专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110195527A1 METHODS AND DEVICES FOR ANALYTE DETECTION 有权
标题翻译：用于分析检测的方法和装置
公开(公告)号：US20110195527A1
公开(公告)日：2011-08-11
申请号：US13092595
申请日：2011-04-22
申请人： Roger A. O'Neill , Marc Glazer , Tom W. Yang , Daniel J. Suich , Karl O. Voss
发明人： Roger A. O'Neill , Marc Glazer , Tom W. Yang , Daniel J. Suich , Karl O. Voss
IPC分类号： G01N33/545 , G01N33/543
CPC分类号： G01N33/54366 , B01L3/502715 , B01L3/50273 , B01L2200/0668 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N27/44726 , G01N27/44795 , G01N33/582
摘要： Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.
摘要翻译：提供了使用等电聚焦，凝胶电泳或其他分离方法来解决流体路径内的分析物的方法和装置。使用与这些分离装置相容的流体路径内的材料将分解的分析物附着到流体路径的壁上。附件来自可触发事件，如光活化，热激活或化学活化。根据本发明的另一方面，毛细管中的材料也可以通过可触发事件或随后的事件（例如熔化或光切割）而被破坏。因此，可以在流体路径内产生开放的内腔或多孔结构，允许从流体路径洗涤未结合的分析物质，以及要洗涤到流体路径中的检测剂。分离相容材料可以是可聚合单体，凝胶，缠结聚合物或其它材料。

2. 发明申请

US20060292649A1 Methods and apparatus for reference lab diagnostics 审中-公开
标题翻译：参考实验室诊断的方法和装置
公开(公告)号：US20060292649A1
公开(公告)日：2006-12-28
申请号：US11431343
申请日：2006-05-09
申请人： Linda Cahill , Roger O'Neill
发明人： Linda Cahill , Roger O'Neill
IPC分类号： G01N33/558
CPC分类号： G01N33/54366 , B01L3/502715 , B01L3/50273 , B01L2200/0668 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N27/44726 , G01N27/44795 , G01N33/558 , G01N33/582 , G01N33/6896 , G01N2800/2828 , Y02A50/57
摘要： Automated protein assay apparatus and methods suitable for use in a reference lab are described. A screening test for a pathogen or disease condition is performed at the reference lab. If the results of the screening test are positive, a definitive assay is performed. One or more analytes are resolved in a fluid path such as that of a capillary by isoelectric focusing. The resolved analytes are immobilized in the capillary by photoimmobilization. A typical analyte is a protein of a biological sample of a subject. Detection agents such as antibodies are flowed through the capillary which bind to or interact with the analytes, forming antibody-protein complexes. A chemiluminescent substrate is flowed through the capillary and detected with a photon detector. The detected locations of the analytes are recorded and the results sent to the referring physician. The assay is preferably performed by a computer-controlled, automated system exhibiting speed, precision and repeatability which are highly desirable for a reference lab diagnostic test.
摘要翻译：描述适用于参考实验室的自动蛋白质测定装置和方法。在参考实验室进行病原体或疾病状况的筛选试验。如果筛选试验的结果为阳性，则进行确定的测定。一个或多个分析物通过等电聚焦在诸如毛细管的流体路径中解析。通过光固化将解析的分析物固定在毛细管中。典型的分析物是受试者的生物样品的蛋白质。诸如抗体的检测剂流过毛细管，其结合或与分析物相互作用，形成抗体 - 蛋白质复合物。化学发光底物流过毛细管并用光子检测器检测。记录检测到的分析物的位置，并将结果发送给转诊医师。该测定优选通过显示速度，精度和重复性的计算机控制的自动化系统进行，这对于参考实验室诊断测试是非常需要的。

3. 发明申请

US20110132761A1 METHODS AND DEVICES FOR ANALYTE DETECTION 有权
标题翻译：用于分析检测的方法和装置
公开(公告)号：US20110132761A1
公开(公告)日：2011-06-09
申请号：US12950660
申请日：2010-11-19
申请人： Tom Weisan Yang , Arunashree Bhamidipati , Andrei V. Bordunov , James Eugene Knittle , Roger A. O'Neill , Karl O. Voss
发明人： Tom Weisan Yang , Arunashree Bhamidipati , Andrei V. Bordunov , James Eugene Knittle , Roger A. O'Neill , Karl O. Voss
IPC分类号： G01N27/447
CPC分类号： G01N33/54306 , B01L2200/0668 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N27/44743 , G01N27/44795 , G01N33/54366 , G01N33/582
摘要： Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.
摘要翻译：提供了在流体路径中检测一种或多种分析物（例如蛋白质）的方法。所述方法包括在诸如毛细管的流体路径中拆分，固定和检测一种或多种分析物。还包括用于进行这种测定的装置和试剂盒。

4. 发明授权

US07935489B2 Methods and devices for analyte detection 有权
公开(公告)号：US07935489B2
公开(公告)日：2011-05-03
申请号：US11185247
申请日：2005-07-19
申请人： Roger A. O'Neill , Marc Glazer , Tom Weisan Yang
发明人： Roger A. O'Neill , Marc Glazer , Tom Weisan Yang
IPC分类号： G01N33/50 , G01N33/53 , G01N33/536 , G01N33/543 , G01N21/00 , G01N21/63 , G01N21/64
CPC分类号： G01N33/582 , B01L3/502715 , B01L3/50273 , B01L2200/0668 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N27/44726 , G01N27/44795 , G01N33/54366
摘要： Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.

5. 发明授权

US07935308B2 Methods and devices for analyte detection 有权
标题翻译：用于分析物检测的方法和装置
公开(公告)号：US07935308B2
公开(公告)日：2011-05-03
申请号：US11981405
申请日：2007-10-30
申请人： Roger A. O'Neill , Marc Glazer , Tom Weisan Yang
发明人： Roger A. O'Neill , Marc Glazer , Tom Weisan Yang
IPC分类号： G01N33/50 , G01N33/53 , G01N33/536 , G01N33/543 , G01N21/00 , G01N21/63 , G01N21/64
CPC分类号： G01N33/582 , B01L3/502715 , B01L3/50273 , B01L2200/0668 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N27/44726 , G01N27/44795 , G01N33/54366
摘要： Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.
摘要翻译：提供了在流体路径中检测一种或多种分析物（例如蛋白质）的方法。所述方法包括在诸如毛细管的流体路径中分解，固定和检测一种或多种分析物。还包括用于进行这种测定的装置和试剂盒。

6. 发明授权

US07776818B2 Methods to treat T-cell disorders using TISF 有权
标题翻译：使用TISF治疗T细胞疾病的方法
公开(公告)号：US07776818B2
公开(公告)日：2010-08-17
申请号：US11529937
申请日：2006-09-29
申请人： Terry Raymond Beardsley
发明人： Terry Raymond Beardsley
IPC分类号： A01N37/18
CPC分类号： A61K38/1709 , A61K38/012
摘要： T4 Immune Stimulating Factor (TISF) selectively induces aberrant T-cells to initiate apoptosis. TISF and peptides that are related to TISF (TISF peptides) are therefore useful for the treatment of disorders characterized by aberrant production, development, or activity of T-cells or other cells of hematopoietic origin. This invention relates to methods of using TISF or a TISF peptide to treat such conditions, compositions containing TISF or a TISF peptide for use in such treatments, and use of TISF or a TISF peptide for the manufacture of pharmaceuticals.
摘要翻译： T4免疫刺激因子（TISF）选择性诱导异常T细胞引发细胞凋亡。因此，与TISF（TISF肽）相关的TISF和肽可用于治疗特征在于T细胞或造血起源的其他细胞的异常产生，发育或活性的疾病。本发明涉及使用TISF或TISF肽来治疗这些病症的方法，含有用于这种治疗的TISF或TISF肽的组合物，以及使用TISF或TISF肽来制造药物。

7. 发明申请

US20080267913A1 METHOD TO ENHANCE HEMATOPOIESIS 审中-公开
标题翻译：增强血压的方法
公开(公告)号：US20080267913A1
公开(公告)日：2008-10-30
申请号：US12126763
申请日：2008-05-23
申请人： Terry Raymond Beardsley , Anthony E. Maida
发明人： Terry Raymond Beardsley , Anthony E. Maida
IPC分类号： A61K38/20 , A61K38/17 , A61K39/395 , A61K39/09 , A61K39/02 , A61P7/00
CPC分类号： A61K38/217 , A61K38/1774 , A61K38/191 , A61K38/20
摘要： The present invention relates generally to the fields of immunology and molecular biology, and particularly to a method for treating hematopoietic disorders. The invention provides a method to treat a deficiency of one or more types of blood cells in a mammal, which includes administering an effective amount of TISF or of a compound that stimulates CD4+ cells like TISF does. In one embodiment, TISF that originates from a mammalian species is administered to a mammalian subject diagnosed as having a deficiency in one or more types of blood cells.
摘要翻译：本发明一般涉及免疫学和分子生物学领域，特别涉及一种治疗造血障碍的方法。本发明提供一种治疗哺乳动物中一种或多种类型血细胞缺乏症的方法，其包括施用有效量的TISF或刺激诸如TISF的CD 4 +细胞的化合物。在一个实施方案中，源自哺乳动物物种的TISF被施用于诊断为在一种或多种类型的血细胞中具有缺陷的哺乳动物受试者。

8. 发明申请

US20080124250A1 Capillary storage and dispensing container for automated micro-volume assay system 审中-公开
标题翻译：用于自动化微量体积测定系统的毛细管储存和分配容器
公开(公告)号：US20080124250A1
公开(公告)日：2008-05-29
申请号：US11893733
申请日：2007-08-17
申请人： Tom W. Yang , David J. Roach
发明人： Tom W. Yang , David J. Roach
IPC分类号： B01L3/00
CPC分类号： G01N35/1065 , G01N2035/1039 , G01N2035/1062
摘要： A polymeric injection-molded container is described which holds capillaries for a biological material assay system in a vertical position. The container includes a two-piece base which is press-fit together. Ninety-six funnel-shaped holes in the top of the base receive the capillaries and support them circumferentially. Ninety-six apertures in the bottom of the base are tapered to guide the bottom ends of the capillaries to positions aligned with the holes in the top of the base. The inserted capillaries extend above the top surface of the base and are covered by a removable cover. The capillaries can be processed and placed in the container by the capillary manufacturer, shipped to a user in the container, and the container can be placed on the capillary holder station of an automated assay system and used by the automated system directly from the container.
摘要翻译：描述了一种聚合物注塑容器，其容纳垂直位置的生物材料测定系统的毛细管。容器包括压配合在一起的两件式底座。底座顶部有九十六个漏斗形的孔容纳毛细管并沿周向支撑。基部底部的九十六个孔径是锥形的，以将毛细管的底端引导到与基座顶部的孔对准的位置。插入的毛细管在基座的顶表面上方延伸并被可移除的盖子覆盖。毛细管可以被毛细管制造商处理并放置在容器中，运送到容器中的使用者，并且容器可以放置在自动化测定系统的毛细管支架站上，并且由自动化系统直接从容器使用。

9. 发明授权

US07935479B2 Methods and devices for analyte detection 有权
标题翻译：用于分析物检测的方法和装置
公开(公告)号：US07935479B2
公开(公告)日：2011-05-03
申请号：US11725769
申请日：2007-03-19
申请人： Roger A. O'Neill , Marc Glazer , Tom W. Yang , Daniel J. Suich , Karl O. Voss
发明人： Roger A. O'Neill , Marc Glazer , Tom W. Yang , Daniel J. Suich , Karl O. Voss
IPC分类号： G01N33/50 , G01N33/53 , G01N33/536 , G01N33/543 , G01N21/00 , G01N21/63 , G01N21/64
CPC分类号： G01N33/54366 , B01L3/502715 , B01L3/50273 , B01L2200/0668 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N27/44726 , G01N27/44795 , G01N33/582
摘要： Methods for detecting one or more analytes, such as a protein, in a fluid path are described herein. In some embodiments a method includes resolving one or more analytes in a fluid path, such as, for example, a capillary. After the one or more analytes are resolved, the one or more analytes are bound to the fluid path upon activation of one or more triggerable agents disposed within the fluid path. The one or more analytes that are bound to the fluid path are detected within the fluid path.
摘要翻译：本文描述了用于检测流体路径中的一种或多种分析物（例如蛋白质）的方法。在一些实施方案中，一种方法包括在流体路径（例如毛细管）中分离一种或多种分析物。在一种或多种分析物被解析之后，一种或多种分析物在激活设置在流体路径内的一种或多种可触发剂时结合到流体路径上。在流体路径内检测结合流体路径的一种或多种分析物。

10. 发明申请

US20100144629A1 METHOD TO TREAT INFLAMMATION 有权
标题翻译：治疗炎症的方法
公开(公告)号：US20100144629A1
公开(公告)日：2010-06-10
申请号：US12527368
申请日：2008-02-13
申请人： Terry Raymond Beardsley
发明人： Terry Raymond Beardsley
IPC分类号： A61K38/18
CPC分类号： A61K38/18 , A61K8/91 , Y10S514/886
摘要： The present invention relates generally to the fields of pharmacology, and particularly to a method for treating inflammation, particularly inflammation of the respiratory system. The invention provides a method to reduce or ameliorate inflammation, by administering an effective amount of a protein factor originally isolated from thymic tissue, and referred to as T4 immune stimulating factor (TISF).
摘要翻译：本发明一般涉及药理学领域，特别涉及用于治疗炎症，特别是呼吸系统炎症的方法。本发明提供了通过施用有效量的最初从胸腺组织分离的蛋白因子（称为T4免疫刺激因子（TISF））来减轻或改善炎症的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式