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1. 发明授权

US12135324B2 Immunochromatographic assay device 有权
公开(公告)号：US12135324B2
公开(公告)日：2024-11-05
申请号：US17422004
申请日：2019-07-31
申请人： GUANGZHOU WONDFO BIOTECH CO., LTD.
发明人： Xuan Meng , Jiaming Du , Xirong Huang
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54389 , B01L3/5023 , B01L2300/069 , B01L2300/08 , B01L2300/0816 , B01L2300/0825 , B01L2300/0838 , B01L2300/0887
摘要： The present invention relates to an immunochromatographic assay device, comprising: a cover plate; an immunochromatographic assay kit; and a sample loading pad. A wet zone is defined by the cover plate and at least part of a sample loading portion of the sample loading pad disposed close to an installation position of the immunochromatographic assay kit. The height of the wet zone satisfies the following condition: when flowing into the wet zone, a sample solution is driven by capillary action to flow from a surface of the sample loading portion toward the immunochromatographic assay kit. A wet zone having a certain length is arranged in front of a sample loading zone of an immunochromatographic assay kit, such that when a sample solution flows into the wet zone, capillary action drives the sample solution to flow into the wet zone, thereby increasing a flow speed of the sample solution in the wet zone, allowing substantially simultaneous sample loading on immunochromatographic assay kits at different installation positions, and accordingly enhancing the consistency and uniformity of sample loading.

2. 发明授权

US12123887B2 Sample analyzing device 有权
公开(公告)号：US12123887B2
公开(公告)日：2024-10-22
申请号：US16613296
申请日：2018-07-17
申请人： HORIBA Advanced Techno, Co., Ltd.
发明人： Hideki Nakayama , Kazuya Nakagawa , Hiroshi Iida , Yoko Nakai
IPC分类号： G01N35/04 , B01L3/00 , B01L9/06 , G01N21/64 , G01N35/10
CPC分类号： G01N35/04 , B01L3/5082 , B01L9/06 , G01N21/6428 , G01N35/1002 , B01L2200/04 , B01L2200/0605 , B01L2300/0609 , B01L2300/08 , G01N2035/103
摘要： The present invention is one for achieving an improvement in analysis accuracy, and a sample analyzing device that measures light emitted by introducing a reagent to a sample contained in a container to analyze the sample, and the sample analyzing device includes: a holder that holds the container; a casing that has a door for taking in/out the holder; a nozzle to/from which a pipette tip for injecting the reagent into the container can be attached/detached; a photodetector that measures the light emitted from the sample in the container supported by the holder; and a disposal box into which the pipette tip after injection is disposed of, in which the disposal box is configured to be arranged in the casing and to be taken in/out via the door.

3. 发明公开

US20240316552A1 MICROFLUIDIC DEVICE FOR CONCENTRATING TARGET PARTICLES IN A FLUID SAMPLE USING DIELECTROPHORESIS 审中-公开
公开(公告)号：US20240316552A1
公开(公告)日：2024-09-26
申请号：US18575009
申请日：2021-06-30
申请人： QuantuMDx Group Limited
发明人： Eduardo BOADA ORTIZ , Lothar SCHMID , Heather MURTON
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L2200/0652 , B01L2300/0645 , B01L2300/08 , B01L2400/0424 , B01L2400/084
摘要： Disclosed herein is a microfluidic device for concentrating target particles in a fluid sample using dielectrophoresis (DEP). The microfluidic device comprises an inlet chamber comprising a fluid inlet for receiving a fluid sample, an outlet chamber comprising a fluid outlet for discharging the fluid sample, and a plurality of DEP channels. Each DEP channel is fluidically connected to the inlet chamber and to the outlet chamber such a fluid path from the fluid inlet to the fluid outlet is provided through each of the DEP channels, wherein the microfluidic device is configured such that each of the fluid paths has substantially the same fluid resistance.

4. 发明授权

US12017222B2 Analysis unit for a transportable microfluidic device, in particular for sample preparation and molecule analysis 有权
公开(公告)号：US12017222B2
公开(公告)日：2024-06-25
申请号：US17465732
申请日：2021-09-02
申请人： STMICROELECTRONICS S.R.L.
发明人： Marco Cereda , Lillo Raia , Danilo Pirola
IPC分类号： B01L3/00 , A61B5/15 , A61B5/154 , B01F33/30 , B01F33/40 , B01F33/452 , B01L9/00 , C12M3/06 , C12Q1/6806 , C12Q1/6844
CPC分类号： B01L3/502753 , A61B5/15003 , A61B5/150221 , A61B5/150351 , A61B5/154 , B01F33/30 , B01F33/406 , B01F33/452 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/5029 , B01L3/508 , B01L3/5082 , B01L3/52 , B01L3/527 , B01L9/527 , C12M23/16 , A61B5/150389 , A61B5/150503 , A61B5/150732 , B01L3/5023 , B01L3/502707 , B01L3/50825 , B01L3/523 , B01L2200/025 , B01L2200/026 , B01L2200/0621 , B01L2200/0642 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/141 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/044 , B01L2300/0609 , B01L2300/0681 , B01L2300/08 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0848 , B01L2300/0851 , B01L2300/0858 , B01L2300/0864 , B01L2300/087 , B01L2300/12 , B01L2300/16 , B01L2300/1827 , B01L2400/04 , B01L2400/0406 , B01L2400/043 , B01L2400/0487 , B01L2400/049 , B01L2400/0677 , C12Q1/6806 , C12Q1/6844 , C12Q1/6806 , C12Q2565/629 , C12Q1/6844 , C12Q2565/629
摘要： An analysis unit formed by an analysis body housing an analysis chamber and having a sample inlet and a supply channel configured to fluidically connect the sample inlet to the analysis chamber. Dried assay reagents are arranged in the analysis chamber and are contained in an alveolar mass. For instance, the alveolar mass is a lyophilized mass formed by excipients and by assay-specific reagents.

5. 发明授权

US11964268B2 Detecting apparatus 有权
公开(公告)号：US11964268B2
公开(公告)日：2024-04-23
申请号：US17576364
申请日：2022-01-14
申请人： Zhejiang Orient Gene Biotech Co., Ltd
发明人： Siyu Lei , Lili Shen , Jianqiu Fang
IPC分类号： B01L1/00 , B01L3/00 , G01N1/10
CPC分类号： B01L1/52 , B01L3/5023 , B01L3/523 , B01L3/565 , G01N1/10 , B01L2300/08 , B01L2300/0809 , B01L2300/123
摘要： The present invention provides a detecting apparatus, including a storage chamber containing a treating fluid; wherein, the detecting apparatus is internally provided with a sharp-pointed portion; the storage chamber may make a movement relative to the sharp-pointed portion; the storage chamber will be pierced by the sharp-pointed portion during the moving process, such that the treating fluid in the storage chamber is released. The detecting apparatus further includes a collecting chamber; the released treating fluid may flow into the collecting chamber; the collecting chamber is disposed inside a first shell and used to contain a sample; an opening is disposed at an upper position of the first shell; the collecting chamber is internally provided with a testing element for detecting an analyte; the testing element is disposed on a carrier, and the carrier has a specific matching form with the collecting chamber. A buffer solution is disposed in an independent chamber of the detecting apparatus, and may be obtained at any time in need of detection and thus, is easy to be used. The carrier has a specific matching form with the collecting chamber in the first shell, such that the carrier has a definite and unique directional position after being inserted into the collecting chamber.

6. 发明授权

US11904315B2 System and self-metering cartridges for point of care bioassays 有权
公开(公告)号：US11904315B2
公开(公告)日：2024-02-20
申请号：US17158130
申请日：2021-01-26
申请人： WAINAMICS, INC.
发明人： Arturo M. Escajeda , Huyen Tran , Ming X. Tan
IPC分类号： C12Q1/6844 , B01L3/00
CPC分类号： B01L3/502715 , C12Q1/6844 , B01L2200/04 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/08
摘要： The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

7. 发明授权

US11850594B2 Microparticle multi-channel time-sharing separation device and method based on arcuate interdigital transducer 有权
公开(公告)号：US11850594B2
公开(公告)日：2023-12-26
申请号：US16977099
申请日：2019-07-12
申请人： ZHEJIANG UNIVERSITY
发明人： Yancheng Wang , Chengyao Xu , Deqing Mei , Chenyang Han
IPC分类号： B01L3/00 , B06B1/02 , B06B1/06 , H10N30/87 , H10N30/80 , H10N30/853
CPC分类号： B01L3/502761 , B01L3/50273 , B01L3/502707 , B01L3/502715 , B06B1/0284 , B06B1/0644 , H10N30/802 , H10N30/8542 , H10N30/87 , B01L2200/0652 , B01L2200/12 , B01L2300/0645 , B01L2300/08 , B01L2300/123 , B01L2400/0436 , B06B2201/55 , B06B2201/77
摘要： The invention discloses microparticle multi-channel time-sharing separation device and method based on an arcuate interdigital transducer. An arcuate interdigitated electrode is connected to an output channel of a signal generator. The arcuate interdigitated electrode and a polydimethylsiloxane (PDMS) microfluidic channel are placed on a lithium niobate chip. The arcuate interdigitated electrode is mainly formed by an interdigitated electrode being asymmetrically bent from a straight line into an arcuate curve. Two electrode ends of the arcuate interdigitated electrodes are asymmetrically arranged with one end big and another end small. The PDMS microfluidic channel includes a main flow channel, two inlet ends, and multiple outlet ends. The main flow channel is an approximately arcuate flow channel arranged around an outer side of the arcuate interdigitated electrode. Particles are patterned in a coverage section of surface acoustic waves to complete separation of microparticles.

8. 发明授权

US11806714B2 Selective delivery of material to cells 有权
公开(公告)号：US11806714B2
公开(公告)日：2023-11-07
申请号：US17075116
申请日：2020-10-20
申请人： Massachusetts Institute of Technology
发明人： Armon R. Sharei , Viktor A. Adalsteinsson , Nahyun Cho , Robert S. Langer , J. Christopher Love , Klavs F. Jensen
IPC分类号： B01L3/00 , C12N5/09 , C12N5/078 , G01N15/14 , C12Q1/04 , G01N33/574 , G01N1/30 , G01N15/10 , B82Y30/00 , C12M3/06 , G01N15/00
CPC分类号： B01L3/502761 , C12N5/0634 , C12N5/0693 , C12Q1/04 , G01N15/1459 , G01N15/1484 , G01N33/574 , B01L2200/0652 , B01L2300/08 , B01L2400/0487 , B82Y30/00 , C12M23/16 , G01N1/30 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081
摘要： Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.

9. 发明公开

US20230234064A1 NANOSTRUCTURED SYSTEM FOR NUCLEIC ACID AMPLIFICATION AND METHOD OF MANUFACTURING THE SAME 审中-公开
公开(公告)号：US20230234064A1
公开(公告)日：2023-07-27
申请号：US18157001
申请日：2023-01-19
申请人： Samsung Electronics Co., Ltd.
发明人： Vinayak Narasimhan , Radwanul Hasan Siddique , Wonjong Jung , Kak Namkoong , Youngzoon Yoon
IPC分类号： B01L3/00 , B82Y40/00 , G01N21/552
CPC分类号： B01L3/50851 , B82Y40/00 , G01N21/554 , B01L2300/08 , B01L2300/1805 , B01L2300/1861
摘要： An assay repository device for photothermal or joule heating includes an assay container having an interior surface and being configured to house an assay solution, and a nanostructure layer conformally integrated onto the assay container and directly contacting the interior surface, the nanostructure layer being plasmonic and thermally conductive, and including a plurality of nanofeatures having non-uniform sizes and/or non-uniform shapes.

10. 发明公开

US20230184637A1 AN APPARATUS FOR PROCESSING BIOLOGICAL MATERIAL 审中-公开
公开(公告)号：US20230184637A1
公开(公告)日：2023-06-15
申请号：US17924279
申请日：2021-05-13
申请人： Andrea RAGGI
发明人： Andrea RAGGI
IPC分类号： G01N1/28 , B01L3/00
CPC分类号： G01N1/286 , B01L3/502 , G01N2001/2873 , B01L2300/049 , B01L2300/027 , B01L2300/043 , B01L2400/02 , B01L2300/08 , B01L2400/0496
摘要： An apparatus for processing biological material includes a supporting structure, provided with a seat and with a rotation device supplied with constraining means, and a container for biological material, provided with a shaped body, with a base, shaped to match the seat of the supporting structure, with at least one valve (24a) for extracting the biological material, and with movable cutting means equipped with coupling means for coupling to the constraining means of the rotation device, in such a way as to acquire a relative motion relative to the container.

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