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1. 发明申请

US20090004171A1 COMPOUND PROFILING METHOD 审中-公开
标题翻译：化合物分析方法
公开(公告)号：US20090004171A1
公开(公告)日：2009-01-01
申请号：US12101719
申请日：2008-04-11
申请人： Masato Miyake , Yoshiji Fujita
发明人： Masato Miyake , Yoshiji Fujita
IPC分类号： A61K38/44 , C12Q1/68 , C40B30/06 , A61P35/00 , C12M1/34
CPC分类号： G01N33/5026 , C12Q1/6886 , C12Q2600/178 , G01N33/5011 , G16B5/00
摘要： The present invention provides a method for deriving an upstream or downstream component of a component necessary for phenotypic alteration of a living organism, the method comprising the steps of: specifying a pathway of interest related to the phenotypic alteration and a reference pathway different from the pathway of interest, and specifying a stimulant of interest and a reference stimulant which respectively stimulate the pathway of interest and the reference pathway; giving the stimulant of interest to the living organism to identify a collection of components of interest necessary for the phenotypic alteration; giving the reference stimulant to the living organism to identify a collection of reference components necessary for the phenotypic alteration; calculating an intersection between the collections of the components of interest and the reference components; and calculating a differential collection by subtracting the intersection from the collection of components of interest.
摘要翻译：本发明提供了一种用于衍生生物体表型改变所必需的组分的上游或下游组分的方法，所述方法包括以下步骤：指定与所述表型改变相关的感兴趣途径和不同于所述途径的参考途径并且指定分别刺激感兴趣途径和参考途径的兴趣兴奋剂和参考刺激物; 给予活体有兴趣的兴奋剂，以确定表型改变所必需的组成部分的集合; 给生物体提供参考刺激物，以确定表型改变所必需的参考组分的集合; 计算感兴趣组件的集合和参考组件之间的交集; 以及通过从所述关注部件的收集中减去所述交叉点来计算差分收集。

2. 发明申请

US20080038824A1 Composition and Method for Elevating Gene Transfer Efficiency 审中-公开
标题翻译：提高基因转移效率的组成和方法
公开(公告)号：US20080038824A1
公开(公告)日：2008-02-14
申请号：US10587776
申请日：2005-01-27
申请人： Masato Miyake , Tomohiro Yoshikawa , Eiichiro Uchimura , Jun Miyake
发明人： Masato Miyake , Tomohiro Yoshikawa , Eiichiro Uchimura , Jun Miyake
IPC分类号： C12N15/00 , C07K14/00 , C07K16/00 , C07K16/28
CPC分类号： C12N15/87 , C07K16/2842
摘要： It is intended to provide a method whereby transfer efficiency can be improved under any conditions in the case of transferring (in particular, transfecting) a target substance that cannot easily be transferred into cells (for example, a DNA, a polypeptide, a sugar, a complex thereof or the like). Namely, a composition for elevating the transfer efficiency of a target substance into cells which contains a cell adhesion-related factor, and a device and a method using the composition.
摘要翻译：旨在提供一种方法，其可以在转移（特别是转染）不容易转移到细胞中的目标物质（例如DNA，多肽，糖，其复合物等）。即，将目标物质的转移效率提高为含有细胞粘附相关因子的细胞的组合物，以及使用该组合物的装置和方法。

3. 发明申请

US20090012766A1 Event Sequencer 审中-公开
标题翻译：事件排序器
公开(公告)号：US20090012766A1
公开(公告)日：2009-01-08
申请号：US10587756
申请日：2005-01-27
申请人： Masato Miyake , Tomohiro Yoshikawa , Jun Miyake
发明人： Masato Miyake , Tomohiro Yoshikawa , Jun Miyake
IPC分类号： G06G7/58
CPC分类号： G16B25/00 , G16B40/00
摘要： There is provided a tool for effectively performing a meaningful analysis of a system state by using a specific index. A part having unusual behavior is extracted as an event timing from time-series data on an index derived from a system. An event descriptor describing the state of the system by using the event timing is generated. A method for generating the event descriptor associated with at least one system includes: a step (A) for acquiring time-series data on at least one index derived from at least one system; a step (B) for providing at least one peculiar behavior associated with the index; and a step (C) for extracting a part having the peculiar behavior as an event timing in the time-series data and generating an event descriptor described by the event timing.
摘要翻译：提供了一种用于通过使用特定索引来有效地执行对系统状态的有意义的分析的工具。从系统导出的索引的时间序列数据中提取具有异常行为的部分作为事件定时。生成描述使用事件定时的系统状态的事件描述符。一种用于生成与至少一个系统相关联的事件描述符的方法，包括：步骤（A），用于获取从至少一个系统导出的至少一个索引的时间序列数据; 用于提供与所述索引相关联的至少一个特有行为的步骤（B）; 以及步骤（C），用于将具有特殊行为的部分提取为时间序列数据中的事件定时，并生成由事件定时描述的事件描述符。

4. 发明申请

US20110165664A1 TRANSFECTION DEVICE UTILIZING SERICIN 审中-公开
标题翻译：转染装置利用丝氨酸
公开(公告)号：US20110165664A1
公开(公告)日：2011-07-07
申请号：US12674836
申请日：2008-08-22
申请人： Yoshiji Fujita , Tomohiro Yoshikawa
发明人： Yoshiji Fujita , Tomohiro Yoshikawa
IPC分类号： C12M1/00
CPC分类号： C12N15/87 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： There is provided a transfection device having a mixture (1) immobilized on a solid-phase support (3), the mixture including: a gene sample; a gene delivery material; and at least one compound selected from the group consisting of sericin, a hydrolysate thereof and a chemically modified product of sericin or a hydrolysate thereof.
摘要翻译：提供了具有固定在固相载体（3）上的混合物（1）的转染装置，所述混合物包括：基因样品; 基因递送材料; 和至少一种选自丝胶蛋白，其水解产物和丝胶蛋白的化学修饰产物或其水解产物的化合物。

5. 发明授权

US07846903B2 Type II cubic liquid crystal composition 失效
标题翻译： II型立方液晶组成
公开(公告)号：US07846903B2
公开(公告)日：2010-12-07
申请号：US11665776
申请日：2005-10-19
申请人： Masakatsu Hato , Yoshiji Fujita , Toshitaka Ota , Masahisa Tanomura , Manzo Shiono
发明人： Masakatsu Hato , Yoshiji Fujita , Toshitaka Ota , Masahisa Tanomura , Manzo Shiono
IPC分类号： C09K19/06 , C07C9/22 , C07H15/04 , C07D307/62 , C07K17/04 , C07K17/10 , A61K31/70 , A61K31/341 , A61K31/185
CPC分类号： A61Q19/00 , A61K8/0295 , A61K8/345 , A61K8/375 , A61K8/66 , A61K31/575 , A61K38/00 , A61K47/69 , A61K2800/522 , A61Q19/02 , C07D307/62 , C09K19/02 , C09K19/04 , C09K19/54 , C12N9/0089 , C12N9/2462
摘要： A cubic liquid crystal composition comprising at least one amphiphilic compound having the following general formula (1) and having an IV/OV value of 0.65 to 0.95, and water or an aqueous medium: wherein R represents a hydrophilic group; X and Y each independently represent a hydrogen atom or together form an oxygen atom; n is an integer of 0 to 4; and m is an integer of 0 to 3.
摘要翻译：一种立方晶体组合物，其包含至少一种具有以下通式（1）的两亲化合物和IV / OV值为0.65至0.95的两亲化合物，以及水或水性介质：其中R表示亲水基团; X和Y各自独立地表示氢原子或一起形成氧原子; n为0〜4的整数。 m为0〜3的整数。

6. 发明申请

US20100210708A1 COMPOUND PROFILING METHOD 审中-公开
标题翻译：化合物分析方法
公开(公告)号：US20100210708A1
公开(公告)日：2010-08-19
申请号：US12595604
申请日：2008-04-07
申请人： Masato Miyake , Yoshiji Fujita
发明人： Masato Miyake , Yoshiji Fujita
IPC分类号： A61K31/7088 , C12Q1/02 , C12Q1/68 , C40B30/06
CPC分类号： G01N33/5026 , C12Q1/6886 , C12Q2600/178 , G01N33/5011 , G16B5/00
摘要： The present invention provides a method for deriving an upstream or downstream component of a component necessary for phenotypic alteration of a living organism, the method comprising the steps of: specifying a pathway of interest related to the phenotypic alteration and a reference pathway different from the pathway of interest, and specifying a stimulant of interest and a reference stimulant which respectively stimulate the pathway of interest and the reference pathway; giving the stimulant of interest to the living organism to identify a collection of components of interest necessary for the phenotypic alteration; giving the reference stimulant to the living organism to identify a collection of reference components necessary for the phenotypic alteration; calculating an intersection between the collections of the components of interest and the reference components; and calculating a differential collection by subtracting the intersection from the collection of components of interest.
摘要翻译：本发明提供了一种用于衍生生物体表型改变所必需的组分的上游或下游组分的方法，所述方法包括以下步骤：指定与所述表型改变相关的感兴趣途径和不同于所述途径的参考途径并且指定分别刺激感兴趣途径和参考途径的兴趣兴奋剂和参考刺激物; 给予活体有兴趣的兴奋剂，以确定表型改变所必需的组成部分的集合; 给生物体提供参考刺激物，以确定表型改变所必需的参考组分的集合; 计算感兴趣组件的集合和参考组件之间的交集; 以及通过从所述关注部件的收集中减去所述交叉点来计算差分收集。

7. 发明授权

US08569282B2 Carboxamide compounds and their use 失效
标题翻译：甲酰胺化合物及其用途
公开(公告)号：US08569282B2
公开(公告)日：2013-10-29
申请号：US12747109
申请日：2008-12-11
申请人： Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
发明人： Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号： C07D471/04 , A61K31/4375
CPC分类号： C07D471/04
摘要： Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译：本文描述了趋化因子受体拮抗剂，特别是作为趋化因子CCR2受体的拮抗剂的式（I-A）化合物，包括药物组合物及其用于治疗或预防与单核细胞积聚，淋巴细胞积聚或白细胞积聚相关的疾病的用途。

8. 发明申请

US20100331298A1 Carboxamide Compounds and Their Use 审中-公开
标题翻译：羧甲酰胺化合物及其用途
公开(公告)号：US20100331298A1
公开(公告)日：2010-12-30
申请号：US12747106
申请日：2008-12-10
申请人： Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
发明人： Efrat Ben-Zeev , Dongli Chen , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumna Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号： A61K31/538 , C07D401/06 , C07D405/06 , C07D413/06 , C07D403/06 , C07D417/06 , C07D413/14 , A61K31/4709 , A61K31/453 , A61K31/454 , A61K31/4725 , A61K31/416 , A61K31/423 , A61K31/496 , A61P19/02 , A61P29/00 , A61P17/06 , A61P9/10 , A61P37/06 , A61P3/10 , A61P3/00 , A61P3/04
CPC分类号： C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D413/14 , C07D417/06
摘要： Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译：本文描述了趋化因子受体拮抗剂，特别是作为趋化因子CCR2受体的拮抗剂的式（I）化合物，包括药物组合物及其用于治疗或预防与单核细胞积聚，淋巴细胞积聚或白细胞积聚相关的疾病的用途。

9. 发明申请

US20100324035A1 Carboxamide Compounds and Their Use 失效
标题翻译：羧甲酰胺化合物及其用途
公开(公告)号：US20100324035A1
公开(公告)日：2010-12-23
申请号：US12747109
申请日：2008-12-11
申请人： Efrat Ben-Zeev , Dongli Chenl , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumma Mohanty , Sharon Shacham , Zhaoda Zhang
发明人： Efrat Ben-Zeev , Dongli Chenl , Merav Fichman , Shomir Ghosh , Steffi Koerner , Jian Lin , Yael Marantz , Rosa E. Melendez , Pradyumma Mohanty , Sharon Shacham , Zhaoda Zhang
IPC分类号： A61K31/538 , A61K31/501 , A61K31/4375 , C07D471/02
CPC分类号： C07D471/04
摘要： Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译：本文描述了趋化因子受体拮抗剂，特别是作为趋化因子CCR2受体的拮抗剂的式（I-A）化合物，包括药物组合物及其用于治疗或预防与单核细胞积聚，淋巴细胞积聚或白细胞积聚相关的疾病的用途。

10. 发明申请

US20100280096A1 TREATMENT OF INFLUENZA 失效
标题翻译：治疗流行性感冒
公开(公告)号：US20100280096A1
公开(公告)日：2010-11-04
申请号：US12666738
申请日：2008-07-02
申请人： Misako Nakazawa , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
发明人： Misako Nakazawa , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
IPC分类号： A61K31/7088 , C07H21/02 , C12N15/63 , C12Q1/70 , A61P31/16
CPC分类号： C12N15/1131 , C12N2310/14
摘要： The present invention provides a double-stranded RNA which inhibits replication of influenza B viruses by RNA interference, in which the double-stranded RNA comprises an RNA having 19 to 25 nucleotides homologous with a part of an mRNA transcribed from a genomic RNA of the influenza B viruses and an antisense RNA thereof.
摘要翻译：本发明提供了通过RNA干扰抑制乙型流感病毒复制的双链RNA，其中双链RNA包含与从流感基因组RNA转录的mRNA的一部分同源的具有19至25个核苷酸的RNA B病毒及其反义RNA。

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