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1. 发明申请

US20170247308A1 NOVEL CANNABIGEROL DERIVATIVES 有权
公开(公告)号：US20170247308A1
公开(公告)日：2017-08-31
申请号：US15122160
申请日：2015-02-12
申请人： VIVACELL BIOTECHNOLOGY ESPAÑA, S.L
发明人： Giovanni APPENDINO , María Luz BELLIDO CABELLO DE ALBA , Eduardo MUÑOZ BLANCO
IPC分类号： C07C50/28 , A61K31/122 , C07C225/28 , A61K31/13 , C07C69/757 , A61K31/215
CPC分类号： C07C50/28 , A61K31/122 , A61K31/13 , A61K31/215 , C07C69/757 , C07C69/95 , C07C225/28 , C07C2601/14 , C07C2601/16
摘要： The present invention relates to novel cannabigerol quinone derivatives of formula (I) wherein R is the carbon atom of a linear or branched group, represented by: aryl, alkenyl, alkynyl or alcoxycarbonil groups; or wherein R is the nitrogen atom of a linear or branched group, represented by: alkylamino, arylamino, alkenylamino or alkynylamino groups; or, alternatively, R represents a bond between 2 molecules of formula (I) forming a dimer. The invention also relates to the use of any of the compounds of formula (I) as medicaments in therapy, particularly for treating PPARg-related diseases due to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.

2. 发明授权

US3114755A Process for preparing bis-(monosubstitutedamino)-benzoquinones and monosubstitutedamino-naphthoquinones 失效
标题翻译：制备双 - （单取代氨基） - 苯醌和单取代氨基 - 萘醌的方法
公开(公告)号：US3114755A
公开(公告)日：1963-12-17
申请号：US9469461
申请日：1961-03-10
申请人： US RUBBER CO
发明人： COVEY RUPERT A
CPC分类号： C07C221/00 , C07C225/28 , C07C225/30

3. 发明授权

US09701618B2 Cannabidiol quinone derivatives 有权
公开(公告)号：US09701618B2
公开(公告)日：2017-07-11
申请号：US15304810
申请日：2014-04-16
申请人： VIVACELL BIOTECHNOLOGY ESPAÑA S.L.
发明人： Giovanni Appendino , María Luz Bellido Cabello De Alba , Eduardo Muñoz Blanco
IPC分类号： C07C225/28 , C07C69/95
CPC分类号： C07C225/28 , C07B2200/07 , C07C69/95 , C07C2601/16 , C07C2602/42
摘要： The present invention relates to novel cannabidiol quinone derivatives of formula (I) (I) wherein R is the carbon atom of a, linear or branched group, represented by: alkyl, aryl, alkenyl, alkynyl, acyl or alkoxycarbonyl groups; or wherein R is the nitrogen atom of a, linear or branched group represented by: alkylamine, arylamine, alkenylamine or alkynylamine groups. The invention also relates to the use of any of the compounds of formula (I) as medicaments in therapy, particularly for treating diseases and conditions responsive to PPARg modulation due to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.

4. 发明申请

US20170044092A1 NOVEL CANNABIDIOL QUINONE DERIVATIVES 有权
标题翻译：新型CANNABIDIOL喹诺酮衍生物
公开(公告)号：US20170044092A1
公开(公告)日：2017-02-16
申请号：US15304810
申请日：2014-04-16
申请人： VIVACELL BIOTECHNOLOGY ESPAÑA S.L.
发明人： Giovanni APPENDINO , María Luz BELLIDO CABELLO DE ALBA , Eduardo MUÑOZ BLANCO
IPC分类号： C07C225/28 , C07C69/95
CPC分类号： C07C225/28 , C07B2200/07 , C07C69/95 , C07C2601/16 , C07C2602/42
摘要： The present invention relates to novel cannabidiol quinone derivatives of formula (I) (I) wherein R is the carbon atom of a, linear or branched group, represented by: alkyl, aryl, alkenyl, alkynyl, acyl or alkoxycarbonyl groups; or wherein R is the nitrogen atom of a, linear or branched group represented by: alkylamine, arylamine, alkenylamine or alkynylamine groups. The invention also relates to the use of any of the compounds of formula (I) as medicamentsin therapy, particularly for treating diseases and conditions responsive to PPARg modulation due to their high PPARg agonistic effect lacking electrophilic (Nrf2 activation) and cytotoxic activities. This invention also provides pharmaceutical compositions comprising said compounds and method of treating diseases with said compounds.
摘要翻译：本发明涉及式（I）（I）的新型大二酚醌衍生物，其中R是直链或支链基团的碳原子，由烷基，芳基，烯基，炔基，酰基或烷氧基羰基表示; 或其中R为由烷基胺，芳基胺，链烯基胺或炔基胺基团表示的直链或支链基团的氮原子。本发明还涉及任何式（I）化合物作为治疗药物的用途，特别是用于治疗由于其不具有亲电子（Nrf2活化）和细胞毒活性的高PPARg激动作用而对PPARg调节有反应的疾病和病症。本发明还提供包含所述化合物的药物组合物和用所述化合物治疗疾病的方法。

5. 发明授权

US09233057B2 Particular quinone direct dyes, dye composition comprising at least one such dye, implementation process therefor and use thereof 有权
标题翻译：特定醌直接染料，包含至少一种这样的染料的染料组合物，其实施方法及其用途
公开(公告)号：US09233057B2
公开(公告)日：2016-01-12
申请号：US14365224
申请日：2012-12-13
申请人： L'OREAL
发明人： Stephane Sabelle
IPC分类号： A61Q5/10 , A61K8/35 , A61K8/41 , C07C215/82 , C07C225/28 , C07C251/82 , A61Q5/06 , C09B23/01
CPC分类号： A61K8/355 , A61K8/41 , A61K8/411 , A61K8/415 , A61K2800/10 , A61Q5/065 , A61Q5/10 , C07C215/82 , C07C225/28 , C07C251/82 , C09B23/0066
摘要： The present invention relates to quinone direct dyes of formula (I) below, organic or mineral acid or base salts thereof, tautomeric forms, optical isomers or geometrical isomers thereof and/or solvates thereof: and also to the use thereof for dyeing keratin fibers, in particular human keratin fibers such as the hair. The invention also relates to a composition for dyeing keratin fibers, comprising such direct dyes in a suitable dyeing medium. Similarly, a subject of the present invention is a process for dyeing keratin fibers, using the said dye composition.
摘要翻译：本发明涉及以下式（I）的醌直接染料，其有机或无机酸或其盐，互变异构形式，光学异构体或其几何异构体和/或溶剂合物：以及其用于染色角蛋白纤维的用途，特别是人角蛋白纤维如头发。本发明还涉及用于染色角蛋白纤维的组合物，其在合适的染色介质中包含这种直接染料。类似地，本发明的主题是使用所述染料组合物染色角蛋白纤维的方法。

6. 发明申请

US20090093521A1 2, 5-Bis-Diamine [1,4] Benzoquinone-Derivatives 审中-公开
标题翻译： 2,5-二 - 二胺[1,4]苯醌衍生物
公开(公告)号：US20090093521A1
公开(公告)日：2009-04-09
申请号：US11917560
申请日：2005-06-13
申请人： Maria Laura Bolognesi , Rita Banzi , Anna Minarini , Carlo Melchiorre
发明人： Maria Laura Bolognesi , Rita Banzi , Anna Minarini , Carlo Melchiorre
IPC分类号： A61K31/135 , C07C211/33 , C07D409/12 , C07D401/12 , A61P25/28 , A61K31/444 , A61K31/381
CPC分类号： C07C225/28 , C07D213/38 , C07D333/20
摘要： Synthesis of 2,5-bis-diamine-[1,4]benzoquinonic derivatives having the general formula (I), products and intermediates of said synthesis; the synthesis involves the use of p-benzoquinones having the general formula (IX) and diamines having the general formula (XI).
摘要翻译：具有通式（I）的2,5-双 - 二胺 - [1,4]苯醌衍生物的合成，所述合成的产物和中间体; 合成涉及使用具有通式（Ⅸ）的对苯醌和具有通式（Ⅺ）的二胺。

7. 发明申请

US20170334871A1 Thymoquinone Derivatives for Treatment of Cancer 审中-公开
公开(公告)号：US20170334871A1
公开(公告)日：2017-11-23
申请号：US15502944
申请日：2014-08-09
申请人： United Arab Emirates University
发明人： Alaa Eldin Salem , Ismail El Haty , Ibrahim Abdou , Abdu Adem , Samir Attoub
IPC分类号： C07D295/13 , C07C225/28 , C07C221/00
CPC分类号： C07D295/13 , A61K31/122 , A61K31/5375 , A61K45/06 , A61P35/00 , C07C221/00 , C07C225/28 , A61K2300/00
摘要： The present invention describes thymoquinone compounds formula (I): (i) These compounds have been identified as being useful in the treatment of cancer.

8. 发明申请

US20160308213A1 Quinone Compound-Graphene Composite Material, Preparation Method Thereof, and Flexible Lithium Secondary Battery 审中-公开
标题翻译：喹诺酮复合石墨烯复合材料及其制备方法和柔性锂二次电池
公开(公告)号：US20160308213A1
公开(公告)日：2016-10-20
申请号：US15195742
申请日：2016-06-28
申请人： Huawei Technologies Co., Ltd.
发明人： Pinghua Wang
IPC分类号： H01M4/60 , H01M4/133 , H01M4/1393 , H01M4/587 , C07C225/28 , H01M4/66 , H01M4/04 , H01M2/16 , H01M10/0585 , C01B31/04 , H01M10/0525 , H01M4/62
CPC分类号： H01M4/60 , C01B32/194 , C07C225/28 , H01M2/162 , H01M2/1653 , H01M2/1686 , H01M4/0404 , H01M4/0433 , H01M4/0471 , H01M4/133 , H01M4/137 , H01M4/1393 , H01M4/1399 , H01M4/587 , H01M4/623 , H01M4/625 , H01M4/661 , H01M10/052 , H01M10/0525 , H01M10/0585 , H01M2004/027 , H01M2004/028 , H01M2220/30
摘要： A quinone compound-graphene composite material, including quinone compound and graphene, where the quinone compound is chemically bonded on the surface of the graphene, and the quinone compound is quinone compound monomer or quinone polymer. The quinone compound-graphene composite material has high energy density, high flexibility, high conductivity, and high stability, and can be used as cathode material for preparing flexible electrode. Additionally, a preparation method of quinone compound-graphene composite material, and flexible lithium secondary battery uses the quinone compound-graphene composite material as cathode active material.
摘要翻译：醌化合物和石墨烯的醌化合物 - 石墨烯复合材料，其中醌化合物化学键合在石墨烯的表面上，醌化合物为醌化合物单体或醌类聚合物。醌化合物 - 石墨烯复合材料具有高能量密度，高柔韧性，高导电性和高稳定性，可用作准备柔性电极的阴极材料。此外，醌化合物 - 石墨烯复合材料和柔性锂二次电池的制备方法使用醌化合物 - 石墨烯复合材料作为阴极活性材料。

9. 发明授权

US5104874A Benzoquinone antiallergy and antinflammatory agents 失效
标题翻译：苯并喹酮抗炎药和抗炎药
公开(公告)号：US5104874A
公开(公告)日：1992-04-14
申请号：US627149
申请日：1990-12-13
申请人： Takafumi Ikeda , Hiroaki Wakabayashi , Masami Nakane
发明人： Takafumi Ikeda , Hiroaki Wakabayashi , Masami Nakane
IPC分类号： A61K31/135 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/33 , A61K31/495 , A61K31/496 , A61P29/00 , A61P43/00 , C07C225/28 , C07C229/14 , C07C229/18 , C07C229/32 , C07C229/42 , C07C229/48 , C07C229/56 , C07C231/12 , C07C235/80 , C07C237/20 , C07C237/30 , C07C311/39 , C07D213/74 , C07D263/56 , C07D295/10 , C07D307/14 , C07D307/52
CPC分类号： C07D213/74 , C07C225/28 , C07C229/14 , C07C229/42 , C07C229/48 , C07C229/56 , C07C235/80 , C07C237/20 , C07C311/39 , C07D307/14 , C07D307/52 , C07C2101/14 , C07C2101/16
摘要： A series of 2-amino-5,6-dimethyl-1,4-benzoquinone derivatives, inhibitors of cyclooxygenase and lipoxygenase and useful as antiallergic and antiinflammatory agents.

10. 发明授权

US2267741A Diamino-i 失效
公开(公告)号：US2267741A
公开(公告)日：1941-12-30
申请号：US2267741D
CPC分类号： C07D209/88 , C07C225/28

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