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1. 发明申请

US20160207013A1 Device For Mixing Fluids 审中-公开
标题翻译：混合流体装置
公开(公告)号：US20160207013A1
公开(公告)日：2016-07-21
申请号：US14988778
申请日：2016-01-06
申请人： Turbulent Energy LLC
发明人： David Livshits
IPC分类号： B01F5/06
CPC分类号： B01F5/0062 , B01F5/0065 , B01F5/0287 , B01F5/18 , B01F2005/0048 , B01F2015/0221
摘要： A device is provided for mixing similar or dissimilar fluids into a homogenous fluids mix. The device operates without consuming additional energy.
摘要翻译：提供了用于将类似或不同流体混合到均匀流体混合物中的装置。该设备在不消耗额外能量的情况下运行。

2. 发明授权

US06299906B1 Process for making submicron particles 失效
标题翻译：制造亚微米颗粒的方法
公开(公告)号：US06299906B1
公开(公告)日：2001-10-09
申请号：US09287409
申请日：1999-04-06
申请人： Alexander Bausch , Pirmin Hidber
发明人： Alexander Bausch , Pirmin Hidber
IPC分类号： A61K914
CPC分类号： B01F3/1214 , A61K9/14 , A61K9/145 , A61K9/1688 , B01F3/1271 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J2/04 , B01J3/008 , B01J13/02 , Y02P20/544 , Y10S977/906
摘要： The present invention relates to a process for manufacturing a pulverous preparation of a submicron-sized biologically active compound comprising the steps of dissolving a biologically active compound under elevated pressure in a compressed gas, liquid or supercritical fluid containing a surface modifier; and rapidly expanding the compressed solution thereby precipitating the dissolved compound. An alternative process comprises dissolving the biologically active compound in compressed dimethylether, which may optionally contain a surface modifier; and spraying the compressed solution into an antisolvent phase, optionally containing a surface modifier, under vacuum, atmospheric pressure or elevated pressure. An optional third step involves converting the antisolvent phase into a pulverous preparation using conventional powder processing.
摘要翻译：本发明涉及一种制造亚微米尺寸生物活性化合物的粉末制剂的方法，包括以下步骤：将生物活性化合物在升高的压力下溶解在含有表面改性剂的压缩气体，液体或超临界流体中; 并迅速膨胀压缩溶液从而使溶解的化合物沉淀。一种替代方法包括将生物活性化合物溶解在可任选地含有表面改性剂的压缩二甲醚中; 并在真空，大气压或升高的压力下将压缩的溶液喷雾到任选含有表面改性剂的抗溶剂相中。可选的第三步涉及使用常规粉末处理将抗溶剂相转变成粉状制剂。

3. 发明申请

US20020018815A1 Methods and apparatus for fine particle formation 审中-公开
标题翻译：细颗粒形成的方法和装置
公开(公告)号：US20020018815A1
公开(公告)日：2002-02-14
申请号：US09858998
申请日：2001-05-16
发明人： Robert E. Sievers , Uwe Karst
IPC分类号： A61K009/14 , B29B009/00
CPC分类号： A61K9/008 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F3/068 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B01J3/008 , B05B7/32 , B05B12/1418 , B05D1/025 , B05D2401/90 , Y02P20/544
摘要： Methods and apparatuses are provided for forming fine particles of a desired substance comprising dissolving said substance in a fluid such as water to form a solution and mixing the solution with a second fluid such as supercritical carbon dioxide which becomes a gas upon rapid pressure release, and with which the first fluid is at least partially immiscible, and releasing the pressure to form an air-borne dispersion or aerosol comprising particles having an average diameter between about 0.1 and about 6.5 nullm.
摘要翻译：提供了用于形成所需物质的细颗粒的方法和装置，包括将所述物质溶解在诸如水的流体中以形成溶液，并将溶液与快速释放时成为气体的第二流体例如超临界二氧化碳混合，以及其中第一流体至少部分地不混溶，并释放压力以形成包含平均直径在约0.1至约6.5μm之间的颗粒的空气传播分散体或气溶胶。

4. 发明授权

US5487965A Processes for the preparation of developer compositions 失效
标题翻译：制备显影剂组合物的方法
公开(公告)号：US5487965A
公开(公告)日：1996-01-30
申请号：US300548
申请日：1994-09-06
申请人： Peter G. Odell
发明人： Peter G. Odell
IPC分类号： B01F3/12 , G03G9/12 , G03G9/125 , G03G9/13 , G03G9/135
CPC分类号： G03G9/1355 , B01F3/1214 , B01F3/1271 , B01F5/0287 , G03G9/122 , G03G9/125 , G03G9/131 , G03G9/135 , B01F2003/0064 , B01F2003/125 , B01F2215/0093
摘要： A process for preparing a liquid developer composition comprising: a) forming a melt mixture comprised of a polymer resin or resins, a colorant, a charge director additive, and a hydrocarbon liquid carrier, to obtain a first suspension of colored polymeric particles with an area average diameter of from about 2 to about 100 microns; b) dispersing said first suspension in a supercritical fluid medium and thereafter continuously feeding the resultant dispersion to a liquid fluidizing means under pressure to obtain a second suspension comprising a supercritical fluid and liquid developer mixture containing colored polymeric particles with an area average diameter of from about 0.1 to about 10 microns; and c) reducing the pressure to evaporate, and optionally recovering, the supercritical fluid medium from said second suspension, wherein there results a liquid developer mixture containing colored polymeric particles with an area average diameter of less than about 3.0 microns and a solids content of about 10 to about 90 weight percent.
摘要翻译：一种制备液体显影剂组合物的方法，包括：a）形成由聚合物树脂或树脂，着色剂，电荷导向剂添加剂和烃液体载体组成的熔融混合物，以获得具有面积的着色聚合物颗粒的第一悬浮液平均直径为约2至约100微米; b）将所述第一悬浮液分散在超临界流体介质中，然后在压力下将所得分散体连续供给到液体流化装置，以获得包含超临界流体和液体显影剂混合物的第二悬浮液，所述超临界流体和液体显影剂混合物含有平均直径为约 0.1至约10微米; 和c）降低压力以从所述第二悬浮液中蒸发并选择性地回收超临界流体介质，其中产生液体显影剂混合物，其含有面积平均直径小于约3.0微米且固体含量约为约3.0微米的着色聚合物颗粒 10至约90重量％。

5. 发明授权

US5301664A Methods and apparatus for drug delivery using supercritical solutions 失效
标题翻译：使用超临界溶液进行药物输送的方法和装置
公开(公告)号：US5301664A
公开(公告)日：1994-04-12
申请号：US846331
申请日：1992-03-06
申请人： Robert E. Sievers , Brooks M. Hybertson , Brian N. Hansen
发明人： Robert E. Sievers , Brooks M. Hybertson , Brian N. Hansen
IPC分类号： A61K9/12 , A61K9/16 , A61K49/00 , A61M15/00 , B01F3/00 , B01F3/06 , B01F5/02 , B01J3/00 , B05B7/32 , B05D1/02 , C09K3/30 , B65D37/00
CPC分类号： B01F3/068 , A61K9/0073 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F5/02 , B01F5/0287 , B01J3/008 , B05B7/32 , B05D1/025 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B05D2401/90 , Y02P20/544
摘要： Methods and apparatus for delivering physiologically active compounds to a target human or animal employ a supercritical fluid solution comprising a supercritical fluid solvent and a physiologically active solute. The supercritical fluid solution is passed into a subcritical region to evaporate the solvent and form a gas-borne dispersion of solute particles. The gas-borne dispersion of solute particles is administered directly to the target human or animal. The apparatus for delivering the physiologically active compound are of the hand-held type.
摘要翻译：将生理活性化合物递送至目标人或动物的方法和装置使用包含超临界流体溶剂和生理活性溶质的超临界流体溶液。将超临界流体溶液进入亚临界区域以蒸发溶剂并形成溶质颗粒的气体分散体。溶质颗粒的气体分散体直接施用于目标人或动物。用于递送生理活性化合物的装置是手持型的。

6. 发明授权

US06974593B2 Insoluble drug delivery 失效
标题翻译：不溶性药物递送
公开(公告)号：US06974593B2
公开(公告)日：2005-12-13
申请号：US10458071
申请日：2003-06-09
申请人： Inge B Henriksen , Awadesh K. Mishra , Gary W. Pace , Keith P. Johnston , Simon Mawson
发明人： Inge B Henriksen , Awadesh K. Mishra , Gary W. Pace , Keith P. Johnston , Simon Mawson
IPC分类号： A61J3/06 , A61K9/14 , A61K9/16 , A61K31/235 , A61K31/405 , A61K38/13 , B01F1/00 , B01F3/12 , B01F5/02 , B01J2/06 , B01J3/00
CPC分类号： B01J3/008 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , B01F1/00 , B01F3/1214 , B01F3/1271 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , Y02P20/544 , Y10S977/896 , Y10S977/906
摘要： Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.
摘要翻译：通过将化合物溶解在溶液中，然后在存在下将溶液喷射到压缩的gaz，液体或超临界流体中来制备水不溶性生物活性化合物，特别是水不溶性药物，平均粒径为100nm至约300nm的颗粒的适当的表面改性剂。

7. 发明授权

US06576264B1 Insoluble drug delivery 有权
标题翻译：不溶性药物递送
公开(公告)号：US06576264B1
公开(公告)日：2003-06-10
申请号：US09202504
申请日：1999-03-12
申请人： Inge B Henriksen , Awadesh K. Mishra , Gary W. Pace , Keith P. Johnston , Simon Mawson
发明人： Inge B Henriksen , Awadesh K. Mishra , Gary W. Pace , Keith P. Johnston , Simon Mawson
IPC分类号： A61K916
CPC分类号： B01J3/008 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , B01F1/00 , B01F3/1214 , B01F3/1271 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , Y02P20/544 , Y10S977/896 , Y10S977/906
摘要： Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.
摘要翻译：通过将化合物溶解在溶液中，然后在存在下将溶液喷射到压缩的gaz，液体或超临界流体中来制备水不溶性生物活性化合物，特别是水不溶性药物，平均粒径为100nm至约300nm的颗粒的适当的表面改性剂。

8. 发明授权

US06177103B1 Processes to generate submicron particles of water-insoluble compounds 有权
标题翻译：生成水不溶性化合物亚微米颗粒的方法
公开(公告)号：US06177103B1
公开(公告)日：2001-01-23
申请号：US09335735
申请日：1999-06-18
申请人： Gary W. Pace , Michael G. Vachon , Awadhesh K. Mishra , Inge B. Henrikson , Val Krukonis
发明人： Gary W. Pace , Michael G. Vachon , Awadhesh K. Mishra , Inge B. Henrikson , Val Krukonis
IPC分类号： A61K914
CPC分类号： A61K9/1688 , A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , B01F3/1214 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J3/008 , Y10S977/773 , Y10S977/801 , Y10S977/906
摘要： Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.
摘要翻译：水不溶性化合物，特别是药物的亚微米颗粒是通过在液化气体中从化合物和表面改性剂的压缩溶液中快速膨胀到水性介质中同时稳定其与表面改性剂分子的微粒悬浮液而制备的，用高压均化器形成悬浮液。

9. 发明授权

US6095134A Methods and apparatus for fine particle formation 失效
标题翻译：细颗粒形成的方法和装置
公开(公告)号：US6095134A
公开(公告)日：2000-08-01
申请号：US847310
申请日：1997-04-24
申请人： Robert E. Sievers , Uwe Karst
发明人： Robert E. Sievers , Uwe Karst
IPC分类号： A61K9/00 , A61K9/12 , A61K9/16 , A61K49/00 , A61M15/00 , B01F3/00 , B01F3/06 , B01F5/02 , B01J3/00 , B05B7/32 , B05D1/02 , C09K3/30 , A61M11/00
CPC分类号： A61K9/0073 , A61K9/0078 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F3/068 , B01F5/02 , B01F5/0287 , B01J2/04 , B01J3/008 , B05B12/1418 , B05B7/32 , B05D1/025 , A61K9/0075 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B05D2401/90 , Y02P20/544
摘要： Methods and apparatuses are provided for forming fine particles of a desired substance comprising dissolving said substance in a fluid such as water to form a solution and mixing the solution with a second fluid such as supercritical carbon dioxide which becomes a gas upon rapid pressure release, and with which the first fluid is at least partially immiscible, and releasing the pressure to form an air-borne dispersion or aerosol comprising particles having an average diameter between about 0.1 and about 6.5 .mu.m.
摘要翻译：提供了用于形成所需物质的细颗粒的方法和装置，包括将所述物质溶解在诸如水的流体中以形成溶液，并将溶液与快速释放时成为气体的第二流体例如超临界二氧化碳混合，以及其中第一流体至少部分地不混溶，并且释放压力以形成包含平均直径在约0.1至约6.5μm之间的颗粒的空气传播分散体或气溶胶。

10. 发明申请

US20170065957A1 LIQUID POLYMER ACTIVATION UNIT WITH IMPROVED HYDRATION CHAMBER 审中-公开
标题翻译：液体聚合物活化单元与改进的水化室
公开(公告)号：US20170065957A1
公开(公告)日：2017-03-09
申请号：US15251226
申请日：2016-08-30
申请人： IPM Systems LLC
发明人： Ryan G. Morerod , Scott Leakey
IPC分类号： B01J14/00 , B05B1/34 , B01F5/02 , B01J19/06 , B01J19/26
CPC分类号： B05B1/3405 , B01F5/0262 , B01F5/0287 , B01F15/00935 , B01F2215/0049
摘要： A polymer activation assembly is provided for separating monomer from the oil in which it is suspended in a polymer forming suspension and mixing the monomer with water supplied from another stream. The supply water is supplied through a primary fluid channel extending through the activation assembly and which transitions to a relatively wide rectangular activation channel. A secondary fluid inlet is formed in a side of the activation assembly for injection of the polymer forming suspension therein. A nozzle section of the secondary fluid inlet is formed between an initial section of the inlet and the activation channel. The nozzle section is generally rectangular in cross section and relatively shallow. The distal end of the nozzle section has a width that approximates the width of the activation channel. The nozzle section angles at an acute angle toward the outlet.
摘要翻译：提供聚合物活化组件用于将单体与其中悬浮在聚合物形成悬浮液中的油分离，并将单体与从另一种流供应的水混合。供水通过延伸穿过激活组件的主流体通道供应，并且转变到相对宽的矩形激活通道。第二流体入口形成在活化组件的侧面，用于在其中注入聚合物形成悬浮液。第二流体入口的喷嘴部分形成在入口的初始部分和激活通道之间。喷嘴部分的横截面通常为矩形并且较浅。喷嘴部分的远端具有接近激活通道宽度的宽度。喷嘴部分朝向出口呈锐角倾斜。

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