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1. 发明授权

US11071980B2 Multiple-use sensor assembly for body fluids 有权
公开(公告)号：US11071980B2
公开(公告)日：2021-07-27
申请号：US16472300
申请日：2017-12-18
申请人： Radiometer Medical ApS
发明人： Christian Strange , Peter Frischauf
IPC分类号： B01L3/00 , G01N33/487
摘要： The present invention relates to a sensor assembly for body fluids. The sensor assembly includes a measurement chamber having side walls and top and bottom walls, each of the walls having a respective wall wettability for aqueous solutions; a first sensor adapted to measure a first parameter of body fluids, having a surface having a first wettability for aqueous solutions exposed to the measurement chamber at a first axial position, and a second sensor adapted to measure a second parameter of body fluids, having a surface having a second wettability for aqueous solutions higher than the first wettability exposed to the measurement chamber at a second axial position upstream or downstream from the first axial position. At the second axial position, the chamber width exceeds the width of the second sensor surface, and the measurement chamber has a widening in a horizontal direction as compared to the first axial position.

2. 发明授权

US11268905B2 Method and sensor for detecting presence or absence of a contaminant 有权
公开(公告)号：US11268905B2
公开(公告)日：2022-03-08
申请号：US16955183
申请日：2018-12-12
申请人： Radiometer Medical ApS
发明人： Peter Frischauf , Michael Taagaard , Flemming Aas
IPC分类号： G01N21/64 , G01N33/49
摘要： The present invention relates in one aspect to a method of detecting a contaminant in a measurement chamber (201) of a sample analyzer (200). The sample analyzer (200) comprises an optical sensor with a sensor layer (205) comprising a luminophor (201), wherein the sensor layer (205) has a sensor surface (206) forming an interface to the measurement chamber (201). The method comprises steps of: filling the measurement chamber with a fluid sample; applying a stimulus to the luminophor in the sensor layer; detecting luminescence emitted from the luminophor in the sensor layer in response to the stimulus as a function of time; obtaining a time sequence of measurement values for the detected luminescence; based on the time sequence, determining an actual value of a first parameter and an actual value of a second parameter, wherein one of the first and second parameters is sensitive to a change in refractive index across the interface between the sensor layer and the measurement chamber, and wherein the other one of the first and second parameters is not sensitive to said change in refractive index across the interface between the sensor layer and the measurement chamber; developing an expected value for the second parameter based on the actual value of the first parameter; comparing the expected value for the second parameter to the actual value of the second parameter; and determining the presence (or absence) of a contaminant based on the comparison. In a further aspect, a sample analyzer configured for detecting contaminants in the measurement chamber using embodiments of the above method is provided.

3. 发明授权

US11860095B2 Method and sensor for detecting presence or absence of a contaminant 有权
公开(公告)号：US11860095B2
公开(公告)日：2024-01-02
申请号：US17649564
申请日：2022-02-01
申请人： Radiometer Medical ApS
发明人： Peter Frischauf , Michael Taagaard , Flemming Aas
IPC分类号： G01N21/64 , G01N33/49
CPC分类号： G01N21/6428 , G01N21/6408 , G01N33/49 , G01N2021/6432 , G01N2021/6439 , G01N2201/062 , G01N2201/06113
摘要： The present invention relates in one aspect to a method of detecting a contaminant in a measurement chamber (201) of a sample analyzer (200). The sample analyzer (200) comprises an optical sensor with a sensor layer (205) comprising a luminophor (201), wherein the sensor layer (205) has a sensor surface (206) forming an interface to the measurement chamber (201). The method comprises steps of: filling the measurement chamber with a fluid sample; applying a stimulus to the luminophor in the sensor layer; detecting luminescence emitted from the luminophor in the sensor layer in response to the stimulus as a function of time; obtaining a time sequence of measurement values for the detected luminescence; based on the time sequence, determining an actual value of a first parameter and an actual value of a second parameter, wherein one of the first and second parameters is sensitive to a change in refractive index across the interface between the sensor layer and the measurement chamber, and wherein the other one of the first and second parameters is not sensitive to said change in refractive index across the interface between the sensor layer and the measurement chamber; developing an expected value for the second parameter based on the actual value of the first parameter; comparing the expected value for the second parameter to the actual value of the second parameter; and determining the presence (or absence) of a contaminant based on the comparison. In a further aspect, a sample analyzer configured for detecting contaminants in the measurement chamber using embodiments of the above method is provided.

4. 发明授权

US11577243B2 Multiple-use sensor assembly for body fluids 有权
公开(公告)号：US11577243B2
公开(公告)日：2023-02-14
申请号：US17355492
申请日：2021-06-23
申请人： Radiometer Medical ApS
发明人： Christian Strange , Peter Frischauf
IPC分类号： B01L3/00 , G01N33/487
摘要： The present invention relates to a sensor assembly (1) for body fluids. The sensor assembly (1) comprises: a measurement chamber (2) extending in an axial direction from an inlet end (3) to an outlet end (4), the measurement chamber having a transverse cross-section with side walls (5, 6) defining a chamber width in a horizontal direction, and with top and bottom walls (8, 7) defining a chamber height in a vertical direction, each of the side walls (5, 6), top wall (8) and bottom wall (7) having a respective wall wettability for aqueous solutions; a first sensor (10a-h) adapted to measure a first parameter of body fluids, the first sensor (10 a-h) having a first sensor surface (11a-h) exposed to the inside of the measurement chamber at a first axial position, the first sensor surface (11a-h) having a first wettability for aqueous solutions; and a second sensor (20) adapted to measure a second parameter of body fluids, the second sensor (20) having a second sensor surface (21) exposed to the inside of the measurement chamber (2) at a second axial position upstream or downstream from the first axial position, the second sensor surface (21) having a second wettability for aqueous solutions higher than the first wettability. At the second axial position, the chamber width exceeds the width of the second sensor surface (21), and the measurement chamber has a widening (22) in a horizontal direction as compared to the first axial position.

5. 发明授权

US11422107B2 System and method for estimating a temperature of a liquid sample 有权
公开(公告)号：US11422107B2
公开(公告)日：2022-08-23
申请号：US16466419
申请日：2017-11-30
申请人： RADIOMETER MEDICAL APS
发明人： Flemming Aas , Peter Frischauf , Erik Helllesø Nicolajsen
IPC分类号： G01N27/327 , G01N33/49
摘要： The disclosure relates to an apparatus for the analysis of biological liquid samples, the apparatus having a measurement chamber defining a sample volume with an inlet and an outlet; a fluid handling system adapted for feeding a liquid to the sample volume through the inlet and for removing the liquid through the outlet; a thermostatic sample heater device adapted for controlling a sample temperature of a liquid sample in the measurement chamber; and a processor unit. An analyte sensor output may be corrected on the basis of the initial temperature thus determined. A corresponding method for the analysis of biological liquid samples is provided. Furthermore, a method of performing a quality control procedure using the apparatus or the method is disclosed.

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