专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US6133268A 1,4-disubstituted piperazines 失效
标题翻译： 1,4-二取代的哌嗪
公开(公告)号：US6133268A
公开(公告)日：2000-10-17
申请号：US271564
申请日：1999-03-18
申请人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
发明人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
IPC分类号： C07D295/06 , A61K31/4427 , A61K31/4436 , A61K31/444 , A61K31/495 , A61K31/496 , A61K31/55 , A61P3/08 , A61P17/04 , A61P25/06 , A61P29/00 , C07D213/74 , C07D213/79 , C07D213/80 , C07D295/073 , C07D295/12 , C07D295/14 , C07D295/155 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14
CPC分类号： C07D213/74 , C07D213/79 , C07D295/073 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07C2103/78
摘要： The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译：本发明涉及以下通式的1,4-二取代哌嗪其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分或其盐中所定义，其制备方法，组合物并且用于临床治疗疼痛，痛觉过敏和/或炎性疾病，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由...引起的或与之相关的适应症胰岛素拮抗肽的分泌和循环，例如非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

2. 发明授权

US5917096A Process for the preparation of .beta.-caryophyllene alcohol 失效
标题翻译：制备β-石竹烯醇的方法
公开(公告)号：US5917096A
公开(公告)日：1999-06-29
申请号：US793568
申请日：1997-06-16
申请人： Hongjun Liu
发明人： Hongjun Liu
IPC分类号： C07C29/06 , C07C29/78 , C07C35/23
CPC分类号： C07C29/78 , C07C29/06 , C07B2200/07 , C07C2103/78
摘要： The present invention discloses a new process for the preparation of .beta.-caryophyllene alcohol, in which the sesquiterpene fraction at 110-120.degree. C./6 mmHg in Chinese pinus massoniana oleoresin composition undergoes isomerization in the presence of sulfuric acid as catalyst and the .beta.-caryophyllene alcohol is thus prepared through separation, re-crystallization and purification of the residue from the bottom of the vessel for the preparation of isolongifolene.
摘要翻译： PCT No.PCT / CN94 / 00068 Sec。 371日期：1997年6月16日 102（e）日期1996年6月16日PCT 1994年8月31日PCT PCT。公开号WO96 / 06818 日期：1996年3月7日本发明公开了一种制备β-石竹烯醇的新方法，其中中国马尾松油树脂组合物中110-120℃/ 6mmHg的倍半萜烯馏分在硫酸存在下进行异构化作为催化剂，通过从容器底部的残留物的分离，重结晶和纯化来制备β-石竹烯醇，用于制备异戊烯。

3. 发明授权

US3976712A 2,4-Exo-ethanobicyclo (3.3.1)nonane 失效
标题翻译： 2,4-异 - 乙烷二环（3.3.1）壬烷
公开(公告)号：US3976712A
公开(公告)日：1976-08-24
申请号：US596618
申请日：1975-07-17
申请人： Naotake Takaishi , Yoshiaki Inamoto , Kiyoshi Tsuchihashi
发明人： Naotake Takaishi , Yoshiaki Inamoto , Kiyoshi Tsuchihashi
IPC分类号： A61K31/045 , A61K31/015 , A61P31/12 , B01J23/00 , C07B61/00 , C07C1/00 , C07C1/20 , C07C13/605 , C07C61/135 , C07C67/00 , C07C13/28
CPC分类号： C10M1/08 , C07C13/605 , C07C61/135 , D06M7/00 , C07C2103/78 , C10M2203/02 , C10M2203/022 , C10M2203/024 , C10M2203/04 , C10N2240/62 , D06M2200/40
摘要： 2,4-EXO-ETHANOBICYCLO[3.3.1]NONANE HAVING THE FORMULA (I): ##SPC1##is prepared by treating 2-endo-hydroxymethyl-2,3-exo-trimethylenenorbornane having the formula (II): ##SPC2##with a hydride donor and an acid catalyst.
摘要翻译： 2,4-EXO-ETHANOBICYCLO [3.3.1]具有公式（I）的NONANE：

4. 发明授权

US6040302A 1,4-disubstituted piperazines 失效
公开(公告)号：US6040302A
公开(公告)日：2000-03-21
申请号：US271565
申请日：1999-03-18
申请人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
发明人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
IPC分类号： C07D295/06 , A61K31/4427 , A61K31/4436 , A61K31/444 , A61K31/495 , A61K31/496 , A61K31/55 , A61P3/08 , A61P17/04 , A61P25/06 , A61P29/00 , C07D213/74 , C07D213/79 , C07D213/80 , C07D295/073 , C07D295/12 , C07D295/14 , C07D295/155 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14
CPC分类号： C07D213/74 , C07D213/79 , C07D295/073 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07C2103/78
摘要： The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

5. 发明授权

US6004961A 1,4-disubstituted piperazines 失效
公开(公告)号：US6004961A
公开(公告)日：1999-12-21
申请号：US271785
申请日：1999-03-18
申请人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
发明人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
IPC分类号： C07D295/06 , A61K31/4427 , A61K31/4436 , A61K31/444 , A61K31/495 , A61K31/496 , A61K31/55 , A61P3/08 , A61P17/04 , A61P25/06 , A61P29/00 , C07D213/74 , C07D213/79 , C07D213/80 , C07D295/073 , C07D295/12 , C07D295/14 , C07D295/155 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14
CPC分类号： C07D213/74 , C07D213/79 , C07D295/073 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07C2103/78
摘要： The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

6. 发明授权

US5958821A Oxidation catalytic system and oxidation process using the same 失效
标题翻译：氧化催化体系和氧化工艺使用相同
公开(公告)号：US5958821A
公开(公告)日：1999-09-28
申请号：US913881
申请日：1997-09-24
申请人： Yasutaka Ishii , Tatsuya Nakano
发明人： Yasutaka Ishii , Tatsuya Nakano
IPC分类号： B01J31/02 , B01J31/12 , B01J31/22 , C07C29/50 , C07C45/33 , C07C45/34 , C07C45/36 , C07C49/453 , C07C49/675 , C07C51/265 , C07C51/31 , C07D207/12 , C07D207/404 , C07D207/448
CPC分类号： C07C51/313 , B01J31/006 , B01J31/0247 , B01J31/2234 , C07C29/50 , C07C45/33 , C07C45/34 , C07C45/36 , C07C49/453 , C07C49/675 , C07C51/265 , B01J2231/70 , B01J2231/72 , B01J2531/16 , B01J2531/22 , B01J2531/26 , B01J2531/31 , B01J2531/46 , B01J2531/48 , B01J2531/56 , B01J2531/64 , B01J2531/72 , B01J2531/842 , B01J2531/845 , C07B2200/09 , C07C2101/10 , C07C2101/14 , C07C2101/16 , C07C2101/18 , C07C2102/08 , C07C2102/20 , C07C2102/28 , C07C2102/42 , C07C2103/18 , C07C2103/68 , C07C2103/74 , C07C2103/78 , C07C2103/86
摘要： A substrate (e.g., a cycloalkane, a polycyclic hydrocarbon, an aromatic compound having a methyl group or methylene group adjacent to an aromatic ring) is oxidized with oxygen in the presence of an oxidation catalyst comprising an imide compound of the following formula (1) (e.g., N-hydroxyphthalimide), and a co-catalyst (except phosphovanadomolybdic acid) containing an element selected from the group consisting of Group 2A elements of the Periodic Table of Elements, transition metals (Group 3A to 7A elements, Group 8 elements, Group 1B elements and Group 2B elements of the Periodic Table of Elements) and Group 3B elements of the Periodic Table of Elements, for the formation of an oxide (e.g., a ketone, an alcohol, a carboxylic acid): ##STR1## wherein R.sup.1 and R.sup.2 represent a substituent such as a hydrogen atom or a halogen atom, or R.sup.1 and R.sup.2 may together form a double bond or an aromatic or nonaromatic 5- to 12-membered ring, X is O or OH, and n is 1 to 3.
摘要翻译： PCT No.PCT / JP97 / 00279 Sec。 371日期：1997年9月24日 102（e）1997年9月24日PCT PCT 1997年2月6日PCT公布。公开号WO97 / 28897 日期1997年8月14日在包含酰亚胺化合物的氧化催化剂的存在下，用氧氧化底物（例如环烷烃，多环烃，具有与芳环相邻的甲基或亚甲基的芳族化合物）下述式（1）表示的化合物（例如，N-羟基邻苯二甲酰亚胺）和含有选自元素周期表的2A族元素的族的过渡金属（3A〜7A族元素）的助催化剂（磷钼酸除外），元素周期表第8族元素，第1B族元素和2B族元素）和元素周期表3B族元素，用于形成氧化物（例如酮，醇，羧酸）：其中R 1和R 2表示取代基如氢原子或卤原子，或者R 1和R 2可以一起形成双键或芳族或非芳族的5至12元环，X为O或OH，n为1 到3。

7. 发明授权

US5916889A 1,4-disubstituted piperazines 失效
标题翻译： 1,4-二取代的哌嗪
公开(公告)号：US5916889A
公开(公告)日：1999-06-29
申请号：US943726
申请日：1997-10-03
申请人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
发明人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
IPC分类号： C07D295/06 , A61K31/4427 , A61K31/4436 , A61K31/444 , A61K31/495 , A61K31/496 , A61K31/55 , A61P3/08 , A61P17/04 , A61P25/06 , A61P29/00 , C07D213/74 , C07D213/79 , C07D213/80 , C07D295/073 , C07D295/12 , C07D295/14 , C07D295/155 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D405/06
CPC分类号： C07D213/74 , C07D213/79 , C07D295/073 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07C2103/78
摘要： The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译：本发明涉及以下通式的1,4-二取代哌嗪其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分或其盐中所定义，其制备方法，组合物并且用于临床治疗疼痛，痛觉过敏和/或炎性疾病，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由...引起的或与之相关的适应症胰岛素拮抗肽的分泌和循环，例如非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

8. 发明授权

US5294638A Phenyalkylaminoalkyl compounds and pharmaceutical compositions containing them 失效
标题翻译：烷基氨基烷基化合物和含有它们的药物组合物
公开(公告)号：US5294638A
公开(公告)日：1994-03-15
申请号：US5457
申请日：1993-01-19
申请人： Insa Hell , Ulf Preuschoff , Hermann Kraehling , Samuel David , Ivan Ban , Marie-Odile Christen
发明人： Insa Hell , Ulf Preuschoff , Hermann Kraehling , Samuel David , Ivan Ban , Marie-Odile Christen
IPC分类号： A61K31/135 , A61P1/00 , A61P1/04 , C07C211/17 , C07C211/27 , C07C217/08 , C07C217/12 , C07C217/56 , C07C217/60 , C07C217/62 , C07C323/25 , C07D317/58 , A61K31/36 , C07C211/19
CPC分类号： C07C323/25 , C07C211/27 , C07C217/08 , C07C217/12 , C07C217/60 , C07C217/62 , C07D317/58 , C07C2101/14 , C07C2103/62 , C07C2103/66 , C07C2103/78
摘要： Pharmacologically active compounds corresponding to the general formula I: ##STR1## wherein m represents 1-4,n represents 2-5,R.sup.1 is hydrogen or lower alkyl,R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen, orR.sup.2 and R.sup.3 are linked to adjacent carbon atoms and together form an alkylenedioxy group with 1-2 carbon atoms,R.sup.4 represents a saturated monocyclic or bicyclic hydrocarbon radical derived from terpenes and having 10 or 11 hydrocarbon atoms, andZ represents oxygen, an N--R.sup.5 group, wherein R.sup.5 is lower alkyl, or if R.sup.4 is a dihydronopyl radical, Z may also be sulfur,and their acid addition salts.
摘要翻译：对应于通式I的药理活性化合物：其中m表示1-4，n表示2-5，R1表示氢或低级烷基，R2表示氢，低级烷基，低级烷氧基，卤素或三氟甲基，R3表示氢，低级烷基，低级烷氧基或卤素，或R 2和R 3与相邻碳原子连接并一起形成具有1-2个碳原子的亚烷基二氧基，R4代表衍生自萜烯的饱和单环或双环烃基，并具有10或11个烃原子，Z表示氧，N-R5基团，其中R5是低级烷基，或者如果R4是二氢缩水甘油基，Z也可以是硫，以及它们的酸加成盐。

9. 发明授权

US5098916A Propanobicyclic amine derivatives for CNS disorders 失效
标题翻译：中枢神经系统疾病的丙酰胆碱胺衍生物
公开(公告)号：US5098916A
公开(公告)日：1992-03-24
申请号：US501216
申请日：1990-03-29
申请人： Nancy M. Gray , Brian K. Cheng
发明人： Nancy M. Gray , Brian K. Cheng
IPC分类号： A61K31/445 , A61K31/495 , A61P9/10 , A61P25/00 , C07C211/38 , C07C211/42 , C07D295/02 , C07D295/03 , C07D295/033 , C07D295/08 , C07D295/088
CPC分类号： C07D295/088 , C07C211/42 , C07D295/03 , C07D295/033 , C07C2103/78
摘要： Certain propanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of the formula ##STR1## wherein each R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and Z is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, phenalkyl, phenyl, alkoxy, phenoxy, phenalkoxy, alkoxyalkyl, halo, haloalkyl and hydroxyalkyl; wherein R.sup.3 and R.sup.4 may be taken together to form oxo;wherein each of R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13 and R.sup.14 is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl, cycloalkylalkyl, alkoxyalkyl, henalkyl and phenyl; wherein G within the nitrogen-containing cyclohetero moiety is selected from ##STR2## wherein R.sup.15 is selected from hydrido, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, phenalkyl, alkoxyalkyl and hydroxyalkyl; wherein each of R.sup.16 and R.sup.17 is independently selected from hydrido, hydroxy, alkyl, phenalkyl, phenyl, alkoxy, fluoroalkyl and fluoro; wherein m is one or two; wherein p is a number selected from zero through four, inclusive; wherein each of q and r is a number independently selected from one through three, inclusive, with the proviso that sum of q and r is a number from three through six, inclusive; with the further proviso that the nitrogen-containing cyclohetero moiety must be attached at one position selected from R.sup.3, R.sup.4, ring-position two, ring-position three and ring-position four; or the pharmaceutically-acceptable salts thereof.

10. 发明授权

US5030739A Process for the catalytic oxidation of isoprenoids having allylic groups 失效
标题翻译：具有烯丙基的类异戊二烯的催化氧化方法
公开(公告)号：US5030739A
公开(公告)日：1991-07-09
申请号：US576096
申请日：1990-08-31
申请人： Joseph Foricher , Claude Furbringer , Karlheinz Pfoertner
发明人： Joseph Foricher , Claude Furbringer , Karlheinz Pfoertner
IPC分类号： C07D207/46 , B01J31/00 , B01J31/02 , C07B31/00 , C07B41/02 , C07B41/06 , C07B61/00 , C07C27/00 , C07C29/132 , C07C29/48 , C07C33/02 , C07C45/00 , C07C45/34 , C07C45/53 , C07C49/453 , C07C49/603 , C07C49/627 , C07C49/653 , C07C67/00 , C07C407/00 , C07C409/04 , C07C409/14 , C07D209/48 , C07D209/66 , C07J9/00
CPC分类号： C07J9/00 , C07C29/48 , C07C33/02 , C07C407/00 , C07C409/04 , C07C409/14 , C07C45/34 , C07C45/53 , C07C2101/16 , C07C2102/26 , C07C2102/42 , C07C2103/66 , C07C2103/78
摘要： The invention is directed to a process for the catalytic oxidation of an isoprenoid containing at least one allylic hydrogen atom, which process comprises reacting the isoprenoid with oxygen or an oxygen-containing gas in an inert solvent in the presence of a N-hydroxydicarboxylic acid imide of the formula ##STR1## wherein A-B stands for CH.sub.2 -CH.sub.2, CH.dbd.CH, an aromatic hydrocarbon residue or a group derived from one of these groups in which one or more hydrogen atoms is/are replaced by alkyl or halogen,to produce a primary of secondary hydroperoxide.The process of the invention is suitable for the manufacture of steroids, vitamins, odorant substances, carotinoids and the like.
摘要翻译：本发明涉及一种用于催化氧化含有至少一个烯丙基氢原子的类异戊二烯的方法，该方法包括在N-羟基二酰亚胺存在下，在惰性溶剂中使类异戊二烯与氧或含氧气体反应其中AB代表CH 2 -CH 2，CH = CH，芳族烃残基或衍生自其中一个或多个氢原子被烷基或卤素取代的这些基团之一的基团，生成次级过氧化氢的主要。本发明的方法适用于制造类固醇，维生素，气味物质，类胡萝卜素等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式