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1. 发明申请

US20100197561A1 Biomarkers for Ovarian Cancer: B2 Microglobulin 审中-公开
标题翻译：卵巢癌生物标志物：B2微球蛋白
公开(公告)号：US20100197561A1
公开(公告)日：2010-08-05
申请号：US11922621
申请日：2006-06-23
申请人： Eric Thomas Fung , Enrique Dalmasso , Valdimir Podust , Zheng Wang
发明人： Eric Thomas Fung , Enrique Dalmasso , Valdimir Podust , Zheng Wang
IPC分类号： A61K38/00 , C40B30/04 , C07K14/00 , C07K16/00 , C40B40/04 , G06N5/02
CPC分类号： G01N33/6851 , G01N33/57449 , G01N2333/70539 , G01N2500/04
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.
摘要翻译：本发明提供了可用于评估患者卵巢癌状态的基于蛋白质的生物标志物和生物标志物组合。特别地，本发明的生物标志物可用于将受试者样品分类为卵巢癌或非卵巢癌。生物标志物可以通过SELDI质谱检测。

2. 发明申请

US20080298740A1 Integrated Optical Waveguide Sensors With Reduced Signal Modulation 审中-公开
标题翻译：集成光波导传感器，具有减少的信号调制
公开(公告)号：US20080298740A1
公开(公告)日：2008-12-04
申请号：US11596824
申请日：2005-05-18
申请人： Louis Hlousek , Rino E. Kunz , Guy Voirin , Kaspar Cottier
发明人： Louis Hlousek , Rino E. Kunz , Guy Voirin , Kaspar Cottier
IPC分类号： G02B6/00
CPC分类号： G01N21/7743 , G01N2021/7776 , G02B2006/12107
摘要： The invention provides an integrated optical waveguide sensor module (200) with reduced signal modulation and increased sensitivity. An optical waveguide sensor module (200) comprises an optically transparent substrate (210) having a first and a second interface and an optical waveguide film (220) disposed on the substrate (210) with the first interface (225) therebetween, wherein the film (220) comprises at least one grating pad (235) that is optically coupled therewith. The substrate (210) and the optical waveguide film (220) are configured to reduce parasitic interference within the substrate.
摘要翻译：本发明提供了具有降低的信号调制和增加的灵敏度的集成光波导传感器模块（200）。光波导传感器模块（200）包括具有第一和第二界面的光学透明衬底（210）和设置在衬底（210）上的第一界面（225）的光波导膜（220），其中膜（220）包括与其光耦合的至少一个光栅焊盘（235）。衬底（210）和光波导膜（220）被配置为减小衬底内的寄生干扰。

3. 发明申请

US20080023630A1 POLYMER PROBE DOPED WITH CONDUCTIVE MATERIAL FOR MASS SPECTROMETRY 审中-公开
标题翻译：聚合物探针与导电材料进行质谱分析
公开(公告)号：US20080023630A1
公开(公告)日：2008-01-31
申请号：US11557286
申请日：2006-11-07
申请人： Egisto Boschetti , Lee O. Lomas
发明人： Egisto Boschetti , Lee O. Lomas
IPC分类号： H01J49/00
CPC分类号： H01J49/0418
摘要： A mass spectrometer probe is formed of a nonconductive polymer that is doped with conductive material. The probe may be used as, or as part of, a repeller plate in a parallel laser ion desorption/ionization time-of-flight mass spectrometer. Transparent locations on the probe enable a sample placed thereon to be visualized before or during mass spectrometry. The conductive nature of the probe maintains the consistency of the electromagnetic field applied to the sample. The probe also displays low outgassing and high mechanical and chemical stability, thereby enabling it to be used repetitively.
摘要翻译：质谱仪探针由掺杂有导电材料的非导电聚合物形成。探针可以用作平行激光离子解吸/电离飞行时间质谱仪中的或作为排斥板的一部分。在探针之前或期间，探针上的透明位置使其上放置的样品可视化。探头的导电性质保持了施加到样品的电磁场的一致性。该探头还显示出低的除气和高的机械和化学稳定性，从而使其能够重复使用。

4. 发明申请

US20070172902A1 Biomarker for ovarian cancer 审中-公开
标题翻译：卵巢癌生物标志物
公开(公告)号：US20070172902A1
公开(公告)日：2007-07-26
申请号：US11473280
申请日：2006-06-21
申请人： Zhen Zhang , Daniel Chan , Eric Fung , Zheng Wang , Fujun Zhang
发明人： Zhen Zhang , Daniel Chan , Eric Fung , Zheng Wang , Fujun Zhang
IPC分类号： G01N33/574 , G06F19/00
CPC分类号： G01N33/57449 , G01N2333/52
摘要： The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarker can be detected by SELDI mass spectrometry.
摘要翻译：本发明提供了一种可用于鉴定患者卵巢癌状态的基于蛋白质的生物标志物。特别地，本发明的生物标志物可用于将受试者样品分类为卵巢癌或非卵巢癌。可通过SELDI质谱法检测生物标志物。

5. 发明授权

US07129483B2 Laser desorption and ionization mass spectrometer with quantitative reproducibility 有权
标题翻译：激光解吸和电离质谱仪具有定量重现性
公开(公告)号：US07129483B2
公开(公告)日：2006-10-31
申请号：US11155302
申请日：2005-06-17
申请人： Michael G. Youngquist , Craig A. Keller
发明人： Michael G. Youngquist , Craig A. Keller
IPC分类号： B01D59/44 , H01J49/40 , H01J49/00
CPC分类号： H01J49/164
摘要： Laser desorption/ionization time-of-flight mass spectrometer (“LDI-TOF-MS”) devices, and methods, that accurately measure the mass of analytes contained in a sample and which also measure the quantities of analytes present in a sample in a consistent manner from instrument-to-instrument and over time on a single instrument. In particular, the invention provides LDI-TOF-MS devices and methods in which: 1) the energy of the laser pulse and the area of the sample illuminated (fluence) is consistent and controlled so as to produce consistent conditions for analyte desorption and ionization; 2) the mass analyzer behaves in a reproducible manner; and 3) the detection system produces a signal that consistently represents the arrival of ions of different masses.
摘要翻译：激光解吸/离子化飞行时间质谱仪（“LDI-TOF-MS”）装置和方法，可精确测量样品中所含分析物的质量，并测量样品中存在的分析物的量从仪器到仪器的一致方式，以及随着时间的推移在单个仪器上。特别地，本发明提供了LDI-TOF-MS装置和方法，其中：1）激光脉冲的能量和照射的样品的面积（注量）一致和控制，以便产生用于分析物解吸和电离的一致条件 ; 2）质量分析仪的行为方式是可重现的; 和3）检测系统产生一致地表示不同质量的离子的到达的信号。

6. 发明申请

US20060177870A1 Immunoassays 审中-公开
标题翻译：免疫测定
公开(公告)号：US20060177870A1
公开(公告)日：2006-08-10
申请号：US10555078
申请日：2004-04-16
申请人： Yip Tai-Tung , Eric Fung
发明人： Yip Tai-Tung , Eric Fung
IPC分类号： G01N33/53
CPC分类号： G01N33/6851 , G16B20/00 , G16B40/00
摘要： Methods for discriminating between related proteins and other analytes in a sample and for correlating protein expression with disease states.
摘要翻译：用于区分样品中相关蛋白质和其他分析物以及将蛋白质表达与疾病状态相关联的方法。

7. 发明申请

US20050112650A1 Reactive polyurethane-based polymers 审中-公开
标题翻译：反应性聚氨酯基聚合物
公开(公告)号：US20050112650A1
公开(公告)日：2005-05-26
申请号：US10965092
申请日：2004-10-14
申请人： Daniel Chang , Scot Weinberger
发明人： Daniel Chang , Scot Weinberger
IPC分类号： B01D20060101 , C08G18/08 , C08G18/28 , C08G18/32 , C08G18/38 , C08G18/64 , C08G18/67 , C12M1/34 , C12Q1/68 , G01N24/00 , G01N33/543 , G01N33/545
CPC分类号： C08G18/285 , C08G18/0814 , C08G18/0823 , C08G18/0828 , C08G18/2825 , C08G18/2845 , C08G18/3231 , C08G18/3872 , C08G18/6484 , C08G18/6755 , C08G2210/00 , G01N33/54353 , G01N33/545
摘要： Polyurethane polymers bearing multiple reactive groups are readily prepared from easily accessible precursors. The reactive groups of the polymers are then derivatized with binding functionalities for analytes, energy absorbing molecules for matrix assisted laser desorption/ionization mass spectrometry, fluorescent moieties and the like. The reactive groups can also be converted to different reactive groups having a desired avidity or specificity for a selected reaction partner. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.
摘要翻译：具有多个反应性基团的聚氨酯聚合物可以容易地从容易获得的前体制备。然后将聚合物的反应性基团用分析物的结合官能团，用于基质辅助激光解吸/电离质谱法的能量吸收分子，荧光部分等衍生化。反应性基团也可以转化为对所选反应配偶体具有所需亲合力或特异性的不同反应性基团。将聚合物并入用于分析，捕获，分离或纯化分析物的装置中。在一个示例性实施方案中，本发明提供涂覆有本发明的聚合物的基材，所述基材适于用作质谱仪的探针。

8. 发明授权

US06867414B2 Electric sector time-of-flight mass spectrometer with adjustable ion optical elements 失效
标题翻译：具有可调式离子光学元件的电扇飞行时间质谱仪
公开(公告)号：US06867414B2
公开(公告)日：2005-03-15
申请号：US10424351
申请日：2003-04-24
申请人： Sidney E. Buttrill, Jr.
发明人： Sidney E. Buttrill, Jr.
IPC分类号： H01J49/28 , H01J49/40
CPC分类号： H01J49/282 , H01J49/408
摘要： The invention provides apparatus and methods for performing time-of-flight (TOF) mass spectrometry. A TOF mass spectrometer of the present invention comprises one or more ion focusing electric sectors. At least one of the electric sectors is associated with an ion optical element. The ion optical elements comprise at least one adjustable electrode, such that the adjustable electrode is able to modify the potential experienced by an ion entering or exiting the electric sector with which it is associated.
摘要翻译：本发明提供了用于执行飞行时间（TOF）质谱的装置和方法。本发明的TOF质谱仪包括一个或多个离子聚焦电扇区。电扇区中的至少一个与离子光学元件相关联。离子光学元件包括至少一个可调电极，使得可调节电极能够改变进入或离开与其相关联的电扇区的离子所经历的电位。

9. 发明申请

US20050013733A1 Trace incorporation of fluorescent monomer facilitating quality control of polymerization reactions 审中-公开
标题翻译：微量掺入荧光单体促进聚合反应的质量控制
公开(公告)号：US20050013733A1
公开(公告)日：2005-01-20
申请号：US10850698
申请日：2004-05-21
申请人： Arkadi Krainev , Wenxi Huang , Charanjit Saini
发明人： Arkadi Krainev , Wenxi Huang , Charanjit Saini
IPC分类号： G01N20060101 , G01N21/64 , G01N21/76
CPC分类号： G01N33/542 , G01N33/545
摘要： The present invention provides a polymer that includes a trace amount of a luminescent moiety. The polymers have unique properties that make them ideally suited for use in diverse analyses, including desorption/ionization mass spectrometry of analytes. The invention also provides a device that incorporates the polymeric compositions of the inventions, methods of using the device to detect, quantify and identify analytes, and a method of preparing a device of the invention. The luminescent moiety provides a detectable tracer that allows for a rapid, simple quality control assay of devices that incorporate the polymer.
摘要翻译：本发明提供了包含微量发光部分的聚合物。聚合物具有独特的性质，使其非常适合用于多种分析，包括分析物的解吸/电离质谱分析。本发明还提供了结合本发明的聚合物组合物的装置，使用该装置检测，定量和鉴定分析物的方法以及制备本发明的装置的方法。发光部分提供可检测的示踪剂，其允许对掺入聚合物的装置进行快速，简单的质量控制测定。

10. 发明授权

US06841936B2 Fast recovery electron multiplier 失效
标题翻译：快速恢复电子倍增器
公开(公告)号：US06841936B2
公开(公告)日：2005-01-11
申请号：US10441939
申请日：2003-05-19
申请人： Craig A. Keller , Fiona L. Plows
发明人： Craig A. Keller , Fiona L. Plows
IPC分类号： H01J29/52 , H01J43/18 , H01J43/30
CPC分类号： H01J43/30 , H01J43/20
摘要： An improved electron multiplier bias network that limits the response of the multiplier when the multiplier is faced with very large input signals, but then permits the multiplier to recover quickly following the large input signal. In one aspect, this invention provides an electron multiplier, having a cathode that emits electrons in response to receiving a particle, wherein the particle is one of a charged particle, a neutral particle, or a photon; an ordered chain of dynodes wherein each dynode receives electrons from a preceding dynode and emits a larger number of electrons to be received by the next dynode in the chain, wherein the first dynode of the ordered chain of dynodes receives electrons emitted by the cathode; an anode that collects the electrons emitted by the last dynode of the ordered chain of dynodes; a biasing system that biases each dynode of the ordered chain of dynodes to a specific potential; a set of charge reservoirs, wherein each charge reservoir of the set of charge reservoirs is connected with one of the dynodes of the ordered chain of dynodes; and an isolating element placed between one of the dynodes and its corresponding charge reservoir, where the isolating element is configured to control the response of the electron multiplier when the multiplier receives a large input signal, so as to permit the multiplier to enter into and exit from saturation in a controlled and rapid manner.
摘要翻译：一个改进的电子倍增器偏置网络，当乘数面临非常大的输入信号时，限制乘法器的响应，但随后允许乘法器在大输入信号之后快速恢复。一方面，本发明提供一种电子倍增器，其具有响应于接收颗粒而发射电子的阴极，其中所述粒子是带电粒子，中性粒子或光子之一; 其中每个倍增电极接收来自前一个倍增电极的电子并且发射更多数量的电子，以被链中的下一个倍增电极接收，其中倍增极的有序链的第一倍增电极接收由阴极发射的电子; 收集由倍增极的有序链的最后一个倍增电极发射的电子的阳极; 偏置系统，其将倍增极的有序链的每个倍增极偏置到特定电位; 一组电荷储存器，其中该组电荷储存器中的每个电荷储存器与倍增极的有序链的一个倍增电极连接; 以及放置在其中一个倍增电极及其对应的电荷储存器之间的隔离元件，其中隔离元件被配置为当乘数接收到大的输入信号时控制电子倍增器的响应，从而允许乘法器进入和退出从受控和快速的饱和。

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