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1. 发明申请

US20120070372A1 NON-INVASIVE DIAGNOSTIC AGENTS OF CANCER AND METHODS OF DIAGNOSING CANCER, ESPECIALLY LEUKEMIA AND LYMPHOMA 有权
标题翻译：癌症非侵入性诊断试剂和诊断癌症的方法，特别是白喉和淋巴瘤
公开(公告)号：US20120070372A1
公开(公告)日：2012-03-22
申请号：US13309972
申请日：2011-12-02
申请人： Jeffrey P. Norenberg , Richard S. Larson
发明人： Jeffrey P. Norenberg , Richard S. Larson
IPC分类号： A61K51/04 , C07F9/94 , A61P29/00 , A61P37/00 , A61P9/10 , A61P9/00 , A61P13/12 , A61P19/02 , A61P17/00 , A61P7/00 , A61P1/00 , A61P37/06 , A61P35/00 , A61P35/04 , A61P11/00 , A61P25/00 , A61P3/10 , A61P27/02 , A61P17/06 , A61P17/12 , A61P35/02 , C07F5/00
CPC分类号： C07F5/003 , A61K47/22 , A61K49/106 , A61K51/0474 , A61K51/0482 , A61K51/0485 , A61K51/0497 , C07F9/94
摘要： The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

2. 发明授权

US08623322B2 Non-invasive diagnostic agents and methods of diagnosing infectious disease 有权
标题翻译：非侵入性诊断试剂和诊断传染病的方法
公开(公告)号：US08623322B2
公开(公告)日：2014-01-07
申请号：US12991253
申请日：2009-06-15
申请人： Jeffrey P. Norenberg
发明人： Jeffrey P. Norenberg
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/0453 , A61K31/4178 , A61K51/00 , A61K51/044 , A61K51/0497 , G01N33/569 , G01N2333/70525 , G01N2333/70553 , Y02A50/47 , Y02A50/481
摘要： The present invention is directed to novel non-invasive diagnostic tools to diagnose numerous infectious disease states or conditions. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to therapeutic treatments and other interventions or therapies used in the treatment of these disease states or conditions. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. Pharmaceutical compositions are also described.
摘要翻译：本发明涉及用于诊断许多传染病状态或病症的新型非侵入性诊断工具。本发明代表了本领域的显着进步，其目前依赖于组织活检以诊断这些疾病状态。该新型成像探针能够检测感染的细胞以及组织。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。这种新型探针也可用于监测患者治疗治疗和治疗这些疾病状态或病症的其他干预措施或疗法的反应。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。还描述了药物组合物。

3. 发明申请

US20110117014A1 NON-INVASIVE DIAGNOSTIC AGENTS AND METHODS OF DIAGNOSING INFECTIOUS DISEASE 有权
标题翻译：非侵入性诊断试剂和诊断感染性疾病的方法
公开(公告)号：US20110117014A1
公开(公告)日：2011-05-19
申请号：US12991253
申请日：2009-06-15
申请人： Jeffrey P. Norenberg
发明人： Jeffrey P. Norenberg
IPC分类号： A61K51/04 , A61P43/00 , A61P31/00 , A61P31/10 , A61P33/00 , A61P31/12 , A61P31/04
CPC分类号： A61K51/0453 , A61K31/4178 , A61K51/00 , A61K51/044 , A61K51/0497 , G01N33/569 , G01N2333/70525 , G01N2333/70553 , Y02A50/47 , Y02A50/481
摘要： The present invention is directed to novel non-invasive diagnostic tools to diagnose numerous infectious disease states or conditions. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. This represents a quanturn step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to therapeutic treatments and other interventions or therapies used in the treatment of these disease states or conditions. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. Pharmaceutical compositions are also described.
摘要翻译：本发明涉及用于诊断许多传染病状态或病症的新型非侵入性诊断工具。本发明代表了本领域的显着进步，其目前依赖于组织活检以诊断这些疾病状态。该新型成像探针能够检测感染的细胞以及组织。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前的量子步骤。这种新型探针也可用于监测患者治疗治疗和治疗这些疾病状态或病症的其他干预措施或疗法的反应。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。还描述了药物组合物。

4. 发明授权

US08435489B2 Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma 有权
标题翻译：癌症的非侵入性诊断剂和诊断癌症的方法，特别是白血病和淋巴瘤
公开(公告)号：US08435489B2
公开(公告)日：2013-05-07
申请号：US13309972
申请日：2011-12-02
申请人： Jeffrey P. Norenberg , Richard S. Larson
发明人： Jeffrey P. Norenberg , Richard S. Larson
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： C07F5/003 , A61K47/22 , A61K49/106 , A61K51/0474 , A61K51/0482 , A61K51/0485 , A61K51/0497 , C07F9/94
摘要： The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

5. 发明申请

US20140086833A1 NON-INVASIVE DIAGNOSTIC AGENTS AND METHODS OF DIAGNOSING INFECTIOUS DISEASE 有权
标题翻译：非侵入性诊断试剂和诊断感染性疾病的方法
公开(公告)号：US20140086833A1
公开(公告)日：2014-03-27
申请号：US14093260
申请日：2013-11-29
申请人： Jeffrey P. Norenberg
发明人： Jeffrey P. Norenberg
IPC分类号： A61K51/04
CPC分类号： A61K51/0453 , A61K31/4178 , A61K51/00 , A61K51/044 , A61K51/0497 , G01N33/569 , G01N2333/70525 , G01N2333/70553 , Y02A50/47 , Y02A50/481
摘要： The present invention is directed to novel non-invasive diagnostic tools to diagnose numerous infectious disease states or conditions. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to therapeutic treatments and other interventions or therapies used in the treatment of these disease states or conditions. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. Pharmaceutical compositions are also described.
摘要翻译：本发明涉及用于诊断许多传染病状态或病症的新型非侵入性诊断工具。本发明代表了本领域的显着进步，其目前依赖于组织活检以诊断这些疾病状态。该新型成像探针能够检测感染的细胞以及组织。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。这种新型探针也可用于监测患者治疗治疗和治疗这些疾病状态或病症的其他干预措施或疗法的反应。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。还描述了药物组合物。

6. 发明授权

US08097237B2 Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma 有权
标题翻译：癌症的非侵入性诊断剂和诊断癌症的方法，特别是白血病和淋巴瘤
公开(公告)号：US08097237B2
公开(公告)日：2012-01-17
申请号：US11507846
申请日：2006-08-22
申请人： Jeffrey P. Norenberg , Richard S. Larson
发明人： Jeffrey P. Norenberg , Richard S. Larson
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： C07F5/003 , A61K47/22 , A61K49/106 , A61K51/0474 , A61K51/0482 , A61K51/0485 , A61K51/0497 , C07F9/94
摘要： The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
摘要翻译：本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

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