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1. 发明授权

US08975215B2 Methods for producing surface bound oligonucleotide on solid substrate and uses thereof 有权
标题翻译：在固体底物上制备表面结合寡核苷酸的方法及其用途
公开(公告)号：US08975215B2
公开(公告)日：2015-03-10
申请号：US12619233
申请日：2009-11-16
申请人： Joon Won Park , Bong Jin Hong , Duk Hoe Kim
发明人： Joon Won Park , Bong Jin Hong , Duk Hoe Kim
IPC分类号： C40B50/14 , B82Y15/00 , B82Y35/00 , C12Q1/68 , G01Q60/42
CPC分类号： B82Y15/00 , B82Y35/00 , C12Q1/6834 , G01Q60/42 , Y10T436/143333 , C12Q2565/601
摘要： The present invention relates to methods for producing an oligonucleotide on a solid substrate surface and methods for using the same. Some aspects of the invention provide methods for selecting a single DNA molecule reproducibily with an atomic force microscope (AFM).
摘要翻译：本发明涉及在固体基质表面上制备寡核苷酸的方法及其使用方法。本发明的一些方面提供了用原子力显微镜（AFM）重复选择单个DNA分子的方法。

2. 发明授权

US08673621B2 Biomolecule interaction using atomic force microscope 有权
标题翻译：使用原子力显微镜的生物分子相互作用
公开(公告)号：US08673621B2
公开(公告)日：2014-03-18
申请号：US11673732
申请日：2007-02-12
申请人： Joon Won Park , Yu Jin Jung , Bong Jin Hong , Saul Tendler , Stephanie Allen
发明人： Joon Won Park , Yu Jin Jung , Bong Jin Hong , Saul Tendler , Stephanie Allen
IPC分类号： C12M1/00 , C12M1/34 , C12M3/00 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6827 , B82Y35/00 , C12Q1/6834 , G01Q60/42 , Y10T436/143333
摘要： The present patent application describes a cantilever for atomic force microscopy (AFM), which includes a cantilever body having a fixed end and a free end, the free end having a surface region being chemically modified by a dendron in which a plurality of termini of the branched region of the dendron are bound to the surface, and a terminus of the linear region of the dendron is functionalized.
摘要翻译：本专利申请描述了一种用于原子力显微镜（AFM）的悬臂，其包括具有固定端和自由端的悬臂体，所述自由端具有通过树枝状化学修饰的表面区域，其中多个末端枝状突起的分支区域与表面结合，并且树突的线性区域的末端被官能化。

3. 发明授权

US08647823B2 Polynucleotide synthesis on a modified surface 有权
标题翻译：改性表面上的多核苷酸合成
公开(公告)号：US08647823B2
公开(公告)日：2014-02-11
申请号：US11625793
申请日：2007-01-22
申请人： Joon-Won Park , Bong-Jin Hong
发明人： Joon-Won Park , Bong-Jin Hong
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04 , C07H21/00
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00387 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B82Y30/00
摘要： The present invention relates to a method for the synthesis of a polynucleotide on a modified surface of a substrate, wherein the modified surface is obtained by chemically modifying with macromolecules in which a plurality of termini of the branched region are bound to the surface and a terminus of the linear region is functionalized.
摘要翻译：本发明涉及一种用于在基材的改性表面上合成多核苷酸的方法，其中所述改性表面通过用其中多个所述分支区的末端与所述表面结合的大分子和末端的线性区域被功能化。

4. 发明授权

US08161798B2 Density sensing device and fuel cell system with it 有权
标题翻译：密度传感装置和燃料电池系统
公开(公告)号：US08161798B2
公开(公告)日：2012-04-24
申请号：US11889028
申请日：2007-08-08
申请人： Won-Hyouk Jang , Do-Young Kim , Si-Hyun Lee , Jung-Kurn Park , Myeong-Ju Ha , Sang-Min Jeon
发明人： Won-Hyouk Jang , Do-Young Kim , Si-Hyun Lee , Jung-Kurn Park , Myeong-Ju Ha , Sang-Min Jeon
IPC分类号： G01N9/00
CPC分类号： G01N9/002 , G01N27/06 , G01N2291/02863 , G01N2291/0427 , H01M8/04194 , H01M8/04373 , H01M8/04447 , H01M8/04738 , H01M8/04798 , H01M8/1011 , H01M2008/1095 , Y02E60/523
摘要： The disclosed is a density sensing device of a fuel cell system and a fuel cell system having the density sensing device. The density sensing device includes a density sensor that includes a collision sensor and a variable resistor coupled to the collision sensor. The collision sensor is dipped into a fuel solution, and the collisions of molecules of the fuel solution are detected in the collision sensor. The resistance of the variable resistor varies depending on an amount of the collision detected by the collision sensor. The resistance further is converted to a density by the use of a table that includes a relationship between resistance and density. The density sensing device can further include a sensor driver. The sensor driver can be a piezoelectric member that is attached to the collision sensor. The collision sensor vibrates together with the piezoelectric member when a driving signal is applied to the piezoelectric member, which improves the accuracy of the measurement of the density.
摘要翻译：所公开的是具有密度感测装置的燃料电池系统和燃料电池系统的密度感测装置。密度感测装置包括密度传感器，其包括碰撞传感器和耦合到碰撞传感器的可变电阻器。将碰撞传感器浸入燃料溶液中，并在碰撞传感器中检测燃料溶液的分子碰撞。可变电阻器的电阻根据碰撞传感器检测到的碰撞量而变化。电阻进一步通过使用包括电阻和密度之间的关系的表转换为密度。密度感测装置还可以包括传感器驱动器。传感器驱动器可以是附接到碰撞传感器的压电元件。当将驱动信号施加到压电元件时，碰撞传感器与压电元件一起振动，这提高了密度测量的精度。

5. 发明授权

US08048996B2 Molecular transporters based on sugar and its analogues and processes for the preparation thereof 有权
公开(公告)号：US08048996B2
公开(公告)日：2011-11-01
申请号：US12860439
申请日：2010-08-20
申请人： Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
发明人： Sung-Kee Chung , Kaustabh Kumar Maiti , Woo Sirl Lee , Ock-Youm Jeon , Seok-Ho Lee
IPC分类号： C07H1/00 , A01N31/00 , A01N33/18 , A01N33/24 , A61K31/45 , A61K31/04 , A61B5/055
CPC分类号： C07H15/04 , Y02P20/55
摘要： The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.

6. 发明申请

US20110177563A1 HIGH THROUGHPUT DEVICE FOR PERFORMING CONTINUOUS-FLOW REACTIONS 审中-公开
标题翻译：用于执行连续流动反应的高通量装置
公开(公告)号：US20110177563A1
公开(公告)日：2011-07-21
申请号：US13025741
申请日：2011-02-11
申请人： Jong Hoon HAHN , Nokyoung PARK , Kwanseop LIM
发明人： Jong Hoon HAHN , Nokyoung PARK , Kwanseop LIM
IPC分类号： C12P19/34 , C12M1/00 , C12M1/34
CPC分类号： B01L7/525 , B01L3/5025 , B01L2300/0838 , B01L2300/1827
摘要： A high-throughput device is structured to perform a continuous-flow reaction, e.g., a polymerase chain reaction (PCR) requiring repetitive temperature control in a timely fashion.
摘要翻译：构建高通量装置以进行连续流动反应，例如需要及时地进行重复温度控制的聚合酶链反应（PCR）。

7. 发明授权

US07964884B2 GaN compound semiconductor light emitting element and method of manufacturing the same 有权
标题翻译： GaN化合物半导体发光元件及其制造方法
公开(公告)号：US07964884B2
公开(公告)日：2011-06-21
申请号：US11577710
申请日：2005-10-21
申请人： Jong-Lam Lee
发明人： Jong-Lam Lee
IPC分类号： H01L33/00
CPC分类号： H01L33/40 , H01L33/0079 , H01L33/32 , H01L33/387 , H01L33/405 , H01L33/44
摘要： The present invention relates to a gallium nitride (GaN) compound semiconductor light emitting element (LED) and a method of manufacturing the same. The present invention provides a vertical GaN LED capable of improving the characteristics of a horizontal LED by means of a metallic protective film layer and a metallic support layer. According to the present invention, a thick metallic protective film layer with a thickness of at least 10 microns is formed on the lateral and/or bottom sides of the vertical GaN LED to protect the element against external impact and to easily separate the chip. Further, a metallic substrate is used instead of a sapphire substrate to efficiently release the generated heat to the outside when the element is operated, so that the LED can be suitable for a high-power application and an element having improved optical output characteristics can also be manufactured. A metallic support layer is formed to protect the element from being distorted or damaged due to impact. Furthermore, a P-type electrode is partially formed on a P—GaN layer in a mesh form to thereby maximize the emission of photons generated in the active layer toward the N—GaN layer.
摘要翻译：本发明涉及一种氮化镓（GaN）化合物半导体发光元件（LED）及其制造方法。本发明提供一种能够通过金属保护膜层和金属支撑层改善水平LED的特性的垂直GaN LED。根据本发明，在垂直GaN LED的侧面和/或底面上形成厚度至少为10微米的厚金属保护膜层，以保护元件免受外部冲击并容易地分离芯片。此外，当元件被操作时，使用金属基板代替蓝宝石基板来有效地将产生的热量释放到外部，使得LED可以适合于大功率应用，并且具有改善的光输出特性的元件也可以制造。形成金属支撑层以保护元件免于由于冲击而变形或损坏。此外，P型电极以网格形式部分地形成在P-GaN层上，从而最大限度地发挥在有源层中朝向N-GaN层产生的光子。

8. 发明授权

US07951779B2 Method of protecting cells against damage and pharmaceutical composition comprising leumorphin 有权
标题翻译：保护细胞免受损伤的方法和包含leumorphin的药物组合物
公开(公告)号：US07951779B2
公开(公告)日：2011-05-31
申请号：US11482480
申请日：2006-07-06
申请人： Byoung Dae Lee , SooMi Kim , Eun-Mi Hur , Yong-Soo Park , Yun-Hee Kim , Taehoon Lee , Kyong-Tai Kim , Pann-Ghill Suh , Sung Ho Ryu
发明人： Byoung Dae Lee , SooMi Kim , Eun-Mi Hur , Yong-Soo Park , Yun-Hee Kim , Taehoon Lee , Kyong-Tai Kim , Pann-Ghill Suh , Sung Ho Ryu
IPC分类号： A61K38/33
CPC分类号： A61K38/33
摘要： The present invention relates to a method of protecting cells against damage caused at least in part by apoptosis, comprising administering to subjects a therapeutic dose of leumorphin having cytoprotective activity, and a pharmaceutical composition comprising an effective amount of leumorphin having a cytoprotective activity.
摘要翻译：本发明涉及一种保护细胞免受至少部分通过细胞凋亡引起的损伤的方法，包括向受试者施用具有细胞保护活性的治疗剂量的亮氨酸，以及包含有效量的具有细胞保护活性的亮氨酸的药物组合物。

9. 发明授权

US07932766B2 Digitally controlled oscillator with the wide operation range 有权
标题翻译：数字控制振荡器具有较宽的工作范围
公开(公告)号：US07932766B2
公开(公告)日：2011-04-26
申请号：US12364173
申请日：2009-02-02
申请人： Kwang Hee Choi , Hong June Park
发明人： Kwang Hee Choi , Hong June Park
IPC分类号： H03H11/26
CPC分类号： H03L7/10 , H03K3/0315 , H03K2005/00058 , H03K2005/00221 , H03L7/0995 , H03L7/0998 , H03L2207/06
摘要： There is provided a digitally controlled oscillator, which is capable of widening its operation range with maintaining its resolution and the maximum frequency at which it operates. The digitally controlled oscillator includes a phase compensation block, a coarse block, and a fine block. The phase compensation block 510 generating a PLL signal PLLCLK and a first clock signal CLK1 which has the same phase and frequency as the PLL signal, in response to a phase control signal DISABLE and a fourth clock signal CLK4. The coarse block 520 generating a second clock signal CLK2 and a third clock signal CLK3 which results from delaying the PLL signal PLLCLK and the first clock signal CLK1 for a given time, in response to a m(integer)-bit coarse A control signal COAR_A and an (m−1)-bit coarse B control signal COAR_B. The fine block generating the fourth clock signal CLK4 by applying interpolation to the second clock signal CLK2 and the third clock signal CLK3 in response to an n(integer)-bit first fine control signal FCB and a n-bit second fine control signal FC.
摘要翻译：提供了数字控制的振荡器，其能够在保持其分辨率和操作的最大频率的情况下扩大其操作范围。数字控制振荡器包括相位补偿块，粗块和精细块。响应于相位控制信号DISABLE和第四时钟信号CLK4，相位补偿块510产生PLL信号PLLCLK和与PLL信号具有相同相位和频率的第一时钟信号CLK1。粗块520产生第二时钟信号CLK2和第三时钟信号CLK3，其响应于am（整数）位粗A控制信号COAR_A，延迟PLL信号PLLCLK和第一时钟信号CLK1给定时间，（m-1）位粗B控制信号COAR_B。精细块响应于n（整数）位第一精细控制信号FCB和n位第二精细控制信号FC，通过对第二时钟信号CLK2和第三时钟信号CLK3施加内插来产生第四时钟信号CLK4。

10. 发明授权

US07932540B2 T-gate forming method for high electron mobility transistor and gate structure thereof 有权
标题翻译：用于高电子迁移率晶体管的T型栅极形成方法及其栅极结构
公开(公告)号：US07932540B2
公开(公告)日：2011-04-26
申请号：US11700946
申请日：2007-02-01
申请人： Yoon-Ha Jeong , Kang-Sung Lee , Young-Su Kim , Yun-Ki Hong , Sung-Woo Jung
发明人： Yoon-Ha Jeong , Kang-Sung Lee , Young-Su Kim , Yun-Ki Hong , Sung-Woo Jung
IPC分类号： H01L29/66
CPC分类号： H01L29/7787 , H01L29/42316 , H01L29/66462
摘要： A T-gate forming method for a high electron mobility transistor includes the steps of: coating a first, a second and a third resist, each having an electron beam sensitivity different from each other, on a semiconductor substrate; performing a first exposure process by using an electron beam on the semiconductor substrate and then selectively developing the third resist; defining a gate head area by selectively developing the second resist to have a developed width wider than that of the third resist; performing a second exposure process by using an electron beam on the semiconductor substrate and then selectively developing the first resist in a bent shape at a temperature lower than in the development of the second and the third steps; and depositing metallic materials on the resists and then removing them to form a T-gate.
摘要翻译：一种用于高电子迁移率晶体管的T形栅形成方法包括以下步骤：在半导体衬底上涂覆各自具有彼此不同的电子束灵敏度的第一，第二和第三抗蚀剂; 通过在半导体衬底上使用电子束然后选择性地显影第三抗蚀剂来执行第一曝光处理; 通过选择性地显影所述第二抗蚀剂来限定栅极头区域，以具有比所述第三抗蚀剂宽的显影宽度; 通过在半导体衬底上使用电子束进行第二曝光处理，然后在低于第二和第三步骤的显影的温度下，以弯曲形状选择性地显影第一抗蚀剂; 并将金属材料沉积在抗蚀剂上，然后去除它们以形成T形栅极。

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