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1. 发明授权

US5614212A Method of transdermally administering high molecular weight drugs with a polymer skin enhancer 失效
标题翻译：用高分子皮肤增强剂透皮给药高分子量药物的方法
公开(公告)号：US5614212A
公开(公告)日：1997-03-25
申请号：US139316
申请日：1993-10-19
申请人： Joseph P. D'Angelo , Henry Schur
发明人： Joseph P. D'Angelo , Henry Schur
IPC分类号： A61K9/70 , A61M37/00 , A61F13/00
CPC分类号： A61K9/703 , A61K9/7084 , A61K9/7092 , A61M2037/0007 , A61M37/0092 , Y10S514/946
摘要： A high molecular weight drug is transdermally administered by applying a polymer skin enhancer and a drug active to the skin of the patient. The drug active has a molecular weight of above 500 daltons. The drug may be encapsulated or the drug solution may be partly encapsulated and partly free. The skin enhancer is preferably polyvinylpyrrolidone (PVP) and it is mixed at between 7 and 35% of the drug. A gelling agent may be optionally added at up to 20% by volume. The chemical system is preferably administered via a multidose transdermal drug patch assembly which includes a drug-impervious support impressed to form a series of compartments. Each compartment is a reservoir for a unit dose of a drug active to be transdermally administered. The support is adhesively secured to the skin of a patient. Individual devices are provided for resealably enclosing the drug active in each of the reservoirs. The individual enclosing devices are removable to release the unit dose into contact with the skin of the patient and are actuable to control the transdermal absorption of the drug actives. The drug may also be administered in a creme.
摘要翻译：通过将聚合物皮肤增强剂和药物活性剂施用于患者的皮肤来透皮施用高分子量药物。药物活性物质的分子量高于500道尔顿。药物可以被包封或药物溶液可以被部分包封并且部分游离。皮肤增强剂优选为聚乙烯吡咯烷酮（PVP），并且其在药物的7至35％之间混合。可以任选地以高达20体积％添加胶凝剂。化学系统优选经由多剂量透皮药物贴剂组合物施用，该药物贴剂组合物包括被压入以形成一系列隔室的药物不渗透性支持物。每个隔室是用于经皮给药的药物活性单位剂量的储存器。支撑体粘合地固定在患者的皮肤上。提供单个装置用于可重新密封地包围每个储存器中的活性物质。单独的包封装置是可移除的，以释放单位剂量与患者的皮肤接触，并且可致动以控制药物活性物质的透皮吸收。药物也可以在奶油中施用。

2. 发明授权

US5462064A Integrated system for biological fluid constituent analysis 失效
标题翻译：生物流体成分分析综合系统
公开(公告)号：US5462064A
公开(公告)日：1995-10-31
申请号：US213213
申请日：1994-03-14
申请人： Joseph P. D'Angelo , Henry B. Schur , Kedu Han , Daniel J. Glenn
发明人： Joseph P. D'Angelo , Henry B. Schur , Kedu Han , Daniel J. Glenn
IPC分类号： A61B10/00 , B01L3/00 , B01L9/00 , G01N21/25 , G01N33/483 , G01N33/52 , A61B5/00
CPC分类号： B01L9/52 , A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150755 , A61B5/150969 , B01L3/5023 , G01N21/251 , G01N33/525 , A61B10/0064 , B01L2300/0803 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406
摘要： A multi-part system to collect and analyze constituents of body fluid. The use of a multilayered gel matrix to facilitate the collection of analytes fluid and a chemistry detection methodology incorporated into the matrix to aid in the visual or electronic determination of the analyte is described.
摘要翻译：收集和分析体液成分的多部分系统。描述了使用多层凝胶基质以促进分析物流体的收集和结合到基质中的化学检测方法以帮助分析物的视觉或电子测定。

3. 发明授权

US5336213A Selectable dosage transdermal delivery system 失效
标题翻译：可选择剂量透皮给药系统
公开(公告)号：US5336213A
公开(公告)日：1994-08-09
申请号：US952049
申请日：1992-09-28
申请人： Joseph P. D'Angelo , Henry Schur
发明人： Joseph P. D'Angelo , Henry Schur
IPC分类号： A61K9/70 , A61M37/00 , A61K9/22 , A61F13/00 , B65D83/04
CPC分类号： A61K9/703 , A61K9/7023 , A61K9/7084 , A61K9/7092 , A61M2037/0007 , A61M37/0092
摘要： A transdermal drug delivery system is disclosed. The system comprises a laminate composite of a patch/skin permeable membrane; a transfer gel layer disposed on said permeable membrane; a permeable membrane disposed on said transfer gel layer; a plurality of sectional drug reservoirs for receiving medicament disposed on the transfer gel layer; and activation means for releasing medicament from said drug reservoirs for contact with skin of a patient. The medicament in contained in the reservoirs at varying amounts and/or concentrations, providing for selectable dosage, for sequential delivery, for sequential activation, for variable unit dose drug delivery in transdermal application.
摘要翻译：公开了透皮药物递送系统。该系统包括贴片/皮肤可渗透膜的层压复合材料; 设置在所述渗透膜上的转移凝胶层; 设置在所述转移凝胶层上的可渗透膜; 用于接收设置在转移凝胶层上的药物的多个部分药物储存器; 以及用于从所述药物储存器释放用于与患者皮肤接触的药物的激活装置。以不同的量和/或浓度包含在储存器中的药物，提供可选剂量，用于顺序递送，用于顺序激活，用于透皮施用中的可变单位剂量药物递送。

4. 发明授权

US5505957A Selectable dosage transdermal delivery system 失效
标题翻译：可选择剂量透皮给药系统
公开(公告)号：US5505957A
公开(公告)日：1996-04-09
申请号：US232826
申请日：1994-04-22
申请人： Joseph P. D'Angelo , Henry Schur
发明人： Joseph P. D'Angelo , Henry Schur
IPC分类号： A61K9/70 , A61M37/00 , A61F13/00
CPC分类号： A61K9/703 , A61K9/7023 , A61K9/7084 , A61K9/7092 , A61M2037/0007 , A61M37/0092
摘要： A transdermal drug delivery system is disclosed. The system comprises a laminate composite of a patch/skin permeable membrane; a transfer gel layer disposed on said permeable membrane; a permeable membrane disposed on said transfer gel layer; a plurality of sectional drug reservoirs for receiving medicament disposed on the transfer gel layer; and activation means for releasing medicament from said drug reservoirs for contact with skin of a patient. The medicament in contained in the reservoirs at varying amounts and/or concentrations, providing for selectable dosage, for sequential delivery, for sequential activation, for variable unit dose drug delivery in transdermal application.
摘要翻译：公开了透皮药物递送系统。该系统包括贴片/皮肤可渗透膜的层压复合材料; 设置在所述渗透膜上的转移凝胶层; 设置在所述转移凝胶层上的可渗透膜; 用于接收设置在转移凝胶层上的药物的多个部分药物储存器; 以及用于从所述药物储存器释放用于与患者皮肤接触的药物的激活装置。以不同的量和/或浓度包含在储存器中的药物，提供可选剂量，用于顺序递送，用于顺序激活，用于透皮施用中的可变单位剂量药物递送。

5. 发明授权

US5405614A Electronic transdermal drug delivery system 失效
标题翻译：电子透皮药物输送系统
公开(公告)号：US5405614A
公开(公告)日：1995-04-11
申请号：US3095
申请日：1993-01-11
申请人： Joseph P. D'Angelo , Henry Schur
发明人： Joseph P. D'Angelo , Henry Schur
IPC分类号： A61K9/70 , A61M37/00 , A61F13/00
CPC分类号： A61K9/7023 , A61K9/703 , A61K9/7084 , A61K9/7092 , A61M2037/0007 , A61M37/0092
摘要： A drug delivery system for transdermally delivering drugs through a given skin area is provided. The delivery system comprises a collapsible container for containing the drug. The container has a drug release opening. A displaceable member is in engagement with the container for expelling the drug from the container via the release opening. A driver is connected with said displaceable member so as to drive the same towards the collapsible container. Conduits are disposed between the release opening and the skin area for conducting the drug to the skin area. An ultrasonic transducer is disposed in the general conduit area for generating ultrasonic waves aimed at the skin area. An ultrasonic waveform generator drives the transducer and an electric control circuit is connected to the flow control for electrically activating the flow control.
摘要翻译：提供了通过给定皮肤区域透皮递送药物的药物递送系统。递送系统包括用于容纳药物的可折叠容器。容器具有药物释放口。可移动构件与容器接合，用于经由释放开口将药物从容器排出。驾驶员与所述可移动构件连接，以将其驱动到可折叠容器。导管布置在释放开口和皮肤区域之间，用于将药物导入皮肤区域。超声换能器设置在通用导管区域中，用于产生针对皮肤区域的超声波。超声波波形发生器驱动换能器，并且电控制电路连接到用于电激活流量控制的流量控制。

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