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1. 发明授权

US4524036A Process for the manufacture of polyurethane resin for electrostatic spinning 失效
标题翻译：制造静电纺丝用聚氨酯树脂的方法
公开(公告)号：US4524036A
公开(公告)日：1985-06-18
申请号：US597968
申请日：1984-04-09
申请人： Denis K. Gilding , Roy M. Clarke
发明人： Denis K. Gilding , Roy M. Clarke
IPC分类号： D01F6/70 , C08G18/00 , C08G18/08 , C08G18/10 , D04H1/56 , B29C6/00 , B29C23/00
CPC分类号： D01F6/70 , C08G18/0852 , C08G18/10 , D01D5/0038 , D04H1/56
摘要： A process for the preparation of polyurethane resins particularly suitable for electrostatic spinning which comprises forming a prepolymer of polyether glycol and a diisocyanate reacted in a molar ratio of about 1:2, and thereafter reacting the prepolymer with additional diisocyanate and a diol extender, the final molar ratio of the polyether, isocyanate and diol reactants being approximately 1:3.7:2.5. The reaction is conducted in an organic solvent at a temperature of about 45.degree. C. to obtain a polymer having an inherent viscosity of from about 2.0 to 2.4 in a solution of 25 to 30 percent solids. The solution is diluted to about 15 percent solids prior to spinning.
摘要翻译：一种制备特别适用于静电纺丝的聚氨酯树脂的方法，其包括形成聚醚二醇和二异氰酸酯的预聚物，其摩尔比为约1:2，然后使预聚物与另外的二异氰酸酯和二醇增量剂反应，聚醚，异氰酸酯和二醇反应物的摩尔比为约1:3.7:2.5。该反应在约45℃的温度下在有机溶剂中进行，得到固体含量为25-30％的固有粘度为约2.0至2.4的聚合物。在旋转之前将溶液稀释至约15％的固体。

2. 发明授权

US10561771B2 Thoracic aorta ventricular assist system 有权
公开(公告)号：US10561771B2
公开(公告)日：2020-02-18
申请号：US15649121
申请日：2017-07-13
申请人： VASCOR, INC.
发明人： Marlin S. Heilman , Charles Robert Kohler , David M. Reilly , Jon David Wagner , Kurt D. Badstibner , Richard A. Bates , Jonathan R. Speicher , Joseph F. Russial
IPC分类号： A61M1/10 , A61M1/12
摘要： An implantable heart assist system includes a compressible pumping chamber including an inlet conduit to be placed in fluid connection with the descending thoracic aorta and an outlet conduit to be placed in fluid connection with the thoracic aorta; and a pump system comprising a first rigid member, a second rigid member positioned so that at least a portion of the pumping chamber may be positioned between the first and second rigid members, a drive system configured to cause the second rigid member to move toward or away from the first rigid member, and a controller in operative connection with the drive system and controlling the drive system, wherein movement of the second rigid member toward the first rigid member results in compresses the pumping chamber and movement of the second rigid member away from the first rigid member expands the pumping chamber.

3. 发明授权

US5383840A Biocompatible ventricular assist and arrhythmia control device including cardiac compression band-stay-pad assembly 失效
标题翻译：生物相容性心室辅助和心律失常控制装置，包括心脏压迫带 - 垫组件
公开(公告)号：US5383840A
公开(公告)日：1995-01-24
申请号：US920732
申请日：1992-07-28
申请人： Marlin S. Heilman , Steve A. Kolenik , Christopher D. Capone , Carl M. Parisi , Edward K. Prem , Vernon L. Speicher
发明人： Marlin S. Heilman , Steve A. Kolenik , Christopher D. Capone , Carl M. Parisi , Edward K. Prem , Vernon L. Speicher
IPC分类号： A61M1/10 , A61H31/00
CPC分类号： A61M1/1068 , A61M1/1046
摘要： A ventricular assist device for a heart includes a compression band-stay-pad assembly for encircling substantially the entire heart perimeter and comprising an elongated band member or chain disposed in a sealed protective structure filled with a lubricating medium. The band member may be fixed at one end and wound upon, or unwound from, a rotatable spool by a drive motor through a speed reducer. Force-transmitting support or stay assemblies are disposed in the protective structure between the band member and a resilient pad assembly for encircling the heart and promoting heart tissue ingrowth therein. The force-transmitting stay assemblies are biased circumferentially, and thus radially outward, by compression return springs disposed therebetween. The resilient pad assembly includes a corrugated surface provided with vertical coil springs, which help prevent damage to heart tissue and facilitate return of the pad assembly to an initial condition, embedded defibrillator electrodes and relatively soft portions to prevent damage to coronary arteries. The device may be constructed so that it can be surgically removed, except for a sealing film and an ingrown pad of the resilient pad assembly, which remain in situ on the heart. A net structure suspended below the device supports the apical portion of the heart.
摘要翻译：用于心脏的心室辅助装置包括用于围绕基本上整个心脏周边的压缩带状支架组件，并且包括设置在填充有润滑介质的密封保护结构中的细长带状构件或链条。带构件可以固定在一端，并通过驱动电动机通过减速器缠绕在可旋转的卷轴上或从其释放。力传递支撑件或支撑组件设置在带构件和弹性垫组件之间的保护结构中，用于环绕心脏并促进其中的心脏组织向内生长。力传递支柱组件通过设置在它们之间的压缩复位弹簧周向地偏置，并因此被径向向外偏压。弹性垫组件包括具有垂直螺旋弹簧的波纹表面，其有助于防止对心脏组织的损伤并且便于将垫组件返回到初始状态，嵌入的除颤器电极和相对较软的部分以防止损伤冠状动脉。除了保留在心脏上的弹性垫组件的密封膜和内衬垫之外，该装置可被构造成能够手术除去。悬挂在装置下面的网状结构支撑心脏的顶端部分。

4. 发明授权

US5098369A Biocompatible ventricular assist and arrhythmia control device including cardiac compression pad and compression assembly 失效
标题翻译：生物相容性心室辅助和心律失常控制装置，包括心脏压缩垫和压缩组件
公开(公告)号：US5098369A
公开(公告)日：1992-03-24
申请号：US522956
申请日：1990-05-14
申请人： Marlin S. Heilman , Steve A. Kolenik , Christopher D. Capone , Carl M. Parisi , Edward K. Prem , Vernon L. Speicher
发明人： Marlin S. Heilman , Steve A. Kolenik , Christopher D. Capone , Carl M. Parisi , Edward K. Prem , Vernon L. Speicher
IPC分类号： A61M1/10 , A61M1/12 , A61N1/362
CPC分类号： A61M1/1068 , A61M1/1046 , A61M1/127 , A61N1/3627
摘要： A ventricular assist device may include a cardiac compression assembly which comprises a gel-filled pad of generally concave configuration, mounted on a pressure plate with peripheral portions of the pad extending beyond the periphery of the plate, to preclude damage to the heart by the peripheral edges of the plate. The gel-filled pad may have undulating opposite sides formed by intersecting rows of raised dimples. The pad also includes portions for suturing the pad to a heart ventricle, and at least some of the dimples on the side of the pad facing the heart ventricle are provided with ventricle tissue growth-promoting islands. An electrode, in the form of a grid having intersecting strips which define dimple-receiving openings therebetween, also may be mounted on the venticle side of the pad. As many as eight circumferentially arranged cardiac compression assemblies, having lower ends pivotally mounted on a support member adapted to be located adjacent the apex of a heart ventricle, may be provided. Operating systems for operating the cardiac compression assemblies may include a motor-driven camming mechanism; a mechanism comprising a device for converting electrical energy to hydraulic fluid energy, two sealed fluid systems, a reversible pump, two bellows and a safety solenoid pump-bypass fluid return valve; or a closed loop system comprising a reversible pump in a fluid supply casing, a hydraulic fluid manifold including a plurality of miniature fluid actuators which may be of arcuate construction to conserve space, and a mechanism for collecting fluid leaking from the actuators and returning it to the fluid supply casing.
摘要翻译：心室辅助装置可以包括心脏压缩组件，该心脏压缩组件包括一个大致凹形构型的凝胶填充垫，安装在压板上，垫的周边部分延伸超过板的周边，以排除周边的心脏损伤板的边缘。凝胶填充的垫可以具有由凸起的凹坑的相交行形成的起伏的相对侧。衬垫还包括用于将垫缝合到心室的部分，并且面向心室的衬垫侧面上的至少一些凹窝设置有心室组织生长促进岛。具有在其间限定凹坑接收开口的相交条带的网格形式的电极也可以安装在垫的通气面上。可以提供多达八个周向布置的心脏压缩组件，其具有可枢转地安装在适于邻近心脏心尖的位置定位的支撑构件上的下端。用于操作心脏压缩组件的操作系统可以包括马达驱动的凸轮机构; 包括用于将电能转换成液压流体能量的装置的机构，两个密封流体系统，可逆泵，两个波纹管和安全螺线管泵旁通流体回流阀; 或包括流体供应壳体中的可逆泵的闭环系统，包括可以具有弓形结构以节省空间的多个微型流体致动器的液压流体歧管以及用于收集从致动器泄漏的流体并将其返回到流体供应套管。

5. 发明授权

US09387284B2 Control of blood flow assist systems 有权
标题翻译：控制血流辅助系统
公开(公告)号：US09387284B2
公开(公告)日：2016-07-12
申请号：US14519764
申请日：2014-10-21
申请人： VASCOR, INC
发明人： Marlin Stephen Heilman , Douglas J. Koebler , Charles Robert Kohler , Jon David Wagner , David M. Reilly
IPC分类号： A61M1/10 , A61M1/12 , A61M39/22
CPC分类号： A61M1/1006 , A61M1/10 , A61M1/1008 , A61M1/101 , A61M1/1013 , A61M1/1086 , A61M1/1087 , A61M1/122 , A61M1/125 , A61M39/22 , A61M39/223 , A61M2039/224 , A61M2039/226 , A61M2205/3334
摘要： A system for assisting blood flow in a patient includes an implantable pump system for assisting in blood flow from the heart and an implantable control system for communicative connection with the implantable pump system. The control system includes a pacemaker system that is operative to control heart rate and the pump system interdependently to achieve a determined level of blood flow assist. The control system is adapted to increase the heart rate of the patient to above a normal heart rate for the patient under the present conditions of the patient via the pacemaker while controlling the pump system to achieve the determined level of blood flow assist based upon the increased heart rate and a level of assist provided by the pump system.
摘要翻译：用于辅助患者血液流动的系统包括用于辅助来自心脏的血液流动的可植入泵系统和用于与可植入泵系统进行通信连接的可植入控制系统。控制系统包括起搏器系统，其可操作以相互依赖地控制心率和泵系统以实现确定的血流辅助水平。控制系统适于在患者的现状通过起搏器的同时将患者的心率提高到高于正常心率，同时基于增加的血液流量来控制泵系统达到所确定的血流量辅助水平心率和泵系统提供的辅助水平。

6. 发明授权

US08764621B2 Transcutaneous power transmission and communication for implanted heart assist and other devices 有权
标题翻译：用于植入心脏辅助和其他装置的经皮电力传输和通讯
公开(公告)号：US08764621B2
公开(公告)日：2014-07-01
申请号：US13546789
申请日：2012-07-11
申请人： Kurt D. Badstibner , Jonathan R. Speicher , Marlin S. Heilman , Richard A. Bates , Charles E. Greene
发明人： Kurt D. Badstibner , Jonathan R. Speicher , Marlin S. Heilman , Richard A. Bates , Charles E. Greene
IPC分类号： A61N1/362
CPC分类号： A61M1/1086 , A61M1/101 , A61M1/12 , A61M1/122 , A61M1/127 , A61M2205/3331 , A61M2205/3523 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/8206 , A61M2205/8243 , H01F38/14 , H02J5/005 , H02J7/025 , H02J50/12 , H02J50/80 , H02J50/90 , H04B5/0037 , H04B5/0062 , H04B5/0075
摘要： A system includes an implantable pump system for assisting blood flow in a patient including at least one movable valve. The movable valve is in a normally open state when the moveable valve is not being powered and a drive system in operative connection with the moveable valve to move the moveable valve under power. The system further includes an energy transfer system to provide energy to the drive system. The energy transfer system includes an external system including a power source and an external coil and an internal system including an internal coil adapted to receive transcutaneous energy transmitted from the external coil. The internal system has at least a first state wherein energy transmission from the external coil is required to provide operational power to the drive system.
摘要翻译：一种系统包括可植入泵系统，用于辅助包括至少一个活动阀在内的患者的血液流动。当可动阀未被供电时，可移动阀处于常开状态，以及与可移动阀操作连接的驱动系统以使可动阀在动力下移动。该系统还包括能量传递系统以向驱动系统提供能量。能量传递系统包括包括电源和外部线圈的外部系统以及包括适于接收从外部线圈传递的经皮能量的内部线圈的内部系统。内部系统具有至少第一状态，其中需要来自外部线圈的能量传输来向驱动系统提供操作功率。

7. 发明授权

US5980448A Single chamber blood pump 失效
公开(公告)号：US5980448A
公开(公告)日：1999-11-09
申请号：US14894
申请日：1998-01-28
申请人： Marlin Stephen Heilman , Christopher David Capone , Edward Karl Prem , Richard Andrew Zehel Sofranko , Carl Michael Parisi , Steve Andrew Kolenik , Daniel Richard Moore
发明人： Marlin Stephen Heilman , Christopher David Capone , Edward Karl Prem , Richard Andrew Zehel Sofranko , Carl Michael Parisi , Steve Andrew Kolenik , Daniel Richard Moore
IPC分类号： A61B17/11 , A61F2/06 , A61F2/24 , A61M1/10 , A61M1/12
CPC分类号： A61F2/064 , A61M1/1008 , A61M1/1037 , A61B2017/1135 , A61F2/24 , A61M1/1046
摘要： A blood pump apparatus can include a pump housing having a drive chamber containing a drive mechanism. A cupped member can be connected to the housing and the drive mechanism can include a motor for rotating an eccentric shaft. A pumping arm can be provided having one end riding on the eccentric shaft, an intermediate portion pivotably attached to the housing and another end connected to a movable plate. A roller bearing can be mounted on the eccentric shaft on which the arm can ride. A compressible blood chamber having an inlet and an outlet connected can be provided sandwiched between the cupped portion and the movable plate. The motor thus rotates the cam causing the pumping arm to pivot which cycles the movable plate against the blood chamber to pump blood. The movable plate can be implanted adjacent a lung such that the lung moves with the plate as blood is pumped and thereby functions as a compliance chamber. A speed reducer can be provided between the motor and the eccentric shaft. A hermetically sealing bellows can be provided to seal the drive chamber and the end of the pumping arm from body fluids. An enclosure bag can be provided surrounding all or a portion of the blood pump to provide a tissue friendly surface and to prevent tissue from becoming caught in the moving parts of the blood pump. A position sensor can be included for determining a volume of blood in the chamber for use by an electronic controller to control the speed of the motor to optimize pumping action.

8. 发明授权

US09707327B2 Thoracic aorta ventricular assist system 有权
公开(公告)号：US09707327B2
公开(公告)日：2017-07-18
申请号：US14776927
申请日：2014-03-17
申请人： VASCOR, INC.
发明人： Marlin S. Heilman , Charles R. Kohler , David M. Reilly , Jon D. Wagner , Kurt D. Badstibner , Richard A. Bates , Jonathan R. Speicher , Joseph F. Russial
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1049 , A61M1/1005 , A61M1/1008 , A61M1/1037 , A61M1/1051 , A61M1/107 , A61M1/1086 , A61M1/122 , A61M1/127 , A61M2205/8243 , A61M2230/005 , A61M2230/04
摘要： An implantable heart assist system, includes a pumping chamber formed of a flexible material and being adapted to be placed in fluid connection with the aorta and a pump system comprising a first rigid member and a spaced apart second rigid member so that at least a portion of the pumping chamber may be positioned therebetween, a drive system comprising a motor. The motor is adapted to cause the second rigid member to move toward the first rigid member to compress the pumping chamber or away from the first rigid member to expand the pumping chamber. A controller is in operative connection with the drive system and controlling the motor.

9. 发明授权

US07258679B2 Inflow conduit for ventricular assist device 失效
标题翻译：心室辅助装置输液管
公开(公告)号：US07258679B2
公开(公告)日：2007-08-21
申请号：US10636431
申请日：2003-08-07
申请人： Daniel Richard Moore , Christopher David Capone , Marlin Stephen Heilman , Steve Andrew Kolenik , Carl Michael Parisi , Edward Karl Prem , Richard Andrew Sofranko
发明人： Daniel Richard Moore , Christopher David Capone , Marlin Stephen Heilman , Steve Andrew Kolenik , Carl Michael Parisi , Edward Karl Prem , Richard Andrew Sofranko
IPC分类号： A61M5/178
CPC分类号： A61M1/10 , A61M1/1008 , A61M1/12
摘要： An inflow conduit of a ventricular assist device configured to prevent formation of recirculation and stagnation zones as well as collapse due to external forces or pump induced suction can be rigid and have a funnel like shape with an elbow to accommodate a patient anatomy. Stiffening elements and pressure sensing devices can also be provided associated with the inflow conduit.
摘要翻译：构造成防止再循环和停滞区形成以及由于外力或泵引起的抽吸而塌陷的心室辅助装置的流入管道可以是刚性的，并且具有用于容纳患者解剖结构的具有弯头的漏斗状形状。加强元件和压力感测装置也可以与流入管道相关联地提供。

10. 发明授权

US6066085A Single chamber blood pump 失效
标题翻译：单室血液泵
公开(公告)号：US6066085A
公开(公告)日：2000-05-23
申请号：US359563
申请日：1999-07-22
申请人： Marlin Stephen Heilman , Christopher David Capone , Edward Karl Prem , Richard Andrew Zehel Sofranko , Carl Michael Parisi , Steve Andrew Kolenik , Daniel Richard Moore
发明人： Marlin Stephen Heilman , Christopher David Capone , Edward Karl Prem , Richard Andrew Zehel Sofranko , Carl Michael Parisi , Steve Andrew Kolenik , Daniel Richard Moore
IPC分类号： A61B17/11 , A61F2/06 , A61F2/24 , A61M1/10 , A61M1/12
CPC分类号： A61F2/064 , A61M1/1008 , A61M1/1037 , A61B2017/1135 , A61F2/24 , A61M1/1046
摘要： A blood pump apparatus can include a pump housing having a drive chamber containing a drive mechanism. A cupped member can be connected to the housing and the drive mechanism can include a motor for rotating an eccentric shaft. A pumping arm can be provided having one end riding on the eccentric shaft, an intermediate portion pivotably attached to the housing and another end connected to a movable plate. A roller bearing can be mounted on the eccentric shaft on which the arm can ride. A compressible blood chamber having an inlet and an outlet connected can be provided sandwiched between the cupped portion and the movable plate. The motor thus rotates the cam causing the pumping arm to pivot which cycles the movable plate against the blood chamber to pump blood. The movable plate can be implanted adjacent a lung such that the lung moves with the plate as blood is pumped and thereby functions as a compliance chamber. A speed reducer can be provided between the motor and the eccentric shaft. A hermetically sealing bellows can be provided to seal the drive chamber and the end of the pumping arm from body fluids. An enclosure bag can be provided surrounding all or a portion of the blood pump to provide a tissue friendly surface and to prevent tissue from becoming caught in the moving parts of the blood pump. A position sensor can be included for determining a volume of blood in the chamber for use by an electronic controller to control the speed of the motor to optimize pumping action.
摘要翻译：血泵装置可以包括具有包含驱动机构的驱动室的泵壳体。杯形构件可以连接到壳体，并且驱动机构可以包括用于旋转偏心轴的马达。可以设置一个泵臂，其一端位于偏心轴上，中间部分可枢转地附接到壳体，另一端连接到可移动板。滚子轴承可以安装在手臂可以骑行的偏心轴上。具有入口和出口连接的可压缩血液室可以被夹在杯状部分和活动板之间。因此，电动机使凸轮旋转，使得泵臂枢转，循环可移动板抵靠血液室以泵送血液。可移动板可以在肺附近植入，使得当血液被泵送时肺随着板移动，从而起到顺应性室的作用。电动机与偏心轴之间可设有减速器。可以提供气密密封的波纹管以将驱动室和泵臂的端部与体液密封。可以围绕血液泵的全部或一部分设置封闭袋，以提供组织友好的表面并防止组织被卡在血液泵的运动部分中。可以包括位置传感器，用于确定腔室中的血液体积，供电子控制器使用，以控制电机的速度以优化泵送动作。

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