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1. 发明公开

US20240044918A1 DETERMINING INTERFERENCE CRITICALITY BASED ON ANALYTE AND CELL-FREE HEMOGLOBIN CONCENTRATIONS 审中-公开
公开(公告)号：US20240044918A1
公开(公告)日：2024-02-08
申请号：US18258592
申请日：2021-12-20
申请人： Radiometer Medical ApS
发明人： Michael TAAGAARD , Peter FRISCHAUF
IPC分类号： G01N33/72
CPC分类号： G01N33/72
摘要： There is presented an apparatus (100) for automatically measuring an analyte concentration in a liquid sample (102) comprising the analyte and cell-free hemoglobin and for automatically determining a cell-free hemoglobin interference criticality, said apparatus comprising one or more sensors (104) for measuring the analyte concentration in the liquid sample, and a cell-free hemoglobin concentration in the liquid sample, and further comprising a data processing device (106) comprising a processor configured to determine the cell-free hemoglobin interference criticality based on the cell-free hemoglobin concentration, and the analyte concentration, and output a signal (108) indicative of the cell-free hemoglobin interference criticality at least in case the cell-free hemoglobin interference criticality is within a predetermined range.

2. 发明公开

US20240027475A1 POROUS UNIT WITHOUT REFLECTIVE LAYER FOR OPTICAL ANALYTE MEASUREMENTS 审中-公开
公开(公告)号：US20240027475A1
公开(公告)日：2024-01-25
申请号：US18258437
申请日：2021-12-20
申请人： Radiometer Medical ApS
发明人： Thomas KJAER , Hans Peter Blaabjerg JAKOBSEN , Peter Jakobsen NEILSON , Michael TAAGAARD
IPC分类号： G01N33/72 , G01N33/68 , B01L3/00
CPC分类号： G01N33/72 , G01N33/6848 , B01L3/502715 , B01L2300/069 , B01L2300/0663 , B01L2300/168 , B01L2300/161
摘要： There is presented a porous unit (1) for detection of an analyte (96) in a liquid (99) by optical probing, comprising a translucent element (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted directly with the liquid (99), or separated from the liquid (99), such as exclusively separated from the liquid (99), by one or more layers at the front side (3) of the translucent element (2), the one or more layers (5) being adapted to be non-reflective to light reaching the one or more layers at least at one angle of incidence, such as at least at normal incidence, from the translucent element (2), and/or allow internal reflection, such as total internal reflection, at an interface, such as an external interface, of light reaching the interface from the translucent element (2), wherein the translucent element (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) fluidically connecting them with the liquid (99) at the front side (3) into the translucent element (2), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte in the liquid (99) to enter the pores (6) via diffusion.

3. 发明公开

US20230393162A1 TRANSMISSION OF ANALYSER SYSTEM DATA 审中-公开
公开(公告)号：US20230393162A1
公开(公告)日：2023-12-07
申请号：US18033136
申请日：2021-10-19
申请人： RADIOMETER MEDICAL APS
发明人： Morten HASTRUP , Rajkamal RAJATHANAKODI , Manoj LENKA
IPC分类号： G01N35/00
CPC分类号： G01N35/00871
摘要： Disclosed is a method for transmitting data from an analyser system (1) comprising one or more analyser devices (5) to a remote server (3), wherein the one or more analyser devices (5) are configured to obtain data from samples and/or measurements taken of a patient. The method comprises determining data to be transmitted based on one or more rules associated with a geographical and/or an organizational location of the analyser system (1), and transmitting the determined data to the remote server (3). Corresponding computer program product, analyser system, remote server, and health care system are also disclosed.

4. 发明授权

US11728027B2 System of medical devices 有权
公开(公告)号：US11728027B2
公开(公告)日：2023-08-15
申请号：US16771785
申请日：2018-12-10
申请人： Radiometer Medical ApS
发明人： Thomas Junker , Jakob Skov , Halina Tomaszewska
IPC分类号： G16H40/20 , G16H10/40 , G16H40/40
CPC分类号： G16H40/20 , G16H10/40 , G16H40/40
摘要： A system of medical devices, the system comprising: a medical device data management system; a plurality of medical devices communicatively connected to the medical device data management system; each medical device being operable to analyze one or more samples of biological material; and to communicate information about an operational state of the medical device to the medical device data management system; a plurality of portable electronic devices, each operable to be carried by an operator, each portable electronic device communicatively connectable to the medical device data management system and configured to receive, from the medical device data management system, information indicative of an operational state of respective medical devices and to display the received information in respect of one or more selected ones of the medical devices.

5. 发明申请

US20220187207A1 METHOD AND SENSOR FOR DETECTING PRESENCE OR ABSENCE OF A CONTAMINANT 有权
公开(公告)号：US20220187207A1
公开(公告)日：2022-06-16
申请号：US17649564
申请日：2022-02-01
申请人： Radiometer Medical ApS
发明人： Peter FRISCHAUF , Michael TAAGAARD , Flemming AAS
IPC分类号： G01N21/64 , G01N33/49
摘要： The present invention relates in one aspect to a method of detecting a contaminant in a measurement chamber (201) of a sample analyzer (200). The sample analyzer (200) comprises an optical sensor with a sensor layer (205) comprising a luminophor (201), wherein the sensor layer (205) has a sensor surface (206) forming an interface to the measurement chamber (201). The method comprises steps of: filling the measurement chamber with a fluid sample; applying a stimulus to the luminophor in the sensor layer; detecting luminescence emitted from the luminophor in the sensor layer in response to the stimulus as a function of time; obtaining a time sequence of measurement values for the detected luminescence; based on the time sequence, determining an actual value of a first parameter and an actual value of a second parameter, wherein one of the first and second parameters is sensitive to a change in refractive index across the interface between the sensor layer and the measurement chamber, and wherein the other one of the first and second parameters is not sensitive to said change in refractive index across the interface between the sensor layer and the measurement chamber; developing an expected value for the second parameter based on the actual value of the first parameter; comparing the expected value for the second parameter to the actual value of the second parameter; and determining the presence (or absence) of a contaminant based on the comparison. In a further aspect, a sample analyzer configured for detecting contaminants in the measurement chamber using embodiments of the above method is provided.

6. 发明申请

US20220099656A1 METHOD OF DETECTING THE PRESENCE OR ABSENCE OF A CLOT IN A LIQUID SAMPLE ANALYZER 有权
公开(公告)号：US20220099656A1
公开(公告)日：2022-03-31
申请号：US17643691
申请日：2021-12-10
申请人： Radiometer Medical ApS
发明人： Peter Aage FRISCHAUF , Michael TAAGAARD , Flemming AAS
IPC分类号： G01N33/49 , A61B5/1495
摘要： A method of detecting a clot in a measurement chamber (2) of a liquid sample analyzer (1), the liquid sample analyzer (1) comprising one or more analyte sensors (3, 4), each one of the one or more analyte sensors (3, 4) being arranged for measuring a physical parameter for a respective analyte in a liquid sample in the measurement chamber (2), wherein detection is performed after conclusion of a rinsing procedure with a primary solution (Call) having a pre-determined primary composition with a primary level of the analyte, the method comprising the steps of (a) at least partly filling the measurement chamber (2) with a secondary solution (Rinse/Call) having a pre-determined secondary composition with a respective secondary level for each of the analytes, wherein the respective secondary level is different from the respective primary level; (b) immediately after filling the measurement chamber (2) with the secondary solution (Rinse/Call), obtaining an initial measurement result by each of the one or more analyte sensors (3, 4); (c) flushing the measurement chamber (2) with the secondary solution (Rinse/Call); (d) after a time delay with respect to the initial measurement result, obtaining a subsequent measurement result by each of the one or more analyte sensors (3, 4); (e) comparing the respective initial and subsequent measurement results; and (f) determining presence or absence of a clot in the measurement chamber based on the comparison.

7. 发明申请

US20210262971A1 ION SELECTIVE MEMBRANES AND THE PREPARATION THEREOF 有权
公开(公告)号：US20210262971A1
公开(公告)日：2021-08-26
申请号：US17256291
申请日：2019-06-21
申请人： Radiometer Medical ApS
发明人： Thomas Steen HANSEN , Thomas Pedersen NYGAARD , Peter Jakobsen NEILSON , Kristian Medom HANSEN , Palle SCHNEIDER
IPC分类号： G01N27/333
摘要： Processes for preparing ion selective membranes are presented which have selectivity for a primary analyte (in particular magnesium) as well as another ion (in particular calcium), wherein said process comprises addition of a) an ionophore (in particular 1,10-phenanthroline), b) a lipophilic salt containing said primary analyte (in particular hemi-magnesium bis[4-octylphenyl]phosphate) and c) a lipophilic salt containing said other ion (in particular hemi-calcium bis[4-octylphenyl]phosphate). Also, ion selective membranes are presented which are prepared using said processes, in particular to membranes selective for magnesium ions. In further aspects, electrodes and potentiometric sensors are presented comprising such membranes and the use thereof for determining ion concentrations in samples.

8. 发明授权

US11071980B2 Multiple-use sensor assembly for body fluids 有权
公开(公告)号：US11071980B2
公开(公告)日：2021-07-27
申请号：US16472300
申请日：2017-12-18
申请人： Radiometer Medical ApS
发明人： Christian Strange , Peter Frischauf
IPC分类号： B01L3/00 , G01N33/487
摘要： The present invention relates to a sensor assembly for body fluids. The sensor assembly includes a measurement chamber having side walls and top and bottom walls, each of the walls having a respective wall wettability for aqueous solutions; a first sensor adapted to measure a first parameter of body fluids, having a surface having a first wettability for aqueous solutions exposed to the measurement chamber at a first axial position, and a second sensor adapted to measure a second parameter of body fluids, having a surface having a second wettability for aqueous solutions higher than the first wettability exposed to the measurement chamber at a second axial position upstream or downstream from the first axial position. At the second axial position, the chamber width exceeds the width of the second sensor surface, and the measurement chamber has a widening in a horizontal direction as compared to the first axial position.

9. 发明申请

US20210162411A1 DEVICE FOR ACCOMMODATING A FLUID SAMPLE 有权
公开(公告)号：US20210162411A1
公开(公告)日：2021-06-03
申请号：US16954733
申请日：2018-12-19
申请人： Radiometer Medical ApS
发明人： Michael TAAGAARD , Peter FRISCHAUF
IPC分类号： B01L3/00
摘要： The invention relates to a multiple-use device (1), wherein a fluid sample, in particular a blood sample, may enter a measuring chamber (3) of the device (1) via an inlet (16), flow through the measuring chamber (3) and leave the measuring chamber (3) via an outlet (17). The device (1) comprises an inner wall surface (9) defining an outer limit of the measuring chamber (3) The inner wall surface (9) comprises a surface structure (13) which is adapted to control a propagation of a flow front (6) of the fluid sample (4) in a direction (x) while the fluid sample (4) enters into the measuring chamber (3) via the inlet (16), while the fluid sample (4) flows through the measuring chamber (3), and while the fluid sample (4) leaves the measuring chamber (3) via the outlet (17). The shape of the surface structure (13) may be selected depending on a flow speed of the flow front (6) of the fluid sample (4), wherein the flow speed may be applied by a difference in pressure between the inlet (16) and the outlet (17) of the measuring chamber (3).

10. 发明申请

US20210020274A1 SYSTEM AND METHOD FOR PROCESSING PATIENT-RELATED MEDICAL DATA 有权
公开(公告)号：US20210020274A1
公开(公告)日：2021-01-21
申请号：US16954443
申请日：2018-12-13
申请人： Radiometer Medical ApS
发明人： Wei LIU , Michael Midtgaard ANDERSEN
IPC分类号： G16H10/40 , G16H10/60
摘要： The invention relates to a patient sample analysis system. The system comprises: at least one medical analysis device adapted to receive a sample, perform a measurement on the sample, and produce a measurement result based on the measurement, wherein the measurement result has a unique identifier; and a medical device management apparatus comprising an input interface adapted to collect the measurement result from the at least one medical analysis device, an output interface adapted to output sample analysis data based on the measurement result towards a point of delivery, and at least one processing module arranged in a data path extending from an upstream end at the input interface to a downstream end at the output interface. The patient sample analysis system further comprises: one or more check points arranged in the data path, wherein each check point is configured to identify the result by the unique identifier and to add a corresponding result status entry in relation to the unique identifier to a check point record, when the result is passed through said check point; and an error handler operable to inspect the check point record, detect the occurrence of an error based on that inspection, determine an error location of the error on the data path, and develop an error correction based on the error location. In a further aspect, a corresponding method for handling medical sample analysis is disclosed.

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