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1. 发明授权

US4797369A Method and apparatus for detecting a blood clot 失效
标题翻译：用于检测血块的方法和装置
公开(公告)号：US4797369A
公开(公告)日：1989-01-10
申请号：US720575
申请日：1985-04-05
申请人： Michael Mintz
发明人： Michael Mintz
IPC分类号： G01N33/49 , G01N33/86
CPC分类号： G01N33/4905
摘要： A sample of whole blood or blood plasma is dispensed into two or more zones. The zones are separated and brought together repeatedly such that the blood sample is divided into multiple parts each associated with a zone. The parts are then rejoined into a single part and the process of separation continues. During the process, a liquid bridge between the separating parts is initially supported by surface tension but eventially collapses at the point of maximum zonal separation. When a fibrin clot is entrained within the rejoined part, it will align in a direction parallel to the direction of the relative motion between the zone. In this manner a thread appears between the parts as they are being separated. This thread is indicative of a clot which clot is capable of being detected by visual or electrical conductivity means. The apparatus depicted performs the above noted operations and automatically provides an output signal upon detection of the fibrin clot.

2. 发明授权

US5518006A Blood sampling device 失效
标题翻译：采血装置
公开(公告)号：US5518006A
公开(公告)日：1996-05-21
申请号：US287828
申请日：1994-08-09
申请人： James A. Mawhirt , Catherine M. Cimini , Anthony Kuklo
发明人： James A. Mawhirt , Catherine M. Cimini , Anthony Kuklo
IPC分类号： A61B5/15 , A61B5/00
CPC分类号： A61B5/15142 , A61B5/150022 , A61B5/150267 , A61B5/150343 , A61B5/150442 , A61B5/15144 , A61B5/150305
摘要： A blood sampling and transferring device including a disposable auto-pricking lancet and a reservoir integrated together for creating a skin incision and collecting a blood sample therefrom in a one-step operation. The reservoir is preferably funnel shaped with a large opening at one end for receiving the blood sample from the patient, and a small opening at the other end which is small enough to prevent unassisted passage of the collected blood therethrough. The blood sample can then be temporarily stored until such time as the sampling device is engaged with a blood testing device that has an aperture to accommodate the small opening of the reservoir and a pump to draw the blood from the reservoir for testing.
摘要翻译：一种血液采集和传送装置，包括一次性自动穿刺刺血针和集成在一起的用于创建皮肤切口并且以一步操作收集血液样本的储存器。储存器优选为漏斗形，其一端具有大的开口，用于接收来自患者的血液样本，另一端的小开口足够小以防止所收集的血液不通过其通过。然后可以临时存储血液样本，直到采样装置与具有孔的血液检查装置接合以适应容器的小开口的时间以及从储存器抽取血液以进行测试的泵。

3. 发明授权

US5134079A Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling 失效
标题翻译：流体样品采集和输送系统和特别适用于体液采样的方法
公开(公告)号：US5134079A
公开(公告)日：1992-07-28
申请号：US329340
申请日：1989-03-27
申请人： Robert F. Cusack , Michael D. Mintz
发明人： Robert F. Cusack , Michael D. Mintz
IPC分类号： G01N35/08
CPC分类号： G01N35/08 , Y10T436/117497 , Y10T436/118339
摘要： There is disclosed apparatus for transporting a sample of body fluid such as blood from a first location to a remote test site location. The apparatus operates in conjunction with a fluid manifold module which has a first sample input port, a second washing fluid input port and a third input port for receiving air. There are tubing means coupled to said first, second and third input ports which are coupled together and coupled to a sample output line which extends from the first location to the remote location. The manifold means contains check valves with one valve for blood and one valve for washing fluid and a diaphragm pump for air. There are logic means which selectively operate the valves and pump to allow the sample line to receive a sample separated by air barriers from washing fluid solution. In this manner, a predetermined volume of sample is transported from the first location to the remote test site location. At the test site location, the presence of sample is detected by detection means and the sample is directed to a test site. The remainder of materials such as the washing fluid and air are discharged at the remote location. The system includes flexible tubing and the fluids as present are pumped from the first locaiton to the remote location by means of a peristaltic pump or other pump in direct contact with the tubing.

4. 发明授权

US5089415A Method for clotting heparized blood by the addition of protamine, thrombin and snake venom 失效
标题翻译：通过加入鱼精蛋白，凝血酶和蛇毒来凝固肝素血的方法
公开(公告)号：US5089415A
公开(公告)日：1992-02-18
申请号：US583164
申请日：1990-09-17
申请人： Frank M. La Duca
发明人： Frank M. La Duca
IPC分类号： G01N33/86 , G01N33/96
CPC分类号： G01N33/86 , G01N33/96 , G01N2333/464 , G01N2333/974 , G01N2400/40 , G01N2496/05 , G01N2496/80
摘要： A cocktail reagent preparation for the rapid production of serum contains thrombin, snake venom, and protamine sulfate. The preparation employs very small quantities of clot promoting substances which behave in a synergistic manner such that rapid clotting of highly heparinized blood is achieved without altering the chemical analysis of the blood enzymes, proteins, sugars, or electrolytes. Thus, clinicians who rely upon the results of such tests can more closely monitor organ and tissue function and adjust patient therapies accordingly.
摘要翻译：用于快速产生血清的鸡尾酒试剂制剂含有凝血酶，蛇毒和硫酸鱼精蛋白。该制剂采用非常少量的凝块促进物质，其以协同的方式表现，使得在不改变血液酶，蛋白质，糖或电解质的化学分析的情况下实现高度肝素化血液的快速凝血。因此，依靠这些检测结果的临床医生可以更密切地监测器官和组织功能并相应地调整患者的疗法。

5. 发明授权

US4671939A Apparatus for analyzing the influence of additive reagents upon the coagulation of blood and related methods 失效
标题翻译：用于分析添加剂对凝血凝血的影响的装置及相关方法
公开(公告)号：US4671939A
公开(公告)日：1987-06-09
申请号：US751325
申请日：1985-07-02
申请人： Michael D. Mintz
发明人： Michael D. Mintz
IPC分类号： G01N33/86
CPC分类号： G01N33/86
摘要： There is shown a cartridge assembly which is used to analyze the coagulation of blood when subjected to an additive reagent. A base plate is divided into two sections as a right and left section by means of a longitudinal groove. Located on the right side of the groove is a plurality of first cylindrical chambers. Located on the left side of the groove is a second plurality of cylindrical chambers. The chambers on the right side of the groove have a top depression with sloping sidewalls which are adapted to receive extending tapered flanges associated with the chambers on the left side of the groove. In this manner upon folding or pivoting the cartridge about the groove, the chambers on the left and right side coact with one another. In operation the chambers on the left side of the groove receive a blood sample while the chambers on the right side of the groove receive a suitable reagent. When the apparatus is closed, the chambers communicate one with the other and a support shelf is formed between the chambers. The assembly can be agitated in order to provide a coagulation test.
摘要翻译：示出了当进行添加剂试剂时用于分析血液凝固的盒组件。基板通过纵向槽分为左右两部分。位于凹槽右侧的是多个第一圆柱形腔室。位于槽的左侧的是第二多个圆柱形腔室。凹槽右侧的腔室具有倾斜侧壁的顶部凹陷，其适于接纳与凹槽左侧的腔室相关联的延伸锥形凸缘。以这种方式，当围绕凹槽折叠或枢转盒时，左侧和右侧的腔室彼此共同作用。在操作中，槽的左侧的腔室接收血液样本，而槽的右侧的腔室接收合适的试剂。当设备关闭时，室与另一个连通，并且在室之间形成支撑架。可以搅拌组件以提供凝结试验。

6. 发明授权

US4551308A Apparatus for analyzing the influence of additive reagents upon the coagulation of blood and related methods 失效
标题翻译：用于分析添加剂对凝血凝血的影响的装置及相关方法
公开(公告)号：US4551308A
公开(公告)日：1985-11-05
申请号：US549070
申请日：1983-12-23
申请人： Michael D. Mintz
发明人： Michael D. Mintz
IPC分类号： G01N33/86 , G01N21/03 , G01N21/75
CPC分类号： G01N33/86
摘要： A sample of blood is divided into a plurality of isolated test chambers. The blood is mixed with additive reagent having previously been measured into each test chamber. A clot detector and analyzer system determines the time required for the blood-reagent mixture in each chamber to form a clot. In a first mode of analyzer system operation there is recorded the time required for a selected number of clots to be detected. A second mode of operation identifies those chambers in which clots have been detected within a specified time interval.
摘要翻译：将血液样本分成多个分离的测试室。将血液与先前已经测量到每个测试室中的添加剂混合。凝块检测器和分析仪系统确定每个室中的血液试剂混合物形成凝块所需的时间。在分析仪系统操作的第一模式中，记录了所选择的凝块数量被检测所需的时间。第二种操作模式识别在指定的时间间隔内检测到血块的那些腔室。

7. 发明授权

US2669875A Liquid level meter 失效
标题翻译：液位计
公开(公告)号：US2669875A
公开(公告)日：1954-02-23
申请号：US28782852
申请日：1952-05-15
申请人： ASKANIA WERKE AG
发明人： GUIDO WUENSCH , HEINZ CASPAR
IPC分类号： G01F23/44
CPC分类号： G01F23/44

8. 发明授权

US5377854A Stopper apparatus for a test tube or similar article 失效
标题翻译：用于试管或类似物品的止动装置
公开(公告)号：US5377854A
公开(公告)日：1995-01-03
申请号：US48810
申请日：1993-04-16
申请人： Robert Cusack
发明人： Robert Cusack
IPC分类号： B65D51/24 , B65D41/28
CPC分类号： B65D51/241
摘要： A stopper assembly for a test tube or similar article comprised of an inner elastomeric stopper and an outer semi-rigid cap member that protects the inner elastomeric stopper and assists in the manual manipulation of the inner elastomeric stopper and provides enhanced visible color coding through the combination of colored stoppers and caps. The elastomeric stopper is dimensioned to fit within the open end of a test tube with an interference fit. The lower end of the elastomeric stopper has grooves disposed across its outer surface. When the lower end of the stopper is inserted into the open end of the test tube, gases are permitted to pass through the grooves, and the test tube is vented to its surrounding environment. The upper end of the elastomeric stopper does not include venting grooves. As such, when the upper end of the stopper is inserted into the open end of the test tube, a gas impervious seal is formed between the stopper and the test tube, thereby isolating the contents of the test tube from the surrounding environment.
摘要翻译：一种用于试管或类似物品的塞子组件，其包括内部弹性止动器和外部半刚性盖构件，其保护内部弹性塞子并有助于手动操纵内部弹性塞子，并通过组合提供增强的可见颜色编码的彩色塞子和帽子。弹性止动器的尺寸被设计成配合在具有过盈配合的试管的开口端内。弹性止动器的下端具有跨越其外表面设置的槽。当止动器的下端插入试管的开口端时，允许气体通过槽，并将试管排放到其周围的环境中。弹性塞子的上端不包括通气槽。因此，当止动件的上端插入试管的开口端时，在止动件和试管之间形成不透气的密封，从而将试管的内容物与周围环境隔离。

9. 发明授权

US5318910A Standard whole blood composition for determining the potency of blood clotting inhibitory substances 失效
标题翻译：用于确定凝血抑制物质效能的标准全血组成
公开(公告)号：US5318910A
公开(公告)日：1994-06-07
申请号：US4495
申请日：1993-01-14
申请人： Frank M. LaDuca
发明人： Frank M. LaDuca
IPC分类号： G01N33/86 , G01N31/00
CPC分类号： G01N33/86 , G01N2400/40 , Y10T436/10 , Y10T436/102499 , Y10T436/106664
摘要： A standard whole blood composition is disclosed, which is useful as a pooled human hemostasis reference standard in blood coagulation assays including Activated Clotting Time (ACT), Whole Blood Prothrombin Time (WBPT), Whole Blood Activated Partial Thromboplastin Time (WBAPTT) and Whole Blood Thrombin time (WBTT). Also disclosed are methods for determining the human standardized potency of heparin and protamine.
摘要翻译：公开了一种标准全血组合物，其可用作血液凝固测定中的汇集人类止血参考标准，包括活化凝血时间（ACT），全血凝血酶原时间（WBPT），全血活化部分凝血活酶时间（WBAPTT）和全血凝血酶时间（WBTT）。还公开了用于确定肝素和鱼精蛋白的人类标准化效力的方法。

10. 发明授权

US5212879A Method for manufacturing a disposable-retractable finger stick device 失效
标题翻译：一次性伸缩指棒装置的制造方法
公开(公告)号：US5212879A
公开(公告)日：1993-05-25
申请号：US868630
申请日：1992-04-14
申请人： Ladislau Biro , Robert F. Cusack , Michael D. Mintz
发明人： Ladislau Biro , Robert F. Cusack , Michael D. Mintz
IPC分类号： A61B5/15 , A61B17/32
CPC分类号： A61B17/32093 , A61B5/150022 , A61B5/150297 , A61B5/150442 , A61B5/15113 , A61B5/15128 , A61B5/15142 , A61B5/15144 , A61B5/15029 , Y10S29/029 , Y10T29/49845 , Y10T29/49861 , Y10T29/49876
摘要： A finger stick device for making a skin incision includes a blade pivot arm having a first end pivotally coupled to a housing and a second end having an upper sloped surface and a lower surface. A blade is affixed to the second end such that its cutting edge extends away from the lower surface. A resilient bias member when actuated traverses the upper surface and depresses the second end of the blade pivot arm, such that the blade exits the housing and incises the skin. The incising operation is complete upon the bias member traversing the sloped upper surface of the blade pivot arm. Also disclosed herein is a method for manufacturing the finger stick device, in which the bias member and blade pivot arm are molded as a monolithic unit. A blade is attached to the blade pivot arm, and the blade and monolithic unit are inserted into the housing. Further disclosed is an embodiment in which the housing is formed of two uniformly shaped halves, which when joined, provide an internal space for the monolithic unit. In this manner, the two halves are joined with the monolithic unit aligned therebetween so that the housing appears as an integral unit.
摘要翻译：用于制造皮肤切口的指棒装置包括刀片枢转臂，刀片枢转臂具有枢转地联接到壳体的第一端和具有上倾斜表面和下表面的第二端。叶片固定到第二端，使得其切割边缘远离下表面延伸。当致动的弹性偏压构件穿过上表面并压下刀片枢转臂的第二端，使得刀片离开外壳并切割皮肤。在偏置构件穿过叶片枢转臂的倾斜上表面时，切割操作完成。本文还公开了一种用于制造指棒装置的方法，其中偏压构件和叶片枢转臂被模制为单片单元。叶片连接到叶片枢转臂，并且叶片和整体单元插入壳体中。进一步公开的是其中壳体由两个均匀成形的半部形成的实施例，当连接时，壳体提供用于整体式单元的内部空间。以这种方式，两个半体与整体单元连接在一起，使得外壳看起来是一体的单元。

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