专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08623396B2 Compositions and methods for delivering clonidine and bupivacaine to a target tissue site 有权
标题翻译：将可乐定和布比卡因递送至目标组织部位的组合物和方法
公开(公告)号：US08623396B2
公开(公告)日：2014-01-07
申请号：US13310240
申请日：2011-12-02
申请人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
发明人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
IPC分类号： A61F2/00 , A61K9/00
CPC分类号： A61K9/0024 , A61K31/167 , A61K31/4168 , A61K31/445 , A61K47/34 , A61K2300/00
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
摘要翻译：提供长时间有效的疼痛治疗。通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，造成背痛和关节疼痛。当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

2. 发明申请

US20120203096A1 METHODS TO DIAGNOSE DEGENERATIVE DISC DISEASE USING PAIN STIMULI 审中-公开
标题翻译：使用疼痛刺激来诊断变应性疾病的方法
公开(公告)号：US20120203096A1
公开(公告)日：2012-08-09
申请号：US13454178
申请日：2012-04-24
申请人： Josee Roy , William F. McKay
发明人： Josee Roy , William F. McKay
IPC分类号： A61B5/00 , A61B5/055 , A61B6/03 , A61B6/00 , A61B6/02
CPC分类号： A61K49/0054 , A61B6/037 , A61B6/506 , A61B6/508 , A61K51/044 , A61K51/0491
摘要： Methods are provided that better describe, and localize the pain generator or suspected pain generator in and around spinal discs in relation to neck, back or leg pain so as to improve the diagnosis of degenerative disc disease. In some embodiments, there are methods for diagnosing a pain generator or a suspected pain generator in a patient suffering from back pain, the methods comprise causing painful stimuli at or near the pain generator or suspected pain generator in the patient suffering from back pain; labeling an inflammatory, vascular, neuronal, and/or metabolic pain marker at a location inside of or adjacent to an intervertebral disc in the patient suffering from back pain to increase an image of the pain marker with an imaging procedure; and imaging the labeled inflammatory, vascular, neuronal, and/or metabolic pain marker in a manner sufficient to diagnose the pain generator or suspected pain generator.
摘要翻译：提供了更好地描述和定位与颈部，背部或腿部疼痛相关的疼痛发生器或疑似疼痛发生器在脊椎盘内和周围的位置，以改善退行性椎间盘疾病的诊断。在一些实施方案中，存在用于诊断患有背痛的患者中的疼痛发生器或疑似疼痛发生器的方法，所述方法包括在患有背部疼痛的患者中引起疼痛发生器或疑似疼痛发生器附近的疼痛刺激; 在患有背部疼痛的患者的椎间盘内部或附近的位置标记炎症，血管，神经元和/或代谢性疼痛标记物，以通过成像程序增加疼痛标记物的图像; 并以足以诊断疼痛发生器或疑似疼痛发生器的方式对标记的炎症，血管，神经元和/或代谢性疼痛标记进行成像。

3. 发明申请

US20120142643A1 CLONIDINE AND GABA COMPOUNDS IN A BIODEGRADABLE POLYMER CARRIER 有权
标题翻译：可生物降解聚合物载体中的克隆和加巴化合物
公开(公告)号：US20120142643A1
公开(公告)日：2012-06-07
申请号：US13309766
申请日：2011-12-02
申请人： Jared T. Wilsey , Danielle L. Biggs , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
发明人： Jared T. Wilsey , Danielle L. Biggs , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
IPC分类号： A61K31/662 , A61P29/00 , A61K31/4168
CPC分类号： A61K31/195 , A61K9/0024 , A61K31/4168 , A61K31/662 , A61K45/06 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译：提供长时间有效的疼痛治疗。通过在目标部位或其附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘突出背痛和关节疼痛，以及手术附带的疼痛。当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

4. 发明申请

US20070287991A1 Devices and methods for detection of markers of axial pain with or without radiculopathy 审中-公开
标题翻译：用于检测具有或不具有神经根病变的轴向疼痛标记物的装置和方法
公开(公告)号：US20070287991A1
公开(公告)日：2007-12-13
申请号：US11449530
申请日：2006-06-08
申请人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
IPC分类号： A61K9/22
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/032 , A61B5/14539 , A61B5/4514 , A61B5/4561 , A61B5/4824 , A61B5/4896 , A61B5/6848 , G01N33/54366 , G01N33/6896 , G01N2800/2842
摘要： The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的装置和相关方法和组合，以及用于筛选潜在地可用于治疗或不发生神经根病变的轴向疼痛的测试化合物的方法。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。退行性椎间盘的疼痛标志物和标志物包括神经元，血管，免疫和基质元件的标记物。

5. 发明申请

US20120142649A1 COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE AND BUPIVACAINE TO A TARGET TISSUE SITE 有权
标题翻译：将CLONIDINE和BUPIVACAINE递送至目标组织网站的组合物和方法
公开(公告)号：US20120142649A1
公开(公告)日：2012-06-07
申请号：US13310240
申请日：2011-12-02
申请人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
发明人： Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Danielle L. Clay , Jared T. Wilsey , John Myers Zanella
IPC分类号： A61K31/56 , A61P29/00 , A61K31/445
CPC分类号： A61K9/0024 , A61K31/167 , A61K31/4168 , A61K31/445 , A61K47/34 , A61K2300/00
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
摘要翻译：提供长时间有效的疼痛治疗。通过施用有效量的即时释放布比卡因或利多卡因和持续释放的可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，造成背痛和关节疼痛。当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

6. 发明申请

US20120142747A1 COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE TO A TARGET TISSUE SITE 审中-公开
标题翻译：组合物和方法将克隆定为目标组织位点
公开(公告)号：US20120142747A1
公开(公告)日：2012-06-07
申请号：US13309759
申请日：2011-12-02
申请人： Jared T. Wilsey , Danielle L. Biggs , Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
发明人： Jared T. Wilsey , Danielle L. Biggs , Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
IPC分类号： A61K31/4168 , A61P29/00
CPC分类号： A61K31/4168 , A61K9/00 , A61K9/0024
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release clonidine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.
摘要翻译：提供长时间有效的疼痛治疗。通过在目标部位或其附近施用有效量的立即释放可乐定和持续释放的可乐定，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱狭窄，狭窄，椎间盘突出背痛和关节疼痛。当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

7. 发明申请

US20080008988A1 Compositions and methods for diagnosis of axial pain with or without radiculopathy 有权
标题翻译：用于诊断具有或不具有神经根病变的轴向疼痛的组合物和方法
公开(公告)号：US20080008988A1
公开(公告)日：2008-01-10
申请号：US11449309
申请日：2006-06-08
申请人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
IPC分类号： C12Q1/00
CPC分类号： A61K49/0004 , A61K49/00
摘要： The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了与成像技术一起使用并且可用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的方法和组合以及用于筛选潜在地可用于治疗具有或没有神经根病变的轴向疼痛的治疗化合物的方法和组合物。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。疼痛标记和变性标记包括神经元，血管，免疫和基质元件的标记。

8. 发明申请

US20070298407A1 Diagnostic kits and methods for diagnosis of axial pain with or without radiculopathy 有权
标题翻译：用于诊断具有或不具有神经根病变的轴向疼痛的诊断试剂盒和方法
公开(公告)号：US20070298407A1
公开(公告)日：2007-12-27
申请号：US11449464
申请日：2006-06-08
申请人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
IPC分类号： C12Q1/00
CPC分类号： G01N33/6896 , G01N2800/2842
摘要： The invention provides kits developed to analyze ex vivo, a sample retrieved from the area of the pathological condition for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供开发用于离体分析的试剂盒，从用于诊断和监测具有或不具有神经根病变的疼痛发生器的疼痛发生器的病理状况区域获取的样品以及用于筛选潜在地可用于治疗轴向疼痛的治疗化合物的方法或没有神经根病。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。退行性椎间盘的疼痛标志物和标志物包括神经元，血管，免疫和基质元件的标记物。

9. 发明授权

US09301946B2 Clonidine and GABA compounds in a biodegradable polymer carrier 有权
标题翻译：可乐定和GABA化合物在可生物降解的聚合物载体中
公开(公告)号：US09301946B2
公开(公告)日：2016-04-05
申请号：US13309766
申请日：2011-12-02
申请人： Jared T. Wilsey , Danielle L. Biggs , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
发明人： Jared T. Wilsey , Danielle L. Biggs , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
IPC分类号： A61K31/66 , A61K31/415 , A61K31/4168 , A61K9/00 , A61K45/06 , A61K31/662 , A61K47/34
CPC分类号： A61K31/195 , A61K9/0024 , A61K31/4168 , A61K31/662 , A61K45/06 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译：提供长时间有效的疼痛治疗。通过在目标部位或其附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘突出背痛和关节疼痛，以及手术附带的疼痛。当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

10. 发明授权

US08840933B2 Method of treating neuronal injury by administering magnesium chloride and PEG 有权
标题翻译：通过施用氯化镁和PEG治疗神经元损伤的方法
公开(公告)号：US08840933B2
公开(公告)日：2014-09-23
申请号：US11418153
申请日：2006-05-03
申请人： Josee Roy , William F. McKay , Jeffrey C Marx
发明人： Josee Roy , William F. McKay , Jeffrey C Marx
IPC分类号： A61K33/14 , A61K31/765 , A61K9/08 , A61K9/00 , A61K31/717 , A61K31/787 , A61K33/06
CPC分类号： A61K33/14 , A61K9/0019 , A61K9/0085 , A61K31/717 , A61K31/765 , A61K31/787 , A61K33/06 , A61K2300/00
摘要： The invention provides methods and kits for treatment of pain or inflammation. In one embodiment, the kit comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, an intra-articular administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
摘要翻译：本发明提供了治疗疼痛或炎症的方法和试剂盒。在一个实施方案中，试剂盒包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。生物膜密封剂和/或生物活性剂，静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，关节内给药，直接施用于或邻近病理状况及其任何组合。或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式