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1. 发明申请

US20080038824A1 Composition and Method for Elevating Gene Transfer Efficiency 审中-公开
标题翻译：提高基因转移效率的组成和方法
公开(公告)号：US20080038824A1
公开(公告)日：2008-02-14
申请号：US10587776
申请日：2005-01-27
申请人： Masato Miyake , Tomohiro Yoshikawa , Eiichiro Uchimura , Jun Miyake
发明人： Masato Miyake , Tomohiro Yoshikawa , Eiichiro Uchimura , Jun Miyake
IPC分类号： C12N15/00 , C07K14/00 , C07K16/00 , C07K16/28
CPC分类号： C12N15/87 , C07K16/2842
摘要： It is intended to provide a method whereby transfer efficiency can be improved under any conditions in the case of transferring (in particular, transfecting) a target substance that cannot easily be transferred into cells (for example, a DNA, a polypeptide, a sugar, a complex thereof or the like). Namely, a composition for elevating the transfer efficiency of a target substance into cells which contains a cell adhesion-related factor, and a device and a method using the composition.
摘要翻译：旨在提供一种方法，其可以在转移（特别是转染）不容易转移到细胞中的目标物质（例如DNA，多肽，糖，其复合物等）。即，将目标物质的转移效率提高为含有细胞粘附相关因子的细胞的组合物，以及使用该组合物的装置和方法。

2. 发明申请

US20100144038A1 Composition And Method For Increasing Efficiency Of Introduction Of Target Substance Into Cell 审中-公开
标题翻译：提高目标物质引入细胞效率的组合和方法
公开(公告)号：US20100144038A1
公开(公告)日：2010-06-10
申请号：US10594349
申请日：2004-03-03
申请人： Masato Miyake , Tomohiro Yoshikawa , Eiichiro Uchimura , Jun Miyake
发明人： Masato Miyake , Tomohiro Yoshikawa , Eiichiro Uchimura , Jun Miyake
IPC分类号： C12N15/09 , C07K14/00 , C12N5/06 , C07K14/78
CPC分类号： C12N15/87 , C07K14/78 , C12N15/111 , C12N2310/14 , C12N2310/53 , C12N2330/31
摘要： The present invention provides a method capable of improving the efficiency of introducing a target substance (e.g., DNA, polypeptides, sugars, or complexes thereof), which is difficult to introduce (particularly, transfect) into a cell in any circumstances. Particularly, the present invention provides a composition for increasing the efficiency of introducing a target substance into a cell, comprising (a) an actin acting substance. The present invention also provides a device and method using such a composition.
摘要翻译：本发明提供能够提高在任何情况下难以引入（特别是转染）细胞的目标物质（例如DNA，多肽，糖或其复合物）的引入效率的方法。特别地，本发明提供了用于提高将靶物质导入细胞的效率的组合物，其包含（a）肌动蛋白作用物质。本发明还提供了使用这种组合物的装置和方法。

3. 发明申请

US20070174009A1 Methods and systems for analyzing a network of biological functions 审中-公开
标题翻译：分析生物功能网络的方法和系统
公开(公告)号：US20070174009A1
公开(公告)日：2007-07-26
申请号：US11262554
申请日：2005-10-28
申请人： Masato Miyake , Tomohiro Yoshikawa , Takanori Ueda , Jun Miyake
发明人： Masato Miyake , Tomohiro Yoshikawa , Takanori Ueda , Jun Miyake
IPC分类号： G06F19/00
CPC分类号： G16B5/00 , G16B20/00
摘要： The present invention provides a method and system for analyzing a network of biological functions, such as transcriptional factors, structural genes, cellular markers, cell surface markers, cell shapes, organelle shapes, cell mobility, enzyme activities, metabolite concentrations, and localization of cellular components, in a biological entity such as a cell. Particularly, an object of the present invention is to provide a system and method for presenting biological information in a global manner without modification where the cell is considered a complex system.
摘要翻译：本发明提供了用于分析转录因子，结构基因，细胞标志物，细胞表面标志物，细胞形状，细胞器形状，细胞迁移率，酶活性，代谢物浓度和细胞定位的生物学功能网络的方法和系统组分，在诸如细胞的生物实体中。特别地，本发明的目的是提供一种用于以全局方式呈现生物信息的系统和方法，而不改变该细胞被认为是复杂的系统。

4. 发明申请

US20070054266A1 Chemical sensor system 审中-公开
标题翻译：化学传感器系统
公开(公告)号：US20070054266A1
公开(公告)日：2007-03-08
申请号：US10516210
申请日：2003-05-28
申请人： Takaaki Sato , Junzo Hirono , Hiroshi Hamana , Masato Miyake , Tomohiro Yoshikawa , Jun Miyake
发明人： Takaaki Sato , Junzo Hirono , Hiroshi Hamana , Masato Miyake , Tomohiro Yoshikawa , Jun Miyake
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N33/502 , G01N33/02 , G01N33/5008 , G01N33/5438
摘要： A chemical sensor utilizing a chemical receptor (for example, one stimulating the sense of taste or smell) is provided. More specifically speaking, such a receptor is introduced into cells and the cells are immobilized on a support to form a chip. This chip is then employed as a component of a sensor. This sensor shows a reaction almost the same as the body's perception of the taste or smell or sense, thereby enabling analysis. Thus, it is also usable as an artificial sensory organ. Moreover, this sensor is usable in diagnosis, which imparts a high industrial usefulness to it.
摘要翻译：提供了利用化学受体（例如刺激味觉或嗅觉的化学受体）的化学传感器。更具体地说，将这种受体引入细胞中，将细胞固定在载体上以形成芯片。然后将该芯片用作传感器的组件。该传感器显示与身体对味道或气味或感觉的感觉几乎相同的反应，从而能够进行分析。因此，它也可用作人造感觉器官。此外，该传感器可用于诊断，赋予其高的工业用途。

5. 发明申请

US20090012766A1 Event Sequencer 审中-公开
标题翻译：事件排序器
公开(公告)号：US20090012766A1
公开(公告)日：2009-01-08
申请号：US10587756
申请日：2005-01-27
申请人： Masato Miyake , Tomohiro Yoshikawa , Jun Miyake
发明人： Masato Miyake , Tomohiro Yoshikawa , Jun Miyake
IPC分类号： G06G7/58
CPC分类号： G16B25/00 , G16B40/00
摘要： There is provided a tool for effectively performing a meaningful analysis of a system state by using a specific index. A part having unusual behavior is extracted as an event timing from time-series data on an index derived from a system. An event descriptor describing the state of the system by using the event timing is generated. A method for generating the event descriptor associated with at least one system includes: a step (A) for acquiring time-series data on at least one index derived from at least one system; a step (B) for providing at least one peculiar behavior associated with the index; and a step (C) for extracting a part having the peculiar behavior as an event timing in the time-series data and generating an event descriptor described by the event timing.
摘要翻译：提供了一种用于通过使用特定索引来有效地执行对系统状态的有意义的分析的工具。从系统导出的索引的时间序列数据中提取具有异常行为的部分作为事件定时。生成描述使用事件定时的系统状态的事件描述符。一种用于生成与至少一个系统相关联的事件描述符的方法，包括：步骤（A），用于获取从至少一个系统导出的至少一个索引的时间序列数据; 用于提供与所述索引相关联的至少一个特有行为的步骤（B）; 以及步骤（C），用于将具有特殊行为的部分提取为时间序列数据中的事件定时，并生成由事件定时描述的事件描述符。

6. 发明授权

US07747390B2 Digital cell 失效
标题翻译：数字电池
公开(公告)号：US07747390B2
公开(公告)日：2010-06-29
申请号：US10562469
申请日：2004-06-25
申请人： Masato Miyake , Tomohiro Yoshikawa , Jun Miyake
发明人： Masato Miyake , Tomohiro Yoshikawa , Jun Miyake
IPC分类号： G06F19/00 , G06F15/00
CPC分类号： G01N33/5005 , C12M41/48
摘要： It is intended to provide a method and system for carrying out data production with respect to the actual status of cells as a profile. It is also intended to provide a system and method for presenting time-lapse and/or real-time information of cell interior directly, or as it is, from the viewpoint of a complex system. It is further intended to provide a method of presenting a digital cell. Thus, there is provided a method of producing profile data relating to cell information, comprising the step (a) of arranging cells in an immobilized form on a support and the step (b) of monitoring over time biological factors on or inside the cells or an aggregate thereof, thereby producing profile data for the cells. Furthermore, there is provided a method of producing a digital cell, comprising procuring experimental data by the use of the above method.
摘要翻译：旨在提供一种用于执行关于作为简档的单元的实际状态的数据生成的方法和系统。本发明还旨在提供一种从复杂系统的观点直接或者原样呈现小区内部的延时和/或实时信息的系统和方法。还旨在提供呈现数字单元的方法。因此，提供了一种产生与细胞信息有关的分布数据的方法，其包括将固定化形式的细胞排列在支持体上的步骤（a）和步骤（b）其聚合，从而产生细胞的轮廓数据。此外，提供了一种制造数字单元的方法，包括通过使用上述方法获得实验数据。

7. 发明申请

US20090055147A1 CELL NETWORK ANALYSIS SYSTEM 审中-公开
标题翻译：细胞网络分析系统
公开(公告)号：US20090055147A1
公开(公告)日：2009-02-26
申请号：US11630814
申请日：2005-06-24
申请人： Masato Miyake , Tomohiro Yoshikawa , Jun Miyake
发明人： Masato Miyake , Tomohiro Yoshikawa , Jun Miyake
IPC分类号： G06G7/48
CPC分类号： G01N33/5005 , G01N33/5008 , G16B25/00 , G16B50/00
摘要： A digital cell database and means for making network analysis using the database and actual data. A method for creating a database of digital cells and a device concerning the method are provided. A method for providing a service to reproduce an experiment according to a parameter to be analyzed on the basis of the results of an experiment on an actual cell using a digital cell by means of a computer system including a service requester and a service provider are also provided. The technique is solved by providing a support through which cells can be arranged in the same environment.
摘要翻译：数字单元数据库和使用数据库和实际数据进行网络分析的手段。提供了一种用于创建数字小区的数据库的方法和涉及该方法的设备。还提供一种根据使用数字小区的实际小区利用包括服务请求者和服务提供者的计算机系统在实验小区上的实验结果根据待分析参数再现实验的服务的方法，提供。该技术通过提供可以在相同环境中布置细胞的支撑物来解决。

8. 发明申请

US20070244568A1 Decellularized Tissue and Method of Preparing the Same 审中-公开
标题翻译：脱细胞组织及其制备方法
公开(公告)号：US20070244568A1
公开(公告)日：2007-10-18
申请号：US10584740
申请日：2004-12-24
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa , Shigemitau Iwai , Takeyoshi Ota , Jun Miyake , Masayuki Hara , Masakazu Furuta , Eiichiro Uchimura
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa , Shigemitau Iwai , Takeyoshi Ota , Jun Miyake , Masayuki Hara , Masakazu Furuta , Eiichiro Uchimura
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61L27/3604
摘要： Decellularization of tissue by means of an amphipathic solvent a well-established practice. However, situations exist where the provision of enhanced decellularization is preferred. There is a demand for treating methods for coping with such situations. Thus, it is intended to provide a method for enhancing decellularization. The method comprises not only the immersing of a tissue in a solution containing an amphiphilic molecule in non-micellar form (for example, 1,2-epoxide polymer) but also performing a radical reaction (for example, treatment selected from the group consisting of exposure to gamma-ray irradiation, ultraviolet irradiation, a free radical supply source, ultrasonication, electron beam irradiation, and X-ray irradiation).
摘要翻译：通过两性溶剂去除细胞组织，这是一个很好的做法。然而，存在提供增强脱细胞化优先的情况。需要处理这种情况的方法。因此，旨在提供一种增强脱细胞化的方法。该方法不仅包括将组织浸入含有非胶束形式的两亲分子（例如1,2-环氧化物聚合物）的溶液中，而且还进行自由基反应（例如，选自由暴露于γ射线照射，紫外线照射，自由基供应源，超声波处理，电子束照射和X射线照射）。

9. 发明申请

US20050256588A1 Decellularized tissue 审中-公开
标题翻译：脱细胞组织
公开(公告)号：US20050256588A1
公开(公告)日：2005-11-17
申请号：US10519814
申请日：2003-06-27
申请人： Yoshiki Sawa , Satoshi Taketani , Shigemitsu Iwai , Hikaru Matsuda , Masayuki Hara , Eiichiro Uchimura , Jun Miyake
发明人： Yoshiki Sawa , Satoshi Taketani , Shigemitsu Iwai , Hikaru Matsuda , Masayuki Hara , Eiichiro Uchimura , Jun Miyake
IPC分类号： A61K35/12 , A61L27/00 , A61L27/36 , A61L27/38 , C12N5/071 , A61F2/02
CPC分类号： C12N5/0697 , A61K35/12 , A61L27/3604 , A61L27/3683 , A61L27/3687 , A61L27/3695 , A61L27/3804 , A61L2430/40 , C12N5/0691
摘要： An objective of the present invention is to overcome a problem that there is an inverse relationship between the decellularization rate and the strength of tissue. This problem was solved by immersing tissue in a solution containing a non-micellar amphipathic molecule (e.g., a 1,2-epoxide polymer). Thus, the present invention provides decellularized tissue, in which the cell survival rate of the tissue is less than a level at which calcification or an immune reaction is elicited in an organism and the tissue damage rate of the tissue is suppressed to a level which permits clinical applications. Tissue prepared by the above-described treatment preferably retains a certain level of tissue strength. Further, the tissue of the present invention has an effect of performing cell replacement.
摘要翻译：本发明的目的是克服脱细胞率与组织强度之间存在反比关系的问题。通过将组织浸入含有非胶束两亲性分子（例如1,2-环氧化物聚合物）的溶液中来解决该问题。因此，本发明提供脱细胞组织，其中组织的细胞存活率小于在生物体中引起钙化或免疫反应的水平，并且组织的组织损伤率被抑制到允许临床应用。通过上述处理制备的组织优选保持一定水平的组织强度。此外，本发明的组织具有进行细胞置换的效果。

10. 发明申请

US20050106721A1 Immobilized cells and liposomes and method of immobilizing the same 失效
标题翻译：固定化细胞和脂质体及其固定方法
公开(公告)号：US20050106721A1
公开(公告)日：2005-05-19
申请号：US10506210
申请日：2003-02-28
申请人： Teruyuki Nagamune , Jun Miyake , Masato Miyake , Koichi Kato
发明人： Teruyuki Nagamune , Jun Miyake , Masato Miyake , Koichi Kato
IPC分类号： C12N5/00 , C12N11/02 , C12N11/06 , C12N11/08 , C12N5/02 , C12N5/06
CPC分类号： C12N11/06 , C12N5/0068 , C12N11/02 , C12N11/08 , C12N2533/20 , C12N2533/30
摘要： In an inexpensive and convenient method for immobilizing a suspension cell, a phospholipid vesicle or the like regardless of the type of cell, on the surface of a solid phase, a cell is immobilized by causing the cell to contact a support having a hydrophobic chain and a hydrophilic chain.
摘要翻译：在固定悬浮细胞，磷脂囊泡等的便宜且方便的方法中，无论细胞类型如何，在固相表面上，通过使细胞与具有疏水性链的载体和亲水链。

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