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1. 发明授权

US07696182B2 Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin 有权
标题翻译：包含牛磺酰胺衍生物和生物可接受的盐和酸的抗微生物锁定溶液，加入少量肝素
公开(公告)号：US07696182B2
公开(公告)日：2010-04-13
申请号：US10979547
申请日：2004-11-02
申请人： Frank R. Prosl
发明人： Frank R. Prosl
IPC分类号： A61K31/727 , A61K31/185 , A61K31/18
CPC分类号： A61L29/16 , A01N25/02 , A01N43/88 , A61K31/18 , A61K31/185 , A61K31/727 , A61L29/00 , A61L29/043 , A61L2300/204 , A61L2300/406 , A61K2300/00
摘要： The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to the device a pharmaceutically effective amount of a composition comprising: (A) at least one taurinamide derivative, (B) at least one compound selected from the group consisting of biologically acceptable acids and biologically acceptable salts thereof; and (C) heparin at a low concentration.
摘要翻译：本发明涉及在血管插入患者之后抑制或预防感染并防止通畅并发症，包括向该装置施用药学有效量的组合物，其包含：（A）至少一种牛磺酰胺衍生物，（B）至少一种选自生物可接受的酸及其生物可接受的盐的化合物; 和（C）低浓度的肝素。

2. 发明授权

US07131962B1 Port device for subcutaneous access to the vascular system of a patient 失效
标题翻译：用于皮下进入患者血管系统的端口装置
公开(公告)号：US07131962B1
公开(公告)日：2006-11-07
申请号：US09522160
申请日：2000-03-09
申请人： Brian K. Estabrook , Paul J. Smith , Harold M. Martins , Frank R. Prosl
发明人： Brian K. Estabrook , Paul J. Smith , Harold M. Martins , Frank R. Prosl
IPC分类号： A61M31/00
CPC分类号： A61M39/12 , A61M39/0208 , A61M2039/0211 , A61M2039/1027 , A61M2039/1088
摘要： A port device for implanting in a patient for subcutaneous access to the vascular system of the patient. The device includes a housing provided with apertures, each for receiving and retaining a needle. The housing is further provided with lock structure for locking catheters to the housing. The housing is configured internally to provide flow paths extending between needles disposed in the apertures and the catheters.
摘要翻译：一种用于植入患者体内用于皮下进入患者血管系统的端口装置。该装置包括设置有孔的壳体，每个孔用于接收和保持针头。壳体还设置有用于将导管锁定到壳体的锁定结构。壳体被配置在内部以提供在设置在孔中的针和导管之间延伸的流路。

3. 发明授权

US06620118B1 Apparatus and method for the dialysis of blood 失效
标题翻译：用于透析血液的装置和方法
公开(公告)号：US06620118B1
公开(公告)日：2003-09-16
申请号：US09448201
申请日：1999-11-23
申请人： Frank R. Prosl , Brian K. Estabrook
发明人： Frank R. Prosl , Brian K. Estabrook
IPC分类号： A61M3700
CPC分类号： A61M39/0247 , A61M1/16 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M1/3661 , A61M25/0028 , A61M25/003 , A61M25/0069 , A61M2025/0025 , A61M2025/0031 , A61M2025/0035 , A61M2025/0037 , A61M2039/0258 , A61M2039/0273
摘要： Improved apparatus and method for the dialysis of blood. The improved apparatus comprises a subcutaneous port and catheter assembly comprising a connector portion comprising a subcutaneous port element, and a catheter portion comprising a catheter element. The improved apparatus also comprises a novel percutaneous catheter assembly comprising a catheter portion comprising a catheter element, and a connector portion comprising an extracorporeal connector element.
摘要翻译：改进血液透析的装置和方法。改进的装置包括皮下端口和导管组件，其包括包括皮下端口元件的连接器部分和包括导管元件的导管部分。改进的装置还包括新颖的经皮导管组件，其包括导管部分，其包括导管元件，以及包括体外连接器元件的连接器部分。

4. 发明授权

US4193397A Infusion apparatus and method 失效
标题翻译：输液装置及方法
公开(公告)号：US4193397A
公开(公告)日：1980-03-18
申请号：US009756
申请日：1979-02-05
申请人： Elton M. Tucker , Frank R. Prosl
发明人： Elton M. Tucker , Frank R. Prosl
IPC分类号： A61M5/142 , A61M5/175 , A61M31/00
CPC分类号： A61M5/14276 , A61M2205/353 , A61M2209/045
摘要： An infusion apparatus and method employs an infusate reservoir connected by way of a first flow restrictor to a mixing chamber and a second infusate reservoir connected via a second flow path having a selected restriction characteristic to the same mixing chamber so that infusate may be conveyed to the mixing chamber in different concentrations or in different types. A normally closed valve is provided in the second flow path so that the two infusates supplement one another in the mixing chamber only when the valve is opened. The reservoir and chamber volumes, infusate concentrations and chamber outlet flow rates are dimensioned to provide an integrated dosage profile suited to the patient. The apparatus can also include an accumulator with a restricted inlet in the second flow path situated between the second reservoir and the valve so that when the valve is opened, infusate flows to the mixing chamber from the second flow path only if the accumulator has been replenished from the second reservoir.
摘要翻译：输液设备和方法使用通过第一限流器连接到混合室的输注储存器和经由具有选择的限制特性的第二流动路径连接到相同混合室的第二输注储存器，使得输注物可以被输送到不同浓度或不同类型的混合室。在第二流路中设置常闭阀，使得仅当阀打开时，两个输液器在混合室中彼此补充。储存器和腔室体积，输注浓度和室出口流速的尺寸被设计成提供适合于患者的综合剂量分布。该装置还可以包括在第二流动路径中具有受限入口的蓄能器，该第二流动路径位于第二储存器和阀之间，使得当阀打开时，只有当蓄能器已经被补充时，输入物才从第二流动路径流入混合室从第二个水库。

5. 发明授权

US4496343A Infusate pump 失效
标题翻译：输液泵
公开(公告)号：US4496343A
公开(公告)日：1985-01-29
申请号：US577301
申请日：1984-02-06
申请人： Frank R. Prosl , Edward J. Sampson
发明人： Frank R. Prosl , Edward J. Sampson
IPC分类号： A61M5/142 , A61M5/00 , A61M31/00
CPC分类号： A61M5/14276 , A61M5/152 , A61M2039/0226
摘要： Infusion apparatus includes a housing with an infusate chamber in the housing and means for conducting infusate from the chamber through a restrictive outlet passage to an additional small chamber having an entrance port closed by a self-sealing penetrable septum. An exit tube from the small chamber leads directly to a cannula at the infusion site so that liquid can be injected into the small chamber through its septum and delivered directly to the infusion site without backflowing into the infusate chamber.
摘要翻译：输液装置包括在壳体中具有输注腔室的壳体，以及用于通过限制性出口通道将输注腔输送到具有通过自密封可穿透隔膜封闭的入口的附加小室的装置。来自小室的出口管直接引导到输注部位处的套管，使得液体可以通过其隔膜被注入到小室中，并且直接输送到输注部位而不回流到输液室中。

6. 发明授权

US4447224A Variable flow implantable infusion apparatus 失效
标题翻译：可变流量植入式输液装置
公开(公告)号：US4447224A
公开(公告)日：1984-05-08
申请号：US419733
申请日：1982-09-20
申请人： Leonard J. DeCant, Jr. , Samir F. Idriss , Frank R. Prosl
发明人： Leonard J. DeCant, Jr. , Samir F. Idriss , Frank R. Prosl
IPC分类号： A61M5/00 , A61M5/142 , A61M5/14
CPC分类号： A61M5/14276 , A61M5/16877 , A61M5/16886 , A61M2205/3523 , A61M2205/353 , A61M2205/50 , Y10S128/12 , Y10S128/13
摘要： Implantable variable flow infusion apparatus comprises a collapsible infusate chamber having an outlet conduit leading to the infusion site by way of series-connected fixed and variable fluid flow restrictors. The infusate in the chamber is maintained under substantially constant pressure by a nonelectric energy storage cell to establish flow from the chamber to the site. The variable restrictor is controlled by commands from a preprogrammed microprocessor and programmable memory powered by a small long-lived battery. The processor sets the variable restrictor to the proper setting to establish the correct infusate flow for the particular time of day. A pressure transducer connected across the fixed restrictor senses the pressure differential across the fixed restrictor which differential indicates actual infusate flow from the chamber. The processor samples the output from the transducer at infrequent sampling intervals and issues command signals to control the variable restrictor whenever the actual infusate flow rate differs from the preprogrammed rate so that the apparatus consumes a minimal amount of battery energy and can thus remain implanted in the body for a prolonged period. The processor can also be reprogrammed and monitored by telemetry.
摘要翻译：可植入式可变流量输注装置包括可折叠输液室，其具有通过串联连接的固定和可变流体流量限制器通向输注位置的出口导管。腔室中的输注物通过非电储能单元保持在基本恒定的压力下，以建立从腔室到现场的流动。可变限流器由预编程的微处理器和可编程存储器的命令控制，该存储器由小型长寿命的电池供电。处理器将变量限制器设置为适当的设置，以便为一天中的特定时间建立正确的输入流。连接在固定限流器上的压力传感器感测固定限流器两端的压力差，该差分表示从腔室流出的实际流体。处理器以不频繁的采样间隔对来自换能器的输出进行采样，并发出命令信号，以便每当实际输入流量与预编程速率不同时，控制变量限制器，使得该装置消耗最小量的电池能量，并因此可以保持植入身体长时间。处理器也可以通过遥测进行重新编程和监控。

7. 发明授权

US4222374A Septum locating apparatus 失效
标题翻译：隔垫定位装置
公开(公告)号：US4222374A
公开(公告)日：1980-09-16
申请号：US916129
申请日：1978-06-16
申请人： Edward J. Sampson , Frank R. Prosl
发明人： Edward J. Sampson , Frank R. Prosl
IPC分类号： A61M39/02 , A61B19/00
CPC分类号： A61M39/0208 , A61M2039/0238
摘要： This invention relates to apparatus for accurately locating the septum through which the fluid reservoir of an implanted prosthetic device may be refilled subcutaneously.
摘要翻译：本发明涉及用于精确定位隔膜的装置，通过该隔膜可以将植入的假体装置的流体储存器皮下注入。

8. 发明授权

US06575945B2 Method and apparatus for overcoming infection in a tissue pocket surrounding an implanted device 有权
公开(公告)号：US06575945B2
公开(公告)日：2003-06-10
申请号：US10140630
申请日：2002-05-08
申请人： Frank R. Prosl , Hans-Dietrich Polaschegg , Brian K. Estabrook , Klaus Sodemann
发明人： Frank R. Prosl , Hans-Dietrich Polaschegg , Brian K. Estabrook , Klaus Sodemann
IPC分类号： A61M3100
CPC分类号： A61L29/16 , A61L27/54 , A61L2300/104 , A61L2300/204 , A61L2300/404 , A61M39/0208
摘要： An improvement in an implantable port of the type including a housing that is implanted within a subcutaneous tissue pocket is disclosed, wherein the improvement comprises the presence of metallic silver, an inorganic silver compound, a silver salt of an organic acid, or other antimicrobial substances such as taurolidine on the surfaces of the port in contact with, or proximate to, the tissue of said pocket.

9. 发明授权

US06447488B2 Apparatus for the dialysis of blood, method for fabricating the same, and method for the dialysis of blood 失效
标题翻译：血液透析用装置及其制造方法以及透析血液的方法
公开(公告)号：US06447488B2
公开(公告)日：2002-09-10
申请号：US09044372
申请日：1998-03-19
申请人： Brian K. Estabrook , Paul J. Smith , Frank R. Prosl , Harold M. Martins
发明人： Brian K. Estabrook , Paul J. Smith , Frank R. Prosl , Harold M. Martins
IPC分类号： A61M2500
CPC分类号： A61M25/005 , A61M2025/0031
摘要： Improved apparatus for the dialysis of blood, a method for fabricating the same, and an improved method for the dialysis of blood.
摘要翻译：用于血液透析的改进的装置，其制造方法和用于血液透析的改进方法。

10. 发明授权

US06350251B1 Biocidal locks 有权
标题翻译：杀生物锁
公开(公告)号：US06350251B1
公开(公告)日：2002-02-26
申请号：US09483966
申请日：2000-01-18
申请人： Frank R. Prosl , Brian K. Estabrook , Klaus Sodemann
发明人： Frank R. Prosl , Brian K. Estabrook , Klaus Sodemann
IPC分类号： A61M1100
CPC分类号： A61L29/14 , A61L29/16 , A61L2300/404 , A61L2300/42 , A61L2300/45 , A61M5/158 , A61M5/427 , A61M39/0208
摘要： Disclosed herein is an internal prosthetic device comprising: (a) device for providing a continuous flowpath, crossing a patient's skin, between an external-to-patient site and an internal-to-patient site; (b) means for blocking the flowpath; and (c) a biocidal lock including: (i) an anticoagulant; and (ii) a non-antibiotic biocide.
摘要翻译：本文公开了一种内部修复装置，其包括：（a）用于在外部与患者部位和内部到患者部位之间提供连续流路，穿过患者皮肤的装置;（b）阻止流路的装置; 和（c）杀生物锁，其包括：（i）抗凝血剂; 和（ii）非抗生素杀生物剂。

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