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1. 发明授权

US08304207B2 Method of measuring blood sample on blood test instrument using a disposable cartridge 有权
标题翻译：使用一次性药筒测量血液检测仪器上的血液样本的方法
公开(公告)号：US08304207B2
公开(公告)日：2012-11-06
申请号：US12910097
申请日：2010-10-22
申请人： Ingemar Berndtsson , Lars Svensson , Lennart Niklason
发明人： Ingemar Berndtsson , Lars Svensson , Lennart Niklason
IPC分类号： C12Q1/02
CPC分类号： G01N33/491 , B01L3/502 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L9/54 , B01L2200/027 , B01L2200/10 , B01L2300/0809 , B01L2300/0867 , B01L2400/0481 , B01L2400/0622 , B01L2400/065 , G01N1/38 , G01N33/4875
摘要： A blood test instrument using a disposable cartridge and a method of measuring a blood sample using the instrument are disclosed. The instrument includes a cell counting station for counting blood cells by electrical resistance measurement, a pressure actuating component adapted to apply a pressure alternately on two flexible receptacles of a disposable cartridge removably placed in the instrument to cause flowing of a mixture of a blood sample and a liquid agent between the two receptacles to obtain proper mixing, and a conduit adapted to deliver the mixture to the cell counting station for counting. After measuring the blood sample, the instrument withdraws a washing liquid contained in another receptacle of the disposable cartridge and uses the washing liquid to clean the instrument and to deliver the mixture back to the cartridge for disposal.
摘要翻译：公开了一种使用一次性药筒的血液检查仪器和使用该仪器测量血液样品的方法。该仪器包括用于通过电阻测量来计数血细胞的细胞计数站，压力致动部件，其适于在可拆卸地放置在仪器中的一次性药筒的两个柔性容器上交替施加压力，以引起血液样本和两个容器之间的液体试剂以获得适当的混合，以及适于将混合物输送到细胞计数站进行计数的导管。在测量血液样本之后，仪器将包含在一次性药筒的另一个容器中的洗涤液体取出并使用洗涤液清洁仪器并将混合物输送到药筒以进行处理。

2. 外观设计

USD645974S1 Hematology test cassette with prefilled reagents 有权
标题翻译：具有预充剂的血液学检测盒
公开(公告)号：USD645974S1
公开(公告)日：2011-09-27
申请号：US29391164
申请日：2011-05-04
申请人： Bjorn Roos , Lennart Niklasson
设计人： Bjorn Roos , Lennart Niklasson

3. 发明授权

US6098471A Diluting and measuring device for particle counting 失效
标题翻译：用于颗粒计数的稀释和测量装置
公开(公告)号：US6098471A
公开(公告)日：2000-08-08
申请号：US91345
申请日：1998-06-17
申请人： Ingemar Berndtsson , Tommy Andersson , Abraham Bottema
发明人： Ingemar Berndtsson , Tommy Andersson , Abraham Bottema
IPC分类号： G01N1/38 , G01N15/12 , G01N15/10
CPC分类号： G01N15/1209 , G01N1/38
摘要： A device for particle counting includes a metering device for metering a volume of a liquid sample containing particles and a cylinder for dosing a volume of a diluting liquid to a dilution chamber. The cylinder has first and second ends and a piston. A conduit connects a first end of the cylinder and the dilution chamber. The metering device introduces the liquid sample in the conduit and movement of the piston towards the first end displaces diluting liquid and sample to the dilution chamber which communicates with the second end of the cylinder and is preferably located therein, whereby movement of the piston towards the second end causes pressurizing of the dilution chamber to displace diluted sample from the dilution chamber through a particle counter. The piston has a piston rod extending through the first cylinder end, whereby movement of the piston towards the first end causes an increase in volume (V.sub.2) in the cylinder on the second piston side that is greater than the decrease in volume (V.sub.1) in the cylinder on the first piston side. The increase causes a lowered pressure on the second piston side that draws air into the dilution chamber.
摘要翻译： PCT No.PCT / SE97 / 01923 Sec。 371日期1998年6月17日第 102（e）日期1998年6月17日PCT 1997年11月17日PCT公布。第WO98 / 22797号公报日期1998年5月28日一种用于颗粒计数的装置包括用于计量一定体积的含有颗粒的液体样品的计量装置和用于将稀释液体积计量到稀释室的圆筒。气缸具有第一和第二端以及活塞。导管连接圆筒的第一端和稀释室。计量装置将液体样品引入管道中，活塞朝向第一端的移动将稀释液体和样品移动到与气缸的第二端连通并且优选位于其中的稀释室，由此活塞向着第二端引起稀释室的加压，以通过颗粒计数器从稀释室置换稀释的样品。活塞具有延伸穿过第一气缸端部的活塞杆，由此活塞朝向第一端的运动导致在第二活塞侧的气缸中的体积（V2）的增加大于体积（V1）的减小第一活塞侧的气缸。该增加导致第二活塞侧的压力降低，其将空气吸入稀释室。

4. 发明授权

US08012432B2 Disposable apparatus for use in blood testing 有权
标题翻译：用于血液检测的一次性装置
公开(公告)号：US08012432B2
公开(公告)日：2011-09-06
申请号：US11493697
申请日：2006-07-27
申请人： Ingemar Berndtsson
发明人： Ingemar Berndtsson
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , A61M39/223 , B01L2300/0645 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , G01N1/38 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A disposable apparatus for use in blood testing and being adapted for simultaneous dilution of a blood sample into two different dilution ratios, said apparatus including a block-shaped housing having integrated therein a first and a second receptacle, one of which as a first blood sample receiver being adapted to receive a blood sample; a first and a second container, each containing a defined volume of a diluting agent; a valve including a valve body having three valve body channels extending therethrough and being positionable in three distinct positions, one of which putting the receptacles in simultaneous communication with a respective one of the containers through pairs of the channels; and displacers for displacing the diluting agent and the diluted sample through said channels between said containers and said receptacles.
摘要翻译：一种用于血液测试并用于将血液样品同时稀释成两种不同稀释比率的一次性装置，所述装置包括块形壳体，其中集成有第一和第二容器，其中之一作为第一血液样品接收器适于接收血液样本; 第一和第二容器，每个容器含有限定体积的稀释剂; 阀门包括具有延伸穿过其中的三个阀体通道并且可定位在三个不同位置的阀体，其中一个通过成对的通道将容器与相应的一个容器同时连通; 以及用于使稀释剂和稀释样品通过所述容器和所述容器之间的所述通道移置的置换器。

5. 外观设计

USD639978S1 Hematology test cassette with prefilled reagents 有权
公开(公告)号：USD639978S1
公开(公告)日：2011-06-14
申请号：US29332999
申请日：2009-03-02
申请人： Björn Roos , Lennart Niklasson
设计人： Björn Roos , Lennart Niklasson

6. 发明授权

US07744819B2 Apparatus for filling a sample volume defining device 有权
标题翻译：用于填充样品体积限定装置的装置
公开(公告)号：US07744819B2
公开(公告)日：2010-06-29
申请号：US11399423
申请日：2006-04-07
申请人： Ingemar Berndtsson , Lennart Niklason
发明人： Ingemar Berndtsson , Lennart Niklason
IPC分类号： B01L3/00 , G01N1/18
CPC分类号： G01N1/38 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , B01L2400/0475 , B01L2400/0478 , B01L2400/065 , B01L2400/0688 , Y10T436/25375 , Y10T436/2575
摘要： An apparatus for filling a sample volume defining device for separating at least one small defined volume of a liquid sample from a relatively larger undefined volume of said sample, said device including a first body and a second body movable relative to each other, whereby said first body has at least one cavity in a surface thereof, said at least one cavity having said defined volume. One of said first or said second body has at least one inlet opening adapted to be placed in a drop of the liquid sample. A defined channel is provided between said first and second body, which channel has fluid connection with said at least one opening and at least beyond said at least one cavity whereby the dimensions of said channel being such that said channel and said at least one cavity is filled with said liquid sample.
摘要翻译：一种用于填充样品体积限定装置的设备，用于从相对较大的未定义体积的所述样品中分离出至少一个小的限定体积的液体样品，所述装置包括可相对于彼此移动的第一体和第二体，主体在其表面中具有至少一个空腔，所述至少一个空腔具有所述限定的体积。所述第一或所述第二主体中的一个具有适于放置在液体样品的液滴中的至少一个入口。限定的通道设置在所述第一和第二主体之间，该通道与所述至少一个开口具有流体连接，并且至少超过所述至少一个空腔，由此所述通道的尺寸使得所述通道和所述至少一个空腔是填充所述液体样品。

7. 发明授权

US07521256B2 Method and a device for defining a small volume of a liquid sample 有权
标题翻译：用于定义小体积液体样品的方法和装置
公开(公告)号：US07521256B2
公开(公告)日：2009-04-21
申请号：US10553866
申请日：2004-11-24
申请人： Ingemar Berndtsson
发明人： Ingemar Berndtsson
IPC分类号： G01N1/18
CPC分类号： B01L3/0293 , B01F5/0683 , B01F5/0689 , B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L2200/0605 , B01L2400/0644 , B01L2400/065 , G01N2035/1034 , Y10T436/118339 , Y10T436/25375 , Y10T436/2575
摘要： A method and a device for separating a small defined volume of a liquid sample from a relatively large undefined volume of the sample. In a surface of a first body (10) at least one cavity (12) having said small defined volume is provided. The relatively large volume of sample is applied onto the surface and into the cavity. A scraping edge (15) is moved relative to the surface and the cavity, thereby scraping a volume of the relatively large volume from the surface and leaving said small defined volume in the cavity.
摘要翻译：一种用于将较小限定体积的液体样品与相对大的未定义体积的样品分离的方法和装置。在第一主体（10）的表面中，提供具有所述小的限定体积的至少一个空腔（12）。将相对较大体积的样品施加到表面上并进入腔中。刮削边缘（15）相对于表面和空腔移动，从而刮擦相对较大体积的体积并从该表面留出所述小的限定体积。

8. 发明授权

US08459130B2 Analytical instrument providing corrected sample volume dependent parameter 失效
标题翻译：提供校正样品体积相关参数的分析仪器
公开(公告)号：US08459130B2
公开(公告)日：2013-06-11
申请号：US13223843
申请日：2011-09-01
申请人： Ingemar Berndtsson , Tommy Andersson
发明人： Ingemar Berndtsson , Tommy Andersson
IPC分类号： G01N1/00
CPC分类号： G01N1/38 , B01L3/5027 , B01L2200/0605 , B01L2200/148 , B01L2300/021 , B01L2300/0867 , B01L2400/0622 , B01L2400/0644 , G01N35/1016 , G01N2035/00851
摘要： The invention provides a device for extraction of a defined sample volume from a larger sample volume. The device includes a body having a reference surface and a measuring cavity extending from a part of the reference surface into the body, thereby forming at least one opening plane substantially uniform with the reference surface. An information carrier is applied to or distributed with the device, having direct or indirect volume information about defined volume established for the cavity. The invention also relates to a method for determining the volume of such a cavity, to a set of at least two such devices, to a method for dilution of at least two liquid samples by using at least two such devices, to an analytic instrument, to a method for operating such an instrument, to a system including the device and the instrument, and to a method for operating the system.
摘要翻译：本发明提供了一种用于从较大样品体积中提取定义的样品体积的装置。该装置包括具有参考表面的主体和从参考表面的一部分延伸到主体中的测量腔，从而形成与参考表面基本一致的至少一个开口平面。信息载体应用于或分布在该设备上，具有关于为空腔建立的限定体积的直接或间接体积信息。本发明还涉及一种用于将至少两个这样的装置的这种空腔的体积确定为通过使用至少两个这样的装置将至少两个液体样品稀释到分析仪器的方法，涉及一种用于操作这种仪器的方法，包括该装置和该仪器的系统，以及一种用于操作该系统的方法。

9. 发明授权

US08033186B2 Device for extraction of a partially defined sample volume from a larger volume 失效
标题翻译：用于从较大体积中提取定义的样品体积的装置
公开(公告)号：US08033186B2
公开(公告)日：2011-10-11
申请号：US12444394
申请日：2007-09-24
申请人： Ingemar Berndtsson , Tommy Andersson
发明人： Ingemar Berndtsson , Tommy Andersson
IPC分类号： G01N1/00
CPC分类号： G01N1/38 , B01L3/5027 , B01L2200/0605 , B01L2200/148 , B01L2300/021 , B01L2300/0867 , B01L2400/0622 , B01L2400/0644 , G01N35/1016 , G01N2035/00851
摘要： The invention provides a device for extraction of a defined sample volume from a larger sample volume. The device includes a body having a reference surface and a measuring cavity extending from a part of the reference surface into the body, thereby forming at least one opening plane substantially uniform with the reference surface, the body being adapted for reception of an excess sample volume at the cavity and elimination of sample above the reference surface to leave in the cavity a measured sample volume having the defined volume. An information carrier is applied to or arranged for distribution with the device, having direct or indirect volume information about the defined volume established for the cavity. The invention also relates to a method for determining the volume of such a cavity, to a set of at least two such devices, to a method for dilution of at least two liquid samples by the use of at least two such devices, to an analytic instrument, to a method for operating such an instrument, to a system including the device and the instrument, and to a method for operating the system.
摘要翻译：本发明提供了一种用于从较大样品体积中提取定义的样品体积的装置。该装置包括具有参考表面的主体和从参考表面的一部分延伸到主体中的测量腔，从而形成与参考表面基本一致的至少一个开口平面，该主体适于接收多余的样本体积在空腔中并且在参考表面上方去除样品以在腔中留下具有确定体积的测量样品体积。将信息载体应用于或布置成与装置一起分发，具有关于为空腔建立的限定体积的直接或间接体积信息。本发明还涉及一种用于将至少两种这样的装置的这种空腔的体积确定为通过使用至少两种这样的装置将至少两种液体样品稀释到分析物的方法的方法仪器，用于操作这种仪器的方法，涉及包括该装置和仪器的系统，以及一种用于操作该系统的方法。

10. 发明授权

US07608223B2 Blood testing apparatus 有权
标题翻译：血液检测仪器
公开(公告)号：US07608223B2
公开(公告)日：2009-10-27
申请号：US10533790
申请日：2003-11-19
申请人： Ingemar Berndtsson , Lars Svensson , Lennart Niklason
发明人： Ingemar Berndtsson , Lars Svensson , Lennart Niklason
IPC分类号： B01L3/00
CPC分类号： G01N33/491 , B01L3/502 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L9/54 , B01L2200/027 , B01L2200/10 , B01L2300/0809 , B01L2300/0867 , B01L2400/0481 , B01L2400/0622 , B01L2400/065 , G01N1/38 , G01N33/4875
摘要： A disposable apparatus for use in blood testing includes a housing (21) having integrated means (41) for receiving a blood sample, a plurality of receptacles (28-33) for diluent and diluted sample, and a plurality of channels (34-39). Depressions are formed in a surface (27) of the housing to form the receptacles (28-33) and the channels. A diaphragm (40) seals the receptacles and the channels relative to said surface (27). When a pressure variation is applied to a portion of the diaphragm sealing a receptacle, liquid is caused to be displaced to or from that receptacle.
摘要翻译：用于血液测试的一次性装置包括具有用于接收血液样本的集成装置（41）的壳体（21），用于稀释剂和稀释样品的多个容器（28-33）和多个通道（34-39 ）。凹陷形成在壳体的表面（27）中以形成插座（28-33）和通道。隔膜（40）相对于所述表面（27）密封容器和通道。当对膜片的一部分施加压力变化来密封容器时，液体被移动到或从该容器移位。

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