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1. 发明授权

US5301664A Methods and apparatus for drug delivery using supercritical solutions 失效
标题翻译：使用超临界溶液进行药物输送的方法和装置
公开(公告)号：US5301664A
公开(公告)日：1994-04-12
申请号：US846331
申请日：1992-03-06
申请人： Robert E. Sievers , Brooks M. Hybertson , Brian N. Hansen
发明人： Robert E. Sievers , Brooks M. Hybertson , Brian N. Hansen
IPC分类号： A61K9/12 , A61K9/16 , A61K49/00 , A61M15/00 , B01F3/00 , B01F3/06 , B01F5/02 , B01J3/00 , B05B7/32 , B05D1/02 , C09K3/30 , B65D37/00
CPC分类号： B01F3/068 , A61K9/0073 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F5/02 , B01F5/0287 , B01J3/008 , B05B7/32 , B05D1/025 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B05D2401/90 , Y02P20/544
摘要： Methods and apparatus for delivering physiologically active compounds to a target human or animal employ a supercritical fluid solution comprising a supercritical fluid solvent and a physiologically active solute. The supercritical fluid solution is passed into a subcritical region to evaporate the solvent and form a gas-borne dispersion of solute particles. The gas-borne dispersion of solute particles is administered directly to the target human or animal. The apparatus for delivering the physiologically active compound are of the hand-held type.
摘要翻译：将生理活性化合物递送至目标人或动物的方法和装置使用包含超临界流体溶剂和生理活性溶质的超临界流体溶液。将超临界流体溶液进入亚临界区域以蒸发溶剂并形成溶质颗粒的气体分散体。溶质颗粒的气体分散体直接施用于目标人或动物。用于递送生理活性化合物的装置是手持型的。

2. 发明授权

US4970093A Chemical deposition methods using supercritical fluid solutions 失效
标题翻译：使用超临界流体溶液的化学沉积方法
公开(公告)号：US4970093A
公开(公告)日：1990-11-13
申请号：US507829
申请日：1990-04-12
申请人： Robert E. Sievers , Brian N. Hansen
发明人： Robert E. Sievers , Brian N. Hansen
IPC分类号： C23C16/44 , B05D1/02 , C23C16/448 , H01L39/24
CPC分类号： B05D1/025 , C23C16/4485 , H01L39/2451 , B05D2401/90
摘要： A method for depositing a film of a desired material on a substrate comprises dissolving at least one reagent in a supercritical fluid comprising at least one solvent. Either the reagent is capable of reacting with or is a precursor of a compound capable of reacting with the solvent to form the desired product, or at least one additional reagent is included in the supercritical solution and is capable of reacting with or is a precursor of a compound capable of reacting with the first reagent or with a compound derived from the first reagent to form the desired material. The supercritical solution is expanded to produce a vapor or aerosol and a chemical reaction is induced in the vapor or aerosol so that a film of the desired material resulting from the chemical reaction is deposited on the substrate surface. In an alternate embodiment, the supercritical solution containing at least one reagent is expanded to produce a vapor or aerosol which is then mixed with a gas containing at least one additional reagent. A chemical reaction is induced in the resulting mixture so that a film of the desired material is deposited.

3. 发明申请

US20100199982A1 Electronically-Controlled, High Pressure Flow Control Valve and Method of Use 有权
标题翻译：电子控制，高压流量控制阀及使用方法
公开(公告)号：US20100199982A1
公开(公告)日：2010-08-12
申请号：US12703351
申请日：2010-02-10
申请人： Brian N. Hansen
发明人： Brian N. Hansen
IPC分类号： A61M11/02 , F16K31/02
CPC分类号： F16K31/02 , A61M15/008 , A61M15/009 , A61M2016/0021 , A61M2202/0225 , A61M2205/0266 , A61M2205/8225 , B65D83/54 , F16K1/14
摘要： A fluid flow control valve comprises (a) a high pressure region adapted to contain a fluid at its supercritical or nearcritical temperature and pressure conditions and connected via an orifice to a low pressure region, (b) a seat adjacent the orifice, (c) a sealing element positionable against the seat to form a seal between the high pressure region and the low pressure region, and (d) an electrically and/or electronically controlled actuator operable to move the sealing element against and/or away from the seat to allow control of fluid flow from the high pressure region to the low pressure region. In a specific embodiment, the high pressure region contains a fluid at its supercritical or nearcritical temperature and pressure conditions. The valve may be used, for example, to provide very low flow rates, for example, for supercritical fluid chromatography, supercritical fluid extraction, critical point drying, supercritical fluid cleaning, and supercritical fluid separation methods. In another embodiment, the valve is suitable for use in methods of delivering a biologically active substance to a patient in need thereof.
摘要翻译：流体流量控制阀包括（a）适于在其超临界或近临界温度和压力条件下容纳流体的高压区域，并通过孔口连接到低压区域，（b）邻近孔口的座，（c）密封元件，其可抵靠座椅定位以在高压区域和低压区域之间形成密封，以及（d）电和/或电子控制的致动器，其可操作以将密封元件移动抵靠和/或远离座椅，以允许控制从高压区到低压区的流体流动。在具体实施例中，高压区域在其超临界或近临界温度和压力条件下包含流体。例如，阀可用于提供非常低的流速，例如用于超临界流体色谱，超临界流体萃取，临界点干燥，超临界流体清洗和超临界流体分离方法。在另一个实施方案中，该阀适用于将生物活性物质递送至有需要的患者的方法。

4. 发明授权

US09010329B2 Electronically-controlled, high pressure flow control valve and method of use 有权
标题翻译：电子控制，高压流量控制阀及使用方法
公开(公告)号：US09010329B2
公开(公告)日：2015-04-21
申请号：US12703351
申请日：2010-02-10
申请人： Brian N. Hansen
发明人： Brian N. Hansen
IPC分类号： A62B9/02 , A61M11/00 , F16K31/02 , A61M15/00 , F16K1/14 , A61M16/00 , B65D83/54
CPC分类号： F16K31/02 , A61M15/008 , A61M15/009 , A61M2016/0021 , A61M2202/0225 , A61M2205/0266 , A61M2205/8225 , B65D83/54 , F16K1/14
摘要： A fluid flow control valve comprises (a) a high pressure region adapted to contain a fluid at its supercritical or nearcritical temperature and pressure conditions and connected via an orifice to a low pressure region, (b) a seat adjacent the orifice, (c) a sealing element positionable against the seat to form a seal between the high pressure region and the low pressure region, and (d) an electrically and/or electronically controlled actuator operable to move the sealing element against and/or away from the seat to allow control of fluid flow from the high pressure region to the low pressure region. In a specific embodiment, the high pressure region contains a fluid at its supercritical or nearcritical temperature and pressure conditions. The valve may be used, for example, to provide very low flow rates, for example, for supercritical fluid chromatography, supercritical fluid extraction, critical point drying, supercritical fluid cleaning, and supercritical fluid separation methods. In another embodiment, the valve is suitable for use in methods of delivering a biologically active substance to a patient in need thereof.
摘要翻译：流体流量控制阀包括（a）适于在其超临界或近临界温度和压力条件下容纳流体的高压区域，并通过孔口连接到低压区域，（b）与孔口相邻的座位，（c）密封元件，其可抵靠座椅定位以在高压区域和低压区域之间形成密封，以及（d）电和/或电子控制的致动器，其可操作以将密封元件移动抵靠和/或远离座椅，以允许控制从高压区到低压区的流体流动。在具体实施例中，高压区域在其超临界或近临界温度和压力条件下包含流体。例如，阀可用于提供非常低的流速，例如用于超临界流体色谱，超临界流体萃取，临界点干燥，超临界流体清洗和超临界流体分离方法。在另一个实施方案中，该阀适用于将生物活性物质递送至有需要的患者的方法。

5. 发明授权

US07772414B1 Process for producing biodiesel fuel products 有权
标题翻译：生产生物柴油燃料产品的工艺
公开(公告)号：US07772414B1
公开(公告)日：2010-08-10
申请号：US11939267
申请日：2007-11-13
申请人： Brooks Michael Hybertson , Brian N. Hansen
发明人： Brooks Michael Hybertson , Brian N. Hansen
IPC分类号： C11C1/10 , C11B1/10
CPC分类号： C11B1/104 , C10G2300/1011 , C10L1/026 , C11C3/003 , Y02E50/13 , Y02P20/544 , Y02P30/20
摘要： A method for producing a biodiesel fuel product from biological material is disclosed which comprises extracting lipids from the biological material with a pure or alcohol-modified supercritical fluid in an extractor, passing the extract directly into a reactor wherein a transesterification reaction is induced between the extracted lipids and alcohol with additional alcohol added if needed, forming glycerol and fatty acid alkyl esters, passing the mixture into one or more separators to remove the glycerol and fatty acid alkyl ester products, removing wastes, and recycling the critical fluid solvent and unreacted alcohol to the extractor. An improvement to biodiesel preparation is afforded by the simplification of the extraction and reaction processes into a single flowing system. According to the invention, a biodiesel fatty acid alkyl ester product can be prepared directly from biological material feedstock, such as oil-containing seeds, without the need for prior isolation of the oil.
摘要翻译：公开了一种从生物材料生产生物柴油燃料产品的方法，该方法包括在提取器中用纯或醇改性的超临界流体从生物材料中提取脂质，将提取物直接送入反应器，其中在提取的脂肪和醇，如果需要，加入另外的醇，形成甘油和脂肪酸烷基酯，将混合物通入一个或多个分离器中以除去甘油和脂肪酸烷基酯产物，除去废物，并将临界流体溶剂和未反应的醇再循环提取器。通过将萃取和反应过程简化为单一流动系统，可以改善生物柴油的制备。根据本发明，生物柴油脂肪酸烷基酯产物可以直接从生物材料原料（例如含油种子）制备，而不需要事先分离油。

6. 发明授权

US6090267A Methods and apparatus for quantitative analysis of a sample 失效
标题翻译：用于样品定量分析的方法和装置
公开(公告)号：US6090267A
公开(公告)日：2000-07-18
申请号：US118023
申请日：1998-07-17
申请人： Brian N. Hansen , Arnold E. Williams
发明人： Brian N. Hansen , Arnold E. Williams
IPC分类号： G01N27/06 , G01N27/404
CPC分类号： G01N27/06
摘要： Methods for determining the amount of volatile electrolyte present in an aqueous liquid sample comprise transferring the electrolyte from the aqueous liquid sample to an absorber solution across a gas-permeable membrane which is non-passable to the aqueous liquid sample and measuring the change in electrical conductivity of the absorber solution during the transfer period. The absorber solution contains a solute which enhances the transfer of the electrolyte. Apparatus for conducting such methods include an absorber solution containing a solute which enhances the transfer of the electrolyte.
摘要翻译：确定水性液体样品中存在的挥发性电解质的量的方法包括将电解质从水性液体样品转移到透过膜的吸收剂溶液中，所述透气膜不可通过含水液体样品并测量电导率的变化的吸收剂溶液。吸收剂溶液含有可以增强电解质转移的溶质。用于进行这种方法的装置包括含有增强电解质转移的溶质的吸收剂溶液。

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