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1. 发明授权

US08764621B2 Transcutaneous power transmission and communication for implanted heart assist and other devices 有权
标题翻译：用于植入心脏辅助和其他装置的经皮电力传输和通讯
公开(公告)号：US08764621B2
公开(公告)日：2014-07-01
申请号：US13546789
申请日：2012-07-11
申请人： Kurt D. Badstibner , Jonathan R. Speicher , Marlin S. Heilman , Richard A. Bates , Charles E. Greene
发明人： Kurt D. Badstibner , Jonathan R. Speicher , Marlin S. Heilman , Richard A. Bates , Charles E. Greene
IPC分类号： A61N1/362
CPC分类号： A61M1/1086 , A61M1/101 , A61M1/12 , A61M1/122 , A61M1/127 , A61M2205/3331 , A61M2205/3523 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/8206 , A61M2205/8243 , H01F38/14 , H02J5/005 , H02J7/025 , H02J50/12 , H02J50/80 , H02J50/90 , H04B5/0037 , H04B5/0062 , H04B5/0075
摘要： A system includes an implantable pump system for assisting blood flow in a patient including at least one movable valve. The movable valve is in a normally open state when the moveable valve is not being powered and a drive system in operative connection with the moveable valve to move the moveable valve under power. The system further includes an energy transfer system to provide energy to the drive system. The energy transfer system includes an external system including a power source and an external coil and an internal system including an internal coil adapted to receive transcutaneous energy transmitted from the external coil. The internal system has at least a first state wherein energy transmission from the external coil is required to provide operational power to the drive system.
摘要翻译：一种系统包括可植入泵系统，用于辅助包括至少一个活动阀在内的患者的血液流动。当可动阀未被供电时，可移动阀处于常开状态，以及与可移动阀操作连接的驱动系统以使可动阀在动力下移动。该系统还包括能量传递系统以向驱动系统提供能量。能量传递系统包括包括电源和外部线圈的外部系统以及包括适于接收从外部线圈传递的经皮能量的内部线圈的内部系统。内部系统具有至少第一状态，其中需要来自外部线圈的能量传输来向驱动系统提供操作功率。

2. 发明授权

US06761532B2 Touch down of blood pump impellers 失效
标题翻译：触碰血泵叶轮
公开(公告)号：US06761532B2
公开(公告)日：2004-07-13
申请号：US10097731
申请日：2002-03-14
申请人： Christopher D. Capone , Ruey C. Dempsey , Marlin S. Heilman , Steve A. Kolenik , Daniel R. Moore , Carl M. Parisi , Edward K. Prem , Richard A. Sofranko , David C. Borzelleca , Greg Burgreen , John A. Holmes , Zhongjun Wu , Ralph Scott Hebbert , James Antaki
发明人： Christopher D. Capone , Ruey C. Dempsey , Marlin S. Heilman , Steve A. Kolenik , Daniel R. Moore , Carl M. Parisi , Edward K. Prem , Richard A. Sofranko , David C. Borzelleca , Greg Burgreen , John A. Holmes , Zhongjun Wu , Ralph Scott Hebbert , James Antaki
IPC分类号： F04D700
CPC分类号： F04D29/047 , A61M1/101 , A61M1/1015 , A61M1/1017 , A61M1/1031 , A61M1/1086 , A61M1/122 , F04D13/064
摘要： A blood pump having rotor and/or stator touch down zones to prevent pump failure or hemolysis which can occur if the rotor comes into contact with the stator due to power failure or mechanical shock. The touch down zones can include forming, or coating, portions of adjacent surfaces of the stator and rotor which can come into contact if a rotor touch down occurs. The materials used to form or coat the touch down zones can have properties which ensure that no consequential damage to the contacting surfaces occurs.
摘要翻译：具有转子和/或定子的血泵触屏，以防止由于电源故障或机械冲击而导致转子与定子接触时可能发生泵故障或溶血。触碰区域可以包括形成或涂覆定子和转子的相邻表面的部分，如果发生转子触碰，则其可以接触。用于形成或涂覆触摸区域的材料可以具有确保不会对接触表面造成相应损害的性质。

3. 发明授权

US4270549A Method for implanting cardiac electrodes 失效
标题翻译：植入心脏电极的方法
公开(公告)号：US4270549A
公开(公告)日：1981-06-02
申请号：US34733
申请日：1979-04-30
申请人： Marlin S. Heilman
发明人： Marlin S. Heilman
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0587
摘要： A method for implanting an electrode adjacent the heart of a patient without requiring major surgery. A skin incision is made in the anterior thoracic region and/or in the abdominal wall, and by means of a specialized implantation tool tunnels are created through which the electrodes may be inserted and placed in contact with the heart. The implantation tool cooperates with the electrode such that after placement of the electrode the tool may be withdrawn from the patient with the electrode remaining in place.
摘要翻译：一种将电极植入邻近患者心脏而不需要大手术的方法。在前胸区和/或腹壁中形成皮肤切口，并且通过专门的植入工具产生隧道，通过该隧道可以将电极插入并放置成与心脏接触。植入工具与电极配合使得在电极放置之后，工具可以在电极保持就位的情况下从病人身上取出。

4. 发明授权

US5569181A Sterility assurance for contrast delivery system 失效
标题翻译：造影剂系统的无菌保证
公开(公告)号：US5569181A
公开(公告)日：1996-10-29
申请号：US144845
申请日：1993-10-28
申请人： Marlin S. Heilman , Arthur E. Uber, III
发明人： Marlin S. Heilman , Arthur E. Uber, III
IPC分类号： A61M5/14 , A61M5/00 , A61M5/142 , A61M5/168 , A61M5/172 , A61M31/00 , A61J3/00
CPC分类号： A61M5/142 , A61M5/007 , A61M5/16827 , A61M5/16886 , A61M5/172 , A61M2205/12
摘要： Apparatus and process for injection of a multiple number of patients with a sterile fluid while assuring sterility by providing devices which control the fluid flow in such ways that injection devices are isolated from each other, as well as from the source of sterile fluid, such as by use of selective valving devices and disposable dosing units.
摘要翻译：用于注射无菌液体的多个患者的装置和方法，同时通过提供以这样的方式控制流体流动的装置来确保无菌性，使得注射装置彼此分离，以及来自无菌流体源，例如通过使用选择性阀装置和一次性配量单元。

5. 外观设计

USD274262S Implantable defibrillator patch electrode or similar article 失效
公开(公告)号：USD274262S
公开(公告)日：1984-06-12
申请号：US457356
申请日：1983-01-12
申请人： Marlin S. Heilman , Alois A. Langer
设计人： Marlin S. Heilman , Alois A. Langer

6. 发明授权

US4928690A Portable device for sensing cardiac function and automatically delivering electrical therapy 失效
标题翻译：用于感应心脏功能和自动递送电疗的便携式设备
公开(公告)号：US4928690A
公开(公告)日：1990-05-29
申请号：US185781
申请日：1988-04-25
申请人： Marlin S. Heilman , Arlan J. Brandt , Larry D. Bowling , Joseph F. Russial
发明人： Marlin S. Heilman , Arlan J. Brandt , Larry D. Bowling , Joseph F. Russial
IPC分类号： A61N1/365 , A61B5/00 , A61N1/04 , A61N1/08 , A61N1/39
CPC分类号： A61B5/6831 , A61N1/39 , A61B5/0006 , A61N2001/083
摘要： A patient-worn harness or vest protects at-risk patients from the possibly fatal results of heart arrhythmias. The harness or vest incorporates sensing electrodes for monitoring heart condition, a microprocessor and memory for processing signals received from the sending electrodes and comparing same with patient's data, and skin-contacting pulsing electrodes for applying electrical pulses to the patient's chest wall responsive to signals received from the microprocessor. The electrodes include automatic tightening and electrolyte gel release mechanisms for reducing impedance at the electrode-skin interface. A servicing subsystem is provided for the harness or vest and may be used to interface with the harness or vest and also to communicate with remote health care personnel through a suitable telephone link.

7. 发明授权

US4765341A Cardiac electrode with attachment fin 失效
标题翻译：心脏电极与附件翅片
公开(公告)号：US4765341A
公开(公告)日：1988-08-23
申请号：US526208
申请日：1983-08-25
申请人： Morton M. Mower , Marlin S. Heilman
发明人： Morton M. Mower , Marlin S. Heilman
IPC分类号： A61N1/05 , A61B1/00
CPC分类号： A61N1/0587
摘要： An implantable cardiac electrode for use in defibrillation and methods of implanting same. The electrode has a metallic mesh electrode surface surrounded by an insulating material. At the proximal end of the electrode there is defined a fin area designed to facilitate placing and securing the electrode proximate the heart. The electrode may be implanted without major surgery in a number of ways, one of which requires a specialized insertion tool which cooperates with a pocket formed in the electrode.
摘要翻译：用于除颤的植入式心脏电极及其植入方法。电极具有由绝缘材料包围的金属网状电极表面。在电极的近端处限定了翅片区域，其被设计成便于将电极靠近心脏放置和固定。电极可以以多种方式植入，无需大手术，其中之一需要与形成在电极中的口袋配合的专门插入工具。

8. 发明授权

US4662377A Cardioverting method and apparatus utilizing catheter and patch electrodes 失效
标题翻译：使用导管和贴片电极的心律转移方法和装置
公开(公告)号：US4662377A
公开(公告)日：1987-05-05
申请号：US795781
申请日：1985-11-07
申请人： Marlin S. Heilman , Stanley M. Bach, Jr.
发明人： Marlin S. Heilman , Stanley M. Bach, Jr.
IPC分类号： A61N1/05 , A61N1/06 , A61N1/372 , A61N1/39 , A61N1/04
CPC分类号： A61N1/06 , A61N1/056 , A61N1/3956
摘要： A novel electrode apparatus and method for use with an automatic implantable cardioverter/defibrillator. The electrode apparatus includes a catheter electrode intravenously positioned within the heart of a patient wherein one electrode, defined by the catheter, is within the right ventricle and a second electrode, defined by the catheter, spaced from the first electrode, is within the superior vena cava. A third electrode, in the form of a flexible, substantially planar patch, is subcutaneously positioned outside the thoracic cavity proximate to the apex of the left ventricle. The third electrode is electrically connected with the second electrode of the catheter. The electrode arrangement can be implanted without opening of the thoracic cavity by intravenously placing the catheter electrode within the heart of a patient and subcutaneously implanting the patch electrode between the skin and the thoracic cavity. The automatic implantable cardioverter/defibrillator senses life-threatening arrhythmic conditions of the heart and issues at least one cardioverting or defibrillating pulse that is applied between the electrode positioned within the right ventricle and the electrode pair comprising the electrodes positioned within the superior vena cava and subcutaneously adjacent the apex of the left ventricle.
摘要翻译：一种用于自动植入式心律转复除颤器的新型电极装置和方法。电极装置包括静脉内定位在患者心脏内的导管电极，其中由导管限定的一个电极在右心室内，并且由导管限定的与第一电极间隔开的第二电极在上腔静脉内静脉。形式为柔性的，基本上平面的贴片的第三电极皮下地位于靠近左心室顶点的胸腔外侧。第三电极与导管的第二电极电连接。可以通过静脉内将导管电极置于患者的心脏内并将皮肤植入皮肤和胸腔之间的皮肤电极而将电极装置植入而不打开胸腔。自动植入式心律转复器/除纤颤器感测心脏的危及生命的心律失常状况，并且发出施加在位于右心室内的电极和包括定位在上腔静脉内的电极的电极对之间的至少一个心跳转复或除颤脉冲邻近左心室的顶点。

9. 发明授权

US4475551A Arrhythmia detection and defibrillation system and method 失效
标题翻译：心律失常检测与除颤系统及方法
公开(公告)号：US4475551A
公开(公告)日：1984-10-09
申请号：US414353
申请日：1982-09-02
申请人： Alois A. Langer , Marlin S. Heilman
发明人： Alois A. Langer , Marlin S. Heilman
IPC分类号： A61N1/39 , A61N1/36
CPC分类号： A61N1/3956 , A61N1/3987
摘要： The invention relates to an arrhythmia detection system and method for defibrillating the heart of a patient experiencing abnormal cardiac rhythm, wherein the abnormal cardiac rhythm (comprising one of fibrillation, high rate tachycardia, and low rate tachycardia) is first detected, the heart rate is sensed so as to distinguish between fibrillation and high rate tachycardia, on the one hand, and low rate tachycardia, on the other hand, and automatic defibrillation of the heart of the patient is implemented when one of fibrillation and high rate tachycardia is determined. In one embodiment, base and apical electrodes are connected to a probability density function (PDF) circuit and a rate circuit. When both abnormal cardiac rhythm and excessively high heart rate are detected, defibrillation of the heart of the patient is implemented. In a second embodiment, a sensing button is also connected to the heart, and a switch is interposed between the electrodes and sensing button, on the one hand, and the interface, on the other hand. During monitoring of cardiac rhythm by the PDF circuit, the switch automatically connects the electrodes to the PDF circuit, while, during sensing of the heart rate, the switch connects the sensing button to the heart rate circuit. Upon detection of the need for defibrillation, the switch automatically connects the defibrillation pulse generator to the electrodes. Further features include a timed reset capability.
摘要翻译：本发明涉及一种心律失常检测系统和方法，用于对经历异常心律的患者的心脏进行去纤维化，其中首先检测异常心律（包括原纤维性颤动，高速率心动过速和低速率心动过速），心率为感觉到一方面区分纤维性颤动和高速率心动过速，另一方面，区分低速心动过速，并且当确定原纤维性颤动和高速率心动过速之一时，实施患者心脏的自动除颤。在一个实施例中，基极和顶电极连接到概率密度函数（PDF）电路和速率电路。当检测到异常心律和过高心率时，实施患者心脏的除颤。在第二实施例中，感测按钮也连接到心脏，另一方面，一方面，电极和感测按钮以及接口之间插入开关。在通过PDF电路监测心律时，开关自动将电极连接到PDF电路，而在感测心率期间，开关将感测按钮连接到心率电路。当检测到需要除颤时，开关自动将除颤脉冲发生器连接到电极。其他功能包括定时复位功能。

10. 发明授权

US4407288A Implantable heart stimulator and stimulation method 失效
标题翻译：植入式心脏刺激器和刺激方法
公开(公告)号：US4407288A
公开(公告)日：1983-10-04
申请号：US243801
申请日：1981-03-16
申请人： Alois A. Langer , Steve A. Kolenik , Marlin S. Heilman , Mieczyslaw Mirowski , Morton M. Mower
发明人： Alois A. Langer , Steve A. Kolenik , Marlin S. Heilman , Mieczyslaw Mirowski , Morton M. Mower
IPC分类号： A61N1/362 , A61N1/372 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3925 , A61N1/37217
摘要： An implantable heart stimulator and related method calls for the determination of a given heart condition from among a plurality of conditions, the selection of at least one mode of operation for treating the determined condition, and the execution of the mode of operation selected, so as to treat the determined condition. In one embodiment of the invention, wherein a plurality of modes of operation for treating the various conditions are provided, the implantable heart stimulator includes processors, each processor being designed to efficiently execute a respective group of modes of operation. A further embodiment of the present invention calls for the implantable heart stimulator to be implemented by at least one programmable microprocessor. A still further embodiment calls for the provision of a data input/output channel, by means of which data can be provided to and retrieved from the implantable heart stimulator. Operations carried out by the implantable heart stimulator includes cardiac pacing, cardioversion, and automatic defibrillation. In a further embodiment of the implantable heart stimulator and related method, sensing circuitry is provided to determine the presence or absence of an R-wave of the heart, the absence of which causes a pacing operation to be implemented, further sensing circuitry being provided to determine the presence or absence of a forced R-wave of the heart, the absence of a forced R-wave causing ventricular defibrillation to be implemented.
摘要翻译：可植入心脏刺激器和相关方法需要从多个条件中确定给定的心脏状况，选择用于治疗所确定的病症的至少一种手术模式以及选择的手术模式的执行，以便治疗确定的病情。在本发明的一个实施例中，其中提供了用于治疗各种条件的多种操作模式，可植入心脏刺激器包括处理器，每个处理器被设计成有效地执行相应的一组操作模式。本发明的另一实施例要求可植入心脏刺激器由至少一个可编程微处理器实现。另一实施例要求提供数据输入/输出通道，通过该数据输入/输出通道可以向可植入心脏刺激器提供数据和从可植入心脏刺激器检索数据。由可植入心脏刺激器进行的手术包括心脏起搏，心脏复律和自动除颤。在可植入心脏刺激器和相关方法的另一实施例中，提供感测电路以确定心脏的R波的存在或不存在，其中不存在可导致起搏操作被实现，将进一步的感测电路提供给确定心脏的强制R波的存在或不存在，不执行导致心室除颤的强制R波。

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