专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20180282346A1 NOVEL MODIFIED MACROCYCLIC COMPOUNDS 审中-公开
公开(公告)号：US20180282346A1
公开(公告)日：2018-10-04
申请号：US15764289
申请日：2016-09-30
申请人： BAYER PHARMA AKTIENGESELLSCHAFT
发明人： Ulrich LÜCKING , Daniel HOG , Jens GEISLER , Arne SCHOLZ , Kirstin PETERSEN , Philip LIENAU , Christian STEGMANN , Dorothee ANDRES , Gerhard SIEMEISTER , Nicolas WERBECK
IPC分类号： C07D498/18 , A61P35/00 , A61P35/02 , A61K31/439 , A61K31/529 , C07D498/08 , C07C53/06 , C07D515/08
CPC分类号： C07D498/18 , A61K31/439 , A61K31/529 , A61P35/00 , A61P35/02 , C07C53/06 , C07D498/08 , C07D515/08
摘要： The present invention relates to novel modified macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

2. 发明申请

US20160264553A1 GDF-8 Inhibitors 有权
标题翻译： GDF-8抑制剂
公开(公告)号：US20160264553A1
公开(公告)日：2016-09-15
申请号：US15043729
申请日：2016-02-15
申请人： Rigel Pharmaceuticals, Inc. , Bristol-Myers Squibb Company
发明人： Pingyu Ding , Marina Gelman , Todd Kinsella , Rajinder Singh , Somasekhar Bhamidipati , Upender Velaparthi , Robert M. Borzilleri , Hasibur Rahaman , Jayakumar Sankara Warrier
IPC分类号： C07D401/14 , C07B59/00 , C07D471/04 , C07D487/04 , C07C53/18 , C07C53/06
CPC分类号： C07D401/14 , C07B59/002 , C07B2200/05 , C07C53/06 , C07C53/18 , C07D471/04 , C07D487/04
摘要： Disclosed are 2,2′-bipyridyl compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, Z and n are as described herein. In certain embodiments, a compound disclosed herein inhibits GDF8, and can be used to treat disease by blocking GDF8 signaling.
摘要翻译：和其药学上可接受的盐，前药和N-氧化物（及其溶剂化物和水合物），其中R1，Z和n如本文所述。在某些实施方案中，本文公开的化合物抑制GDF8，并且可以用于通过阻断GDF8信号传导来治疗疾病。

3. 发明申请

US20160229852A1 KINASE INHIBITORS 审中-公开
公开(公告)号：US20160229852A1
公开(公告)日：2016-08-11
申请号：US15131401
申请日：2016-04-18
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： Monique Bodil VAN NIEL , Nicholas Charles RAY , Lilian ALCARAZ , Terry Aaron PANCHAL , Andrew Stephen Robert JENNINGS , Elisabetta ARMANI , Andrew Peter CRIDLAND , Christopher HURLEY
IPC分类号： C07D471/04 , C07D519/00 , C07D231/40 , C07D401/12 , C07D403/12
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

4. 发明授权

US09388125B2 Compositions, methods, and systems for the synthesis and use of imaging agents 有权
标题翻译：用于合成和使用成像剂的组合物，方法和系统
公开(公告)号：US09388125B2
公开(公告)日：2016-07-12
申请号：US13697287
申请日：2011-05-11
申请人： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Joel Lazewatsky , L. Veronica Lee , Richard R. Cesati , Richard J. Looby , Heike S. Radeke
发明人： Ajay Purohit , Pedro Benites , Edward H. Cheesman , Joel Lazewatsky , L. Veronica Lee , Richard R. Cesati , Richard J. Looby , Heike S. Radeke
IPC分类号： A61K51/00 , A61M36/14 , C07C277/08 , A61K51/04 , C07B59/00 , C07C53/06 , C07C217/58 , C07C255/54 , C07C279/10 , C07C279/24 , C07C309/65 , C07C309/66 , C07C309/73 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C303/28 , C07C303/30 , C07C309/04 , C07C309/30 , C07C277/00
CPC分类号： C07C303/30 , A61K51/00 , A61K51/04 , A61K51/0406 , C07B59/001 , C07B2200/05 , C07C53/06 , C07C53/10 , C07C53/18 , C07C63/08 , C07C213/02 , C07C217/58 , C07C255/54 , C07C277/00 , C07C277/08 , C07C279/10 , C07C279/24 , C07C303/28 , C07C309/04 , C07C309/30 , C07C309/65 , C07C309/66 , C07C309/73 , C07C279/08
摘要： The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.
摘要翻译：本发明一般涉及可用于医学成像的新型合成方法，系统，试剂盒，盐和前体。在一些实施方案中，本发明提供了包含可以使用本文所述的合成方法形成的成像剂前体的组合物。可以使用本文所述的方法将成像剂转化成成像剂。在某些情况下，成像剂富集于18F。在一些情况下，包括盐形式的成像剂（例如抗坏血酸盐）可用于对受试者感兴趣的区域进行成像，包括但不限于心脏，心血管系统，心脏血管，脑和其他器官。

5. 发明授权

US09365577B2 Pyrimidinone compounds as human neutrophil elastase inhibitors 有权
标题翻译：嘧啶酮化合物作为人嗜中性粒细胞弹性蛋白酶抑制剂
公开(公告)号：US09365577B2
公开(公告)日：2016-06-14
申请号：US14108904
申请日：2013-12-17
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： Lilian Alcaraz , Robert Andrew Heald , Jonathan Mark Sutton , Elisabetta Armani , Carmelida Capaldi
IPC分类号： C07D487/04 , A61K31/519 , C07C309/20 , C07C309/29 , C07D453/02 , C07D487/08
CPC分类号： C07D487/04 , A61K9/0053 , A61K9/007 , C07C47/19 , C07C53/06 , C07C309/04 , C07C309/08 , C07C309/20 , C07C309/29 , C07D453/02 , C07D487/08 , C07D519/00
摘要： Pyrimidinone compounds defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HINE is implicated.
摘要翻译：本文定义的嘧啶酮化合物显示人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HINE的疾病和病症。

6. 发明申请

US20160016953A1 KINASE INHIBITORS 审中-公开
标题翻译：激酶抑制剂
公开(公告)号：US20160016953A1
公开(公告)日：2016-01-21
申请号：US14868516
申请日：2015-09-29
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： Lilian ALCARAZ , Christopher HURLEY , Andrew Peter CRIDLAND , Andrew Stephen Robert JENNINGS
IPC分类号： C07D471/04 , C07D519/00 , C07C53/06
CPC分类号： C07D471/04 , C07C53/06 , C07D519/00
摘要： Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract
摘要翻译：本文所述的式（I）化合物是p38MAPK抑制剂，并且可用作抗炎剂，特别是治疗呼吸道疾病

7. 发明申请

US20150344475A1 KINASE INHIBITORS 审中-公开
标题翻译：激酶抑制剂
公开(公告)号：US20150344475A1
公开(公告)日：2015-12-03
申请号：US14819722
申请日：2015-08-06
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： Monique Bodil VAN NIEL , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
摘要翻译：式（I）化合物及其药学上可接受的盐：其中R2，W，A，Y和R1如说明书中所定义，是p38 MAPK抑制剂，并且可用作抗炎剂，呼吸道疾病

8. 发明授权

US09175407B2 Integrated process for producing carboxylic acids from carbon dioxide 有权
标题翻译：从二氧化碳生产羧酸的综合方法
公开(公告)号：US09175407B2
公开(公告)日：2015-11-03
申请号：US13724339
申请日：2012-12-21
申请人： Liquid Light, Inc.
发明人： Jerry J. Kaczur , Kyle Teamey
IPC分类号： C25B3/04 , C25B1/22 , C07C51/02 , C25B3/02 , C25B9/08 , C25B3/06 , C07C51/10 , C07C51/41
CPC分类号： C25B1/22 , C07C51/02 , C07C51/10 , C07C51/41 , C25B3/02 , C25B3/04 , C25B3/06 , C25B9/08 , Y02P20/125 , Y02P20/133 , Y02P20/582 , C07C53/06 , C07C55/07
摘要： The present disclosure is a method and system for production of carboxylic based chemicals, including carboxylic acids and salts. A method for producing at oxalic acid may include receiving an anolyte feed at an anolyte region of an electrochemical cell including an anode and receiving a catholyte feed including carbon dioxide and an alkali metal hydroxide at a catholyte region of the electrochemical cell including a cathode. Method may include applying an electrical potential between the anode and cathode sufficient to reduce the carbon dioxide to at least one reduction product and converting the at least one reduction product and the alkali metal hydroxide to an alkali metal oxalate via a thermal reactor. The method may further include receiving the alkali metal oxalate at an electrochemical acidification electrolyzer and converting the alkali metal oxalate to oxalic acid at the electrochemical acidification electrolyzer.
摘要翻译：本公开是用于生产羧基化学品的方法和系统，包括羧酸和盐。草酸生产方法可包括在包括阳极的电化学电池的阳极电解液区域接收阳极电解液进料，并在包括阴极的电化学电池的阴极电解液区域接收包含二氧化碳和碱金属氢氧化物的阴极电解质进料。方法可以包括在阳极和阴极之间施加足以将二氧化碳还原成至少一种还原产物的电势，并通过热反应器将至少一种还原产物和碱金属氢氧化物转化成碱金属草酸盐。该方法可以进一步包括在电化学酸化电解器处接收碱金属草酸盐，并在电化学酸化电解器中将碱金属草酸盐转化成草酸。

9. 发明授权

US08946462B2 Process for preparing formic acid by reaction of carbon dioxide with hydrogen 有权
标题翻译：通过二氧化碳与氢气反应制备甲酸的方法
公开(公告)号：US08946462B2
公开(公告)日：2015-02-03
申请号：US13672055
申请日：2012-11-08
申请人： BASF SE
发明人： Thomas Schaub , Marek Pazicky , Donata Maria Fries , Rocco Paciello , Anton Meier
IPC分类号： C07F15/00 , C07C53/00 , C07C51/15 , B01J31/24 , C07C51/02 , C07C51/41 , C07C51/44 , C07C51/48
CPC分类号： C07C51/15 , B01J31/0202 , B01J31/0237 , B01J31/24 , B01J2231/625 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/98 , C07C51/02 , C07C51/41 , C07C51/44 , C07C51/48 , C07C53/06 , C07C53/02
摘要： The invention relates to a process for preparing formic acid by reaction of carbon dioxide with hydrogen in a hydrogenation reactor in the presence of a transition metal complex as a catalyst comprising at least one element from group 8, 9 or 10 of the Periodic Table and at least one phosphine ligand with at least one organic radical having at least 13 carbon atoms, of a tertiary amine and of a polar solvent to form a formic acid-amine, adduct, which is subsequently dissociated thermally to formic acid and the corresponding tertiary amine. on unit.
摘要翻译：本发明涉及一种通过二氧化碳与氢气在氢化反应器中在作为催化剂的过渡金属络合物存在下制备甲酸的方法，所述过渡金属络合物包含元素周期表第8,9或10族中的至少一种元素，以及在具有至少一个具有至少13个碳原子的有机基团的至少一个膦配体，叔胺和极性溶剂以形成甲酸 - 胺，加合物，其随后与甲酸和相应的叔胺解离。单位。

10. 发明申请

US20140323470A1 KINASE INHIBITORS 审中-公开
标题翻译：激酶抑制剂
公开(公告)号：US20140323470A1
公开(公告)日：2014-10-30
申请号：US14330145
申请日：2014-07-14
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： Monique Bodil VAN NIEL , Nicholas Charles Ray , Lilian Alcaraz , Terry Aaron Panchal , Andrew Stephen Robert Jennings , Elisabetta Armani , Andrew Peter Cridland , Christopher Hurley
IPC分类号： C07D498/08 , C07D487/08 , C07D403/12 , C07D471/04 , C07D401/12
CPC分类号： C07D471/04 , C07C53/06 , C07D231/40 , C07D401/12 , C07D403/12 , C07D487/08 , C07D498/08 , C07D519/00
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
摘要翻译：式（I）化合物及其药学上可接受的盐：其中R2，W，A，Y和R1如说明书中所定义，是p38MAPK抑制剂，并且可用作抗炎剂，呼吸道疾病

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式