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1. 发明授权

US4061313A Apparatus for the static mixing of flowable substances 失效
标题翻译：用于静态混合可流动物质的装置
公开(公告)号：US4061313A
公开(公告)日：1977-12-06
申请号：US700645
申请日：1976-06-28
申请人： Dieter Brauner , Hans-Joachim Kaluza , Edgar Muschelknautz
发明人： Dieter Brauner , Hans-Joachim Kaluza , Edgar Muschelknautz
IPC分类号： B01F5/00 , B01F5/06 , B01J8/06 , B01F15/02
CPC分类号： B01F5/0619 , B01F5/0695 , B01F2215/0431 , B01F2215/0468 , B01F2215/049 , B01F2215/0495
摘要： For the static mixing of flowable substances a tubular housing is used having a mixing insert therein, consisting of a plurality of plates having webs in intersecting planes inclined to the axis of the housing, between which slots are provided, the free spaces within the housing being filled with packing material.
摘要翻译：对于可流动物质的静态混合，使用管状壳体，其中具有混合插入件，其由多个板组成，多个板在与壳体的轴线倾斜的相交平面中具有腹板，在其间设有槽，壳体内的自由空间为充满包装材料。

2. 发明申请

US20040180005A1 Method for the production of nanodispersions 审中-公开
标题翻译：生产纳米分散体的方法
公开(公告)号：US20040180005A1
公开(公告)日：2004-09-16
申请号：US10478601
申请日：2003-11-19
发明人： Kai Christian Jurgens , Bernd Kuhn
IPC分类号： A61L009/04 , A61K009/14
CPC分类号： A61K9/5123 , A61K9/1075 , A61K9/5146 , A61K9/5192 , B01F3/04 , B01F3/12 , B01F5/0256 , B01F13/0059 , B01F2215/0431 , B01F2215/045 , B01F2215/0468 , B01F2215/049 , B01J2219/00889
摘要： A method for the production of nanodispersions, in which at least two metered partial streams are brought together in such a way that they are subject to thorough mixing caused by turbulence. The partial streams have a flow rate in the range from 0.1 to 500 ml/h and the mixed stream has an overall flow rate in the range from 1 ml/h to 500 ml/h. The turbulent mixing leads to the formation of a disperse phase in a continuous phase with a dispersity of 0.1 to 5000 nm. Another object of the invention is a method for the in-situ formulation of a pharmaceutical dispersion, with in-line application of the pharmaceutical dispersion.
摘要翻译：一种用于生产纳米分散体的方法，其中至少两个计量的部分流以使得它们受到由湍流引起的充分混合的方式组合在一起。部分流的流速为0.1至500ml / h，混合流的总流速为1ml / h至500ml / h。湍流混合导致在分散相为0.1〜5000nm的连续相中形成分散相。本发明的另一个目的是通过在线施用药物分散体来原位制备药物分散体的方法。

3. 发明授权

US11660577B2 Fractal flow distribution system 有权
公开(公告)号：US11660577B2
公开(公告)日：2023-05-30
申请号：US16602498
申请日：2018-04-20
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
发明人： Jim Patel , Maciej Mazur , Tejas Bhatelia , Benny Kuan
IPC分类号： B01F25/00 , B01F35/71 , B01F25/41 , B33Y80/00 , B01F101/59
CPC分类号： B01F25/12 , B01F25/41 , B01F35/7182 , B01F2101/59 , B01F2215/045 , B01F2215/049 , B01F2215/0427 , B01F2215/0431 , B33Y80/00
摘要： A flow distribution system for distributing and dividing the flows of at least two separate fluids, the distribution system comprising: a three-dimensional nested structure of at least two fluid transporting fractals comprising at least a first fluid transporting fractal and a second fluid transporting fractal, each fluid transporting fractal having a respective fluid inlet which bifurcates to a plurality of fluid outlets, each fluid transporting fractal being configured to facilitate a flow therethrough independent from a flow in the other fluid transporting fractal, each fluid transporting fractal extending along and about a central axis between fluid inlet and a plurality of fluid outlets; wherein each fluid transporting fractals comprises of a series of recursive bifurcation units assembled in a selected number of stages, each bifurcation unit comprising a Y-shaped bifurcated element which is fluidly connected to two successive bifurcation units, each successive bifurcation unit being rotated relative to the central axis by an angle of between 60 and 120 degrees relative to the previous stage; each fluid transporting fractal is intertwined with the other fluid transporting fractal; each fluid transporting fractal is positioned offset from the other fluid transporting fractal about the central axis and are arranged such that each fluid outlet from one of the fluid transporting fractals is located adjoining a fluid outlet of the other fluid transporting fractal, and each fluid transporting fractal is centered about a flow axis which is laterally inclined from greater than 0 to 20 degrees from the central axis and longitudinally inclined from greater than 0 to 20 degrees from the central axis.

4. 发明申请

US20070008812A1 Process for making slurries 有权
标题翻译：制浆的过程
公开(公告)号：US20070008812A1
公开(公告)日：2007-01-11
申请号：US11451783
申请日：2006-06-13
申请人： John Bush , I. Chang-Mateu
发明人： John Bush , I. Chang-Mateu
IPC分类号： B28C5/00
CPC分类号： B01F5/102 , B01F3/1207 , B01F3/1221 , B01F3/22 , B01F3/2261 , B01F5/104 , B01F7/0075 , B01F15/00396 , B01F15/0437 , B01F2003/1285 , B01F2013/1052 , B01F2215/005 , B01F2215/0427 , B01F2215/044 , B01F2215/049 , B01F2215/0495 , C04B40/0028 , C04B14/365 , C04B26/06 , C04B2103/40 , C04B2103/44 , C04B2103/50 , C04B24/2641 , C04B28/14 , C04B14/303
摘要： A process for making slurries is provided. The process comprises providing a liquid component and a solids component; introducing the liquid component into a mixing vessel having pitched blade turbines; adding at least 25% of the solids component into the mixing vessel; initiating an in-line rotor stator positioned to receive the mixture from the mixing vessel; and re-circulating the mixture from the mixing vessel through the in-line rotor stator and back to the mixing vessel.
摘要翻译：提供了制备浆料的方法。该方法包括提供液体组分和固体组分; 将液体组分引入具有桨叶式涡轮机的混合容器中; 将至少25％的固体组分加入到混合容器中; 启动定位成接收来自混合容器的混合物的在线转子定子; 并将混合物从混合容器再循环通过在线转子定子并返回混合容器。

5. 发明授权

US08517595B2 Apparatus and method for mixing by producing shear and/or cavitation, and components for apparatus 有权
标题翻译：通过产生剪切和/或空化以及用于装置的部件混合的装置和方法
公开(公告)号：US08517595B2
公开(公告)日：2013-08-27
申请号：US12147629
申请日：2008-06-27
申请人： Lowen Robert Morrison, Jr. , Ke-Ming Quan , Raul Victorino Nunes , Vesselin Nikolov Shanov , Paul Alfred Cimiluca
发明人： Lowen Robert Morrison, Jr. , Ke-Ming Quan , Raul Victorino Nunes , Vesselin Nikolov Shanov , Paul Alfred Cimiluca
IPC分类号： B01F11/00 , B01F15/02
CPC分类号： B01F5/0682 , A61K31/60 , A61K33/245 , B01F3/04978 , B01F3/0819 , B01F3/1242 , B01F5/0688 , B01F11/0208 , B01F2215/0431 , B01F2215/0468 , B01F2215/049 , A61K2300/00
摘要： An apparatus and method for mixing by producing shear and/or cavitation, and components for the apparatus are disclosed. In one embodiment, the apparatus includes a mixing and/or cavitation chamber with an element such as an orifice component that is located adjacent the entrance of the cavitation chamber. The apparatus may further include a blade, such as a knife-like blade, disposed inside the mixing and/or cavitation chamber opposite the orifice component. In one version of such an embodiment, at least some of the portions of the orifice component surrounding the orifice and/or the blade are made of a material or materials that have a Vickers hardness of greater than or equal to about 20 GPa. A process for mixing by producing shear and/or cavitation in a fluid is also contemplated herein.
摘要翻译：公开了一种通过产生剪切和/或空化以及该装置的部件进行混合的装置和方法。在一个实施例中，该装置包括具有诸如孔部件的元件的混合和/或空化室，其邻近空化室的入口定位。该装置还可以包括设置在与孔部件相对的混合和/或空化腔室内的刀片，例如刀状刀片。在这种实施例的一种形式中，围绕孔和/或叶片的孔组件的至少部分部分由维氏硬度大于或等于约20GPa的材料制成。本文还考虑通过在流体中产生剪切和/或空化进行混合的方法。

6. 发明授权

US07637651B2 Process for making slurries 有权
标题翻译：制浆的过程
公开(公告)号：US07637651B2
公开(公告)日：2009-12-29
申请号：US11451783
申请日：2006-06-13
申请人： John W. Bush , I. Midey Chang-Mateu
发明人： John W. Bush , I. Midey Chang-Mateu
IPC分类号： B01F13/10
CPC分类号： B01F5/102 , B01F3/1207 , B01F3/1221 , B01F3/22 , B01F3/2261 , B01F5/104 , B01F7/0075 , B01F15/00396 , B01F15/0437 , B01F2003/1285 , B01F2013/1052 , B01F2215/005 , B01F2215/0427 , B01F2215/044 , B01F2215/049 , B01F2215/0495 , C04B40/0028 , C04B14/365 , C04B26/06 , C04B2103/40 , C04B2103/44 , C04B2103/50 , C04B24/2641 , C04B28/14 , C04B14/303
摘要： A process for making slurries is provided. The process comprises providing a liquid component and a solids component; introducing the liquid component into a mixing vessel having pitched blade turbines; adding at least 25% of the solids component into the mixing vessel; initiating an in-line rotor stator positioned to receive the mixture from the mixing vessel; and re-circulating the mixture from the mixing vessel through the in-line rotor stator and back to the mixing vessel.
摘要翻译：提供了制备浆料的方法。该方法包括提供液体组分和固体组分; 将液体组分引入具有桨叶式涡轮机的混合容器中; 将至少25％的固体组分加入到混合容器中; 启动定位成接收来自混合容器的混合物的在线转子定子; 并将混合物从混合容器再循环通过在线转子定子并返回混合容器。

7. 发明申请

US20090003123A1 APPARATUS AND METHOD FOR MIXING BY PRODUCING SHEAR AND/OR CAVITATION, AND COMPONENTS FOR APPARATUS 有权
标题翻译：通过生产剪刀和/或加工混合的装置和方法以及装置的组件
公开(公告)号：US20090003123A1
公开(公告)日：2009-01-01
申请号：US12147629
申请日：2008-06-27
申请人： Lowen Robert Morrison, JR. , Ke-Ming Quan , Raul Victorine Nunes , Vesselin Nikolov Shanov , Paul Alfred Cimiluca
发明人： Lowen Robert Morrison, JR. , Ke-Ming Quan , Raul Victorine Nunes , Vesselin Nikolov Shanov , Paul Alfred Cimiluca
IPC分类号： B01F11/00 , B01F15/02
CPC分类号： B01F5/0682 , A61K31/60 , A61K33/245 , B01F3/04978 , B01F3/0819 , B01F3/1242 , B01F5/0688 , B01F11/0208 , B01F2215/0431 , B01F2215/0468 , B01F2215/049 , A61K2300/00
摘要： An apparatus and method for mixing by producing shear and/or cavitation, and components for the apparatus are disclosed. In one embodiment, the apparatus includes a mixing and/or cavitation chamber with an element such as an orifice component that is located adjacent the entrance of the cavitation chamber. The apparatus may further include a blade, such as a knife-like blade, disposed inside the mixing and/or cavitation chamber opposite the orifice component. In one version of such an embodiment, at least some of the portions of the orifice component surrounding the orifice and/or the blade are made of a material or materials that have a Vickers hardness of greater than or equal to about 20 GPa. A process for mixing by producing shear and/or cavitation in a fluid is also contemplated herein.
摘要翻译：公开了一种通过产生剪切和/或空化以及该装置的部件进行混合的装置和方法。在一个实施例中，该装置包括具有诸如孔部件的元件的混合和/或空化室，其邻近空化室的入口定位。该装置还可以包括设置在与孔部件相对的混合和/或空化腔室内的刀片，例如刀状刀片。在这种实施例的一种形式中，围绕孔和/或叶片的孔组件的至少部分部分由维氏硬度大于或等于约20GPa的材料制成。本文还考虑通过在流体中产生剪切和/或空化进行混合的方法。

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