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1. 发明授权

US06179773B2 Magnetically suspended fluid pump and control system 失效
标题翻译：磁悬浮液泵和控制系统
公开(公告)号：US06179773B2
公开(公告)日：2001-01-30
申请号：US09288413
申请日：1999-04-08
申请人： Edward K. Prem , Steve A. Kolenik
发明人： Edward K. Prem , Steve A. Kolenik
IPC分类号： A61M112
CPC分类号： F04D29/048 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1017 , A61M1/1018 , A61M1/1031 , A61M1/1087 , A61M1/122 , F04D13/0646 , F16C32/0444 , F16C32/047 , F16C2316/18 , F16C2360/44
摘要： A blood pump for assisting a heart is provided having a stator and a rotor. The rotor is magnetically radially supported creating a suspension gap between the stator and the rotor. The rotor can be supported axially by a Lorentz force bearing and can be magnetically rotated. The stator can have a single or double volute pump chamber and the rotor can have an impeller portion for pumping blood. The rotor can have a center bore as a primary blood flowpath. The suspension gap can be a secondary blood flowpath. The blood pump can also have an axial position controller and a flow rate controller. The axial position controller can cause the axial bearing to adjust the position of the rotor. The flow rate controller can have a member for measuring a dimension of a heart ventricle to control the flow rate to avoid overly distending or contracting the ventricle. A method of operating the flow rate controller to create a pulsatile flow rate is also provided. Additionally, the blood pump can be part of a cardiac assist and arrhythmia control system. Moreover, a method of operating the flow rate controller can be provided which reduces the amount of energy needed to treat fibrillation. The method can include operating the flow rate controller to reduce a radial dimension of the ventricle prior to delivering defibrillation energy such that the ventricle contains less blood which absorbs less energy so that a larger fraction of the energy is delivered to the heart.
摘要翻译：提供了一种用于辅助心脏的血泵，其具有定子和转子。转子被磁力径向支撑，在定子和转子之间产生悬挂间隙。转子可以由洛伦兹力轴承轴向支撑，并可以磁旋转。定子可以具有单个或双重蜗壳泵室，并且转子可以具有用于泵送血液的叶轮部分。转子可以具有作为主血流径的中心孔。悬浮间隙可以是二次血流路径。血泵还可以具有轴向位置控制器和流量控制器。轴向位置控制器可以使轴向轴承调整转子的位置。流量控制器可以具有用于测量心室尺寸的部件以控制流速以避免过度膨胀或收缩心室。还提供了一种操作流量控制器以产生脉动流量的方法。此外，血液泵可以是心脏辅助和心律失常控制系统的一部分。此外，可以提供操作流量控制器的方法，其减少了治疗原纤维化所需的能量的量。该方法可以包括操作流速控制器以在递送除颤能量之前减小心室的径向尺寸，使得心室含有较少的血液，其吸收更少的能量，从而将更大部分的能量输送到心脏。

2. 发明授权

US06761532B2 Touch down of blood pump impellers 失效
标题翻译：触碰血泵叶轮
公开(公告)号：US06761532B2
公开(公告)日：2004-07-13
申请号：US10097731
申请日：2002-03-14
申请人： Christopher D. Capone , Ruey C. Dempsey , Marlin S. Heilman , Steve A. Kolenik , Daniel R. Moore , Carl M. Parisi , Edward K. Prem , Richard A. Sofranko , David C. Borzelleca , Greg Burgreen , John A. Holmes , Zhongjun Wu , Ralph Scott Hebbert , James Antaki
发明人： Christopher D. Capone , Ruey C. Dempsey , Marlin S. Heilman , Steve A. Kolenik , Daniel R. Moore , Carl M. Parisi , Edward K. Prem , Richard A. Sofranko , David C. Borzelleca , Greg Burgreen , John A. Holmes , Zhongjun Wu , Ralph Scott Hebbert , James Antaki
IPC分类号： F04D700
CPC分类号： F04D29/047 , A61M1/101 , A61M1/1015 , A61M1/1017 , A61M1/1031 , A61M1/1086 , A61M1/122 , F04D13/064
摘要： A blood pump having rotor and/or stator touch down zones to prevent pump failure or hemolysis which can occur if the rotor comes into contact with the stator due to power failure or mechanical shock. The touch down zones can include forming, or coating, portions of adjacent surfaces of the stator and rotor which can come into contact if a rotor touch down occurs. The materials used to form or coat the touch down zones can have properties which ensure that no consequential damage to the contacting surfaces occurs.
摘要翻译：具有转子和/或定子的血泵触屏，以防止由于电源故障或机械冲击而导致转子与定子接触时可能发生泵故障或溶血。触碰区域可以包括形成或涂覆定子和转子的相邻表面的部分，如果发生转子触碰，则其可以接触。用于形成或涂覆触摸区域的材料可以具有确保不会对接触表面造成相应损害的性质。

3. 发明授权

US4049003A Digital cardiac pacer 失效
标题翻译：数字心脏起搏器
公开(公告)号：US4049003A
公开(公告)日：1977-09-20
申请号：US654504
申请日：1976-02-02
申请人： Robert A. Walters , Steve A. Kolenik
发明人： Robert A. Walters , Steve A. Kolenik
IPC分类号： A61N1/362 , A61N1/365 , A61N1/36
CPC分类号： A61N1/365
摘要： A digital cardiac pacer has an asynchronous interval counter to count clock pulses to establish a stimulation interval at the end of which it produces a pulse for initiating a stimulation pulse. A control counter to which amplified naturally occurring heat pulses or stimulation pulses are applied controls the delivery of a resetting pulse to the asynchronous interval counter to reinitiate its count. If the stimulation, heart, or an interference pulse is detected during the count of a "refractory period," the control counter is reset and the refractory period is extended. If another stimulation, heart, or interference, pulse is detected during the extended refractory period, no resetting pulse is delivered, and the asynchronous interval counter continues its normal count. If during the period of time following the extended refractory period a stimulation, heart, or interference pulse is received, the control counter produces a resetting pulse to reset the asynchronous interval counter. A delay circuit between the control and asynchronous counters causes the stimulation interval to be shortened during the reception of interference pulses.
摘要翻译：数字心脏起搏器具有异步间隔计数器，用于计数时钟脉冲，以在其结束时建立刺激间隔，其产生用于启动刺激脉冲的脉冲。施加放大的自然发生的热脉冲或刺激脉冲的控制计数器控制将复位脉冲传送到异步间隔计数器以重新启动其计数。如果在“不应期”的计数期间检测到刺激，心脏或干扰脉冲，则控制计数器被复位并且不应期延长。如果在延长的不应期内检测到另一种刺激，心脏或干扰脉冲，则不会传送复位脉冲，异步间隔计数器继续其正常计数。如果在延长的不应期后的一段时间内接收到刺激，心脏或干扰脉冲，则控制计数器产生复位脉冲以复位异步间隔计数器。控制和异步计数器之间的延迟电路在接收干扰脉冲期间引起刺激间隔的缩短。

4. 发明授权

US5383840A Biocompatible ventricular assist and arrhythmia control device including cardiac compression band-stay-pad assembly 失效
标题翻译：生物相容性心室辅助和心律失常控制装置，包括心脏压迫带 - 垫组件
公开(公告)号：US5383840A
公开(公告)日：1995-01-24
申请号：US920732
申请日：1992-07-28
申请人： Marlin S. Heilman , Steve A. Kolenik , Christopher D. Capone , Carl M. Parisi , Edward K. Prem , Vernon L. Speicher
发明人： Marlin S. Heilman , Steve A. Kolenik , Christopher D. Capone , Carl M. Parisi , Edward K. Prem , Vernon L. Speicher
IPC分类号： A61M1/10 , A61H31/00
CPC分类号： A61M1/1068 , A61M1/1046
摘要： A ventricular assist device for a heart includes a compression band-stay-pad assembly for encircling substantially the entire heart perimeter and comprising an elongated band member or chain disposed in a sealed protective structure filled with a lubricating medium. The band member may be fixed at one end and wound upon, or unwound from, a rotatable spool by a drive motor through a speed reducer. Force-transmitting support or stay assemblies are disposed in the protective structure between the band member and a resilient pad assembly for encircling the heart and promoting heart tissue ingrowth therein. The force-transmitting stay assemblies are biased circumferentially, and thus radially outward, by compression return springs disposed therebetween. The resilient pad assembly includes a corrugated surface provided with vertical coil springs, which help prevent damage to heart tissue and facilitate return of the pad assembly to an initial condition, embedded defibrillator electrodes and relatively soft portions to prevent damage to coronary arteries. The device may be constructed so that it can be surgically removed, except for a sealing film and an ingrown pad of the resilient pad assembly, which remain in situ on the heart. A net structure suspended below the device supports the apical portion of the heart.
摘要翻译：用于心脏的心室辅助装置包括用于围绕基本上整个心脏周边的压缩带状支架组件，并且包括设置在填充有润滑介质的密封保护结构中的细长带状构件或链条。带构件可以固定在一端，并通过驱动电动机通过减速器缠绕在可旋转的卷轴上或从其释放。力传递支撑件或支撑组件设置在带构件和弹性垫组件之间的保护结构中，用于环绕心脏并促进其中的心脏组织向内生长。力传递支柱组件通过设置在它们之间的压缩复位弹簧周向地偏置，并因此被径向向外偏压。弹性垫组件包括具有垂直螺旋弹簧的波纹表面，其有助于防止对心脏组织的损伤并且便于将垫组件返回到初始状态，嵌入的除颤器电极和相对较软的部分以防止损伤冠状动脉。除了保留在心脏上的弹性垫组件的密封膜和内衬垫之外，该装置可被构造成能够手术除去。悬挂在装置下面的网状结构支撑心脏的顶端部分。

5. 发明授权

US5098369A Biocompatible ventricular assist and arrhythmia control device including cardiac compression pad and compression assembly 失效
标题翻译：生物相容性心室辅助和心律失常控制装置，包括心脏压缩垫和压缩组件
公开(公告)号：US5098369A
公开(公告)日：1992-03-24
申请号：US522956
申请日：1990-05-14
申请人： Marlin S. Heilman , Steve A. Kolenik , Christopher D. Capone , Carl M. Parisi , Edward K. Prem , Vernon L. Speicher
发明人： Marlin S. Heilman , Steve A. Kolenik , Christopher D. Capone , Carl M. Parisi , Edward K. Prem , Vernon L. Speicher
IPC分类号： A61M1/10 , A61M1/12 , A61N1/362
CPC分类号： A61M1/1068 , A61M1/1046 , A61M1/127 , A61N1/3627
摘要： A ventricular assist device may include a cardiac compression assembly which comprises a gel-filled pad of generally concave configuration, mounted on a pressure plate with peripheral portions of the pad extending beyond the periphery of the plate, to preclude damage to the heart by the peripheral edges of the plate. The gel-filled pad may have undulating opposite sides formed by intersecting rows of raised dimples. The pad also includes portions for suturing the pad to a heart ventricle, and at least some of the dimples on the side of the pad facing the heart ventricle are provided with ventricle tissue growth-promoting islands. An electrode, in the form of a grid having intersecting strips which define dimple-receiving openings therebetween, also may be mounted on the venticle side of the pad. As many as eight circumferentially arranged cardiac compression assemblies, having lower ends pivotally mounted on a support member adapted to be located adjacent the apex of a heart ventricle, may be provided. Operating systems for operating the cardiac compression assemblies may include a motor-driven camming mechanism; a mechanism comprising a device for converting electrical energy to hydraulic fluid energy, two sealed fluid systems, a reversible pump, two bellows and a safety solenoid pump-bypass fluid return valve; or a closed loop system comprising a reversible pump in a fluid supply casing, a hydraulic fluid manifold including a plurality of miniature fluid actuators which may be of arcuate construction to conserve space, and a mechanism for collecting fluid leaking from the actuators and returning it to the fluid supply casing.
摘要翻译：心室辅助装置可以包括心脏压缩组件，该心脏压缩组件包括一个大致凹形构型的凝胶填充垫，安装在压板上，垫的周边部分延伸超过板的周边，以排除周边的心脏损伤板的边缘。凝胶填充的垫可以具有由凸起的凹坑的相交行形成的起伏的相对侧。衬垫还包括用于将垫缝合到心室的部分，并且面向心室的衬垫侧面上的至少一些凹窝设置有心室组织生长促进岛。具有在其间限定凹坑接收开口的相交条带的网格形式的电极也可以安装在垫的通气面上。可以提供多达八个周向布置的心脏压缩组件，其具有可枢转地安装在适于邻近心脏心尖的位置定位的支撑构件上的下端。用于操作心脏压缩组件的操作系统可以包括马达驱动的凸轮机构; 包括用于将电能转换成液压流体能量的装置的机构，两个密封流体系统，可逆泵，两个波纹管和安全螺线管泵旁通流体回流阀; 或包括流体供应壳体中的可逆泵的闭环系统，包括可以具有弓形结构以节省空间的多个微型流体致动器的液压流体歧管以及用于收集从致动器泄漏的流体并将其返回到流体供应套管。

6. 发明授权

US4614192A Implantable cardiac defibrillator employing bipolar sensing and telemetry means 失效
标题翻译：采用双极感测和遥测手段的植入心脏除颤器
公开(公告)号：US4614192A
公开(公告)日：1986-09-30
申请号：US478038
申请日：1983-03-23
申请人： Mir Imran , Stanley M. Bach, Jr. , Steve A. Kolenik
发明人： Mir Imran , Stanley M. Bach, Jr. , Steve A. Kolenik
IPC分类号： A61B7/00 , A61N1/04 , A61N1/05 , A61N1/37 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3931 , A61B7/00 , A61N1/0563 , A61N1/37 , A61N1/3925
摘要： An implantable cardioversion system employing a bipolar electrode for R-wave sensing, the system utilizing heart rate averaging and probability density function techniques in determining whether or not the heart of a patient is to be automatically cardioverted. An improved bipolar electrode facilitates acquisition of a highly accurate R-wave. The implantable system is further provided with the capabilities of (1) providing, upon magnet-type interrogation, an audible indication of proper placement of the bipolar electrode in the body of a patient, (2) providing an audible indication to verify the status of the implanted device (activated or deactivated), (3) the capability of providing, upon request, a transmitted signal modulated with stored information corresponding to the number of times cardioversion of the patient has taken place, (4) the capability of preventing external cardioversion shock from being shunted across the electrodes, and (5) the capability of detecting average heart rate.
摘要翻译：使用用于R波感测的双极电极的可植入心脏复律系统，使用心率平均和概率密度函数技术的系统来确定患者的心脏是否将被自动心律转复。改进的双极电极有助于获得高精度的R波。该可植入系统进一步具有以下能力：（1）在磁性询问时提供双极电极在患者体内适当放置的可听见的指示，（2）提供可听见的指示以验证患者的状态植入装置（激活或去激活），（3）根据请求提供与存储的信息调制的发送信号的能力，所述信息对应于患者心脏复律的次数，（4）防止外部心脏复律的能力从电极分流的冲击，（5）检测平均心率的能力。

7. 发明授权

US5558617A Cardiac compression band-stay-pad assembly and method of replacing the same 失效
标题翻译：心脏压迫带 - 垫组件及其替代方法
公开(公告)号：US5558617A
公开(公告)日：1996-09-24
申请号：US341188
申请日：1994-11-18
申请人： Marlin S. Heilman , Steve A. Kolenik , Christopher D. Capone , Carl M. Parisi , Edward K. Prem , Vernon L. Speicher
发明人： Marlin S. Heilman , Steve A. Kolenik , Christopher D. Capone , Carl M. Parisi , Edward K. Prem , Vernon L. Speicher
IPC分类号： A61M1/10 , A61H31/00
CPC分类号： A61M1/1068 , A61M1/1046
摘要： A ventricular assist device for a heart includes a compression band-stay-pad assembly for encircling substantially the heart perimeter and comprising an elongated band member or chain disposed in a sealed protective structure filled with a lubricating medium. The band member may be fixed at one end and wound upon, or unwound from, a rotatable spool by a drive motor through a speed reducer. Force-transmitting support or stay assemblies are disposed in the protective structure between the band member and a resilient pad assembly for encircling the heart and promoting heart tissue ingrowth therein. The force-transmitting stay assemblies are biased circumferentially, and thus radially outward, by compression return springs disposed therebetween. The resilient pad assembly includes a corrugated surface provided with vertical coil springs, which help prevent damage to heart tissue and facilitate return of the pad assembly to an initial condition, embedded defibrillator electrodes and relatively soft portions to prevent damage to coronary arteries. The device may be constructed so that it can be surgically removed, except for a sealing film and an ingrown pad assembly, which remain in situ on the heart. A net structure suspended below the device supports the apical portion of the heart. In certain embodiments, power or motor devices are provided between respective ones of the force-transmitting stay assemblies to contract and expand the device. The circumferential length of the assembly may be adjustable and/or may comprise two band members movable in opposite directions.
摘要翻译：用于心脏的心室辅助装置包括用于围绕心脏周边环绕的压缩带状拉杆组件，并且包括设置在填充有润滑介质的密封保护结构中的细长带状构件或链条。带构件可以固定在一端，并通过驱动电动机通过减速器缠绕在可旋转的卷轴上或从其释放。力传递支撑件或支撑组件设置在带构件和弹性垫组件之间的保护结构中，用于环绕心脏并促进其中的心脏组织向内生长。力传递支柱组件通过设置在它们之间的压缩复位弹簧周向地偏置，并因此被径向向外偏压。弹性垫组件包括具有垂直螺旋弹簧的波纹表面，其有助于防止对心脏组织的损伤并且便于将垫组件返回到初始状态，嵌入的除颤器电极和相对较软的部分以防止损伤冠状动脉。该装置可以被构造成使得其可被外科手术除去，除了保留在心脏上的原位的密封膜和内嵌垫组件。悬挂在装置下面的网状结构支撑心脏的顶端部分。在某些实施例中，功率或电动机装置设置在相应的力传递支架组件之间以收缩并膨胀该装置。组件的圆周长度可以是可调节的和/或可以包括可沿相反方向移动的两个带状构件。

8. 发明授权

US4925443A Biocompatible ventricular assist and arrhythmia control device 失效
标题翻译：生物相容性心室辅助和心律失常控制装置
公开(公告)号：US4925443A
公开(公告)日：1990-05-15
申请号：US19701
申请日：1987-02-27
申请人： Marlin S. Heilman , Steve A. Kolenik
发明人： Marlin S. Heilman , Steve A. Kolenik
IPC分类号： A61M1/10 , A61M1/12 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/365 , A61M1/1068 , A61N1/3956 , A61M1/1046 , A61M1/127 , A61N1/3627
摘要： A device for compressing a ventricle of a heart from one or more sides in synchronism with the natural contraction of the ventricle (systole), and providing arrhythmia control of the heart, is completely implantable in the body of a patient user externally of the heart. Compression of the ventricle is produced by a plurality of spaced compression plate assemblies and a ventricle apex-compression plate, a single compression plate-band assembly or tightenable bands. The compression plate assemblies comprise suitably located electrodes for heart monitoring purposes. A power supply of the implanted device can be recharged transcutaneously, and various other components of the device can be noninvasively programmed and interrogated by external circuits. The compression plate assemblies may be operated by a small brushless DC motor. An implantable manual pump mechanism, for operating the compression plate assemblies, also is provided for emergency purposes. The components of the implanted device also include a cardiac pacer, a defibrillator/cardioverter, a recorder and an alarm.

9. 发明授权

US3983880A Apparatus for generating heart stimulation pulses upon demand 失效
标题翻译：用于在需求上产生心脏刺激脉搏的装置
公开(公告)号：US3983880A
公开(公告)日：1976-10-05
申请号：US624406
申请日：1975-10-20
申请人： Steve A. Kolenik
发明人： Steve A. Kolenik
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/365
摘要： Apparatus for generating electrical stimulation pulses in the absence of naturally occurring "R" heart waves includes a free running multivibrator for generating pulses at the desired heart stimulation rate and an output amplifier and voltage multiplier for amplifying the generated pulses for application to the heart. A plural stage filter-amplifier amplifies any naturally occurring "R" waves to trigger a normally nonconducting multivibrator to activate disabling transistors, in turn, which discharge the timing capacitors of the free running multivibrator.The apparatus can be used with either a chemical or nuclear battery or other load dependent low voltage source.

10. 发明授权

US06363276B1 Magnetically suspended fluid pump and control system with defibrillator 失效
标题翻译：磁悬浮液泵和除颤器控制系统
公开(公告)号：US06363276B1
公开(公告)日：2002-03-26
申请号：US09626680
申请日：2000-07-27
申请人： Edward K. Prem , Steve A. Kolenik
发明人： Edward K. Prem , Steve A. Kolenik
IPC分类号： A61N139
CPC分类号： F04D29/048 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1017 , A61M1/1018 , A61M1/1031 , A61M1/1087 , A61M1/122 , F04D13/0646 , F16C32/0444 , F16C32/047 , F16C2316/18 , F16C2360/44
摘要： A blood pump for assisting a heart is provided having a stator and a rotor. The rotor is magnetically radially supported creating a suspension gap between the stator and the rotor. The rotor can be supported axially by a Lorentz force bearing and can be magnetically rotated. The stator can have a single or double volute pump chamber and the rotor can have an impeller portion for pumping blood. The rotor can have a center bore as a primary blood flowpath. The suspension gap can be a secondary blood flowpath. The blood pump can also have an axial position controller and a flow rate controller. The axial position controller can cause the axial bearing to adjust the position of the rotor. The flow rate controller can have a member for measuring a dimension of a heart ventricle to control the flow rate to avoid overly distending or contracting the ventricle. A method of operating the flow rate controller to create a pulsatile flow rate is also provided. Additionally, the blood pump can be part of a cardiac assist and arrhythmia control system. Moreover, a method of operating the flow rate controller can be provided which reduces the amount of energy needed to treat fibrillation. The method can include operating the flow rate controller to reduce a radial dimension of the ventricle prior to delivering defibrillation energy such that the ventricle contains less blood which absorbs less energy so that a larger fraction of the energy is delivered to the heart.
摘要翻译：提供了一种用于辅助心脏的血泵，其具有定子和转子。转子被磁力径向支撑，在定子和转子之间产生悬挂间隙。转子可以由洛伦兹力轴承轴向支撑，并可以磁旋转。定子可以具有单个或双重蜗壳泵室，并且转子可以具有用于泵送血液的叶轮部分。转子可以具有作为主血流径的中心孔。悬浮间隙可以是二次血流路径。血泵还可以具有轴向位置控制器和流量控制器。轴向位置控制器可以使轴向轴承调整转子的位置。流量控制器可以具有用于测量心室尺寸的部件以控制流速以避免过度膨胀或收缩心室。还提供了一种操作流量控制器以产生脉动流量的方法。此外，血液泵可以是心脏辅助和心律失常控制系统的一部分。此外，可以提供操作流量控制器的方法，其减少了治疗原纤维化所需的能量的量。该方法可以包括操作流速控制器以在递送除颤能量之前减小心室的径向尺寸，使得心室含有较少的血液，其吸收更少的能量，从而将更大部分的能量输送到心脏。

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