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1. 发明授权

US09638452B2 Method and scalable devices for hyper-fast cooling and warming 有权
公开(公告)号：US09638452B2
公开(公告)日：2017-05-02
申请号：US14011799
申请日：2013-08-28
申请人： Igor Katkov , Vladimir Fedorovich Bolyukh
发明人： Igor Katkov , Vladimir Fedorovich Bolyukh
IPC分类号： A01N1/02 , F25D3/10 , F25D3/11 , F25D25/00 , F25D13/06 , G01N1/42 , F25D25/04
CPC分类号： F25D3/10 , A01N1/0236 , A01N1/0252 , A01N1/0257 , A01N1/0268 , A01N1/0284 , F17C2227/045 , F25D3/105 , F25D3/11 , F25D13/06 , F25D13/062 , F25D25/00 , F25D25/005 , F25D25/04 , G01N1/42
摘要： The present invention, in some embodiments thereof, relates to a method and scalable devices for hyperfast cooling and re-warming of samples. More specifically, it relates to cryogenic preservation of biological samples via vitrification. It includes: a liquid sample placed at ambient temperature in a flat thermo conductive container that in some embodiments additionally contains a detachable disposable or sterilizable thermo conductive spiral; transferring the sample to a cooling chamber using a linear percussion stepping motor drive; hyperfast cooling of the sample using streams of pressurized liquid coolant; transferring the sample to a detachable shipping/storage chamber filled with liquid coolant, from which the sample can be transferred to another vessel that contains liquid cryogenic coolant and moved back to the shipping/storage chamber. This chamber can be then attached to a re-warming chamber, in which the sample is heated to a biologically tolerant temperature above 0 degrees Celsius in a hyperfast manner.

2. 发明申请

US20160217309A1 PORTABLE RFID TAGGED CARRIER FOR STERILE IMPLANTS AND BIOLOGICAL PRODUCTS 审中-公开
公开(公告)号：US20160217309A1
公开(公告)日：2016-07-28
申请号：US15088794
申请日：2016-04-01
申请人： WARSAW ORTHOPEDIC, INC.
发明人： Wesley J. Clement , Steven M. Tethrake
IPC分类号： G06K7/10
CPC分类号： G06K7/10366 , A01N1/0236 , A01N1/0273 , A61B10/0096 , B01L3/545 , B01L2200/147 , B01L2200/18 , G06K19/07758 , G06Q10/08 , G06Q50/22
摘要： Intelligent portable carrier device for supporting movement in product tracking and monitoring of regulated products, such as tissue and biologics. Embodiments of the invention use product identification technology, such as radio-frequency identification (RFID) tags and readers, to uniquely identify the regulated products as they are added to or removed from the intelligent portable carrier device. Embodiments of the invention may also be configured to monitor and report temperature and other environmental conditions associated with the intelligent portable carrier device.

3. 发明申请

US20160165881A1 Recovery Assembly for Cryopreservation Applications 审中-公开
标题翻译：冷冻保存应用的恢复组件
公开(公告)号：US20160165881A1
公开(公告)日：2016-06-16
申请号：US14908182
申请日：2014-08-05
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： Petra Arndt , Volker Derdau , Verena Siefke-Henzler
IPC分类号： A01N1/02 , B01L3/00
CPC分类号： A01N1/0263 , A01N1/0236 , A01N1/0257 , B01L3/56 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/0615 , B01L2300/0609 , B01L2300/1883
摘要： The present invention relates to a recovery assembly for a cooling agent in a cryopreservation device, the recovery assembly comprises a cone-shaped funnel assembly comprising a support for mounting the funnel assembly to an access opening of a container to be at least partially filled with a cooling agent.
摘要翻译：本发明涉及一种用于冷冻保存装置中的冷却剂的回收组件，该回收组件包括锥形漏斗组件，该锥形漏斗组件包括用于将漏斗组件安装到容器的进入开口的支撑件，至少部分地填充有冷却剂。

4. 发明授权

US09253976B2 Methods and devices for preserving tissues 有权
标题翻译：保存组织的方法和装置
公开(公告)号：US09253976B2
公开(公告)日：2016-02-09
申请号：US13572323
申请日：2012-08-10
申请人： Lisa Maria Anderson , Jared Alden Judson
发明人： Lisa Maria Anderson , Jared Alden Judson
IPC分类号： A01N1/02 , A01N1/00
CPC分类号： A01N1/0247 , A01N1/02 , A01N1/0236
摘要： Methods and apparatus for preserving detached tissues, especially digits and limbs, which are detached as a result of traumatic amputation. By using the methods and apparatus, detached tissues can be preserved for greater lengths of time and are ultimately in a better condition for replantation surgery.
摘要翻译：用于保存分离的组织，特别是数字和四肢的方法和装置，其由于创伤性截肢而分离。通过使用方法和装置，分离的组织可以保存更长的时间，并且最终在补充手术的更好条件下。

5. 发明申请

US20140349273A1 SYSTEM FOR HYPOTHERMIC TRANSPORT OF SAMPLES 审中-公开
标题翻译：用于样品的高压输送系统
公开(公告)号：US20140349273A1
公开(公告)日：2014-11-27
申请号：US14458035
申请日：2014-08-12
申请人： Paragonix Technologies, Inc.
发明人： Lisa Maria Anderson , Jared Alden Judson
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/00 , A01N1/02 , A01N1/0236 , A01N1/0247 , A01N1/0284 , C12M21/08 , C12M45/22
摘要： A method for preserving an extracorporeal organ during hypothermic transport of the organ. The method includes placing an organ in a self-purging preservation apparatus to suspend the sample in preservation fluid, and filling the apparatus with a cold preservation solution. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature, thereby increasing the distance that the organ can be transported without compromising organ function.
摘要翻译：一种在器官低温运输期间保存体外器官的方法。该方法包括将器官置于自清洁保存装置中以将样品悬浮在保存液中，并用冷藏液填充该装置。自清洁保存装置放置在具有冷却介质的绝缘运输容器中。当组装时，系统允许生物样品在稳定的温度下延长的时间的运输，从而增加器官可以运输的距离而不损害器官功能。

6. 发明申请

US20140272924A1 TRANSPLANTATION AND GROWTH OF HUMAN FETAL ORGANS IN NON-HUMAN ANIMAL HOSTS 审中-公开
标题翻译：人类动物园中人类器官的迁移和增长
公开(公告)号：US20140272924A1
公开(公告)日：2014-09-18
申请号：US14205871
申请日：2014-03-12
申请人： Ganogen, Inc.
发明人： Nicholas Chang , Jay Gu , Eugene Gu , Don Hannula
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0236
摘要： Embodiments described herein relate generally to devices, systems and methods for transplanting and growing human fetal organs within non-human animal hosts. In some embodiments, a method for transplanting an organ from a human fetus in a non-human animal host includes fluidically coupling the fetal organ to the blood circulation system of an immunocompromised non-human animal host such that the organ receives arterial blood flow from the non-human animal host. The blood pressure of the arterial blood flow entering the fetal organ is controlled to be compatible with the blood pressure of the organ from the human fetus. In some embodiments, the blood pressure of the blood flow to the fetal organ is controlled using a blood flow control device that includes an inflatable cuff in pressure contact with a blood vessel of the non-human animal host.
摘要翻译：本文描述的实施方案一般涉及在非人动物宿主内移植和培养人胎儿器官的装置，系统和方法。在一些实施方案中，用于在非人动物宿主中移植来自人胎儿的器官的方法包括将胎儿器官流体耦合到免疫受损的非人动物宿主的血液循环系统，使得器官接收来自非人类动物宿主。控制进入胎儿器官的动脉血流的血压与来自人胎儿的器官的血压相适应。在一些实施例中，使用包括与非人动物宿主的血管压力接触的可充气袖带的血流控制装置来控制流向胎儿器官的血流的血压。

7. 发明申请

US20120301952A1 SYSTEM FOR HYPOTHERMIC TRANSPORT OF SAMPLES 有权
标题翻译：用于样品的高压输送系统
公开(公告)号：US20120301952A1
公开(公告)日：2012-11-29
申请号：US13572315
申请日：2012-08-10
申请人： Lisa Maria Anderson , Jared Alden Judson
发明人： Lisa Maria Anderson , Jared Alden Judson
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/00 , A01N1/02 , A01N1/0236 , A01N1/0247 , A01N1/0284 , C12M21/08 , C12M45/22
摘要： A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend the sample in preservation fluid, and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature, while self-purging trapped gases.
摘要翻译：生物样品（如组织，器官或体液）的低温运输系统。该系统包括将样品悬浮在保存液中的自净化保存装置，并用保鲜液灌注纸巾。自清洁保存装置放置在具有冷却介质的绝缘运输容器中。当组装时，系统允许生物样品在稳定的温度下长时间运输，同时自动清除被捕获的气体。

8. 发明申请

US20120060541A1 Sample Storage Cassette for Ultra-Low or Cryogenic Temperatures 有权
标题翻译：样品储存盒用于超低温或低温温度
公开(公告)号：US20120060541A1
公开(公告)日：2012-03-15
申请号：US13228662
申请日：2011-09-09
申请人： Frank Hunt , Julian Warhurst , Bruce Zandi , Robert Cloutier
发明人： Frank Hunt , Julian Warhurst , Bruce Zandi , Robert Cloutier
IPC分类号： F25D3/10 , A47B96/02 , A47B87/00 , F17C3/00 , F25D13/02
CPC分类号： G01N35/04 , A01N1/0236 , A01N1/0252 , B01L7/50 , B01L9/06 , B01L2200/026 , B01L2200/04 , B01L2300/021 , B01L2300/04 , B65G1/00 , F17C3/085 , F25D25/00 , F25D25/04 , G01N1/42 , G01N35/0099 , G01N2035/00346 , G01N2035/00435 , G01N2035/042 , G01N2035/0425 , G01N2035/0462
摘要： A storage cassette including a plurality of generally vertical compartments for storing sample tube racks and/or SBS formatted plates is constructed to be flexible along its substantially vertical axis thereby facilitating reliable robotic placement and retrieval of the cassette from nesting tubes located within a horizontal freezer compartment. Insulated walls and solid shelves minimize heat transfer from storage racks or plates placed in the storage cassette when the cassette is removed from an ultra-low temperature or cryogenic freezer. The outer walls of the cassette includes mechanical indexing locations to ensure appropriate positioning when robotically removing storage racks or plates from the cassette.
摘要翻译：包括用于存储样品管架和/或SBS格式化板的多个大致垂直的隔室的存储盒被构造成沿其基本垂直的轴线是柔性的，从而便于从位于水平冷冻室内的嵌套管的可靠的机器人放置和取出盒。当超低温或低温冷冻箱中取出盒子时，绝缘墙和固体搁板可最大限度地减少从存储盒中放置的存储架或板的热传递。盒子的外壁包括机械分度位置，以确保在将存储架或板从盒中机械地移除时的适当定位。

9. 发明申请

US20070190649A1 Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells 有权
标题翻译：非胚胎多能干细胞的脉冲灌注提取方法
公开(公告)号：US20070190649A1
公开(公告)日：2007-08-16
申请号：US11654553
申请日：2007-01-18
申请人： Fred Gage
发明人： Fred Gage
IPC分类号： C12N5/02 , C12N5/00 , A01N1/02
CPC分类号： C12N5/0647 , A01N1/021 , A01N1/0236 , A01N1/0247 , A01N1/0289 , A61L27/3683 , A61L27/3834 , A61L27/507 , C12N5/0605
摘要： A method for extracting stem cells from a non-embryonic stem cell source, including providing a non-embryonic stem cell source including stem cells; perfusing the non-embryonic stem cell source with a pulsatile flow of a perfusion solution to produce a perfusate including stem cells and a perfused non-embryonic stem cell source; and isolating the stem cells from the perfusate to produce isolated stem cells, is provided. Also provided is a non-embryonic stem cell line derived from a non-embryonic stem cell obtained using the pulsatile perfusion extraction method.
摘要翻译：一种从非胚胎干细胞来源提取干细胞的方法，包括提供包括干细胞在内的非胚胎干细胞来源; 用灌注溶液的脉冲流灌注非胚胎干细胞来产生包括干细胞和灌注的非胚胎干细胞来源的灌注液; 并提供干细胞与灌注液分离以产生分离的干细胞。还提供了源自使用脉冲灌注提取方法获得的非胚胎干细胞的非胚胎干细胞系。

10. 发明授权

US06773425B1 Container for biological products requiring cellular stasis 失效
标题翻译：用于需要细胞停滞的生物制品的容器
公开(公告)号：US06773425B1
公开(公告)日：2004-08-10
申请号：US10364816
申请日：2003-02-11
申请人： Yehuda Tamari
发明人： Yehuda Tamari
IPC分类号： B65D8118
CPC分类号： F26B5/06 , A01N1/0236 , A01N1/0252 , A01N1/0263 , A61J1/05 , A61L2/26 , A61L2202/181 , A61L2202/21 , A61L2202/22 , A61M1/0277
摘要： The invention is an improved container for collecting, freeze-drying, storing, reconstituting, and administering biological solutions and, in particular, blood products. The container features a pliable bottom wall providing intimate thermal contact with the cooling/heating shelf of the lyophilizer; a top wall incorporating a hydrophobic membrane providing a path for water vapor and a bacterial barrier; and side walls sufficiently stiff to support the ceiling but preferably also sufficiently flexible to collapse and minimize storage space especially once lyophilization is complete. The walls incorporate sealable ports that can be used to load the solution for processing and/or adding reconstituting liquids and/or administering the reconstituted solution to a patient. The top wall may incorporate a removable cover that protects the membrane before freeze-drying takes place. A secondary pouch encloses the container immediately post-lyophilization and may incorporate means to evacuate its inner space thereby reducing space and limiting the gas volume the final product is exposed to during storage.
摘要翻译：本发明是用于收集，冷冻干燥，储存，重建和施用生物溶液，特别是血液制品的改进的容器。容器具有柔韧的底壁，与冷冻机的冷却/加热架保持热密接触; 包含提供水蒸气和细菌屏障路径的疏水膜的顶壁; 并且侧壁足够坚固以支撑天花板，但是优选还具有足够的柔性以使塌缩和最小化储存空间，特别是一旦冻干完成。该壁包括可密封的端口，其可以用于将溶液加载和/或添加重构液体和/或将重构溶液施用于患者。顶壁可以包含可冷冻干燥之前保护膜的可移除盖。二次袋在紧随冻结后立即封闭容器，并且可以包括用于抽空其内部空间的装置，从而减少空间并限制最终产品在储存期间暴露于其中的气体体积。

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