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1. 发明授权

US11684777B2 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation 有权
公开(公告)号：US11684777B2
公开(公告)日：2023-06-27
申请号：US16335444
申请日：2017-09-22
申请人： INOVIO PHARMACEUTICALS, INC.
发明人： Paul Fisher , Kate Broderick , Jay McCoy
IPC分类号： A61N1/32 , A61N1/04
CPC分类号： A61N1/327 , A61N1/0416 , A61N1/0404
摘要： A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surf ace and the second contact surface define a treatment zone therebetween. The method including positioning a fold of tissue between the first and second electrodes such that the treatment zone formed between the two electrodes includes an adipose layer of tissue and no skeletal muscle.

2. 发明授权

US11666754B2 Apparatus and method of non-invasive directional tissue treatment 有权
公开(公告)号：US11666754B2
公开(公告)日：2023-06-06
申请号：US16177481
申请日：2018-11-01
申请人： DASYO TECHNOLOGY LTD.
发明人： Yoni Iger , Dan David Albeck
IPC分类号： A61N1/32 , A61B18/18 , A61N1/04 , A61B18/14 , A61B18/12 , A61N1/06 , A61N1/40 , A61B18/00
CPC分类号： A61N1/328 , A61B18/1206 , A61B18/1402 , A61B18/18 , A61N1/0404 , A61N1/06 , A61B2018/0016 , A61B2018/0047 , A61B2018/00577 , A61B2018/00589 , A61B2018/00642 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1467 , A61N1/40
摘要： Some embodiments of the invention may be related to an apparatus for non-invasive directional tissue treatment. The apparatus includes a radiofrequency (RF) generator and an array of RF energy delivery elements in monopolar configuration, in active communication with the RF generator, at least one of: a return electrode and a return pad, and a power source and a controller. In some embodiments, each of the RF energy delivery elements comprises a monopolar electrode such that each monopolar electrode has a first dimension and a second dimension, the first dimension perpendicular to the second dimension. In some embodiments, the first dimension of each monopolar electrode and the distance between the monopolar electrodes in each pair are configured to create an elongated heated volume of tissue when the RF generator is activated and at least one of the RF delivery elements is in contact with the tissue.

3. 发明申请

US20190099078A1 INTERACTIVE DISPLAY OF SELECTED ECG CHANNELS 审中-公开
公开(公告)号：US20190099078A1
公开(公告)日：2019-04-04
申请号：US15722667
申请日：2017-10-02
申请人： Biosense Webster (Israel) Ltd.
发明人： Ziyad ZEIDAN , Gal HAYAM
IPC分类号： A61B5/00 , A61N1/37 , A61N1/372
CPC分类号： A61B5/0006 , A61B5/0422 , A61B5/044 , A61B5/748 , A61N1/0404 , A61N1/3702 , A61N1/37247 , G16H40/63
摘要： An ECG signal correlation and display system is provided which includes memory configured to store ECG data corresponding to electrical signals, acquired over time, from different areas of a heart and location data corresponding to acquired location signals indicating locations of the different areas of the heart from which the electrical signals are acquired. The system also includes a processing device configured to generate, from the ECG data and the location data, mapping information for displaying a map of the heart and determine a location of an anatomical region of the heart on the map. The processing device is also configured to determine which of the plurality of electrical signals are acquired from the anatomical region of the heart and generate correlated ECG signal information for displaying the electrical signals determined to be acquired from the anatomical region of the heart.

4. 发明申请

US20180197653A1 POLYMERIZABLE MONOMER, POLYMER COMPOUND, BIOLOGICAL ELECTRODE COMPOSITION, BIOLOGICAL ELECTRODE, AND METHOD FOR PRODUCING BIOLOGICAL ELECTRODE 审中-公开
公开(公告)号：US20180197653A1
公开(公告)日：2018-07-12
申请号：US15858365
申请日：2017-12-29
申请人： SHIN-ETSU CHEMICAL CO., LTD.
发明人： Jun HATAKEYAMA , Osamu WATANABE , Motoaki IWABUCHI , Takayuki FUJIWARA
IPC分类号： H01B1/24 , A61L27/50 , A61L31/12
CPC分类号： H01B1/24 , A61L27/50 , A61L31/126 , A61L2420/02 , A61N1/00 , A61N1/0404
摘要： The present invention provides: a biological electrode composition formable a living body contact layer for a biological electrode which is excellent in conductivity and biocompatibility, as well as light in the weight thereof and producible at a low cost, and in addition, which does not cause a significant decrease in the conductivity thereof regardless of under a water-wet condition and a dry condition; a polymer compound which can be suitably used for the biological electrode composition; a polymerizable monomer suitable as a raw material of the polymer compound; a biological electrode having a living body contact layer formed of the biological electrode composition; and a method for producing the same; and wherein, the polymerizable monomer is represented by the following general formula (1).

5. 发明申请

US20160015962A1 Smart Patch For Wound Management 审中-公开
标题翻译：伤口管理智能补丁
公开(公告)号：US20160015962A1
公开(公告)日：2016-01-21
申请号：US14801134
申请日：2015-07-16
申请人： Mehdi Shokoueinejad Maragheh , Sarah R. Sandock , Akshay Kumar , Yei Hwan Jung
发明人： Mehdi Shokoueinejad Maragheh , Sarah R. Sandock , Akshay Kumar , Yei Hwan Jung
IPC分类号： A61N1/04 , A61N5/06 , A61F13/00
CPC分类号： A61N1/0468 , A61B5/0059 , A61B5/01 , A61B5/0531 , A61B5/445 , A61B5/447 , A61F13/00021 , A61F13/00034 , A61F13/00055 , A61F13/00059 , A61N1/0404 , A61N1/0492 , A61N1/32 , A61N5/0616 , A61N2005/0645 , A61N2005/0652 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662
摘要： A flexible patch is provided that is capable of emitting light in the UV, visible, and/or infrared electromagnetic spectrums. The patch contains a feedback process and system using one or more sensors and a controller on the patch to (1) accelerate the wound healing process by providing adaptable, controlled light exposure and electrical stimulation, (2) monitor the healing process for signs of infection (3) eliminate bacterial infections by sanitizing the infected site and (4) relaying the information wirelessly to a central location for storage and interpretation by a physician as well as by providing the ability to receive feedback and operating instructions from the physician from a remote location.
摘要翻译：提供了能够在UV，可见光和/或红外电磁光谱中发射光的柔性贴片。补丁包含一个反馈过程和系统，使用一个或多个传感器和贴片上的控制器（1）通过提供适应性强的受控光照和电刺激来加速伤口愈合过程，（2）监测愈合过程的感染迹象（3）通过消毒感染部位消除细菌感染，（4）将信息无线中继到中心位置，以便由医师进行存储和解释，以及通过提供接收来自远程位置的医生的反馈和操作指令的能力。

6. 发明授权

US09061162B2 Dynamic modification of modulation throughout a therapy period 有权
标题翻译：整个治疗期间动态调节调节
公开(公告)号：US09061162B2
公开(公告)日：2015-06-23
申请号：US14306968
申请日：2014-06-17
申请人： Adi Mashiach , Itzik Mashiach
发明人： Adi Mashiach , Itzik Mashiach
IPC分类号： A61N1/00 , A61N1/375 , A61N1/36 , A61N1/372
CPC分类号： A61N1/37223 , A61B5/0031 , A61B5/01 , A61B5/0488 , A61B5/11 , A61B5/113 , A61B5/4519 , A61B5/4818 , A61B5/682 , A61B5/6822 , A61B5/6833 , A61B5/6876 , A61B7/04 , A61B17/30 , A61B2560/0219 , A61B2562/16 , A61B2562/164 , A61B2562/227 , A61F5/566 , A61N1/0404 , A61N1/0456 , A61N1/0492 , A61N1/0514 , A61N1/0526 , A61N1/0553 , A61N1/36003 , A61N1/3601 , A61N1/36014 , A61N1/3605 , A61N1/36057 , A61N1/36075 , A61N1/3611 , A61N1/36117 , A61N1/36135 , A61N1/36139 , A61N1/36146 , A61N1/37229 , A61N1/3756 , A61N1/3758 , A61N1/3787 , A61N2/006 , A61N2/02 , A61N2001/37294
摘要： A device for controlling operation of a nerve-modulating implant unit from a location external to the body of the subject is provided. The device may include a flexible substrate configured for removable attachment to a subject's skin, a primary antenna disposed on the flexible substrate, and at least one processing device. The processing device may be configured to cause generation of a modulation control signal and application of the modulation control signal to the primary antenna in order to wirelessly transmit the modulation control signal to a secondary antenna on the implant unit to cause modulation of at least one nerve using energy transmitted wirelessly from the primary antenna to the secondary antenna, and cause a plurality of predetermined alterations of at least one characteristic of the modulation control signal over successive applications of the modulation control signal during a therapy period.
摘要翻译：提供了一种用于从对象身体外部的位置控制神经调节植入单元的操作的装置。该装置可以包括被配置为可移除地连接到受试者的皮肤的柔性基底，设置在柔性基底上的主要天线以及至少一个处理装置。处理装置可以被配置为产生调制控制信号和将调制控制信号施加到主天线，以便将调制控制信号无线地传送到植入单元上的辅助天线，以引起至少一个神经的调制使用从主天线无线地传输到次天线的能量，并且在治疗期间连续应用调制控制信号，引起调制控制信号的至少一个特性的多个预定的改变。

7. 发明申请

US20140371822A1 Dynamic Modification of Modulation Throughout a Therapy Period 有权
标题翻译：整个治疗期间调节的动态修改
公开(公告)号：US20140371822A1
公开(公告)日：2014-12-18
申请号：US14306968
申请日：2014-06-17
申请人： Adi Mashiach , Itzik Mashiach
发明人： Adi Mashiach , Itzik Mashiach
IPC分类号： A61N1/372 , A61N1/36
CPC分类号： A61N1/37223 , A61B5/0031 , A61B5/01 , A61B5/0488 , A61B5/11 , A61B5/113 , A61B5/4519 , A61B5/4818 , A61B5/682 , A61B5/6822 , A61B5/6833 , A61B5/6876 , A61B7/04 , A61B17/30 , A61B2560/0219 , A61B2562/16 , A61B2562/164 , A61B2562/227 , A61F5/566 , A61N1/0404 , A61N1/0456 , A61N1/0492 , A61N1/0514 , A61N1/0526 , A61N1/0553 , A61N1/36003 , A61N1/3601 , A61N1/36014 , A61N1/3605 , A61N1/36057 , A61N1/36075 , A61N1/3611 , A61N1/36117 , A61N1/36135 , A61N1/36139 , A61N1/36146 , A61N1/37229 , A61N1/3756 , A61N1/3758 , A61N1/3787 , A61N2/006 , A61N2/02 , A61N2001/37294
摘要： A device for controlling operation of a nerve-modulating implant unit from a location external to the body of the subject is provided. The device may include a flexible substrate configured for removable attachment to a subject's skin, a primary antenna disposed on the flexible substrate, and at least one processing device. The processing device may be configured to cause generation of a modulation control signal and application of the modulation control signal to the primary antenna in order to wirelessly transmit the modulation control signal to a secondary antenna on the implant unit to cause modulation of at least one nerve using energy transmitted wirelessly from the primary antenna to the secondary antenna, and cause a plurality of predetermined alterations of at least one characteristic of the modulation control signal over successive applications of the modulation control signal during a therapy period.
摘要翻译：提供了一种用于从对象身体外部的位置控制神经调节植入单元的操作的装置。该装置可以包括被配置为可移除地连接到受试者的皮肤的柔性基底，设置在柔性基底上的主要天线以及至少一个处理装置。处理装置可以被配置为产生调制控制信号和将调制控制信号施加到主天线，以便将调制控制信号无线地传送到植入单元上的辅助天线，以引起至少一个神经的调制使用从主天线无线地传输到次天线的能量，并且在治疗期间连续应用调制控制信号，引起调制控制信号的至少一个特性的多个预定的改变。

8. 发明授权

US08463388B2 Electronic low-frequency pulse patch of a one-piece structure and method for manufacturing the same 有权
标题翻译：一体式电子低频脉冲贴片及其制造方法
公开(公告)号：US08463388B2
公开(公告)日：2013-06-11
申请号：US12719976
申请日：2010-03-09
申请人： Tuan Wei
发明人： Tuan Wei
IPC分类号： A61N1/36 , A61N1/04
CPC分类号： A61N1/0404 , A61N1/0408 , A61N1/048 , A61N1/0492 , A61N1/0496 , A61N1/36021 , Y10T29/49002
摘要： An electronic low-frequency pulse patch of a one-piece structure comprises a flexible top cover body, a hollow supporting enclosure, a circuit control unit, a power supply unit, a base and a coupling output conductive flexible film. Flexible top cover body is coupled to the coupling output conductive flexible film with hollow supporting enclosure located therebetween. Circuit control unit and the power supply unit are coupled to the base for providing respective low-frequency electric pulses. Electrical conduction is accomplished by electrically connecting the first and the second conductive ends of the base to respective conductive contact lugs of the coupling output conductive flexible film. At either side of which, first and second low-frequency pulse output regions are disposed, such that the electronic low-frequency pulse patch is bendable for conforming to curvature at different locations of the human body without using screw or other means.
摘要翻译：一体结构的电子低频脉冲贴片包括柔性顶盖体，中空支撑壳体，电路控制单元，电源单元，基座和耦合输出导电柔性膜。柔性顶盖主体联接到耦合输出导电柔性膜，其间具有中空支撑外壳。电路控制单元和电源单元耦合到基座，以提供相应的低频电脉冲。通过将基座的第一和第二导电端电连接到耦合输出导电柔性膜的相应导电接触片来实现电传导。在其任一侧，设置第一和第二低频脉冲输出区域，使得电子低频脉冲片可以在人体的不同位置处弯曲以适应曲率而不使用螺钉或其它装置。

9. 发明申请

US20130053865A1 ADJUSTABLE WIRE LENGTH STYLET HANDLE 有权
标题翻译：可调电线长度手柄
公开(公告)号：US20130053865A1
公开(公告)日：2013-02-28
申请号：US13222018
申请日：2011-08-31
申请人： Elliot W. BRIDGEMAN , Tom E. WALCH , Lawrence KANE
发明人： Elliot W. BRIDGEMAN , Tom E. WALCH , Lawrence KANE
IPC分类号： A61N1/378 , B23P11/00 , A61B19/00
CPC分类号： A61N1/0551 , A61M25/0102 , A61M25/0105 , A61M25/0133 , A61M25/0136 , A61M2025/09116 , A61M2025/09125 , A61N1/04 , A61N1/0404 , A61N1/05 , A61N1/0558 , A61N1/3605 , Y10T29/49908
摘要： A stylet-lead assembly including a therapy delivery element and a stylet. The therapy delivery element includes a proximal end with a plurality of electrical contacts adapted to electrically couple with an implantable pulse generator, a distal end with a plurality of electrodes electrically coupled to the electrical contacts, and a lumen having a lumen length extending from the proximal end to almost the distal end. The stylet handle includes a locking insert has a first channel adapted to receive the proximal end of the stylet wire. The portion of the stylet wire extending beyond a proximal end of the locking insert includes at least one bend. A stylet handle has an opening at a distal end adapted to compressively engage the proximal end of the stylet wire to the locking insert, such that an exposed portion of the stylet wire measured from the distal end of the stylet wire to a distal end of the locking insert generally comprises the lumen length.
摘要翻译：包括治疗递送元件和探针的指针针组件。治疗递送元件包括具有适于与可植入脉冲发生器电耦合的多个电触头的近端，具有电耦合到电触点的多个电极的远端以及具有从近端结束到几乎远端。探针手柄包括锁定插入件，其具有适于容纳探针线的近端的第一通道。延伸超过锁定插入件的近端的探针线的部分包括至少一个弯曲部。探针手柄在远端具有开口，该开口适于将通孔针线的近端压缩地接合到锁定插入件，使得从通孔针线的远端测量到探针线的远端的暴露部分的探针线锁定插入件通常包括管腔长度。

10. 发明申请

US20020077578A1 Myofascial strap 有权
标题翻译：肌筋带
公开(公告)号：US20020077578A1
公开(公告)日：2002-06-20
申请号：US09738791
申请日：2000-12-15
发明人： Peter M. Bonutti
IPC分类号： A61F013/00
CPC分类号： A61N1/00 , A61F5/00 , A61F5/0104 , A61F5/03 , A61F13/022 , A61F13/0273 , A61F13/06 , A61F13/108 , A61N1/0404 , A61N1/0452 , A61N1/0472 , A61N1/18 , Y10S602/903
摘要： An improved strap has a base end portion, a second end portion and a main portion which is disposed between the base and the second end portions of the strap. A first side of the strap has a layer formed of foam. A second side of the strap has a layer formed of fabric. The second side of a base end portion of the strap has a layer formed of foam. The layer formed of foam on the first side of the strap is placed in engagement with skin on a body of a patient. The base end portion of the strap is retained against movement relative to the body of the patient by wrapping the strap around a portion of the body of the patient and positioning a portion of the layer formed of foam and disposed on the first side of the strap in engagement with foam disposed on the second side of the base end portion of the strap. A second end portion of the strap is connected with the fabric layer on the second side of the strap at a location between the end portions of the strap.
摘要翻译：改进的带子具有基端部分，第二端部部分和设置在基部与带子的第二端部之间的主要部分。带的第一面具有由泡沫形成的层。带的第二面具有由织物形成的层。带子的基端部分的第二面具有由泡沫形成的层。在带的第一侧上由泡沫形成的层被放置成与患者身体上的皮肤接合。通过将带缠绕在患者身体的一部分上并且定位由泡沫形成的层的一部分并且布置在带的第一侧上，带的基端部被保持抵靠相对于患者的身体的运动与布置在带的基端部分的第二侧上的泡沫配合。带的第二端部在带的第二侧上的织物层与带的端部之间的位置连接。

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