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1. 发明授权

US08485980B2 Electrode positioning 有权
标题翻译：电极定位
公开(公告)号：US08485980B2
公开(公告)日：2013-07-16
申请号：US12239134
申请日：2008-09-26
申请人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
发明人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
IPC分类号： A61B5/08 , A61B5/042
CPC分类号： A61B5/08 , A61B5/0421 , A61B5/0488 , A61M16/00 , A61M16/024 , A61M2016/0021 , A61M2202/0208 , A61M2210/1014 , A61M2210/105 , A61M2230/04 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： In a method and device for positioning a linear array of electrodes mounted on a distal end section of an elongated flexible member in a patient's respiratory airways at the level of the patient's diaphragm, a length of the elongated flexible member pre-determined to position the linear array of electrodes at the level of the patient's diaphragm is inserted through the patient's respiratory airways. Signals representative of an electrical activity of the patient's diaphragm (EAdi) are detected through the electrodes of the linear array, a presence or absence of ECG signal components is detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways is detected in response to the presence or absence of the ECG signal components in the EAdi signals. Also, lower esophageal sphincter activity may be detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways determined in response to the detected lower esophageal sphincter. Finally, an end-expiratory occlusion of the patient's respiratory airways may be performed to verify that the electrical activity of the diaphragm coincides with a negative deflection of the patient's respiratory airways pressure again in view of determining adequate positioning of the linear array of electrodes.
摘要翻译：在用于定位安装在患者呼吸气道中的细长柔性构件的远端部分上的电极的线性阵列的方法和装置中，该患者的呼吸气道位于患者隔膜的水平面处，预定的细长柔性构件的长度定位成线性患者隔膜水平面上的电极阵列插入病人的呼吸道。通过线性阵列的电极检测代表患者隔膜（EADi）的电活动的信号，在EAdi信号中检测到ECG信号分量的存在或不存在，以及患者的电极线性阵列的位置响应EADi信号中ECG信号分量的存在或不存在来检测呼吸气道。此外，可以在EAdi信号中检测到较低的食管括约肌活动，并且响应于检测到的食管下括约肌确定患者呼吸气道中的电极线性阵列的位置。最后，考虑到确定电极的线性阵列的适当定位，可以执行患者呼吸气道的呼气末阻塞以验证隔膜的电活动与患者的呼吸气道压力的负偏转重合。

2. 发明申请

US20090137911A1 Electrode Positioning 有权
标题翻译：电极定位
公开(公告)号：US20090137911A1
公开(公告)日：2009-05-28
申请号：US12239134
申请日：2008-09-26
申请人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
发明人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
IPC分类号： A61B18/00 , A61B5/02
CPC分类号： A61B5/08 , A61B5/0421 , A61B5/0488 , A61M16/00 , A61M16/024 , A61M2016/0021 , A61M2202/0208 , A61M2210/1014 , A61M2210/105 , A61M2230/04 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： In a method and device for positioning a linear array of electrodes mounted on a distal end section of an elongated flexible member in a patient's respiratory airways at the level of the patient's diaphragm, a length of the elongated flexible member pre-determined to position the linear array of electrodes at the level of the patient's diaphragm is inserted through the patient's respiratory airways. Signals representative of an electrical activity of the patient's diaphragm (EAdi) are detected through the electrodes of the linear array, a presence or absence of ECG signal components is detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways is detected in response to the presence or absence of the ECG signal components in the EAdi signals. Also, lower esophageal sphincter activity may be detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways determined in response to the detected lower esophageal sphincter. Finally, an end-expiratory occlusion of the patient's respiratory airways may be performed to verify that the electrical activity of the diaphragm coincides with a negative deflection of the patient's respiratory airways pressure again in view of determining adequate positioning of the linear array of electrodes.
摘要翻译：在用于定位安装在患者呼吸气道中的细长柔性构件的远端部分上的电极的线性阵列的方法和装置中，该患者的呼吸气道位于患者隔膜的水平面处，预定的细长柔性构件的长度定位成线性患者隔膜水平面上的电极阵列插入病人的呼吸道。通过线性阵列的电极检测代表患者隔膜（EADi）的电活动的信号，在EAdi信号中检测到ECG信号分量的存在或不存在，以及患者的电极线性阵列的位置响应EADi信号中ECG信号分量的存在或不存在来检测呼吸气道。此外，可以在EAdi信号中检测到较低的食管括约肌活动，并且响应于检测到的食管下括约肌确定患者呼吸气道中的电极线性阵列的位置。最后，考虑到确定电极的线性阵列的适当定位，可以执行患者呼吸气道的呼气末阻塞以验证隔膜的电活动与患者的呼吸气道压力的负偏转重合。

3. 发明授权

US08256419B2 Method and device using myoelectrical activity for optimizing a patient's ventilatory assist 有权
标题翻译：使用肌电活动来优化患者通气辅助的方法和装置
公开(公告)号：US08256419B2
公开(公告)日：2012-09-04
申请号：US10589385
申请日：2005-02-18
申请人： Christer Sinderby , Jennifer Beck , Jadranka Spahija , Lars Lindstrom
发明人： Christer Sinderby , Jennifer Beck , Jadranka Spahija , Lars Lindstrom
IPC分类号： A61M11/00
CPC分类号： A61B5/6853 , A61B5/037 , A61B5/0488 , A61B5/0492 , A61M16/026 , A61M2016/0036 , A61M2210/1014 , A61M2230/08 , A61M2230/60
摘要： The present invention relates to a method and device for determining a level of ventilatory assist to a ventilator-dependent patient, in which a critical threshold of a respiration-related feature is calculated. Fatigue of a respiratory muscle of the ventilator-dependent patient develops when the critical threshold is reached by the respiration-related feature. The level of ventilatory assist to the ventilator-dependent patient is controlled in relation to the critical threshold of the respiration-related feature so as to prevent fatigue of the patient's respiratory muscle.
摘要翻译：本发明涉及一种用于确定通气机构依赖患者的通气辅助水平的方法和装置，其中计算呼吸相关特征的临界阈值。当与呼吸机相关的特征达到临界阈值时，依赖呼吸机的患者的呼吸肌肉的疲劳发展。相对于呼吸相关特征的临界阈值控制对通气机相关患者的通气辅助水平，以防止患者呼吸肌的疲劳。

4. 发明申请

US20120006327A1 Method and Device for Determining a Level of Ventilatory Assist to a Patient 有权
标题翻译：用于确定患者通气辅助水平的方法和装置
公开(公告)号：US20120006327A1
公开(公告)日：2012-01-12
申请号：US13144129
申请日：2010-01-14
申请人： Christer Sinderby , Jennifer Beck
发明人： Christer Sinderby , Jennifer Beck
IPC分类号： A61M16/00
CPC分类号： A61M16/0051 , A61B5/0488 , A61B5/08 , A61M16/026 , A61M2016/0027
摘要： A method and device for determining a level of ventilatory assist to be delivered to a patient by a mechanical ventilator in response to a measure of a patient's neural respiratory drive multiplied by an amplification factor, wherein an existing predicted ventilatory assist pressure is calculated and an existing resulting pressure delivered to the patient by the mechanical ventilator is measured. The amplification factor is changed from an existing amplification factor to a new amplification factor, a new predicted ventilatory assist pressure is calculated using the new amplification factor, and a new resulting pressure delivered to the patient by the mechanical ventilator after the amplification factor has been changed is measured. The new and existing predicted ventilatory assist pressures are compared to determine an anticipated change in pressure that will be delivered to the patient, and the new and existing resulting pressures are compared to determine an actual change in pressure delivered to the patient by the mechanical ventilator. The anticipated and actual changes in pressure are compared and a decision to increase, maintain or decrease the amplification factor is delivered in response to the comparison between the anticipated change and the actual change in pressure.
摘要翻译：一种方法和装置，用于响应于患者的神经呼吸驱动器的乘积乘以放大系数来确定由机械呼吸机传送给患者的通气辅助水平，其中计算现有预测的通气辅助压力并存在现有的测量由机械呼吸机输送给病人的压力。放大因子从现有的放大因子改变为新的放大因子，使用新的放大因子计算新的预测的通气辅助压力，并且在放大因子被改变之后由机械呼吸机传递给患者的新的所得压力被测量。比较新的和现有的预测的通气辅助压力以确定将被递送给患者的预期压力变化，并且比较新的和现有的所得压力，以确定由机械呼吸机传递给患者的压力的实际变化。比较压力的预期和实际变化，并响应于预期变化与实际压力变化之间的比较来提供增加，维持或降低放大系数的决定。

5. 发明授权

US07661427B2 Proportional pressure assist ventilation controlled by a diaphragm electromyographic signal 有权
标题翻译：比例压力辅助通气由隔膜肌电信号控制
公开(公告)号：US07661427B2
公开(公告)日：2010-02-16
申请号：US10405291
申请日：2003-04-02
申请人： Christer Sinderby , Jennifer Beck
发明人： Christer Sinderby , Jennifer Beck
IPC分类号： A61B5/04 , F16K31/02
CPC分类号： A61B5/0492 , A61M16/0051 , A61M16/026 , A61M2210/1014 , A61M2230/08 , A61M2230/60 , Y10S128/925
摘要： A closed loop system uses (a) the intensity of the diaphragm electromyogram (EMG) for a given inspiratory volume; (b) the inspiratory volume for a given EMG intensity; or (c) a combination of (a) and (b); in view of controlling the level of gas flow, gas volume or gas pressure delivered by a mechanical (lung) ventilator. The closed loop ventilator system enables for automatic or manual adjustment of the level of inspiratory support in proportion to changes in the neuro-ventilatory efficiency such that the neural drive remains stable at a desired target level. An alarm can also be used to detect changes in neuroventilatory efficiency in view of performing manual adjustments.
摘要翻译：闭环系统使用（a）给定吸气体积的隔膜肌电图（EMG）的强度; （b）给定EMG强度的吸气量; 或（c）（a）和（b）的组合; 考虑到控制由机械（肺）通气机输送的气体流量，气体体积或气体压力的水平。闭环呼吸机系统能够与神经通气效率的变化成比例地自动或手动地调整吸气支持水平，使得神经驱动器保持稳定在期望的目标水平。鉴于执行手动调整，报警器也可用于检测神经病效率的变化。

6. 发明授权

US07021310B1 Proportional pressure assist ventilation controlled by a diaphragm electromyographic signal 有权
公开(公告)号：US07021310B1
公开(公告)日：2006-04-04
申请号：US09701824
申请日：1999-06-04
申请人： Christer Sinderby , Jennifer Beck
发明人： Christer Sinderby , Jennifer Beck
IPC分类号： A61M16/00 , A62B7/00 , F16K31/02
CPC分类号： A61B5/0492 , A61M16/0051 , A61M16/026 , A61M2210/1014 , A61M2230/08 , A61M2230/60 , Y10S128/925
摘要： A closed loop system uses (a) the intensity of the diaphragm electromyogram (EMG) for a given inspiratory volume; (b) the inspiratory volume for a given EMG intensity; or (c) a combination of (a) and (b); in view of controlling the level of gas flow, gas volume or gas pressure delivered by a mechanical (lung) ventilator. The closed loop ventilator system enables for automatic or manual adjustment of the level of inspiratory support in proportion to changes in the neuro-ventilatory efficiency such that the neural drive remains stable at a desired target level. An alarm can also be used to detect changes in neuroventilatory efficiency in view of performing manual adjustments.

7. 发明授权

US09968750B2 Method and system for patient-synchronized ventilatory assist with endotracheal through-flow 有权
公开(公告)号：US09968750B2
公开(公告)日：2018-05-15
申请号：US13806816
申请日：2011-06-29
申请人： Christer Sinderby , Jennifer Beck
发明人： Christer Sinderby , Jennifer Beck
IPC分类号： A61M16/00 , A61M16/04 , A61M16/10 , A61M16/12 , A61M16/16 , A61M16/20 , A61B5/0488 , A61B5/087 , A61B5/00
CPC分类号： A61M16/0003 , A61B5/0488 , A61B5/087 , A61B5/4836 , A61M16/00 , A61M16/0012 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/04 , A61M16/042 , A61M16/0486 , A61M16/1005 , A61M16/12 , A61M16/125 , A61M16/16 , A61M16/161 , A61M16/202 , A61M16/205 , A61M2016/0018 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2202/0208 , A61M2210/1014 , A61M2230/08 , A61M2230/60
摘要： A ventilatory assist system and method are disclosed. The system comprises a tube for connection to a patient's airway, inspiratory and expiratory tube lumens connected to the tube, an inspiratory air source connected to the inspiration tube lumen, and a controller of air pressure in the expiratory tube lumen. The pressure controller is responsive to a physiological breathing signal representative of patient's inspiratory effort to allow air flow through the expiratory tube lumen during a patient's expiration phase, partially restricting the air flow through the expiratory tube lumen to a so minimum air flow during a patient's inspiration phase. During both respiratory phases, a unidirectional air flow is produced through the inspiratory and expiratory tube lumens to prevent air expired by the patient from being breathed again. The physiological breathing signal allows synchronization of the ventilatory assist with breathing efforts of the patient.

8. 发明授权

US07909034B2 Combined positive and negative pressure assist ventilation 有权
标题翻译：联合正负压辅助通气
公开(公告)号：US07909034B2
公开(公告)日：2011-03-22
申请号：US10576636
申请日：2004-10-21
申请人： Christer Sinderby , Jennifer Beck , Christer Ström
发明人： Christer Sinderby , Jennifer Beck , Christer Ström
IPC分类号： A61M16/00
CPC分类号： A61H31/02 , A61H2031/025 , A61H2201/5061 , A61H2205/083 , A61M16/022 , A61M2230/08 , A61M2230/60
摘要： The present invention relates to a method of delivering combined positive and negative pressure assist ventilation to a patient, wherein a positive pressure is applied to the patient's airways to inflate the patient's lungs, a negative pressure is applied around the patient's ribcage and/or abdomen in order to reduce a load imposed by the ribcage and/or abdomen on the patient's lungs, and application of the positive and negative pressures is synchronized. The present invention also relates to a system for delivering combined positive and negative pressure assist ventilation to a patient, comprising a positive pressure ventilator connected to the patient's airways for applying a positive pressure to the patient's airways to inflate the patient's lungs, a negative pressure ventilator installed on the patient's ribcage and/or abdomen for applying a negative pressure around the patient's ribcage and/or abdomen in order to reduce a load imposed by the ribcage and/or abdomen on the patient's lungs, and a controller for synchronizing operation of the positive and negative pressure ventilators.
摘要翻译：本发明涉及一种向患者输送组合的正压力和负压辅助通气的方法，其中向患者的气道施加正压以使患者的肺膨胀，在患者的胸部和/或腹部周围施加负压以减轻胸腔和/或腹部对患者肺部的负荷，同时施加正压和负压。本发明还涉及一种用于向患者输送组合的正压力和负压辅助通气的系统，包括连接到患者气道的正压呼吸机，用于向患者的气道施加正压以使患者的肺膨胀，负压呼吸机安装在患者的胸腔和/或腹部上，以在患者胸部和/或腹部周围施加负压，以便减少胸腔和/或腹部对患者的肺部施加的负荷，以及控制器，用于使阳性和负压通气机。

9. 发明授权

US07472702B2 Method and device responsive to diaphragmatic activity for adjusting positive pressure assist during expiration 有权
标题翻译：响应于隔膜活动的方法和装置，用于调节呼气期间的正压辅助
公开(公告)号：US07472702B2
公开(公告)日：2009-01-06
申请号：US10808722
申请日：2004-03-25
申请人： Jennifer Beck , Christer Sinderby
发明人： Jennifer Beck , Christer Sinderby
IPC分类号： A61M11/00
CPC分类号： A61M16/024 , A61M2016/0021 , A61M2210/1014 , A61M2230/63
摘要： A method and device for controlling positive pressure assist to a patient during expiration, measure a level of electrical activity of a patient's respiration-related muscle during expiration. In response to the measured level of electrical activity, a level of positive pressure assist to the patient during expiration is adjusted in view of minimizing the level of electrical activity of the patient's respiration-related muscle during expiration.
摘要翻译：一种用于在呼气期间控制对患者的正压辅助的方法和装置，测量在呼气期间患者呼吸相关肌肉的电活动水平。考虑到所测量的电活动水平，考虑到在呼气期间最小化患者呼吸相关肌肉的电活动水平，调整在呼气期间向患者辅助的正压水平。

10. 发明申请

US20080121231A1 Method and Device Using Myoelectrical Activity for Optimizing a Patient's Ventilatory Assist 有权
标题翻译：使用肌电活动优化患者通气辅助的方法和装置
公开(公告)号：US20080121231A1
公开(公告)日：2008-05-29
申请号：US10589385
申请日：2005-02-18
申请人： Christer Sinderby , Jennifer Beck , Jadranka Spahija , Lara Lindstrom
发明人： Christer Sinderby , Jennifer Beck , Jadranka Spahija , Lara Lindstrom
IPC分类号： A61M16/00
CPC分类号： A61B5/6853 , A61B5/037 , A61B5/0488 , A61B5/0492 , A61M16/026 , A61M2016/0036 , A61M2210/1014 , A61M2230/08 , A61M2230/60
摘要： The present invention relates to a method and device for determining a level of ventilatory assist to a ventilator-dependent patient, in which a critical threshold of a respiration-related feature is calculated. Fatigue of a respiratory muscle of the ventilator-dependent patient develops when the critical threshold is reached by the respiration-related feature. The level of ventilatory assist to the ventilator-dependent patient is controlled in relation to the critical threshold of the respiration-related feature so as to prevent fatigue of the patient's respiratory muscle.
摘要翻译：本发明涉及一种用于确定通气机构依赖患者的通气辅助水平的方法和装置，其中计算呼吸相关特征的临界阈值。当与呼吸机相关的特征达到临界阈值时，依赖呼吸机的患者的呼吸肌肉的疲劳发展。相对于呼吸相关特征的临界阈值控制对通气机相关患者的通气辅助水平，以防止患者呼吸肌的疲劳。

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