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1. 发明公开

US20240277877A1 TARGETING COMPOUNDS AND METHODS FOR THEIR PRODUCTION 审中-公开
公开(公告)号：US20240277877A1
公开(公告)日：2024-08-22
申请号：US18597131
申请日：2024-03-06
申请人： Clarity Pharmaceuticals Ltd
发明人： Paul Stephen Donnelly , Nicholas Alan Zia
IPC分类号： A61K51/04 , C07D487/08
CPC分类号： A61K51/0482 , A61K51/044 , C07D487/08
摘要： The present invention is directed to sarcophagine based compounds of formula (I). The compounds can complex a radioisotope, such as 64-copper and hence are useful in radioimaging and radiotherapy of cancers, e.g. colorectal cancer. The compounds work via a pre-targeting imaging approach in which the tetrazine reacts via click chemistry with a functional group such as a transcyclooctene which is pre-bound to a ligand such as a tumour specific antibody.

2. 发明授权

US11951189B2 Targeting compounds and methods for their production 有权
公开(公告)号：US11951189B2
公开(公告)日：2024-04-09
申请号：US17046053
申请日：2019-04-11
申请人： THE UNIVERSITY OF MELBOURNE
发明人： Paul Stephen Donnelly , Nicholas Alan Zia
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K51/04 , C07D487/08
CPC分类号： A61K51/0482 , A61K51/044 , C07D487/08
摘要： The present invention is directed to sarcophagine based compounds of formula (I). The compounds can complex a radioisotope, such as 64-copper and hence are useful in radioimaging and radiotherapy of cancers, e.g. colorectal cancer. The compounds work via a pre-targeting imaging approach in which the tetrazine reacts via click chemistry with a functional group such as a transcyclooctene which is pre-bound to a ligand such as a tumour specific antibody.

3. 发明申请

US20180009767A9 PSMA TARGETED FLUORESCENT AGENTS FOR IMAGE GUIDED SURGERY 审中-公开
公开(公告)号：US20180009767A9
公开(公告)日：2018-01-11
申请号：US15618788
申请日：2017-06-09
申请人： THE JOHNS HOPKINS UNIVERSITY , INTUITIVE SURGICAL OPERATIONS, INC.
发明人： MARTIN G. POMPER , RONNIE C. MEASE , YING CHEN , SANGEETA RAY , JONATHAN SORGER
IPC分类号： C07D257/02 , A61K49/00 , C07F5/02 , C07D311/82 , C07D311/20 , C07F13/00 , C07D255/02 , C07D249/04 , C07D213/04 , C07D209/14 , C07D209/12 , A61K51/04 , G01N33/50 , C07D311/14
CPC分类号： C07D257/02 , A61K49/0032 , A61K49/0052 , A61K51/0421 , A61K51/044 , A61K51/0446 , A61K51/0453 , A61K51/0472 , C07D209/12 , C07D209/14 , C07D213/04 , C07D249/04 , C07D255/02 , C07D311/14 , C07D311/20 , C07D311/82 , C07F5/027 , C07F13/005 , G01N33/5091 , G01N2800/342
摘要： Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

4. 发明授权

US09789211B2 Methods and compositions for positron emission tomography myocardial perfusion imaging 有权
公开(公告)号：US09789211B2
公开(公告)日：2017-10-17
申请号：US14401470
申请日：2013-03-15
申请人： Peter S. Conti , Shuanglong Liu , Zibo Li
发明人： Peter S. Conti , Shuanglong Liu , Zibo Li
IPC分类号： A61K51/08 , A61K51/04 , A61K49/04 , A61B6/03 , A61B6/00
CPC分类号： A61K51/044 , A61B6/037 , A61B6/503 , A61K49/04 , A61K51/0482 , A61K51/0497 , A61K51/088
摘要： This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled with 64Cu or 18F. Also provided are methods for synthesizing the compounds, methods for derivatizing the compounds, and derivatives thereof.

5. 发明授权

US09211349B2 Molecular probes for multimodality imaging of anionic membrane surfaces 有权
标题翻译：阴离子膜表面多模态成像的分子探针
公开(公告)号：US09211349B2
公开(公告)日：2015-12-15
申请号：US13909684
申请日：2013-06-04
申请人： Molecular Targeting Technologies, Inc.
发明人： Brian Gray , Kai Chen , Koon Y. Pak
IPC分类号： A61K51/04 , A61K49/00 , A61K51/08 , A61M5/00 , G01N33/50 , A61B5/00 , A61B6/03
CPC分类号： A61K51/044 , A61B5/0035 , A61B5/0059 , A61B6/032 , A61B6/037 , A61K49/0002 , A61K49/0032 , A61K49/0043 , A61K51/0472 , A61K51/08 , A61M5/007 , G01N33/5005
摘要： Embodiments provide dual modality probes for imaging phosphatidylserine (PS) exposure and other anionic membrane surfaces. In various embodiments, the probes were constructed by utilizing a) the high selectivity of synthetic zinc (II) dipicolylamine coordination complexes (Zn-DPA) for targeting externalized PS which over-expresses in apoptotic and necrotic cells, b) a near-infrared (NIR) dye for optical imaging, and c) a widely used clinically approved radionuclide for PET (or SPECT) imaging. A variety of linking elements were incorporated into the probes between the Zn-DPA and radionuclide motif to modulate the pharmacokinetics. The in vitro and in vivo data of radiolabeled dipicolylamine probes demonstrated their utilities for imaging PS exposure with multiple imaging modalities.
摘要翻译：实施例提供用于成像磷脂酰丝氨酸（PS）暴露和其它阴离子膜表面的双重模态探针。在各种实施方案中，通过利用a）合成锌（II）二偶氮胺配位络合物（Zn-DPA）的高选择性来构建探针，用于靶向在凋亡和坏死细胞中过表达的外化PS，b）近红外 NIR）用于光学成像的染料，以及c）广泛使用的临床批准的用于PET（或SPECT）成像的放射性核素。在Zn-DPA和放射性核素基序之间的探针中掺入各种连接元件以调节药代动力学。放射性标记的二吡啶胺探针的体外和体内数据证明了它们用于用多种成像模式成像PS暴露的实用性。

6. 发明申请

US20140086833A1 NON-INVASIVE DIAGNOSTIC AGENTS AND METHODS OF DIAGNOSING INFECTIOUS DISEASE 有权
标题翻译：非侵入性诊断试剂和诊断感染性疾病的方法
公开(公告)号：US20140086833A1
公开(公告)日：2014-03-27
申请号：US14093260
申请日：2013-11-29
申请人： Jeffrey P. Norenberg
发明人： Jeffrey P. Norenberg
IPC分类号： A61K51/04
CPC分类号： A61K51/0453 , A61K31/4178 , A61K51/00 , A61K51/044 , A61K51/0497 , G01N33/569 , G01N2333/70525 , G01N2333/70553 , Y02A50/47 , Y02A50/481
摘要： The present invention is directed to novel non-invasive diagnostic tools to diagnose numerous infectious disease states or conditions. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to therapeutic treatments and other interventions or therapies used in the treatment of these disease states or conditions. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. Pharmaceutical compositions are also described.
摘要翻译：本发明涉及用于诊断许多传染病状态或病症的新型非侵入性诊断工具。本发明代表了本领域的显着进步，其目前依赖于组织活检以诊断这些疾病状态。该新型成像探针能够检测感染的细胞以及组织。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。这种新型探针也可用于监测患者治疗治疗和治疗这些疾病状态或病症的其他干预措施或疗法的反应。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。还描述了药物组合物。

7. 发明申请

US20120203096A1 METHODS TO DIAGNOSE DEGENERATIVE DISC DISEASE USING PAIN STIMULI 审中-公开
标题翻译：使用疼痛刺激来诊断变应性疾病的方法
公开(公告)号：US20120203096A1
公开(公告)日：2012-08-09
申请号：US13454178
申请日：2012-04-24
申请人： Josee Roy , William F. McKay
发明人： Josee Roy , William F. McKay
IPC分类号： A61B5/00 , A61B5/055 , A61B6/03 , A61B6/00 , A61B6/02
CPC分类号： A61K49/0054 , A61B6/037 , A61B6/506 , A61B6/508 , A61K51/044 , A61K51/0491
摘要： Methods are provided that better describe, and localize the pain generator or suspected pain generator in and around spinal discs in relation to neck, back or leg pain so as to improve the diagnosis of degenerative disc disease. In some embodiments, there are methods for diagnosing a pain generator or a suspected pain generator in a patient suffering from back pain, the methods comprise causing painful stimuli at or near the pain generator or suspected pain generator in the patient suffering from back pain; labeling an inflammatory, vascular, neuronal, and/or metabolic pain marker at a location inside of or adjacent to an intervertebral disc in the patient suffering from back pain to increase an image of the pain marker with an imaging procedure; and imaging the labeled inflammatory, vascular, neuronal, and/or metabolic pain marker in a manner sufficient to diagnose the pain generator or suspected pain generator.
摘要翻译：提供了更好地描述和定位与颈部，背部或腿部疼痛相关的疼痛发生器或疑似疼痛发生器在脊椎盘内和周围的位置，以改善退行性椎间盘疾病的诊断。在一些实施方案中，存在用于诊断患有背痛的患者中的疼痛发生器或疑似疼痛发生器的方法，所述方法包括在患有背部疼痛的患者中引起疼痛发生器或疑似疼痛发生器附近的疼痛刺激; 在患有背部疼痛的患者的椎间盘内部或附近的位置标记炎症，血管，神经元和/或代谢性疼痛标记物，以通过成像程序增加疼痛标记物的图像; 并以足以诊断疼痛发生器或疑似疼痛发生器的方式对标记的炎症，血管，神经元和/或代谢性疼痛标记进行成像。

8. 发明申请

US20180177901A1 EVALUATION OF PRESENCE OF AND VULNERABILITY TO ATRIAL FIBRILLATION AND OTHER INDICATIONS USING MATRIX METALLOPROTEINASE-BASED IMAGING 审中-公开
公开(公告)号：US20180177901A1
公开(公告)日：2018-06-28
申请号：US15722958
申请日：2017-10-02
申请人： Lantheus Medical Imaging, Inc. , Yale University
发明人： Albert J. Sinusas , Joseph G. Akar , Richard R. Cesati , Heike S. Radeke , Stephen B. Haber
IPC分类号： A61K51/04 , A61K51/08
CPC分类号： A61K51/044 , A61B2576/023 , A61K51/0459 , A61K51/0476 , A61K51/0478 , A61K51/0497 , A61K51/08
摘要： The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of responding to particular AF therapies using imaging agents comprising an MMP inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining MMP levels.

9. 发明申请

US20170283384A1 PSMA TARGETED FLUORESCENT AGENTS FOR IMAGE GUIDED SURGERY 审中-公开
公开(公告)号：US20170283384A1
公开(公告)日：2017-10-05
申请号：US15618788
申请日：2017-06-09
申请人： THE JOHNS HOPKINS UNIVERSITY , INTUITIVE SURGICAL OPERATIONS, INC.
发明人： MARTIN G. POMPER , RONNIE C. MEASE , YING CHEN , SANGEETA RAY , JONATHAN SORGER
IPC分类号： C07D257/02 , A61K51/04 , C07D311/82 , C07D213/04 , C07D209/14 , C07D249/04 , C07F5/02 , C07D209/12 , C07D255/02 , A61K49/00 , G01N33/50 , C07D311/14 , C07D311/20 , C07F13/00
CPC分类号： C07D257/02 , A61K49/0032 , A61K49/0052 , A61K51/0421 , A61K51/044 , A61K51/0446 , A61K51/0453 , A61K51/0472 , C07D209/12 , C07D209/14 , C07D209/24 , C07D213/04 , C07D249/04 , C07D255/02 , C07D311/14 , C07D311/20 , C07D311/82 , C07F5/027 , C07F13/005 , G01N33/5091 , G01N2800/342
摘要： Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

10. 发明授权

US09447122B2 Arginase inhibitors and methods of use thereof 有权
标题翻译：精氨酸酶抑制剂及其使用方法
公开(公告)号：US09447122B2
公开(公告)日：2016-09-20
申请号：US14662325
申请日：2015-03-19
申请人： AstraZeneca AB
发明人： Bruce Edward Tomczuk , Gary Lee Olson , Richard Scott Pottorf , Lijuan Jane Wang , Bhaskara Rao Nallaganchu , Yanqun Zhang
IPC分类号： C07F5/02 , A61K31/69 , A61K51/04 , C07J43/00 , A61K49/00
CPC分类号： C07F5/025 , A61K31/69 , A61K49/0004 , A61K51/044 , C07F5/02 , C07J43/003 , Y02A50/411
摘要： The present invention includes arginase enzyme inhibitors, compositions comprising these arginase inhibitors, and methods of treating or diagnosing conditions characterized either by abnormally high arginase activity or abnormally low nitric oxide levels in a mammal, comprising administering compositions of the invention to the mammal.
摘要翻译：本发明包括精氨酸酶抑制剂，包含这些精氨酸酶抑制剂的组合物，以及治疗或诊断以哺乳动物异常高的精氨酸酶活性或异常低的一氧化氮水平为特征的病症的方法，包括向哺乳动物施用本发明的组合物。

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