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1. 发明申请

US20100280096A1 TREATMENT OF INFLUENZA 失效
标题翻译：治疗流行性感冒
公开(公告)号：US20100280096A1
公开(公告)日：2010-11-04
申请号：US12666738
申请日：2008-07-02
申请人： Misako Nakazawa , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
发明人： Misako Nakazawa , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
IPC分类号： A61K31/7088 , C07H21/02 , C12N15/63 , C12Q1/70 , A61P31/16
CPC分类号： C12N15/1131 , C12N2310/14
摘要： The present invention provides a double-stranded RNA which inhibits replication of influenza B viruses by RNA interference, in which the double-stranded RNA comprises an RNA having 19 to 25 nucleotides homologous with a part of an mRNA transcribed from a genomic RNA of the influenza B viruses and an antisense RNA thereof.
摘要翻译：本发明提供了通过RNA干扰抑制乙型流感病毒复制的双链RNA，其中双链RNA包含与从流感基因组RNA转录的mRNA的一部分同源的具有19至25个核苷酸的RNA B病毒及其反义RNA。

2. 发明申请

US20090004171A1 COMPOUND PROFILING METHOD 审中-公开
标题翻译：化合物分析方法
公开(公告)号：US20090004171A1
公开(公告)日：2009-01-01
申请号：US12101719
申请日：2008-04-11
申请人： Masato Miyake , Yoshiji Fujita
发明人： Masato Miyake , Yoshiji Fujita
IPC分类号： A61K38/44 , C12Q1/68 , C40B30/06 , A61P35/00 , C12M1/34
CPC分类号： G01N33/5026 , C12Q1/6886 , C12Q2600/178 , G01N33/5011 , G16B5/00
摘要： The present invention provides a method for deriving an upstream or downstream component of a component necessary for phenotypic alteration of a living organism, the method comprising the steps of: specifying a pathway of interest related to the phenotypic alteration and a reference pathway different from the pathway of interest, and specifying a stimulant of interest and a reference stimulant which respectively stimulate the pathway of interest and the reference pathway; giving the stimulant of interest to the living organism to identify a collection of components of interest necessary for the phenotypic alteration; giving the reference stimulant to the living organism to identify a collection of reference components necessary for the phenotypic alteration; calculating an intersection between the collections of the components of interest and the reference components; and calculating a differential collection by subtracting the intersection from the collection of components of interest.
摘要翻译：本发明提供了一种用于衍生生物体表型改变所必需的组分的上游或下游组分的方法，所述方法包括以下步骤：指定与所述表型改变相关的感兴趣途径和不同于所述途径的参考途径并且指定分别刺激感兴趣途径和参考途径的兴趣兴奋剂和参考刺激物; 给予活体有兴趣的兴奋剂，以确定表型改变所必需的组成部分的集合; 给生物体提供参考刺激物，以确定表型改变所必需的参考组分的集合; 计算感兴趣组件的集合和参考组件之间的交集; 以及通过从所述关注部件的收集中减去所述交叉点来计算差分收集。

3. 发明申请

US20120232128A1 TREATMENT OF INFLUENZA 失效
标题翻译：治疗流行性感冒
公开(公告)号：US20120232128A1
公开(公告)日：2012-09-13
申请号：US13470154
申请日：2012-05-11
申请人： Misako NAKAZAWA , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
发明人： Misako NAKAZAWA , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
IPC分类号： A61K31/713 , A61P31/16
CPC分类号： C12N15/1131 , C12N2310/14
摘要： The present invention provides a double-stranded RNA which inhibits replication of influenza B viruses by RNA interference, in which the double-stranded RNA comprises an RNA having 19 to 25 nucleotides homologous with a part of an mRNA transcribed from a genomic RNA of the influenza B viruses and an antisense RNA thereof.
摘要翻译：本发明提供了通过RNA干扰抑制乙型流感病毒复制的双链RNA，其中双链RNA包含与从流感基因组RNA转录的mRNA的一部分同源的具有19至25个核苷酸的RNA B病毒及其反义RNA。

4. 发明授权

US08198256B2 Treatment of influenza 失效
标题翻译：治疗流感
公开(公告)号：US08198256B2
公开(公告)日：2012-06-12
申请号：US12666738
申请日：2008-07-02
申请人： Misako Nakazawa , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
发明人： Misako Nakazawa , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
IPC分类号： C12N15/11 , C07H21/04
CPC分类号： C12N15/1131 , C12N2310/14
摘要： The present invention provides a double-stranded RNA which inhibits replication of influenza B viruses by RNA interference, in which the double-stranded RNA comprises an RNA having 19 to 25 nucleotides homologous with a part of an mRNA transcribed from a genomic RNA of the influenza B viruses and an antisense RNA thereof.
摘要翻译：本发明提供了通过RNA干扰抑制乙型流感病毒复制的双链RNA，其中双链RNA包含与从流感基因组RNA转录的mRNA的一部分同源的具有19至25个核苷酸的RNA B病毒及其反义RNA。

5. 发明申请

US20100210708A1 COMPOUND PROFILING METHOD 审中-公开
标题翻译：化合物分析方法
公开(公告)号：US20100210708A1
公开(公告)日：2010-08-19
申请号：US12595604
申请日：2008-04-07
申请人： Masato Miyake , Yoshiji Fujita
发明人： Masato Miyake , Yoshiji Fujita
IPC分类号： A61K31/7088 , C12Q1/02 , C12Q1/68 , C40B30/06
CPC分类号： G01N33/5026 , C12Q1/6886 , C12Q2600/178 , G01N33/5011 , G16B5/00
摘要： The present invention provides a method for deriving an upstream or downstream component of a component necessary for phenotypic alteration of a living organism, the method comprising the steps of: specifying a pathway of interest related to the phenotypic alteration and a reference pathway different from the pathway of interest, and specifying a stimulant of interest and a reference stimulant which respectively stimulate the pathway of interest and the reference pathway; giving the stimulant of interest to the living organism to identify a collection of components of interest necessary for the phenotypic alteration; giving the reference stimulant to the living organism to identify a collection of reference components necessary for the phenotypic alteration; calculating an intersection between the collections of the components of interest and the reference components; and calculating a differential collection by subtracting the intersection from the collection of components of interest.
摘要翻译：本发明提供了一种用于衍生生物体表型改变所必需的组分的上游或下游组分的方法，所述方法包括以下步骤：指定与所述表型改变相关的感兴趣途径和不同于所述途径的参考途径并且指定分别刺激感兴趣途径和参考途径的兴趣兴奋剂和参考刺激物; 给予活体有兴趣的兴奋剂，以确定表型改变所必需的组成部分的集合; 给生物体提供参考刺激物，以确定表型改变所必需的参考组分的集合; 计算感兴趣组件的集合和参考组件之间的交集; 以及通过从所述关注部件的收集中减去所述交叉点来计算差分收集。

6. 发明授权

US08710024B2 Treatment of influenza 失效
标题翻译：治疗流感
公开(公告)号：US08710024B2
公开(公告)日：2014-04-29
申请号：US13470154
申请日：2012-05-11
申请人： Misako Nakazawa , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
发明人： Misako Nakazawa , Shin-etsu Kadowaki , Yoshiji Fujita , Masato Miyake , Takanori Ueda , Tomohiro Yoshikawa
IPC分类号： C07H21/04 , C12N15/11
CPC分类号： C12N15/1131 , C12N2310/14
摘要： The present invention provides a double-stranded RNA which inhibits replication of influenza B viruses by RNA interference, in which the double-stranded RNA comprises an RNA having 19 to 25 nucleotides homologous with a part of an mRNA transcribed from a genomic RNA of the influenza B viruses and an antisense RNA thereof.
摘要翻译：本发明提供了通过RNA干扰抑制乙型流感病毒复制的双链RNA，其中双链RNA包含与从流感基因组RNA转录的mRNA的一部分同源的具有19至25个核苷酸的RNA B病毒及其反义RNA。

7. 发明申请

US20070174009A1 Methods and systems for analyzing a network of biological functions 审中-公开
标题翻译：分析生物功能网络的方法和系统
公开(公告)号：US20070174009A1
公开(公告)日：2007-07-26
申请号：US11262554
申请日：2005-10-28
申请人： Masato Miyake , Tomohiro Yoshikawa , Takanori Ueda , Jun Miyake
发明人： Masato Miyake , Tomohiro Yoshikawa , Takanori Ueda , Jun Miyake
IPC分类号： G06F19/00
CPC分类号： G16B5/00 , G16B20/00
摘要： The present invention provides a method and system for analyzing a network of biological functions, such as transcriptional factors, structural genes, cellular markers, cell surface markers, cell shapes, organelle shapes, cell mobility, enzyme activities, metabolite concentrations, and localization of cellular components, in a biological entity such as a cell. Particularly, an object of the present invention is to provide a system and method for presenting biological information in a global manner without modification where the cell is considered a complex system.
摘要翻译：本发明提供了用于分析转录因子，结构基因，细胞标志物，细胞表面标志物，细胞形状，细胞器形状，细胞迁移率，酶活性，代谢物浓度和细胞定位的生物学功能网络的方法和系统组分，在诸如细胞的生物实体中。特别地，本发明的目的是提供一种用于以全局方式呈现生物信息的系统和方法，而不改变该细胞被认为是复杂的系统。

8. 发明申请

US20060253258A1 Digital cell 失效
标题翻译：数字电池
公开(公告)号：US20060253258A1
公开(公告)日：2006-11-09
申请号：US10562469
申请日：2004-06-25
申请人： Masato Miyake
发明人： Masato Miyake
IPC分类号： G06F19/00 , C12Q1/00 , C12Q1/68
CPC分类号： G01N33/5005 , C12M41/48
摘要： It is intended to provide a method and system for carrying out data production with respect to the actual status of cells as a profile. It is also intended to provide a system and method for presenting time-lapse and/or real-time information of cell interior directly, or as it is, from the viewpoint of a complex system. It is further intended to provide a method of presenting a digital cell. Thus, there is provided a method of producing profile data relating to cell information, comprising the step (a) of arranging cells in an immobilized form on a support and the step (b) of monitoring over time biological factors on or inside the cells or an aggregate thereof, thereby producing profile data for the cells. Furthermore, there is provided a method of producing a digital cell, comprising procuring experimental data by the use of the above method.
摘要翻译：旨在提供一种用于执行关于作为简档的单元的实际状态的数据生成的方法和系统。本发明还旨在提供一种从复杂系统的观点直接或者原样呈现小区内部的延时和/或实时信息的系统和方法。还旨在提供呈现数字单元的方法。因此，提供了一种产生与细胞信息相关的分布数据的方法，其包括将固定化形式的细胞排列在支持体上的步骤（a）和步骤（b）其聚合，从而产生细胞的轮廓数据。此外，提供了一种制造数字单元的方法，包括通过使用上述方法获得实验数据。

9. 发明授权

US5627258A Binder for use in metal powder injection molding and debinding method by the use of the same 失效
标题翻译：用于金属粉末注射成型和脱粘方法的粘合剂通过使用相同
公开(公告)号：US5627258A
公开(公告)日：1997-05-06
申请号：US403199
申请日：1995-03-13
申请人： Takemori Takayama , Masato Miyake , Yoshitaka Ohyama , Katsuyoshi Saito , Hiroshi Ono
发明人： Takemori Takayama , Masato Miyake , Yoshitaka Ohyama , Katsuyoshi Saito , Hiroshi Ono
IPC分类号： B22F1/00 , B22F3/22 , C08K3/08 , C08K5/16 , C08G73/10 , C08K5/20 , C08K5/3477
CPC分类号： B22F3/225 , B22F1/0059 , B22F3/22 , C08K3/08 , C08K5/16 , B22F2001/0066 , B22F2998/00
摘要： By the use of a binder comprising (a) 40 to 70 wt % of a water-soluble amide material and/or water-soluble amine material and (b) 25 to 60 wt % of a polyamide resin component substantially composed of a polyamide resin material having 10 carbon atoms or more on average between amido groups, a molded article is produced by metal powder injection molding.From such a molded article, the water-soluble amide material and/or water-soluble amine material is eluted by a water-based solvent and then, the polyamide resin component is removed by heating.
摘要翻译：通过使用包含（a）40至70重量％的水溶性酰胺材料和/或水溶性胺材料的粘合剂和（b）25至60重量％的基本上由聚酰胺树脂组成的聚酰胺树脂组分在酰胺基之间平均具有10个或更多个碳原子的材料，通过金属粉末注射成型制备模塑制品。从这样的成型品中，通过水性溶剂洗脱水溶性酰胺物质和/或水溶性胺物质，然后通过加热除去聚酰胺树脂成分。

10. 发明授权

US07946592B2 Bearing seal 有权
标题翻译：轴承密封
公开(公告)号：US07946592B2
公开(公告)日：2011-05-24
申请号：US11666516
申请日：2005-11-01
申请人： Hiroshi Yamamoto , Jun Maruyama , Masato Miyake , Kazuhiro Hatake , Toru Matsuyama
发明人： Hiroshi Yamamoto , Jun Maruyama , Masato Miyake , Kazuhiro Hatake , Toru Matsuyama
IPC分类号： F16J15/32
CPC分类号： F16J15/3224
摘要： A bearing seal includes: a ring-shaped outer seal portion; a ring-shaped inner seal portion provided inside the outer seal portion; a connecting portion for connecting the inner seal portion and the outer seal portion; and a ring-shaped rigid portion provided at the connecting portion. The outer seal portion, the inner seal portion, and the connecting portion are integrally formed of the same material consisting of an elastic material. The inner seal portion has rigidity higher than that of the outer seal portion, and has a ring-shaped seal surface gradually approaching a ring center axis of the inner seal portion while extending from a ring-shaped base end side connected to the connecting portion toward a distal end side.The inner seal portion is formed in a tapered cylindrical shape having the ring-shaped seal surface on an inner peripheral surface thereof, and has a thickness which gradually decreases from the base end side toward the distal end side. The inner seal portion includes only one inner seal portion.
摘要翻译：轴承密封件包括：环形外密封部分; 设置在所述外密封部内的环状的内密封部; 用于连接内部密封部分和外部密封部分的连接部分; 以及设置在连接部分处的环形刚性部分。外密封部分，内密封部分和连接部分由与弹性材料相同的材料一体地形成。内密封部具有比外密封部高的刚性，并且从连接到连接部的环状基端侧延伸的环状密封面逐渐接近内密封部的环心轴线，远端侧。内密封部形成为在其内周面上具有环状密封面的锥形圆筒形状，并且具有从基端侧朝向前端侧逐渐减小的厚度。内密封部仅包括一个内密封部。

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