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1. 发明申请

US20070138705A1 Shape manipulation of nanostructures 审中-公开
标题翻译：纳米结构的形状操纵
公开(公告)号：US20070138705A1
公开(公告)日：2007-06-21
申请号：US11559539
申请日：2006-11-14
申请人： William Mickelson , Shaul Aloni , Steve Konsek , Alex Zettl , Thomas Yuzvinsky
发明人： William Mickelson , Shaul Aloni , Steve Konsek , Alex Zettl , Thomas Yuzvinsky
IPC分类号： B29C35/08
CPC分类号： H01L51/0014 , B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L51/0048
摘要： A method for reshaping a nanostructure. The method includes: providing a nanostructure having an initial shape; applying energy from a non-chemical energy source to the nanostructure; and thereby reshaping the nanostructure to a reshaped geometry different from the initial shape. The nanostructure may additionally be optionally cleaned with the application of energy from the non-chemical energy source.
摘要翻译：一种重新形成纳米结构的方法。该方法包括：提供具有初始形状的纳米结构; 将能量从非化学能源施加到纳米结构; 从而将纳米结构重新形成为与初始形状不同的重新形状的几何形状。另外可以通过施加来自非化学能源的能量任选地清洁纳米结构。

2. 发明授权

US5744317A Diagnostic test for replicative senescence in T cells 失效
标题翻译： T细胞复制衰老的诊断试验
公开(公告)号：US5744317A
公开(公告)日：1998-04-28
申请号：US755291
申请日：1996-11-22
申请人： Rita B. Effros
发明人： Rita B. Effros
IPC分类号： G01N33/53 , C07K16/28 , G01N33/533 , G01N33/569 , G01N33/577 , C07K16/00 , G01N33/555 , G01N33/567
CPC分类号： G01N33/56972 , C07K16/28 , C07K16/2809 , C07K16/2818 , Y10S435/81 , Y10S435/974 , Y10S436/811
摘要： A method for distinguishing replicatively senescent T cells from replicatively non-senescent T cells in a cell population comprises the steps of: (1) providing a cell population of peripheral blood mononuclear cells; (2) reacting the cell population with a first monoclonal antibody specific for CD3 antigens which is present on all T cells, the antibody being labeled with a first detectable label, so that the monoclonal antibody binds to all T cells in the cell population; (3) simultaneously reacting the cell population with a second monoclonal antibody specific for CD28 antigen, the antibody being labeled with a second detectable label distinguishable from the first detectable label, so that the second monoclonal antibody binds to T cells positive for CD28; and (4) in the cell population of peripheral blood mononuclear cells, detecting the T cells that simultaneously react with the first monoclonal antibody and the second monoclonal antibody by observing the first detectable label bound to the cells simultaneously with the second detectable label bound to the cells, thereby distinguishing replicatively senescent T cells, which are CD28-negative, from replicatively non-senescent T cells, which are CD28-positive, and determining any of: (a) the number of replicatively senescent T cells in the cell population; (b) the number of replicatively non-senescent T cells in the cell population; or (c) the proportion of replicatively senescent T cells to replicatively non-senescent T cells in the cell population. The method can also be used to separate and isolate cells showing immunological senescence from non-senescent cells.
摘要翻译：在细胞群体中区分复制性衰老T细胞与复制性非衰老T细胞的方法包括以下步骤：（1）提供外周血单核细胞的细胞群; （2）使细胞群与存在于所有T细胞上的CD3抗原特异性的第一单克隆抗体反应，所述抗体用第一可检测标记标记，使得所述单克隆抗体结合细胞群体中的所有T细胞; （3）同时使细胞群与CD28抗原特异性的第二单克隆抗体反应，所述抗体用可区别于第一可检测标记的第二可检测标记进行标记，使得第二单克隆抗体结合CD28阳性的T细胞; 和（4）在外周血单核细胞的细胞群体中，检测与第一单克隆抗体和第二单克隆抗体同时反应的T细胞，通过观察与结合至细胞的第二可检测标记物同时结合到细胞的第一可检测标记物细胞，从而区别复制性衰老T细胞，其是CD28阴性的复制性非衰老T细胞，其是CD28阳性的，并且确定以下任何一种：（a）细胞群体中复制衰老T细胞的数量; （b）细胞群中复制非衰老T细胞的数量; 或（c）细胞群中复制性衰老T细胞与复制性非衰老T细胞的比例。该方法还可用于分离和分离显示来自非衰老细胞的免疫衰老的细胞。

3. 发明授权

US5254638A Composite materials of interpenetrating inorganic and organic polymer networks 失效
标题翻译：互穿无机和有机聚合物网络的复合材料
公开(公告)号：US5254638A
公开(公告)日：1993-10-19
申请号：US674849
申请日：1991-03-25
申请人： Bruce M. Novak , Mark W. Ellsworth
发明人： Bruce M. Novak , Mark W. Ellsworth
IPC分类号： C08F2/44 , C03C14/00 , C08F20/26 , C08F20/28 , C08F290/00 , C08F290/14 , C08F292/00 , C08F299/02 , C08F299/08 , C08G61/06 , C08G61/08 , C08G77/442 , C08G77/50 , C08G79/00 , C08F283/12
CPC分类号： C03C14/00 , C08F290/148 , C08F292/00 , C08F299/08 , C08G77/442 , C08G77/50 , C03C2214/12 , C03C2214/32 , Y10S525/903
摘要： This invention relates to sol-gel methods for forming non-shrinking, high-glass composite materials and the products. Also taught is an inorganic-organic composite material having a solid interwoven network of an inorganic polymer matrix with interpenetrating polymerized alcohols. The inorganic matrix can be based on either Si or Ti atoms.
摘要翻译：本发明涉及用于形成不收缩的高玻璃复合材料和产品的溶胶 - 凝胶方法。还教导了具有无机聚合物基质与互穿聚合醇的固体交织网络的无机 - 有机复合材料。无机基质可以基于Si或Ti原子。

4. 发明授权

US5212988A Plate-mode ultrasonic structure including a gel 失效
标题翻译：板状超声波结构包括凝胶
公开(公告)号：US5212988A
公开(公告)日：1993-05-25
申请号：US775631
申请日：1991-10-10
申请人： Richard M. White , Stuart W. Wenzel , Benedict J. Costello
发明人： Richard M. White , Stuart W. Wenzel , Benedict J. Costello
IPC分类号： B01L3/00 , G01H13/00 , G01H17/00 , G01L9/00 , G01N29/02 , G01P15/08 , G10K11/36 , H03H9/42
CPC分类号： G01N29/2437 , B01L3/5027 , G01H13/00 , G01H17/00 , G01L9/0025 , G01N29/022 , G01P15/08 , G10K11/36 , H03H9/42 , B01L2300/0663 , B01L2300/1827 , B01L2400/0421 , G01N2291/014 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/02827 , G01N2291/02854 , G01N2291/0427
摘要： An ultrasonic structure which has a thin planar sheet of material forming a Lamb wave propagation medium The propagation medium is coated with a gel. The structure may also include a Lamb wave generator for generating Lamb waves in the propagation medium and an output device for producing an electrical signal representative of the propagation characteristics of the Lamb waves propagating along the propagation medium. A measuring device can be included to measure selected characteristics of the output electrical signal. The propagation medium has some physical characteristics that are determined by the value of a measurand acting on the medium and the determined physical characteristics determine the propagation characteristics of the Lamb waves which are propagated along the medium. When the sensor is acted on by a measurand to determine the physical characteristics of the propagation medium, the characteristics of the electrical signal are also determined. The measuring device measures the electrical signal and provides an indication of the measurand value.
摘要翻译：具有形成兰姆波传播介质的薄平板材料的超声波结构传播介质用凝胶涂覆。该结构还可以包括用于在传播介质中产生兰姆波的兰姆波发生器和用于产生表示沿着传播介质传播的兰姆波传播特性的电信号的输出装置。可以包括测量装置来测量输出电信号的选定特性。传播介质具有由作用在介质上的被测量的值确定的一些物理特性，并且所确定的物理特性确定沿着介质传播的兰姆波的传播特性。当传感器被被测量作用以确定传播介质的物理特性时，也确定电信号的特性。测量设备测量电信号并提供被测量值的指示。

5. 发明授权

US5744625A Cationic transport reagents 失效
标题翻译：阳离子运输试剂
公开(公告)号：US5744625A
公开(公告)日：1998-04-28
申请号：US648543
申请日：1996-05-16
申请人： Michael H. Nantz , Michael J. Bennett , Robert W. Malone
发明人： Michael H. Nantz , Michael J. Bennett , Robert W. Malone
IPC分类号： C12N15/09 , A61K9/00 , A61K9/127 , A61K47/18 , A61K47/48 , A61K48/00 , C07C217/40 , C07C219/06 , C07C219/08 , C07F7/18 , C12N15/88 , C07C229/30
CPC分类号： C07C219/08 , A61K47/48815 , A61K9/1272 , C07C217/40 , C07C219/06 , C12N15/88
摘要： For use transporting biologically active species into and through membrane barriers, a symmetrical cationic diamine compound having the general structure ##STR1##
摘要翻译：为了将生物活性物质运送到膜屏障中并通过膜屏障，使用具有一般结构的对称阳离子二胺化合物

6. 发明授权

US5591740A Use of debromohymenialdisine for treating osteoarthritis 失效
标题翻译：使用去血管麻黄碱治疗骨关节炎
公开(公告)号：US5591740A
公开(公告)日：1997-01-07
申请号：US472902
申请日：1995-06-07
申请人： Stewart Chipman , David J. Faulkner
发明人： Stewart Chipman , David J. Faulkner
IPC分类号： C07D487/04 , A61K31/55 , A61K45/00 , A61K45/06 , A61P43/00
CPC分类号： A61K45/06 , A61K31/55
摘要： Disclosed is a method of treating osteoarthritis. The method comprises administering a therapeutic amount of debromohymenialdisine to an individual or animal with osteoarthritis. Debromohymenialdisine is able to slow the joint deterioration and cartilage degradation associated with the disease.
摘要翻译：公开了一种治疗骨关节炎的方法。所述方法包括向具有骨关节炎的个体或动物施用治疗量的去血管麻黄碱。肾上腺素能够减缓与疾病相关的关节恶化和软骨退化。

7. 发明授权

US5266684A Peptide mixtures 失效
标题翻译：肽混合物
公开(公告)号：US5266684A
公开(公告)日：1993-11-30
申请号：US525899
申请日：1990-05-18
申请人： William J. Rutter , Daniel V. Santi
发明人： William J. Rutter , Daniel V. Santi
IPC分类号： A61K38/02 , C07K1/04 , C07K1/14 , C07K1/36 , C07K5/00 , C07K7/00 , G01N33/68 , C07K1/08
CPC分类号： C07K1/047 , C07K1/36 , G01N33/68
摘要： A method to obtain selected individual peptides or families thereof which have a target property and optionally to determine the amino acid sequence of a selected peptide or peptides to permit synthesis in practical quantities is disclosed. In general outline, the method of the invention comprises synthesizing a mixture of randomly or deliberately generated peptides using standard synthesis techniques, but adjusting the individual concentrations of the components of a mixture of sequentially added amino acids according to the coupling constants for each amino acid/amino acid coupling. The subgroup of peptides having the target property can then be selected, and either each peptide isolated and sequenced, or analysis performed on the mixture to permit its composition to be reproduced. Also included in the invention is an efficient method to determine the relevant coupling constants.
摘要翻译：公开了获得具有目标特性并任选地确定所选择的肽或肽的氨基酸序列以允许实际合成的所选单独肽或其家族的方法。总的来说，本发明的方法包括使用标准合成技术合成随机或故意产生的肽的混合物，但是根据每个氨基酸/偶联物的偶联常数调节相继添加的氨基酸的混合物的组分的个体浓度，氨基酸偶联。然后可以选择具有靶特性的肽亚组，并且分离和测序每个肽，或对混合物进行分析以允许其复制其组成。本发明还包括确定相关耦合常数的有效方法。

8. 发明授权

US4116949A Water-soluble, physiologically active, synthetic copolypeptides 失效
标题翻译：水溶性，生理活性，合成共聚物
公开(公告)号：US4116949A
公开(公告)日：1978-09-26
申请号：US679032
申请日：1976-04-21
申请人： Murray Goodman , Michael S. Verlander , Nathan O. Kaplan , J. Craig Venter
发明人： Murray Goodman , Michael S. Verlander , Nathan O. Kaplan , J. Craig Venter
IPC分类号： C07K1/00 , C07C103/52 , A61K37/00
CPC分类号： C07K1/006 , Y10S930/29
摘要： Water-soluble copolypeptides having high physiological activity for prolonged periods of time comprise water-soluble, linear copolypeptides having attached to their polymeric backbone at least one substituent having the structure: ##STR1## wherein Z is an aromatic group derived from a physiologically active compound and x is an integer and equal to 0 or 1.

9. 发明授权

US08594777B2 System and method for reconstructing cardiac activation information 有权
标题翻译：用于重建心脏激活信息的系统和方法
公开(公告)号：US08594777B2
公开(公告)日：2013-11-26
申请号：US13438534
申请日：2012-04-03
申请人： Carey Robert Briggs , Sanjiv Narayan
发明人： Carey Robert Briggs , Sanjiv Narayan
IPC分类号： A61B5/04
CPC分类号： A61B5/02405 , A61B5/0002 , A61B5/0205 , A61B5/0255 , A61B5/04011 , A61B5/04012 , A61B5/0422 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/4836 , A61B5/6852 , A61B5/7203 , A61B5/7217 , A61B5/7239 , A61B5/7246 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B5/743 , A61B18/02 , A61B18/12 , A61B18/18 , A61B2018/00577 , A61B2562/046
摘要： An example system and method of reconstructing biological activation information are disclosed. A first biological signal and a second biological signal associated with an organ are processed via a computing device to determine whether there is a point of change in a derivative of the first biological signal with respect to a derivative of the second biological signal above a threshold. An activation onset time is assigned in the first biological signal at the point of change to define biological activation associated with the organ in the first biological signal if it is determined that the point of change is above the threshold.
摘要翻译：公开了重建生物激活信息的示例系统和方法。经由计算装置处理与器官相关联的第一生物信号和第二生物信号，以确定相对于高于阈值的第二生物信号的导数，第一生物信号的导数是否存在变化点。如果确定变化点高于阈值，则在变化点的第一生物信号中分配激活起始时间以限定与第一生物信号中的器官相关联的生物激活。

10. 发明授权

US6077429A Bacterial removal of perchlorate and nitrate 失效
标题翻译：细菌去除高氯酸盐和硝酸盐
公开(公告)号：US6077429A
公开(公告)日：2000-06-20
申请号：US172888
申请日：1998-10-15
申请人： William T. Frankenberger, Jr. , David Herman
发明人： William T. Frankenberger, Jr. , David Herman
IPC分类号： B09C1/10 , C02F3/34
CPC分类号： C02F3/34 , B09C1/10 , C02F2101/12 , C02F2101/16 , Y10S435/822
摘要： Methods and compositions for removing perchlorate and/or nitrate from contaminated material utilizing perc1ace bacteria under anaerobic conditions. Perc1ace is a gram-negative, curved rod, facultative anaerobe which is deposited with the American Type Culture Collection under ATCC No. 202172. Perc1ace may be used as a substitute for anaerobic bacteria which are presently being used in biological systems for removing perchlorate and/or nitrate from water and other contaminated materials, such as soil.
摘要翻译：在厌氧条件下利用海藻细菌从被污染物质中除去高氯酸盐和/或硝酸盐的方法和组合物。 Perc1ace是一种革兰氏阴性，弯曲的棒，兼性厌氧菌，其保藏在ATCC 202172号下的美国典型培养物保藏中心.Percace可用作厌氧细菌的替代物，目前用于除去高氯酸盐和/ 或来自水和其他污染物质如土壤的硝酸盐。

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