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    • 9. 发明申请
    • Non-uniform porosity tissue implant
    • 非均匀孔隙组织植入物
    • US20020062154A1
    • 2002-05-23
    • US09957829
    • 2001-09-21
    • Reed A. Ayers
    • A61F002/28
    • A61L27/56A61F2/28A61F2/2875A61F2/30767A61F2/32A61F2/38A61F2002/2817A61F2002/2889A61F2002/30011A61F2002/30062A61F2002/30092A61F2002/30971A61F2210/0004A61F2210/0014A61F2250/0023A61F2310/00796
    • The present invention is generally directed to a method for the production of tissue implants and prosthetics, including but not limited to orthopedic implants and prosthetics which have a controlled and directional gradient of porosity moving through all or one or more portions of the implant, as well as the implants produced by such a method. The non-uniform porosity gradient may be linear or more complex, and is preferably produced to have a continuous gradient within the desired regions. The desired effect is to create an implant which more closely mimics the natural structure of bone, and which improves the quality of the bone growth that occurs within the implant. In addition, implants can be created with varying porosity in different regions of the implant which are specifically designed to optimize ingrowth of different tissue and cells, to optimize the ability of the implant to withstand varying mechanical loads at specific regions of the implant, and to deliver growth agents to various portions of the implant in a controlled manner.
    • 本发明一般涉及一种用于生产组织植入物和假体的方法,包括但不限于矫形植入物和假体,其具有移动通过植入物的全部或一个或多个部分的孔隙的受控和定向梯度,以及 作为通过这种方法产生的植入物。 非均匀孔隙度梯度可以是线性的或更复杂的,并且优选地产生为在期望的区域内具有连续的梯度。 期望的效果是产生更接近地模仿骨骼的天然结构并且改善在植入物内发生的骨生长质量的植入物。 此外,可以在植入物的不同区域中产生具有不同孔隙度的植入物,其特别设计用于优化不同组织和细胞的向内生长,以优化植入物承受在植入物的特定区域处的变化的机械负载的能力,以及 以可控的方式将生长剂递送到植入物的各个部分。