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1. 发明申请

US20190009271A1 DIAGNOSTIC CARTRIDGES HAVING FLEXIBLE SEALS 审中-公开
公开(公告)号：US20190009271A1
公开(公告)日：2019-01-10
申请号：US16129094
申请日：2018-09-12
申请人： Nanosphere, Inc.
发明人： Tom WESTBERG , Bruce RICHARDSON , Ryan GRISWOLD , Chris LEWIS
IPC分类号： B01L3/00
摘要： Disclosed are cartridges and modules that may be utilized in diagnostic systems and methods. The cartridge includes a flexible seal that caps the cartridge. The flexible seal has an opening for a pipette tip, and the flexible seal is configured to create a sealed environment when a pipette tip is positioned in the opening of the flexible seal and when the pipette tip is moved in the X-axis, Y-axis, and Z-axis.

2. 发明申请

US20090111094A1 Methods for preparing hybrid substrates comprising DNA and antibodies and uses thereof 审中-公开
标题翻译：制备包含DNA和抗体的杂交底物的方法及其用途
公开(公告)号：US20090111094A1
公开(公告)日：2009-04-30
申请号：US11506280
申请日：2006-08-18
申请人： James J. Storhoff , Michael J. Senical
发明人： James J. Storhoff , Michael J. Senical
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34
CPC分类号： B82Y5/00 , B01J2219/00547 , B01J2219/00572 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , C12Q1/6834 , G01N33/54366 , G01N33/54386 , C12Q2525/205
摘要： The invention provides substrates that have antibodies and aptamers bound thereto. The invention also provides methods of detecting target analytes in a sample comprising detecting binding of a target analyte to capture probes on a substrate, wherein some of the capture probes comprise antibodies and other capture probes comprise aptamers, and all of the capture probes are bound to the substrate. In addition, the invention provides substrates that have capture probes and capture oligonucleotides bound thereto, wherein the capture oligonucleotides can hybridize to DNA barcodes. The invention also provides methods of detecting target analytes in a sample comprising contacting the sample with a substrate that has capture probes and capture oligonucleotides bound thereto.
摘要翻译：本发明提供具有与其结合的抗体和适体的底物。本发明还提供了检测样品中目标分析物的方法，包括检测靶分析物与底物上捕获探针的结合，其中一些捕获探针包含抗体，而其它捕获探针包含适体，并且所有捕获探针均与底物。此外，本发明提供了具有捕获探针和捕获与其结合的寡核苷酸的底物，其中捕获寡核苷酸可以与DNA条形码杂交。本发明还提供了检测样品中目标分析物的方法，包括使样品与具有捕获探针和捕获与其结合的寡核苷酸的底物接触。

3. 发明授权

US07485469B2 Method for attachment of silylated molecules to glass surfaces 有权
公开(公告)号：US07485469B2
公开(公告)日：2009-02-03
申请号：US11656219
申请日：2007-01-19
申请人： Viswanadham Garimella , Yasmith Bernal
发明人： Viswanadham Garimella , Yasmith Bernal
IPC分类号： G01N33/543 , G01N33/551 , G01N33/552 , G01N33/00 , C12Q1/00 , C12Q1/68 , C12N11/00
CPC分类号： G01N33/552 , C03C17/30 , C12Q1/6834 , Y10T436/17 , Y10T436/172307 , Y10T436/20
摘要： A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.

4. 发明申请

US20080085508A1 Non-nucleic acid based biobarcode assay for detection of biological materials 审中-公开
标题翻译：用于检测生物材料的基于非核酸的生物条码检测
公开(公告)号：US20080085508A1
公开(公告)日：2008-04-10
申请号：US11803012
申请日：2007-05-11
申请人： Tai-Fen Wei , Hao An , Yijia Bao
发明人： Tai-Fen Wei , Hao An , Yijia Bao
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/573
CPC分类号： G01N33/54346 , G01N33/587
摘要： The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes non-nucleic acid reporter markers as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution.
摘要翻译：本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如，生物分子。特别地，本发明涉及一种利用非核酸报告基因标记物作为生化条形码来检测溶液中多种蛋白质结构或其他目标分析物的方法。

5. 发明授权

US07297553B2 Method for attachment of silylated molecules to glass surfaces 失效
公开(公告)号：US07297553B2
公开(公告)日：2007-11-20
申请号：US10447073
申请日：2003-05-28
申请人： Viswanadham Garimella , Yasmith Bernal
发明人： Viswanadham Garimella , Yasmith Bernal
IPC分类号： G01N33/543 , C08G77/04 , C12Q1/68 , G01N15/06 , C07F7/22
CPC分类号： G01N33/552 , C03C17/30 , C12Q1/6834 , Y10T436/17 , Y10T436/172307 , Y10T436/20
摘要： A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.

6. 发明授权

US07253277B2 Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes 有权
标题翻译：纳米粒子聚阴离子共轭物及其在检测分析物中的应用方法
公开(公告)号：US07253277B2
公开(公告)日：2007-08-07
申请号：US10612422
申请日：2003-07-02
申请人： James J. Storhoff , Robert L. Letsinger , Susan R. Hagenow
发明人： James J. Storhoff , Robert L. Letsinger , Susan R. Hagenow
IPC分类号： C07H19/04 , C07K16/00 , C12Q1/68 , C12Q1/00 , C07H21/02
CPC分类号： G01N33/588 , B82Y15/00 , G01N33/54346 , G01N33/54353 , G01N33/545 , G01N2333/726 , Y10S977/702 , Y10T428/2982
摘要： This invention provides polyanionic polymer conjugates containing non-nucleotide polyanionic polymers that are useful in detecting target analytes such as proteins or small molecules. The invention also provides nanoparticles bound to polyanionic polymer conjugates and methods of preparation and use thereof. The polyanionic polymer conjugates have the formula: L-O—[PO2—O-Z-O]n—PO2—O—X wherein n ranges from 1 to 200; L represents a moiety comprising a functional group for attaching the polyanion polymer to the nanoparticle surface; Z represents a bridging group, and X represents Q, X′ or -Q-X′, wherein Q represents a functional group for attaching a recognition probe to the polyanion polymer, and X′ represents a recognition probe.
摘要翻译：本发明提供含有非核苷酸聚阴离子聚合物的聚阴离子聚合物缀合物，其可用于检测目标分析物如蛋白质或小分子。本发明还提供结合聚阴离子聚合物共轭物的纳米颗粒及其制备和使用方法。聚阴离子聚合物共轭物具有下式：<？in-line-formula description =“In-line Formulas”end =“lead”？> LO- [PO 2 -OZO] n < 其中n的范围为1至200;或其中n的范围为1至200; L表示包含用于将聚阴离子聚合物附着到纳米颗粒表面的官能团的部分; Z表示桥连基，X表示Q，X'或-Q-X'，其中Q表示用于将识别探针附着到聚阴离子聚合物上的官能团，X'表示识别探针。

7. 发明申请

US20070172872A1 Method for attachment of silylated molecules to glass surfaces 审中-公开
公开(公告)号：US20070172872A1
公开(公告)日：2007-07-26
申请号：US11655714
申请日：2007-01-19
申请人： Viswanadham Garimella , Yasmith Bernal
发明人： Viswanadham Garimella , Yasmith Bernal
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： G01N33/552 , C03C17/30 , C12Q1/6834 , Y10T436/17 , Y10T436/172307 , Y10T436/20
摘要： A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.

8. 发明授权

US07238472B2 Non-alloying core shell nanoparticles 有权
标题翻译：非合金核壳纳米粒子
公开(公告)号：US07238472B2
公开(公告)日：2007-07-03
申请号：US10034451
申请日：2001-12-28
申请人： Chad A. Mirkin , Yun-Wei Cao , Rongchao Jin
发明人： Chad A. Mirkin , Yun-Wei Cao , Rongchao Jin
IPC分类号： C12Q1/68 , C07H21/02 , B82B1/00 , B82B3/00
CPC分类号： B22F1/0062 , A61K47/6923 , B22F1/0059 , B22F1/025 , B22F9/24 , B22F2998/00 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y25/00 , B82Y30/00 , C01B19/007 , C01G7/00 , C01G11/02 , C01G49/08 , C01P2002/82 , C01P2004/04 , C01P2004/64 , C01P2004/84 , C01P2006/42 , C12Q1/6813 , C12Q1/6816 , C12Q1/6834 , G01N33/543 , G01N33/5434 , G01N33/54393 , G01N33/553 , G01N33/588 , H01F1/0054 , H01L29/127 , Y10S977/704 , Y10S977/722 , Y10S977/773 , Y10S977/81 , Y10T428/12014 , C12Q2563/155 , B22F1/0018
摘要： The present invention relates composite core/shell nanoparticles and a two-step method for their preparation. The present invention further relates to biomolecule-core/shell nanoparticle conjugates and methods for their preparation. The invention also relates to methods of detection of biomolecules comprising the biomolecule or specific binding substance-core/shell nanoparticle conjugates.
摘要翻译：本发明涉及复合核/壳纳米颗粒和两步法的制备方法。本发明还涉及生物分子 - 核/壳纳米颗粒缀合物及其制备方法。本发明还涉及检测包含生物分子或特异性结合物质 - 核/壳纳米颗粒共轭物的生物分子的方法。

9. 发明申请

US20070148665A1 Method for automatically detecting spots on a substrate 审中-公开
标题翻译：自动检测基板上的斑点的方法
公开(公告)号：US20070148665A1
公开(公告)日：2007-06-28
申请号：US11530138
申请日：2006-09-08
申请人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
发明人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
IPC分类号： C12Q1/68 , G06T7/00
CPC分类号： G01N33/54346 , G01N21/253
摘要： An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, an illumination module, a power module, an input module, and an output module. The apparatus may have a stationary substrate holder and imaging module which are proximate to one another. The apparatus provided for a compact sized system without the need for complex motorized devices to move the camera across the substrate. Further, the apparatus and method provide for automatic detection of the spots/wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics.
摘要翻译：提供了一种用于成像金属纳米颗粒的设备和方法。优选地，本发明提供了用于检测金胶体颗粒并且准确地向操作者报告的装置和方法。该装置包括用于保持基板的基板支架，处理器和存储装置，成像模块，照明模块，电源模块，输入模块和输出模块。该装置可以具有彼此靠近的固定衬底保持器和成像模块。该设备提供了一种紧凑型系统，而不需要复杂的电动装置来使相机移动穿过基板。此外，该装置和方法提供对基板上的点/孔的自动检测，基板上的点的自动定量，以及基于判定统计的斑点的自动解释。

10. 发明申请

US20070141615A1 Method for attachment of silylated molecules to glass surfaces 有权
公开(公告)号：US20070141615A1
公开(公告)日：2007-06-21
申请号：US11656303
申请日：2007-01-19
申请人： Viswanadham Garimella , Yasmith Bernal
发明人： Viswanadham Garimella , Yasmith Bernal
IPC分类号： C12Q1/68 , G01N33/53 , B05D3/00 , C12M3/00
CPC分类号： G01N33/552 , C03C17/30 , C12Q1/6834 , Y10T436/17 , Y10T436/172307 , Y10T436/20
摘要： A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.

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