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1. 发明公开

US20240254208A2 COMPOSITIONS AND METHODS FOR USING BISPECIFIC ANTIBODIES TO BIND COMPLEMENT AND A TARGET ANTIGEN 审中-公开
公开(公告)号：US20240254208A2
公开(公告)日：2024-08-01
申请号：US17430117
申请日：2020-02-12
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Christos Kyratsous , Chia-Yang Lin , Andrew Murphy , Brinda Prasad , Neil Stahl
IPC分类号： C07K16/12 , A61P31/04 , A61P31/16 , C07K16/10 , C07K16/28
CPC分类号： C07K16/1271 , A61P31/04 , A61P31/16 , C07K16/1018 , C07K16/1214 , C07K16/2878 , C07K16/2887 , A61K2039/505
摘要： According to certain embodiments, the present disclosure provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds a target antigen and a second antigen binding domain that binds a complement component. In certain embodiments, the bispecific antigen-binding molecules of the present disclosure are capable of binding to the target antigen with an EC50 of about 10 nM or less, and/or are capable of promoting complement deposition on the target antigen with an EC50 of about 10 nM. In certain embodiments, the bispecific antigen-binding molecules of the disclosure are useful for treating diseases in which inhibition or reduction of the growth of an infectious agent or cancer cell is desired and/or therapeutically beneficial.

2. 发明申请

US20190100772A1 NON-HUMAN ANIMALS EXPRESSING HUMANIZED C1Q COMPLEX 审中-公开
公开(公告)号：US20190100772A1
公开(公告)日：2019-04-04
申请号：US16144156
申请日：2018-09-27
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Brinda Prasad , Naxin Tu , Karolina Meagher , Lynn Macdonald , Andrew Murphy , Sean Stevens
IPC分类号： C12N15/85 , A01K67/027
摘要： Disclosed herein are nucleic acids encoding for and proteins expressing chimeric C1q polypeptides, non-human animals comprising said nucleic acids, and methods of making or using said non-human animals.

3. 发明申请

US20180030099A1 Apelin Fusion Proteins and Uses Thereof 审中-公开
公开(公告)号：US20180030099A1
公开(公告)日：2018-02-01
申请号：US15665973
申请日：2017-08-01
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Panayiotis Stevis , Andrew Murphy
IPC分类号： C07K14/47 , C07K14/435 , A61K38/00
摘要： The invention provides a fusion protein or polypeptide comprising an apelin peptide fused to a multimerizing component. The invention also provides a fusion protein or polypeptide comprising an apelin peptide fused to an Fc domain, a fragment of an Fc domain, or a variant of an Fc domain. Apelin Fc-fusion polypeptides are capable of binding to the apelin receptor (APLNR). Apelin Fc-fusion polypeptides are capable of activating the APLNR and have improved pharmacokinetic properties compared to apelin peptides that are not fused to an Fc or an Fc fragment. Apelin Fc-fusion polypeptides are useful in diseases and conditions related to cardiovascular function, diabetes, cancer, obesity and other apelin-related conditions.

4. 发明授权

US09565841B2 Humanized IL-4 and IL-4Rα animals 有权
标题翻译：人源化IL-4和IL-4Rα动物
公开(公告)号：US09565841B2
公开(公告)日：2017-02-14
申请号：US14706319
申请日：2015-05-07
申请人： REGENERON PHARMACEUTICALS, INC.
发明人： Li-Hsien Wang , Yingzi Xue , Andrew Murphy , Sean Stevens
IPC分类号： G01N33/00 , A01K67/00 , A01K67/027 , C07K14/54 , C07K14/715
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/20 , A01K2227/105 , A01K2267/01 , A01K2267/0368 , A01K2267/0393 , C07K14/5406 , C07K14/7155
摘要： Non-human animals comprising a human or humanized IL-4 and/or IL-4Rα nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4Rα gene with a human IL-4 gene and/or IL-4Rα gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4Rα gene under control of non-human IL-4Rα regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4Rα-encoding sequence with human or humanized IL-4Rα-encoding sequence at an endogenous non-human C IL-4Rα locus. Non-human animals comprising human or humanized IL-4 gene and/or IL-4Rα sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided.
摘要翻译：提供包含人或人源化IL-4和/或IL-4Rα核酸序列的非人动物。全部或部分包含用人IL-4基因和/或IL-4Rα基因替代内源性IL-4基因和/或IL-4Rα基因的非人动物，以及制备和使用非 - - 人类动物，被描述。还提供包含非人IL-4调节元件控制下的人或人源化IL-4基因的非人动物，包括用人IL替代非人IL-4编码序列的非人动物 -4编码序列在内源非人IL-4基因座。还提供了包含非人IL-4Rα调节元件控制下的人或人源化IL-4Rα基因的非人动物，其包括非人类动物，其具有人或人类IL-4Rα编码序列的非人IL-4Rα编码序列在内源性非人C IL-4Rα基因座处人源化IL-4Rα编码序列。提供包含人或人源化IL-4基因和/或IL-4Rα序列的非人动物，其中非人类动物是啮齿动物，例如小鼠或大鼠。

5. 发明公开

US20230340105A1 NOVEL ANTIGEN BINDING MOLECULE FORMATS 审中-公开
公开(公告)号：US20230340105A1
公开(公告)日：2023-10-26
申请号：US18318871
申请日：2023-05-17
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chia-Yang Lin , Samuel Davis
IPC分类号： A61K39/395 , C07K16/28 , C07K16/24 , A61K47/68 , C07K16/30
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , C07K16/2809 , C07K16/30 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

6. 发明授权

US11732030B2 Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments 有权
公开(公告)号：US11732030B2
公开(公告)日：2023-08-22
申请号：US17207524
申请日：2021-03-19
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Robert Babb , Alina Baum , Gang Chen , Cindy Gerson , Johanna Hansen , Tammy Huang , Christos Kyratsous , Wen-Yi Lee , Marine Malbec , Andrew Murphy , William Olson , Neil Stahl , George D. Yancopoulos
IPC分类号： C07K16/10 , A61K45/06 , A61K39/395 , A61K39/15
CPC分类号： C07K16/10 , A61K39/15 , A61K39/395 , A61K45/06 , C07K2317/31 , C07K2317/52 , C07K2317/565
摘要： The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

7. 发明申请

US20220235126A1 NOVEL ANTIGEN BINDING MOLECULE FORMATS 有权
公开(公告)号：US20220235126A1
公开(公告)日：2022-07-28
申请号：US17666107
申请日：2022-02-07
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Tong Zhang , Erica Pyles , Michael Rosconi , Nina Liu , Supriya Patel , Eric Smith , Andrew Murphy , Chiayang Lin , Samuel Davis
IPC分类号： C07K16/24 , A61K47/68
摘要： Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

8. 发明授权

US11186848B2 Non-human animals expressing humanized C1Q complex 有权
公开(公告)号：US11186848B2
公开(公告)日：2021-11-30
申请号：US16144156
申请日：2018-09-27
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Brinda Prasad , Naxin Tu , Karolina Meagher , Lynn Macdonald , Andrew Murphy , Sean Stevens
IPC分类号： A01K67/027 , C12N15/85 , C07K14/47
摘要： Disclosed herein are nucleic acids encoding for and proteins expressing chimeric C1q polypeptides, non-human animals comprising said nucleic acids, and methods of making or using said non-human animals.

9. 发明授权

US10954289B1 Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments 有权
公开(公告)号：US10954289B1
公开(公告)日：2021-03-23
申请号：US17021286
申请日：2020-09-15
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Robert Babb , Alina Baum , Gang Chen , Cindy Gerson , Johanna Hansen , Tammy Huang , Christos Kyratsous , Wen-Yi Lee , Marine Malbec , Andrew Murphy , William Olson , Neil Stahl , George D. Yancopoulos
IPC分类号： C07K16/10 , A61K45/06 , A61K39/15 , A61K39/395
摘要： The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

10. 发明授权

US09795121B2 Humanized C3 animals 有权
公开(公告)号：US09795121B2
公开(公告)日：2017-10-24
申请号：US14703818
申请日：2015-05-04
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Ying Hu , Adrianna Latuszek , Jingtai Cao , Alexander Mujica , Stanley Wiegand , John McWhirter , Andrew Murphy , Lynn Macdonald
IPC分类号： A01K67/027 , A61K49/00 , C07K14/47
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2227/105 , A01K2267/03 , A01K2267/0368 , A61K49/0008 , C07K14/472
摘要： Non-human animals comprising a human or humanized C3 and/or C5 nucleic acid sequence are provided as well as methods for using the same to identify compounds capable of modulating the complement system. Non-human animals that comprise a replacement of the endogenous C5 gene and/or C3 gene with a human or humanized C5 gene and/or C3 gene, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized C5 gene under control of non-human C5 regulatory elements is also provided, including non-human animals that have a replacement of non-human C5-encoding sequence with human C5-encoding sequence at an endogenous non-human C5 locus. Non-human animals comprising a human or humanized C3 gene under control of non-human C3 regulatory elements is also provided, including non-human animals that have a replacement of non-human C3 protein-encoding sequence with human or humanized C3 protein-encoding sequence at an endogenous non-human C3 locus. Non-human animals comprising human or humanized C3 and/or C5 sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided.

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