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1. 发明申请

US20080298740A1 Integrated Optical Waveguide Sensors With Reduced Signal Modulation 审中-公开
标题翻译：集成光波导传感器，具有减少的信号调制
公开(公告)号：US20080298740A1
公开(公告)日：2008-12-04
申请号：US11596824
申请日：2005-05-18
申请人： Louis Hlousek , Rino E. Kunz , Guy Voirin , Kaspar Cottier
发明人： Louis Hlousek , Rino E. Kunz , Guy Voirin , Kaspar Cottier
IPC分类号： G02B6/00
CPC分类号： G01N21/7743 , G01N2021/7776 , G02B2006/12107
摘要： The invention provides an integrated optical waveguide sensor module (200) with reduced signal modulation and increased sensitivity. An optical waveguide sensor module (200) comprises an optically transparent substrate (210) having a first and a second interface and an optical waveguide film (220) disposed on the substrate (210) with the first interface (225) therebetween, wherein the film (220) comprises at least one grating pad (235) that is optically coupled therewith. The substrate (210) and the optical waveguide film (220) are configured to reduce parasitic interference within the substrate.
摘要翻译：本发明提供了具有降低的信号调制和增加的灵敏度的集成光波导传感器模块（200）。光波导传感器模块（200）包括具有第一和第二界面的光学透明衬底（210）和设置在衬底（210）上的第一界面（225）的光波导膜（220），其中膜（220）包括与其光耦合的至少一个光栅焊盘（235）。衬底（210）和光波导膜（220）被配置为减小衬底内的寄生干扰。

2. 发明授权

US06492654B1 Scanning system with flexible drive assembly 失效
标题翻译：具有灵活驱动装置的扫描系统
公开(公告)号：US06492654B1
公开(公告)日：2002-12-10
申请号：US09782923
申请日：2001-02-13
申请人： Edward P. Donlon , Joseph R. Rimsa , Louis Hlousek
发明人： Edward P. Donlon , Joseph R. Rimsa , Louis Hlousek
IPC分类号： G01N2304
CPC分类号： G01N23/046 , A61B6/14 , G01N2223/419
摘要： A system is provided for scanning an object, the system comprising: a drive shaft having a proximal portion and a longitudinal axis; a motor including a motor shaft having a rotational axis, the motor serving to rotate the motor shaft about the rotational axis; a flexible joint coupling the drive shaft to the motor shaft by the proximal portion of the drive shaft, the flexible joint having a range of motion which allows the longitudinal axis of the drive shaft to move relative to the rotational axis of the motor shaft; and an object attached to the drive shaft which is movable along the longitudinal axis of the drive shaft in response to the drive shaft being rotated by the motor. This system may be used in a drum scanner system and may be used to read storage layer radiation screens.
摘要翻译：提供一种用于扫描物体的系统，该系统包括：具有近端部分和纵向轴线的驱动轴; 包括具有旋转轴线的马达轴的马达，所述马达用于使所述马达轴绕所述旋转轴线旋转; 柔性接头通过驱动轴的近侧部分将驱动轴连接到电动机轴，柔性接头具有允许驱动轴的纵向轴线相对于电动机轴的旋转轴线移动的运动范围; 以及附接到所述驱动轴的物体，所述物体响应于所述驱动轴由所述马达旋转而沿着所述驱动轴的纵向轴线移动。该系统可以用于鼓式扫描器系统中，并且可以用于读取存储层辐射屏幕。

3. 发明授权

US5043928A Resampling system using data interpolation to eliminate time effects 失效
标题翻译：使用数据插值重采样系统消除时间效应
公开(公告)号：US5043928A
公开(公告)日：1991-08-27
申请号：US367818
申请日：1989-06-19
申请人： Kirk C. Odencrantz , Louis Hlousek , Scot R. Weinberger
发明人： Kirk C. Odencrantz , Louis Hlousek , Scot R. Weinberger
IPC分类号： G01N30/60 , G01N30/74 , G01N30/86 , G06F17/00
CPC分类号： G01N30/8693 , G01N30/74 , Y10T436/11
摘要： Absorbance and wavelength data which is generated by a liquid chromatography apparatus is orthogonalized and resampled by a cubic splining technique in order to provide a smooth spectra curve showing absorbance versus wavelength, with the time factor eliminated. This has the advantage of eliminating from the data any changes in the sample over time. The method results in the orthogonalization with respect to time of the data. The invention is applicable to analysis of data other than liquid chromatography data. Higher or lower order curve fitting techniques may be used instead of the cubic splining analysis method.
摘要翻译：通过液相色谱仪产生的吸光度和波长数据被正交化并通过三次样条技术重新采样，以提供显示吸光度对波长的平滑光谱曲线，消除时间因子。这具有从数据中消除随时间变化的样本的优点。该方法导致数据相对于时间的正交化。本发明适用于液相色谱数据以外的数据分析。可以使用更高或更低阶的曲线拟合技术来代替三次样条分析方法。

4. 发明授权

US06198111B1 Scanning system with flexible drive assembly 失效
标题翻译：具有灵活驱动装置的扫描系统
公开(公告)号：US06198111B1
公开(公告)日：2001-03-06
申请号：US09172808
申请日：1998-10-14
申请人： Edward P. Donlon , Joseph R. Rimsa , Louis Hlousek
发明人： Edward P. Donlon , Joseph R. Rimsa , Louis Hlousek
IPC分类号： G01N2304
CPC分类号： G01N23/046 , A61B6/14 , G01N2223/419
摘要： A system is provided for scanning an object, the system comprising: a drive shaft having a proximal portion and a longitudinal axis; a motor including a motor shaft having a rotational axis, the motor serving to rotate the motor shaft about the rotational axis; a flexible joint coupling the drive shaft to the motor shaft by the proximal portion of the drive shaft, the flexible joint having a range of motion which allows the longitudinal axis of the drive shaft to move relative to the rotational axis of the motor shaft; and an object attached to the drive shaft which is movable along the longitudinal axis of the drive shaft in response to the drive shaft being rotated by the motor. This system may be used in a drum scanner system and may be used to read storage layer radiation screens.
摘要翻译：提供一种用于扫描物体的系统，该系统包括：具有近端部分和纵向轴线的驱动轴; 包括具有旋转轴线的马达轴的马达，所述马达用于使所述马达轴绕所述旋转轴线旋转; 柔性接头通过驱动轴的近侧部分将驱动轴连接到电动机轴，柔性接头具有允许驱动轴的纵向轴线相对于电动机轴的旋转轴线移动的运动范围; 以及附接到所述驱动轴的物体，所述物体响应于所述驱动轴由所述马达旋转而沿着所述驱动轴的纵向轴线移动。该系统可以用于鼓式扫描器系统中，并且可以用于读取存储层辐射屏幕。

5. 发明授权

US5053115A Automated neutral marker for capillary electrophoresis 失效
标题翻译：用于毛细管电泳的自动中性标记
公开(公告)号：US5053115A
公开(公告)日：1991-10-01
申请号：US470202
申请日：1990-01-25
申请人： Scot R. Weinberger , Louis Hlousek
发明人： Scot R. Weinberger , Louis Hlousek
IPC分类号： G01N27/447
CPC分类号： G01N27/44721 , G01N27/44704 , G01N27/44708
摘要： An electrophoresis instrument includes a capillary tube mounted in an air cooled cartridge. The cartridge also supports a spherical lens which is part of the optical detection apparatus. The cartridge rests in a manifold which includes the sample and buffer reservoirs. The temperature of the capillary tube is controlled by measuring the electrical resistance of the capillary tube during the electrophoresis process and then cooling or heating the cartridge by circulating temperature controlled air over the tube. The optical path associated with the instrument is a fiber optic bundle bifurcated close to dual detectors into a reference arm and a sample arm so as to provide similar reference and sample optical paths. The instrument may be used for temperature control for gradient electrophoresis and also, a neutral marker for determining electro-osmotic flow may be automatically detected.
摘要翻译：电泳仪包括安装在空气冷却筒中的毛细管。墨盒还支持作为光学检测装置的一部分的球面透镜。墨盒位于包含样品和缓冲液储存器的歧管中。通过在电泳过程中测量毛细管的电阻，然后通过将温度受控的空气循环通过管冷却或加热来控制毛细管的温度。与仪器相关联的光路是将近双重检测器分叉到参考臂和样品臂中的光纤束，以便提供相似的参考和样品光路。该仪器可用于梯度电泳的温度控制，并且可以自动检测用于确定电渗流的中性标记。

6. 发明授权

US5015069A Off axis rotation of diffraction grating 失效
$Off axis rotation of diffraction grating$
标题翻译：衍射光栅的离轴旋转
公开(公告)号：US5015069A
公开(公告)日：1991-05-14
申请号：US312537
申请日：1989-02-17
申请人： Raymond G. Bryan , Louis Hlousek
发明人： Raymond G. Bryan , Louis Hlousek
IPC分类号： G01J3/06 , G01J3/18 , G02B26/08
CPC分类号： G02B26/0808 , G01J3/06 , G01J2003/066 , G01J3/18
摘要： In a spectrophotometer application where high speed positioning is critical, a galvanometer in conjunction with a microprocessor controlled hybrid digital/analog servo system is used to rotate a diffraction grating for wavelength selection. A table containing digital position information for all wavelengths is accessed by the microprocessor to perform wavelength changes. The use of the table permits the determination of grating position to yield a desired wavelength for a system where the axis of rotation does not intersect a point on the surface of the diffraction grating. That is, the diffraction grating can be rotated about an axis coinciding with its center of gravity.
摘要翻译：在高速定位至关重要的分光光度计应用中，使用与微处理器控制的混合数字/模拟伺服系统结合的电流计旋转用于波长选择的衍射光栅。微处理器访问包含所有波长的数字位置信息的表以执行波长改变。使用该表格允许确定光栅位置以产生用于旋转轴线不与衍射光栅表面上的点相交的系统的期望波长。也就是说，衍射光栅可以围绕与其重心一致的轴线旋转。

7. 发明授权

US5488240A Apparatus and method for rotating an optical element using a moving coil in a constant magnetic field 失效
标题翻译：在恒定磁场中使用运动线圈旋转光学元件的装置和方法
公开(公告)号：US5488240A
公开(公告)日：1996-01-30
申请号：US172899
申请日：1993-12-27
申请人： Louis Hlousek , K. C. Odencrantz , Richard K. Oswald , Donald W. Dahlin , Saied Motaei , Paul W. Siggins , Kenny Wong , Ronald A. Smith , Philip M. Scheinert
发明人： Louis Hlousek , K. C. Odencrantz , Richard K. Oswald , Donald W. Dahlin , Saied Motaei , Paul W. Siggins , Kenny Wong , Ronald A. Smith , Philip M. Scheinert
IPC分类号： G01J3/18 , G02B7/00 , G02B7/182 , H01J31/50
CPC分类号： G02B7/1828 , G01J3/18 , G02B7/005
摘要： An apparatus and method for rotating an optical element, such as a diffraction grating or mirror, utilizes a moving coil actuator and an optical encoder to provide precise element position control. The moving coil actuator, which is coupled to the optical element, is comprised of a coil immersed in a magnetic field created by a pair of magnets. Current flowing in the coil windings causes the coil, and ultimately the optical element, to rotate. An optical encoder monitors the rotation of the element and provides rotation signals representative of the instantaneous element position to an actuator control circuit. The actuator control circuit phase shifts the rotation signals and compares the phase shifted rotation signals to a desired reference signal to generate position and velocity error signals. In a track follow mode, the position error signal is applied to the moving coil actuator via a loop compensator. When the apparatus is operating in an optimal seek mode, a trajectory generator receives the velocity error signals and generates an optimum velocity signal based on a preprogrammed velocity curve. The optimum velocity signal is then applied to the moving coil actuator via the loop compensator.
摘要翻译：用于旋转光学元件（例如衍射光栅或反射镜）的装置和方法利用移动线圈致动器和光学编码器来提供精确的元件位置控制。耦合到光学元件的移动线圈致动器包括浸入由一对磁体产生的磁场中的线圈。在线圈绕组中流动的电流使得线圈和最终的光学元件旋转。光学编码器监测元件的旋转并且向致动器控制电路提供表示瞬时元件位置的旋转信号。致动器控制电路使旋转信号相移，并将相移的旋转信号与期望的参考信号进行比较，以产生位置和速度误差信号。在跟踪跟踪模式中，位置误差信号通过环路补偿器施加到动圈线圈致动器。当装置以最佳搜索模式操作时，轨迹发生器接收速度误差信号，并且基于预编程的速度曲线产生最佳速度信号。然后通过环路补偿器将最佳速度信号施加到运动线圈致动器。

8. 发明授权

US5172117A Analog to digital conversion using an integrater and a sample and hold circuit 失效
标题翻译：使用积分器和采样保持电路进行模数转换
公开(公告)号：US5172117A
公开(公告)日：1992-12-15
申请号：US367830
申请日：1989-06-19
申请人： James L. Mills , Louis Hlousek
发明人： James L. Mills , Louis Hlousek
IPC分类号： H03M1/60
CPC分类号： H03M1/60
摘要： An analog to digital signal converter includes an integrator and a sample and hold circuit. Precisely repeatable timing signals for both the integrator and sample and hold circuit are provided by a microprocessor. The device provides low pass filtering without the phase lag normally associated with linear filters. The device allows one set of data to be acquired while the previous set of data is being digitized. The device is especially applicable to analysis of data generated by a spectrophotometer.
摘要翻译：模数转换器包括积分器和采样保持电路。积分器和采样保持电路的精确重复定时信号由微处理器提供。该器件提供低通滤波，无需通常与线性滤波器相关的相位滞后。该设备允许在前一组数据被数字化的同时获取一组数据。该装置特别适用于分光光度计产生的数据分析。

9. 发明授权

US4968122A Galvanometer gimbal mount 失效
标题翻译：电流计云台安装
公开(公告)号：US4968122A
公开(公告)日：1990-11-06
申请号：US313683
申请日：1989-02-21
申请人： Louis Hlousek , Raymond G. Bryan
发明人： Louis Hlousek , Raymond G. Bryan
IPC分类号： G01J3/06 , G02B7/00
CPC分类号： G01J3/06 , G02B7/00 , Y10S359/90
摘要： An improved mounting for a rotating diffraction grating assembly as used in a spectrophotometer directly connects the grating to the galvanometer that rotates the grating. The galvanometer is gimbally mounted on a plate so that its position, and that of the grating, can be adjusted so that the plane of dispersion of the grating passes through a desired point when the grating is rotated.
摘要翻译：在分光光度计中使用的旋转衍射光栅组件的改进的安装将光栅直接连接到旋转光栅的电流计。电流计平板地安装在板上，使得其位置和光栅的位置可以被调节，使得当光栅旋转时光栅的色散平面通过期望的点。

10. 发明授权

US07046357B2 Apparatus for microfluidic processing and reading of biochip arrays 失效
标题翻译：用于微流体处理和读取生物芯片阵列的装置
公开(公告)号：US07046357B2
公开(公告)日：2006-05-16
申请号：US10769293
申请日：2004-01-29
申请人： Scot R. Weinberger , Louis Hlousek
发明人： Scot R. Weinberger , Louis Hlousek
IPC分类号： G01N21/00 , G01N33/00
CPC分类号： G01N33/54366 , B01L3/502715 , B01L9/527 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , B01L2400/0605 , G01N21/553 , G01N27/44782 , G01N30/6095 , G01N33/54386 , Y10T436/24
摘要： A method and a device for detecting an analyte, including a substrate having a chemically selective surface; and a fluidic system disposed on the substrate, the manifold having at least one fluid path in communication with at least a discrete region of the surface, wherein the one fluid path and the discrete region together define a contained sample region on the surface. The fluidic system has a removable portion, wherein the removal of the removable portion of the fluidic system renders the discrete region directly interrogatable by a surface-based analytical tool.
摘要翻译：一种用于检测分析物的方法和装置，包括具有化学选择性表面的基底; 以及设置在所述基底上的流体系统，所述歧管具有与所述表面的至少一个离散区域连通的至少一个流体路径，其中所述一个流体路径和所述离散区域一起限定所述表面上包含的样品区域。流体系统具有可移除部分，其中流体系统的可移除部分的移除使离散的区域通过基于表面的分析工具可直接询问。

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