过将环状三磷腈环中引入树枝状四肽和亲水性聚乙二醇制备的式1所示的环三磷腈,其制备方法和包含式1的环三磷腈的药物载体。根据本发明的化合物可以形成 强分子水凝胶的浓度为2w / w%以下。 此外,使用式1化合物制备的水凝胶显示生物降解性,体温周围的热敏感性,与蛋白质药物的生物相容性,以及在释放的早期阶段,缓释性能良好而不发生突发作用的简便方法。 因此,本发明的环三磷腈分子水凝胶可以有效地用作药物载体,用于药物,特别是蛋白质药物的持续释放。