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1. 发明授权

US09304133B2 Methods and devices for analyte detection 有权
标题翻译：用于分析物检测的方法和装置
公开(公告)号：US09304133B2
公开(公告)日：2016-04-05
申请号：US13092595
申请日：2011-04-22
申请人： Roger A. O'Neill , Marc Glazer , Tom W. Yang , Daniel J. Suich , Karl O. Voss
发明人： Roger A. O'Neill , Marc Glazer , Tom W. Yang , Daniel J. Suich , Karl O. Voss
IPC分类号： G01N33/50 , G01N33/543 , B01L3/00 , G01N27/447 , G01N33/58
CPC分类号： G01N33/54366 , B01L3/502715 , B01L3/50273 , B01L2200/0668 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N27/44726 , G01N27/44795 , G01N33/582
摘要： Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.
摘要翻译：提供了使用等电聚焦，凝胶电泳或其他分离方法来解决流体路径内的分析物的方法和装置。使用与这些分离装置相容的流体路径内的材料将分解的分析物附着到流体路径的壁上。附件来自可触发事件，如光活化，热激活或化学活化。根据本发明的另一方面，毛细管中的材料也可以通过可触发事件或随后的事件（例如熔化或光切割）而被破坏。因此，可以在流体路径内产生开放的内腔或多孔结构，允许从流体路径洗涤未结合的分析物质，以及要洗涤到流体路径中的检测剂。分离相容材料可以是可聚合单体，凝胶，缠结聚合物或其它材料。

2. 发明申请

US20110195527A1 METHODS AND DEVICES FOR ANALYTE DETECTION 有权
标题翻译：用于分析检测的方法和装置
公开(公告)号：US20110195527A1
公开(公告)日：2011-08-11
申请号：US13092595
申请日：2011-04-22
申请人： Roger A. O'Neill , Marc Glazer , Tom W. Yang , Daniel J. Suich , Karl O. Voss
发明人： Roger A. O'Neill , Marc Glazer , Tom W. Yang , Daniel J. Suich , Karl O. Voss
IPC分类号： G01N33/545 , G01N33/543
CPC分类号： G01N33/54366 , B01L3/502715 , B01L3/50273 , B01L2200/0668 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N27/44726 , G01N27/44795 , G01N33/582
摘要： Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.
摘要翻译：提供了使用等电聚焦，凝胶电泳或其他分离方法来解决流体路径内的分析物的方法和装置。使用与这些分离装置相容的流体路径内的材料将分解的分析物附着到流体路径的壁上。附件来自可触发事件，如光活化，热激活或化学活化。根据本发明的另一方面，毛细管中的材料也可以通过可触发事件或随后的事件（例如熔化或光切割）而被破坏。因此，可以在流体路径内产生开放的内腔或多孔结构，允许从流体路径洗涤未结合的分析物质，以及要洗涤到流体路径中的检测剂。分离相容材料可以是可聚合单体，凝胶，缠结聚合物或其它材料。

3. 发明授权

US07935479B2 Methods and devices for analyte detection 有权
标题翻译：用于分析物检测的方法和装置
公开(公告)号：US07935479B2
公开(公告)日：2011-05-03
申请号：US11725769
申请日：2007-03-19
申请人： Roger A. O'Neill , Marc Glazer , Tom W. Yang , Daniel J. Suich , Karl O. Voss
发明人： Roger A. O'Neill , Marc Glazer , Tom W. Yang , Daniel J. Suich , Karl O. Voss
IPC分类号： G01N33/50 , G01N33/53 , G01N33/536 , G01N33/543 , G01N21/00 , G01N21/63 , G01N21/64
CPC分类号： G01N33/54366 , B01L3/502715 , B01L3/50273 , B01L2200/0668 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , G01N27/44726 , G01N27/44795 , G01N33/582
摘要： Methods for detecting one or more analytes, such as a protein, in a fluid path are described herein. In some embodiments a method includes resolving one or more analytes in a fluid path, such as, for example, a capillary. After the one or more analytes are resolved, the one or more analytes are bound to the fluid path upon activation of one or more triggerable agents disposed within the fluid path. The one or more analytes that are bound to the fluid path are detected within the fluid path.
摘要翻译：本文描述了用于检测流体路径中的一种或多种分析物（例如蛋白质）的方法。在一些实施方案中，一种方法包括在流体路径（例如毛细管）中分离一种或多种分析物。在一种或多种分析物被解析之后，一种或多种分析物在激活设置在流体路径内的一种或多种可触发剂时结合到流体路径上。在流体路径内检测结合流体路径的一种或多种分析物。

4. 发明授权

US07704756B2 Fluorogenic dyes 失效
标题翻译：荧光染料
公开(公告)号：US07704756B2
公开(公告)日：2010-04-27
申请号：US11343886
申请日：2006-01-30
申请人： Daniel J. Suich , Ronald N. Zuckermann
发明人： Daniel J. Suich , Ronald N. Zuckermann
IPC分类号： G01N33/533 , C07D311/82 , C07D311/88
CPC分类号： C07D493/10 , C09B11/24 , C09B49/126 , Y10T436/173845 , Y10T436/182
摘要： Fluorogenic or chromogenic dyes are useful as reporter molecules for detecting cell entry by a specific molecule.
摘要翻译：荧光或显色染料可用作用于检测特定分子进入细胞的报道分子。

5. 发明授权

US07026166B2 Fluorogenic dyes 失效
公开(公告)号：US07026166B2
公开(公告)日：2006-04-11
申请号：US10349256
申请日：2003-01-21
申请人： Daniel J. Suich , Ronald N. Zuckermann
发明人： Daniel J. Suich , Ronald N. Zuckermann
IPC分类号： G01N21/76
CPC分类号： G01N33/5008 , C09B11/24 , C09B49/126 , G01N33/502 , G01N33/54373 , G01N33/582 , Y10S435/961 , Y10S436/80 , Y10T436/14 , Y10T436/173845 , Y10T436/174614 , Y10T436/18 , Y10T436/182 , Y10T436/196666 , Y10T436/201666
摘要： The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.

6. 发明授权

US07482018B2 Use of oligomers and polymers for drug solubilization, stabilization, and delivery 失效
标题翻译：低聚物和聚合物用于药物溶解，稳定和递送的应用
公开(公告)号：US07482018B2
公开(公告)日：2009-01-27
申请号：US10328898
申请日：2002-12-23
申请人： David S. Soane , Daniel J. Suich
发明人： David S. Soane , Daniel J. Suich
IPC分类号： A61K9/10 , C07K2/00 , C07K5/107
CPC分类号： B82Y5/00 , A61K9/1075 , A61K47/6907
摘要： The invention relates to the use of oligomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action. This invention further relates to processes for the preparation of such oligomers and polymers, and to compositions containing them. In some instances, surfactants, which can include an oligomer, polymer, small molecule, or other material, can be used to form a micelle for encapsulating the drug. The miscelle can be used to protect the drug until the drug is to be released.
摘要翻译：本发明涉及能够使不溶性药物溶解的低聚物和聚合物的使用，保护不稳定的药物以及促进将药物运送到其作用部位。本发明还涉及制备这种低聚物和聚合物的方法以及含有它们的组合物。在一些情况下，可以使用可包括低聚物，聚合物，小分子或其它材料的表面活性剂来形成用于包封药物的胶束。该药物可用于保护药物，直到药物释放。

7. 发明授权

US07897563B2 Use of oligomers and polymers for drug solubilization, stabilization, and delivery 有权
标题翻译：低聚物和聚合物用于药物溶解，稳定和递送的应用
公开(公告)号：US07897563B2
公开(公告)日：2011-03-01
申请号：US12337991
申请日：2008-12-18
申请人： David S. Soane , Daniel J. Suich
发明人： David S. Soane , Daniel J. Suich
IPC分类号： A61K38/02 , A61K47/30 , A61K47/36 , A61K47/42
CPC分类号： B82Y5/00 , A61K9/1075 , A61K47/6907
摘要： The invention relates to the use of oligomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action. This invention further relates to processes for the preparation of such oligomers and polymers, and to compositions containing them. In some instances, oligomers, polymers, and/or mixtures thereof can be used to protect a protein drug. Such structures can include at least one recognition element covalently attached to a hydrophilic element, wherein said recognition element or elements interact noncovalently with the protein drug to form a complex in which said protein drug is protected from degradation, recognition by the immune system, and/or renal excretion.
摘要翻译：本发明涉及能够使不溶性药物溶解的低聚物和聚合物的使用，保护不稳定的药物以及促进将药物运送到其作用部位。本发明还涉及制备这种低聚物和聚合物的方法以及含有它们的组合物。在一些情况下，可以使用低聚物，聚合物和/或其混合物来保护蛋白质药物。这种结构可以包括共价连接到亲水元件的至少一个识别元件，其中所述识别元件或元件与蛋白质药物非共价相互作用以形成复合物，其中所述蛋白质药物被保护免于降解，免疫系统的识别和/ 或肾脏排泄。

8. 发明授权

US08945361B2 Electrophoresis standards, methods and kits 有权
标题翻译：电泳标准，方法和试剂盒
公开(公告)号：US08945361B2
公开(公告)日：2015-02-03
申请号：US11524630
申请日：2006-09-20
申请人： Erik Gentalen , Daniel J. Suich
发明人： Erik Gentalen , Daniel J. Suich
IPC分类号： G01N27/447 , C07K1/13 , C07K1/26 , C07K1/28 , C07K7/06 , C07K7/08
CPC分类号： G01N27/44726 , C07K1/13 , C07K1/26 , C07K1/28 , C07K7/06 , C07K7/08 , G01N2550/00
摘要： Electrophoresis Compositions, methods and kits useful for, among other things, detecting, quantifying and/or characterizing analytes are provided. The compositions are useful as electrophoresis standards for determine the isoelectric point and molecular weight of an analyte. The electrophoresis standards generally comprise at least one label moiety and one or more reactive moieties that when activated attach the standard to a substrate.
摘要翻译：提供了用于检测，量化和/或表征分析物的组合物，方法和试剂盒。该组合物可用作用于测定分析物的等电点和分子量的电泳标准品。电泳标准品通常包含至少一个标记部分和一个或多个反应性部分，当活化时将标准物附着到基底上。

9. 发明申请

US20090156692A1 USE OF OLIGOMERS AND POLYMERS FOR DRUG SOLUBILIZATION, STABILIZATION, AND DELIVERY 有权
标题翻译：使用低聚物和聚合物进行药物溶解，稳定和分送
公开(公告)号：US20090156692A1
公开(公告)日：2009-06-18
申请号：US12337991
申请日：2008-12-18
申请人： David S. Soane , Daniel J. Suich
发明人： David S. Soane , Daniel J. Suich
IPC分类号： A61K47/42 , A61K47/36
CPC分类号： B82Y5/00 , A61K9/1075 , A61K47/6907
摘要： The invention relates to the use of oilgomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action. This invention further relates to processes for the preparation of such oilgomers and polymers, and to compositions containing them.
摘要翻译：本发明涉及能够使不溶性药物溶解，保护不稳定药物以及促进将药物运送到其作用部位的油性载体和聚合物的用途。本发明进一步涉及制备这种石油化合物和聚合物的方法，以及含有它们的组合物。

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