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1. 发明授权

US6024975A Method of transdermally administering high molecular weight drugs with a polymer skin enhancer 失效
标题翻译：用高分子皮肤增强剂透皮给药高分子量药物的方法
公开(公告)号：US6024975A
公开(公告)日：2000-02-15
申请号：US745496
申请日：1996-11-12
申请人： Joseph P. D'Angelo , Henry Schur
发明人： Joseph P. D'Angelo , Henry Schur
IPC分类号： A61K9/70 , A61M37/00 , A61F13/00
CPC分类号： A61K9/703 , A61K9/7092 , A61M2037/0007 , A61M37/0092 , Y10S514/944 , Y10S514/946
摘要： A high molecular weight drug is transdermally administered by applying a polymer skin enhancer and a drug active to the skin of the patient. The drug active has a molecular weight of above 50 daltons and takes at least 15% by weight of the system. The drug may be encapsulated or the drug solution may be partly encapsulated and partly free. The skin enhancer is polyvinylpyrrolidone (PVP) and it is mixed at between 7 and 35% of the drug. A gelling agent may be optionally added at up to 20% by volume. The chemical system is preferably administered via a multidose transdermal drug patch assembly which includes a drug-impervious support impressed to form a series of compartments. Each compartment is a reservoir for a unit dose of a drug active to be transdermally administered. The support is adhesively secured to the skin of a patient. Individual devices are provided for resealably enclosing the drug active in each of the reservoirs. The individual enclosing devices are removable to release the unit dose into contact with the skin of the patient and are actuable to control the transdermal absorption of the drug actives. The drug may also be administered in a creme.
摘要翻译：通过将聚合物皮肤增强剂和药物活性剂施用于患者的皮肤来透皮施用高分子量药物。药物活性物质的分子量高于50道尔顿，至少占系统重量的15％。药物可以被包封或药物溶液可以被部分包封并且部分游离。皮肤增强剂是聚乙烯吡咯烷酮（PVP），并且在药物的7至35％之间混合。可以任选地以高达20体积％添加胶凝剂。化学系统优选经由多剂量透皮药物贴剂组合物施用，该药物贴剂组合物包括被压入以形成一系列隔室的药物不渗透性支持物。每个隔室是用于经皮给药的药物活性单位剂量的储存器。支撑体粘合地固定在患者的皮肤上。提供单个装置用于可重新密封地包围每个储存器中的活性物质。单独的包封装置是可移除的，以释放单位剂量与患者的皮肤接触，并且可致动以控制药物活性物质的透皮吸收。药物也可以在奶油中施用。

2. 发明授权

US5989840A Estimation of active infection by heliobacter pylori 失效
标题翻译：用幽门螺杆菌预测活跃感染
公开(公告)号：US5989840A
公开(公告)日：1999-11-23
申请号：US865089
申请日：1997-05-29
申请人： Joseph P. D'Angelo , Jin Zhe
发明人： Joseph P. D'Angelo , Jin Zhe
IPC分类号： C12Q1/04 , G01N31/22 , G01N33/554
CPC分类号： C12Q1/04 , G01N31/22 , G01N31/221 , G01N2333/205 , Y10T436/175383
摘要： Disclosed is a diagnostic apparatus for estimating an active Heliobacter pylori infectious agent in saliva, comprising in combination an immunoassay chamber in which a first portion of said saliva is subjected to serological test for antibody to said infectious agent and a chemical reaction chamber in which a second portion of said saliva is subjected to chemical analysis for an ammonia constituent thereof.
摘要翻译：公开了一种用于估计唾液中活性的幽门螺杆菌感染因子的诊断装置，其包括组合的免疫测定室，其中所述唾液的第一部分进行针对所述感染因子的抗体的血清学试验和化学反应室，其中第二对所述唾液的一部分进行氨成分的化学分析。

3. 发明授权

US5932240A Multidose transdermal drug delivery system 失效
标题翻译：多剂量透皮给药系统
公开(公告)号：US5932240A
公开(公告)日：1999-08-03
申请号：US986370
申请日：1997-12-08
申请人： Joseph P. D'Angelo , Henry Schur
发明人： Joseph P. D'Angelo , Henry Schur
IPC分类号： A61K9/70 , A61M37/00 , A61F13/00
CPC分类号： A61K9/703 , A61K9/7023 , A61K9/7084 , A61K9/7092 , A61M2037/0007 , A61M37/0092
摘要： A multidose transdermal drug delivery system comprises a laminate composite with a plurality of compartments. Each compartment is a reservoir for a unit dose of a drug active to be transdermally administered. The assembly is adhesively secured to the skin of a patient. Individual seals are provided for resealably enclosing the drug active in each of the reservoirs. The individual enclosing seals are removable to release the unit dose into contact with the skin of the patient and are actuable to control the transdermal absorption of the drug actives. Provisions are also made to automatically indicate the activation of the drug and to prevent an accidental release of medicament.
摘要翻译：多剂量透皮药物递送系统包括具有多个隔室的层压复合材料。每个隔室是用于经皮给药的药物活性单位剂量的储存器。该组件被粘合地固定到患者的皮肤上。提供单独的密封件用于在每个储存器中重新密封地包封活性物质。单独的封闭密封件是可移除的，以释放单位剂量与患者的皮肤接触，并且可致动以控制药物活性物质的透皮吸收。还规定了自动指示药物的激活和防止药物的意外释放。

4. 发明授权

US5614212A Method of transdermally administering high molecular weight drugs with a polymer skin enhancer 失效
标题翻译：用高分子皮肤增强剂透皮给药高分子量药物的方法
公开(公告)号：US5614212A
公开(公告)日：1997-03-25
申请号：US139316
申请日：1993-10-19
申请人： Joseph P. D'Angelo , Henry Schur
发明人： Joseph P. D'Angelo , Henry Schur
IPC分类号： A61K9/70 , A61M37/00 , A61F13/00
CPC分类号： A61K9/703 , A61K9/7084 , A61K9/7092 , A61M2037/0007 , A61M37/0092 , Y10S514/946
摘要： A high molecular weight drug is transdermally administered by applying a polymer skin enhancer and a drug active to the skin of the patient. The drug active has a molecular weight of above 500 daltons. The drug may be encapsulated or the drug solution may be partly encapsulated and partly free. The skin enhancer is preferably polyvinylpyrrolidone (PVP) and it is mixed at between 7 and 35% of the drug. A gelling agent may be optionally added at up to 20% by volume. The chemical system is preferably administered via a multidose transdermal drug patch assembly which includes a drug-impervious support impressed to form a series of compartments. Each compartment is a reservoir for a unit dose of a drug active to be transdermally administered. The support is adhesively secured to the skin of a patient. Individual devices are provided for resealably enclosing the drug active in each of the reservoirs. The individual enclosing devices are removable to release the unit dose into contact with the skin of the patient and are actuable to control the transdermal absorption of the drug actives. The drug may also be administered in a creme.
摘要翻译：通过将聚合物皮肤增强剂和药物活性剂施用于患者的皮肤来透皮施用高分子量药物。药物活性物质的分子量高于500道尔顿。药物可以被包封或药物溶液可以被部分包封并且部分游离。皮肤增强剂优选为聚乙烯吡咯烷酮（PVP），并且其在药物的7至35％之间混合。可以任选地以高达20体积％添加胶凝剂。化学系统优选经由多剂量透皮药物贴剂组合物施用，该药物贴剂组合物包括被压入以形成一系列隔室的药物不渗透性支持物。每个隔室是用于经皮给药的药物活性单位剂量的储存器。支撑体粘合地固定在患者的皮肤上。提供单个装置用于可重新密封地包围每个储存器中的活性物质。单独的包封装置是可移除的，以释放单位剂量与患者的皮肤接触，并且可致动以控制药物活性物质的透皮吸收。药物也可以在奶油中施用。

5. 发明授权

US5443080A Integrated system for biological fluid constituent analysis 失效
公开(公告)号：US5443080A
公开(公告)日：1995-08-22
申请号：US173635
申请日：1993-12-22
申请人： Joseph P. D'Angelo , Henry Schur , Kedu Han , Daniel J. Glenn
发明人： Joseph P. D'Angelo , Henry Schur , Kedu Han , Daniel J. Glenn
IPC分类号： A61B10/00 , B01L3/00 , B01L9/00 , G01N21/25 , G01N33/483 , G01N33/52 , A61B5/00
CPC分类号： B01L9/52 , A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150755 , A61B5/150969 , B01L3/5023 , G01N21/251 , G01N33/525 , A61B10/0064 , B01L2300/0803 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406
摘要： A multi-part system to collect and analyze constituents of body fluid. The use of a multilayered gel matrix to facilitate the collection of analytes fluid and a chemistry detection methodology incorporated into the matrix to aid in the visual or electronic determination of the analyte is described.

6. 发明授权

US5462064A Integrated system for biological fluid constituent analysis 失效
标题翻译：生物流体成分分析综合系统
公开(公告)号：US5462064A
公开(公告)日：1995-10-31
申请号：US213213
申请日：1994-03-14
申请人： Joseph P. D'Angelo , Henry B. Schur , Kedu Han , Daniel J. Glenn
发明人： Joseph P. D'Angelo , Henry B. Schur , Kedu Han , Daniel J. Glenn
IPC分类号： A61B10/00 , B01L3/00 , B01L9/00 , G01N21/25 , G01N33/483 , G01N33/52 , A61B5/00
CPC分类号： B01L9/52 , A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150755 , A61B5/150969 , B01L3/5023 , G01N21/251 , G01N33/525 , A61B10/0064 , B01L2300/0803 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406
摘要： A multi-part system to collect and analyze constituents of body fluid. The use of a multilayered gel matrix to facilitate the collection of analytes fluid and a chemistry detection methodology incorporated into the matrix to aid in the visual or electronic determination of the analyte is described.
摘要翻译：收集和分析体液成分的多部分系统。描述了使用多层凝胶基质以促进分析物流体的收集和结合到基质中的化学检测方法以帮助分析物的视觉或电子测定。

7. 发明授权

US5336213A Selectable dosage transdermal delivery system 失效
标题翻译：可选择剂量透皮给药系统
公开(公告)号：US5336213A
公开(公告)日：1994-08-09
申请号：US952049
申请日：1992-09-28
申请人： Joseph P. D'Angelo , Henry Schur
发明人： Joseph P. D'Angelo , Henry Schur
IPC分类号： A61K9/70 , A61M37/00 , A61K9/22 , A61F13/00 , B65D83/04
CPC分类号： A61K9/703 , A61K9/7023 , A61K9/7084 , A61K9/7092 , A61M2037/0007 , A61M37/0092
摘要： A transdermal drug delivery system is disclosed. The system comprises a laminate composite of a patch/skin permeable membrane; a transfer gel layer disposed on said permeable membrane; a permeable membrane disposed on said transfer gel layer; a plurality of sectional drug reservoirs for receiving medicament disposed on the transfer gel layer; and activation means for releasing medicament from said drug reservoirs for contact with skin of a patient. The medicament in contained in the reservoirs at varying amounts and/or concentrations, providing for selectable dosage, for sequential delivery, for sequential activation, for variable unit dose drug delivery in transdermal application.
摘要翻译：公开了透皮药物递送系统。该系统包括贴片/皮肤可渗透膜的层压复合材料; 设置在所述渗透膜上的转移凝胶层; 设置在所述转移凝胶层上的可渗透膜; 用于接收设置在转移凝胶层上的药物的多个部分药物储存器; 以及用于从所述药物储存器释放用于与患者皮肤接触的药物的激活装置。以不同的量和/或浓度包含在储存器中的药物，提供可选剂量，用于顺序递送，用于顺序激活，用于透皮施用中的可变单位剂量药物递送。

8. 发明授权

US5910122A Saliva collector with an aspirating pipette 失效
标题翻译：唾液收集器与抽吸移液器
公开(公告)号：US5910122A
公开(公告)日：1999-06-08
申请号：US869098
申请日：1997-06-04
申请人： Joseph P. D'Angelo
发明人： Joseph P. D'Angelo
IPC分类号： A61B10/00 , A61B5/00
CPC分类号： A61B10/0051 , A61B2010/0009
摘要： Saliva samples are collected for body fluid constituent analysis by placing a sponge member into a patient's oral cavity. The sponge member is formed similarly to a pacifier nipple. Saliva is absorbed. The saliva is then expelled from the sponge member into a pipette. A filter may be placed between the sponge member and the pipette, through which the saliva is cleaned and molecular weight-selectively prepared by letting only substances through with a molecular weight below a cut-off weight. The integral unit is dismembered after the saliva has been transferred into the collection pipette, and the latter is tightly closed off for further handling.
摘要翻译：通过将海绵构件放入患者的口腔中来收集唾液样品用于体液成分分析。海绵构件类似于安抚奶嘴形成。唾液被吸收。然后将唾液从海绵部件排出成移液管。过滤器可以放置在海绵构件和移液管之间，唾液被清洁，并且通过仅使物质通过分子量低于截止重量来分子量选择性地制备。在唾液已经转移到收集移液管中后，整体单元被分解，后者紧密关闭以进一步处理。

9. 发明授权

US07387899B1 Saliva sample collection system 失效
标题翻译：唾液样本收集系统
公开(公告)号：US07387899B1
公开(公告)日：2008-06-17
申请号：US08500535
申请日：1995-07-11
申请人： Joseph P. D'Angelo
发明人： Joseph P. D'Angelo
IPC分类号： G01N1/10 , G01N21/03 , C12M1/30 , C12M1/28 , B01L11/00
CPC分类号： A61B10/0051 , G01N21/03 , G01N21/07 , G01N21/78 , G01N2001/028 , G01N2021/0321 , G01N2021/0325 , G01N2021/0364 , G01N2021/7766 , Y10T436/255
摘要： Test kit whereby the sponge portion of kit is used to swab saliva. The saliva is then extracted from sponge by either squeezing it out or through the use of a centrifuge. The sponge portion of the kit is attached to a collection container when used in the centrifuge. A filter can be placed between these two portions of the kit to filter out only substances of certain molecular weights and to clean saliva. When the saliva is collected by squeezing, the sponge is placed in soft walled vial that is squeezed to extract saliva. After extracted from the sponge, the collected saliva can be removed from kit by twisting off cap. This test kit can be used for, but not limited to, testing for HIV antibodies, hepatitis and drugs.
摘要翻译：试剂盒，其中试剂盒的海绵部分用于拭子唾液。然后通过挤出或通过使用离心机从海绵中提取唾液。当在离心机中使用时，试剂盒的海绵部分连接到收集容器。过滤器可以放置在试剂盒的这两个部分之间，以过滤出仅某些分子量的物质并清洁唾液。当通过挤压收集唾液时，将海绵放置在软壁小瓶中，挤压以提取唾液。从海绵中提取后，收集的唾液可以从试剂盒中除去帽子。该测试试剂盒可用于但不限于HIV抗体，肝炎和药物的检测。

10. 发明授权

US5756117A Multidose transdermal drug delivery system 失效
标题翻译：多剂量透皮给药系统
公开(公告)号：US5756117A
公开(公告)日：1998-05-26
申请号：US927837
申请日：1992-08-10
申请人： Joseph P. D'Angelo , Henry Schur
发明人： Joseph P. D'Angelo , Henry Schur
IPC分类号： A61K9/70 , A61M37/00 , A61F13/00
CPC分类号： A61K9/703 , A61K9/7023 , A61K9/7084 , A61K9/7092 , A61M2037/0007 , A61M37/0092
摘要： A multidose transdermal drug delivery system comprises a laminate composite with a plurality of compartments. Each compartment is a reservoir for a unit dose of a drug active to be transdermally administered. The assembly is adhesively secured to the skin of a patient. Individual seals are provided for resealably enclosing the drug active in each of the reservoirs. The individual enclosing seals are removable to release the unit dose into contact with the skin of the patient and are actuable to control the transdermal absorption of the drug actives. Provisions are also made to automatically indicate the activation of the drug and to prevent an accidental release of medicament.
摘要翻译：多剂量透皮药物递送系统包括具有多个隔室的层压复合材料。每个隔室是用于经皮给药的药物活性单位剂量的储存器。该组件被粘合地固定到患者的皮肤上。提供单独的密封件用于在每个储存器中重新密封地包封活性物质。单独的封闭密封件是可移除的，以释放单位剂量与患者的皮肤接触，并且可致动以控制药物活性物质的透皮吸收。还规定了自动显示药物的激活并防止意外释放药物。

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