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1. 发明授权

US5955627A Process for the preparation of cyclopropylacetylene derivatives 失效
标题翻译：环丙基乙炔衍生物的制备方法
公开(公告)号：US5955627A
公开(公告)日：1999-09-21
申请号：US989412
申请日：1997-12-12
申请人： Makoto Nakazawa , Toshimichi Mitani , Yoichi Satake , Shigeo Oozono , Goro Asanuma , Manzo Shiono
发明人： Makoto Nakazawa , Toshimichi Mitani , Yoichi Satake , Shigeo Oozono , Goro Asanuma , Manzo Shiono
IPC分类号： C07C1/26 , C07C13/04 , C07C17/00 , C07C22/00 , C07C51/353 , C07C51/363 , C07C67/307 , C07C67/343 , C07C51/377 , C07C67/317
CPC分类号： C07C67/307 , C07C1/26 , C07C13/04 , C07C17/00 , C07C22/00 , C07C51/353 , C07C51/363 , C07C67/343 , C07C2101/02 , Y02P20/55
摘要： According to the present invention, a process for the preparation of a cyclopropylacetylene derivative represented by the following formula (III): ##STR1## is provided, which comprises reacting a cyclopropylacrylic acid derivative represented by the following formula (I): ##STR2## with a halogenating agent to obtain a halogenocyclopropylpropionic acid derivative represented by the following formula (II): ##STR3## and reacting the halogenocyclopropylpropionic acid derivative with a base.
摘要翻译：根据本发明，提供了制备由下式（III）表示的环丙基乙炔衍生物的方法：包括使下式（I）表示的环丙基丙烯酸衍生物与卤化剂反应，得到由下式（II）表示的卤代环丙基丙酸衍生物：使卤代环丙基丙酸衍生物与碱反应。

2. 发明授权

US5600047A Process for producing optically active olefin 失效
标题翻译：光学活性烯烃的制造方法
公开(公告)号：US5600047A
公开(公告)日：1997-02-04
申请号：US459637
申请日：1995-06-02
申请人： Tadakatsu Mandai , Jiro Tsuji , Manzo Shiono
发明人： Tadakatsu Mandai , Jiro Tsuji , Manzo Shiono
IPC分类号： B01J31/24 , C07B31/00 , C07B53/00 , C07B61/00 , C07C1/213 , C07C13/47 , C07C68/06 , C07C69/96 , C07C401/00 , C07F7/18 , C07J3/00 , C07J9/00 , C07J51/00 , C07J75/00 , C07C1/20 , C07C1/32
CPC分类号： C07J9/00 , C07C401/00 , C07C69/96 , C07J51/00
摘要： A process for producing an optically active olefin represented by a formula ##STR1## wherein R.sup.1 represents an organic group and X represents a polycyclic carbon ring group, by reacting a corresponding optically active ester derivative represented by a formula ##STR2## wherein R.sup.1 and X are as defined above and R represents a hydrogen atom, an alkoxy group, an alkenyloxy group or a substituted or unsubstituted aralkyloxy group, with formic acid or a salt thereof in the presence of a catalyst comprising a palladium salt and a tertiary phosphine.Said process makes it possible to produce, at a high yield at a high selectivity, an optically active olefin which has a physiological activity and is useful as a medicine or is useful as an intermediate for the synthesis of physiologically active steroids. Further, said process uses no harmful reagent such as mercury or the like. Thus, it is advantageous as an industrial process.
摘要翻译：其中R 1表示有机基团，X表示多环碳环基团，其中R 1和X是相应的由下式表示的光学活性酯衍生物：其中R1和X为如上所述，R表示氢原子，烷氧基，烯氧基或取代或未取代的芳烷氧基，与甲酸或其盐在钯盐和叔膦的催化剂存在下反应。所述方法使得可以高选择性地产生具有生理活性的光学活性烯烃并且可用作药物或可用作合成生理活性类固醇的中间体。此外，所述方法不使用诸如汞等的有害试剂。因此，作为工业过程是有利的。

3. 发明授权

US07846903B2 Type II cubic liquid crystal composition 失效
标题翻译： II型立方液晶组成
公开(公告)号：US07846903B2
公开(公告)日：2010-12-07
申请号：US11665776
申请日：2005-10-19
申请人： Masakatsu Hato , Yoshiji Fujita , Toshitaka Ota , Masahisa Tanomura , Manzo Shiono
发明人： Masakatsu Hato , Yoshiji Fujita , Toshitaka Ota , Masahisa Tanomura , Manzo Shiono
IPC分类号： C09K19/06 , C07C9/22 , C07H15/04 , C07D307/62 , C07K17/04 , C07K17/10 , A61K31/70 , A61K31/341 , A61K31/185
CPC分类号： A61Q19/00 , A61K8/0295 , A61K8/345 , A61K8/375 , A61K8/66 , A61K31/575 , A61K38/00 , A61K47/69 , A61K2800/522 , A61Q19/02 , C07D307/62 , C09K19/02 , C09K19/04 , C09K19/54 , C12N9/0089 , C12N9/2462
摘要： A cubic liquid crystal composition comprising at least one amphiphilic compound having the following general formula (1) and having an IV/OV value of 0.65 to 0.95, and water or an aqueous medium: wherein R represents a hydrophilic group; X and Y each independently represent a hydrogen atom or together form an oxygen atom; n is an integer of 0 to 4; and m is an integer of 0 to 3.
摘要翻译：一种立方晶体组合物，其包含至少一种具有以下通式（1）的两亲化合物和IV / OV值为0.65至0.95的两亲化合物，以及水或水性介质：其中R表示亲水基团; X和Y各自独立地表示氢原子或一起形成氧原子; n为0〜4的整数。 m为0〜3的整数。

4. 发明授权

US6111111A Intermediates for producing pyridine derivatives 有权
标题翻译：制备吡啶衍生物的中间体
公开(公告)号：US6111111A
公开(公告)日：2000-08-29
申请号：US175958
申请日：1998-10-21
申请人： Hideki Matsuda , Goro Asanuma , Takanobu Shin , Manzo Shiono , Shigeki Kikuyama
发明人： Hideki Matsuda , Goro Asanuma , Takanobu Shin , Manzo Shiono , Shigeki Kikuyama
IPC分类号： C07D491/04 , C07D491/048 , C07D495/04
CPC分类号： C07D491/04
摘要： A pyridine alcohol derivative represented by General Formula III ##STR1## (where A represents a divalent organic group which may contain one to three oxygen atoms, nitrogen atoms and/or sulfur atoms, wherein A may form a 5-, 6-, 7-, or 8-membered ring together with two bonded carbon atoms, where said ring may form a condensed ring with one or more additional rings; R.sup.5 represents a hydrogen atom, --CHR.sup.1 R.sup.2, or an alkenyl group, an aryl group or an aralkyl group which may be substituted; R.sup.1 and R.sup.2 each independently represent a hydrogen atom or a hydrocarbon group which may be substituted; and R.sup.6 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group or an aralkyl group which may be substituted), is produced by:reacting a pyridine ester derivative represented by General Formula I-1 ##STR2## (where Z.sup.1 represents --COX; X represents an alkoxyl group, an alkenyloxy group, an aryloxy group or an aralkyloxy group which may be substituted; and A is the same as above)with a reducing agent, an alkylating agent, an alkenylating agent, an arylating agent or an aralkylating agent to obtain a pyridine carbonyl derivative represented by General Formula II ##STR3## (where A and R.sup.5 are the same as above); and reacting the resulting pyridine carbonyl derivative with a reducing agent, an alkylating agent, an alkenylating agent, an arylating agent or an aralkylating agent to obtain the pyridine alcohol derivative of the General Formula III.
摘要翻译：由通式III表示的吡啶醇衍生物（其中A表示可含有1-3个氧原子的二价有机基团，氮原子和/或硫原子，其中A可以形成5-，6-，7-或8- 其中所述环可以与一个或多个另外的环形成稠环; R 5表示氢原子，-CHR 1 R 2或链烯基，芳基或可被取代的芳烷基 ; R 1和R 2各自独立地表示氢原子或可以被取代的烃基; R 6表示氢原子，烷基，链烯基，芳基或可被取代的芳烷基）由：使由通式I-1表示的吡啶酯衍生物（其中Z1表示-COX; X表示烷氧基，烯氧基，芳氧基或可被取代的芳烷氧基），A与上述相同）用还原剂，烷基化剂，烯化剂，芳基化剂或芳烷基化剂，得到通式II所示的吡啶羰基衍生物（其中A和R5与上述相同）; 并使所得到的吡啶羰基衍生物与还原剂，烷化剂，烯化剂，芳基化剂或芳烷基化剂反应，得到通式Ⅲ的吡啶醇衍生物。

5. 发明授权

US06342606B2 Method for producing pyridine derivatives 有权
标题翻译：制备吡啶衍生物的方法
公开(公告)号：US06342606B2
公开(公告)日：2002-01-29
申请号：US09862615
申请日：2001-05-23
申请人： Hideki Matsuda , Goro Asanuma , Takanobu Shin , Manzo Shiono , Shigeki Kikuyama
发明人： Hideki Matsuda , Goro Asanuma , Takanobu Shin , Manzo Shiono , Shigeki Kikuyama
IPC分类号： C07D491048
CPC分类号： C07D491/04
摘要： A pyridine alcohol derivative represented by General Formula III (where A represents a divalent organic group which may contain one to three oxygen atoms, nitrogen atoms and/or sulfur atoms, wherein A may form a 5-, 6-, 7-, or 8-membered ring together with two bonded carbon atoms, where said ring may form a condensed ring with one or more additional rings; R6 represents a hydrogen atom, —CHR1R2, or an alkenyl group, an aryl group or an aralkyl group which may be substituted; R1 and R2 each independently represent a hydrogen atom or a hydrocarbon group which may be substituted; and R represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group or an aralkyl group which may be substituted), is produced by: reacting a pyridine ester derivative represented by General Formula I-1
摘要翻译：由通式III表示的吡啶醇衍生物（其中A表示可含有1-3个氧原子的二价有机基团，氮原子和/或硫原子，其中A可以形成5-，6-，7-或8- 其中所述环可以与一个或多个另外的环形成稠环; R 6表示氢原子，-CHR 1 R 2或链烯基，芳基或可被取代的芳烷基 ; R 1和R 2各自独立地表示氢原子或可被取代的烃基; R表示氢原子，烷基，烯基，芳基或可被取代的芳烷基）由：使由通式I-1表示的吡啶酯衍生物反应

6. 发明授权

US06222057B1 Process for the preparation of 2-chloro-5-chloromethyl-1,3-thiazole 失效
标题翻译：制备2-氯-5-氯甲基-1,3-噻唑的方法
公开(公告)号：US06222057B1
公开(公告)日：2001-04-24
申请号：US09545349
申请日：2000-04-07
申请人： Hideki Matsuda , Goro Asanuma , Manzo Shiono
发明人： Hideki Matsuda , Goro Asanuma , Manzo Shiono
IPC分类号： C07C33104
CPC分类号： C07D277/32
摘要： According to the present invention, provided are (1) a process for the preparation of 2-chloro-5-chloromethyl-1,3-thiazole, by reacting 3-chloro-1-isothiocyanato-1-propene with a chlorinating agent, (2) a process for the preparation of 3-chloro-1-isocyanato-1-propene, by rearranging 3-chloro-1-thiocyanato-2-propene in the presence of a salt of one or more than one metal selected from the group consisting of metals belonging to Group 2A, Group 7A, Group 8 and Group 1B of the long-form periodic table, and (3) a process for the preparation of 3-chloro-1-thiocyanato-2-propene, by reacting 1,3-dichloropropene and a thiocyanate salt (a) in the presence of water, (b) in the presence of an organic solvent which is water-soluble and has a boiling point of 150° C. or lower, or (c) in an organic solvent in the presence of a phase transfer catalyst.
摘要翻译：根据本发明，提供了（1）通过使3-氯-1-异硫氰酸酯-1-丙烯与氯化剂反应制备2-氯-5-氯甲基-1,3-噻唑的方法（ 2）制备3-氯-1-异氰酸基-1-丙烯的方法，通过在一种或多于一种选自下组的金属的存在下重排3-氯-1-氰硫基-2-丙烯：由属于2A型，7A类，8类和1B类长金属元素周期表的金属组成，和（3）通过使1,1-二氯苯甲酸反应制备3-氯-1-氰硫基-2-丙烯的方法，（a）在水存在下，（b）在水溶性且沸点为150℃或更低的有机溶剂存在下，或（c）在有机溶剂在相转移催化剂存在下进行。

7. 发明授权

US5334740A Cyclohexanetriol derivatives 失效
标题翻译：环己烷三醇衍生物
公开(公告)号：US5334740A
公开(公告)日：1994-08-02
申请号：US851943
申请日：1992-03-13
申请人： Takashi Takahashi , Manzo Shiono
发明人： Takashi Takahashi , Manzo Shiono
IPC分类号： C07C69/732 , C07C33/14 , C07C35/17 , C07C43/178 , C07C43/188 , C07C43/196 , C07C47/267 , C07C49/337 , C07C49/35 , C07C69/734 , C07C401/00 , C07D261/20 , C07D311/74 , C07D311/76 , C07D317/20 , C07D317/46 , C07D493/04 , C07D498/04 , C07F7/18 , C07D311/02 , C07D262/20 , C07C69/74
CPC分类号： C07D493/04 , C07D261/20 , C07D311/76 , C07D317/46 , C07F7/1856 , Y02P20/55
摘要： Cyclohexanetriol derivatives represented by the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different, and each denotes a hydrogen atom or a protecting group of a hydroxyl group,X denotes an oxygen atom, .dbd.CHCH.sub.2 OR.sup.4, .dbd.CHCHO or .dbd.CHCO.sub.2 R.sup.5, Y denotes a hydrogen atom and Z denotes --OR.sup.6, or Y and Z together form a single bond; or X and Z together form .dbd.NO--, .dbd.CHCH(OR.sup.7)O-- or .dbd.CHCO.sub.2 -- and Y is a hydrogen atom, R.sup.4 and R.sup.6 denote a hydrogen atom or a protecting group of a hydroxyl group respectively, R.sup.5 denotes a lower alkyl group, and R.sup.7 denotes a hydrogen atom or a lower alkyl group.Said derivatives are useful as synthetic intermediates of 1-hydroxyvitamin D derivatives.
摘要翻译：式中，R 1，R 2和R 3相同或不同，表示氢原子或羟基保护基，X表示氧原子，= CHCH 2 OR 4 = CHCHO或= CHCO 2 R 5表示的环己烷三醇衍生物，Y表示氢原子，Z表示-OR6，或Y和Z一起形成单键; 或X和Z一起形成= NO-，= CHCH（OR7）O-或= CHCO2-，Y为氢原子，R4和R6分别表示氢原子或羟基的保护基，R5表示低级烷基，R7表示氢原子或低级烷基。所述衍生物可用作1-羟基维生素D衍生物的合成中间体。

8. 发明授权

US5015746A 11.beta., 17.alpha.,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] 失效
标题翻译： 11β，17α，21-三羟基-1,4-孕二烯-3,20-二酮21 - [（E，E）-3,7,11-三甲基-2,6,10-十二碳三烯酸酯]
公开(公告)号：US5015746A
公开(公告)日：1991-05-14
申请号：US299681
申请日：1989-01-23
申请人： Yutaka Mizushima , Keiko Hoshi , Rie Igarashi , Hirofusa Ajioka , Noriyuki Yamamoto , Masahito Komuro , Koichi Kanehira , Masayuki Inoue , Takashi Nishida , Manzo Shiono , Michio Terasawa , Kenzo Arizono
发明人： Yutaka Mizushima , Keiko Hoshi , Rie Igarashi , Hirofusa Ajioka , Noriyuki Yamamoto , Masahito Komuro , Koichi Kanehira , Masayuki Inoue , Takashi Nishida , Manzo Shiono , Michio Terasawa , Kenzo Arizono
IPC分类号： C07J5/00
CPC分类号： C07J5/0053
摘要： 11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.

9. 发明授权

US4959393A Skin depigmental agent 失效
标题翻译：皮肤脱色素
公开(公告)号：US4959393A
公开(公告)日：1990-09-25
申请号：US343571
申请日：1989-04-27
申请人： Masahiro Torihara , Yoshin Tamai , Manzo Shiono , Kenji Tasaka
发明人： Masahiro Torihara , Yoshin Tamai , Manzo Shiono , Kenji Tasaka
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/34 , A61Q1/00 , A61Q1/02 , A61Q1/12 , A61Q19/00 , A61Q19/02
CPC分类号： A61K8/347 , A61Q1/02 , A61Q19/02
摘要： A skin depigmental agent characterized by comprising a resorcinol derivative having a linear alkyl group is provided.

10. 发明授权

US4523024A 3,4-Dihydro-2H-benzopyran derivatives, a method of producing them, a method of using them as stabilizers for organic materials, and organic compositions containing such stabilizers 失效
标题翻译： 3,4-二氢-2H-苯并吡喃衍生物，其制备方法，使用它们作为有机材料的稳定剂的方法，以及含有这些稳定剂的有机组合物
公开(公告)号：US4523024A
公开(公告)日：1985-06-11
申请号：US552068
申请日：1983-11-15
申请人： Manzo Shiono , Yoshiji Fujita , Takashi Nishida
发明人： Manzo Shiono , Yoshiji Fujita , Takashi Nishida
IPC分类号： C07D311/72 , C07D311/92 , C08K5/1545
CPC分类号： C08K5/1545 , C07D311/72 , C07D311/92
摘要： There is provided a class of novel 3,4-dihydro-2H-benzopyran derivatives which either have excellent inhibitory activity against unfavorable effects of heat, light and oxidative factors or are of use as precursors of compounds having such activity, and methods for producing these derivatives. Also provided are methods of using such 3,4-dihydro-2H-benzopyran derivatives as stabilizers for organic materials sensitive to heat, light or/and oxidative factors, and organic compositions containing such stabilizers.
摘要翻译：提供了一类新的3,4-二氢-2H-苯并吡喃衍生物，其具有优异的抑制热，光和氧化因子的不利影响的抑制活性，或者可用作具有这种活性的化合物的前体，以及制备这些活性的方法衍生品还提供了使用这种3,4-二氢-2H-苯并吡喃衍生物作为对热，光或/和氧化因子敏感的有机材料的稳定剂的方法和含有这种稳定剂的有机组合物。

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