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1. 发明授权

US5426031A Extraction methods for preparing thromboplastin reagents 失效
标题翻译：制备凝血激酶试剂的提取方法
公开(公告)号：US5426031A
公开(公告)日：1995-06-20
申请号：US70875
申请日：1993-05-25
申请人： Pamela L. H. Hawkins , James R. Maynard
发明人： Pamela L. H. Hawkins , James R. Maynard
IPC分类号： A61K38/43 , A61K35/30 , A61K38/00 , A61P7/04 , C07K1/14 , C07K14/435 , C07K14/745 , C12P21/00 , C12Q1/56 , G01N33/86
CPC分类号： C07K14/745 , A61K38/00 , G01N2333/7454
摘要： The Prothrombin Time (PT) is used as a screening test for blood coagulation factor deficiencies and for monitoring oral anti-coagulant therapy using coumadin. Thromboplastin reagents activate the extrinsic pathway of coagulation and are the basis for the Prothrombin Time (PT) test. This invention describes the use of barium sulfate and chaotropic agents, and nonionic detergents, for the extraction of sensitive thromboplastin reagents from tissue. Extraction with sodium thiocyanate alone also greatly enhances thromboplastin sensitivity. This invention should be useful for all thromboplastins and will improve their sensitivity for all PT-based tests and specific assays.
摘要翻译：凝血酶原时间（PT）用作凝血因子缺乏症的筛选试验，并用于使用香豆素监测口服抗凝血剂治疗。凝血酶原激活凝血因子的外在途径，是凝血酶原时间（PT）检测的基础。本发明描述了硫酸钡和离液剂以及非离子型洗涤剂用于从组织中提取敏感的凝血激酶原试剂。单独使用硫氰酸钠的提取也大大增强凝血活酶敏感性。本发明对于所有的凝血活酶都应该是有用的，并且将提高它们对所有基于PT的试验和特异性测定的敏感性。

2. 发明授权

US5352963A Specimen processing and analyzing systems with variable zener-diode flyback stepper motor control 失效
标题翻译：具有可变齐纳二极管反激式步进电机控制的样品处理和分析系统
公开(公告)号：US5352963A
公开(公告)日：1994-10-04
申请号：US785553
申请日：1991-10-31
申请人： Steven A. Garand , Carl P. Daniel
发明人： Steven A. Garand , Carl P. Daniel
IPC分类号： H02P8/16 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , H02P8/00
CPC分类号： G01N35/1002 , G01N35/028 , G01N2021/1759 , G01N2035/00079 , G01N2035/00455 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G01N2035/0475 , G01N2201/0407 , G01N2201/0446 , G01N2201/08 , G01N2201/1283 , G01N35/025
摘要： An improved control system for a stepper motor coil includes a flyback circuit that dissipates coil energy slowly while the coil is energized and operated in the chopping mode, while dissipating coil energy rapidly when the coil is switched to its de-energized phase.
摘要翻译：用于步进电动机线圈的改进的控制系统包括回扫电路，其在线圈被通电并且以斩波模式操作时缓慢地消散线圈能量，同时当线圈切换到其断电阶段时迅速消散线圈能量。

3. 发明授权

US5308665A Impurity scavenger pillow 失效
标题翻译：杂质清道夫枕头
公开(公告)号：US5308665A
公开(公告)日：1994-05-03
申请号：US617310
申请日：1990-11-16
申请人： Paul Sadek , Jim Pyzybytek , James Westra
发明人： Paul Sadek , Jim Pyzybytek , James Westra
IPC分类号： B01D53/04 , B01D53/26 , B01J20/28 , B01D50/00
CPC分类号： B01J20/2805 , B01D53/0407 , B01D53/261 , B01J20/28052 , B01J20/28085 , B01D2253/116 , B01D2253/308 , B01D2257/80 , B01D2259/40088 , Y10S428/913 , Y10T428/1334 , Y10T428/1341 , Y10T428/1345 , Y10T428/1352 , Y10T428/23 , Y10T428/239 , Y10T428/2419 , Y10T428/24273
摘要： An impurity scavenger pillow or capsule and method for removing water or keeping water levels low in a solvent container with minimal particulate or chemical contamination, comprising a pillow consisting essentially of a porous bag containing a desiccant material, said pillow being formed through folding and sealing adjacent layers of the bag or comprising a capsule consisting essentially of a solid cylinder with the end or ends being a porous material.
摘要翻译：一种杂质清除剂枕头或胶囊以及用于清除水分或保持水分含量低的溶剂容器中的微量或化学污染物的方法，包括基本上由含有干燥剂材料的多孔袋组成的枕头，所述枕头通过折叠和密封相邻形成该袋子包括基本上由实心圆筒组成的胶囊，其末端或端部为多孔材料。

4. 发明授权

US5266462A Measurement of platelet activities 失效
标题翻译：测量血小板活性
公开(公告)号：US5266462A
公开(公告)日：1993-11-30
申请号：US892865
申请日：1992-06-03
申请人： Hendrik C. Hemker , Robert J. Wagenvoord
发明人： Hendrik C. Hemker , Robert J. Wagenvoord
IPC分类号： C12Q1/37 , C12Q1/56 , G01N33/50 , G01N33/86 , G01N33/92 , A01N37/10 , C12Q1/32
CPC分类号： G01N33/86 , C12Q1/56 , C12Q2337/12 , G01N2333/96444 , G01N2333/974 , G01N2405/04
摘要： Methods are provided for measuring the procoagulant activity of platelets in blood by means of a chromogenic assay which is specific for procoagulant phospholipids. These methods include the determination of the resting activity and/or excitability of platelets, which determines the threshold at which activating clotting factors (circulating in blood) are dangerous. Also methods are provided for screening drugs for their potential inhibitory effect on the activation of platelets.
摘要翻译：提供了用于通过对促凝血磷脂特异的显色测定来测量血液中血小板促凝血活性的方法。这些方法包括测定血小板的静息活动和/或兴奋性，其确定激活凝血因子（血液中循环）是危险的阈值。还提供了用于筛选药物对血小板活化的潜在抑制作用的方法。

5. 发明授权

US5270451A Extraction method for preparing thromboplastin reagents 失效
标题翻译：制备凝血激酶试剂的提取方法
公开(公告)号：US5270451A
公开(公告)日：1993-12-14
申请号：US926134
申请日：1992-08-06
申请人： Pamela L. H. Hawkins , James R. Maynard
发明人： Pamela L. H. Hawkins , James R. Maynard
IPC分类号： A61K38/00 , C07K14/745 , C07K3/02 , C07K3/74 , C07K13/00
CPC分类号： C07K14/745 , A61K38/00 , G01N2333/7454
摘要： The Prothrombin Time (PT) is used as a screening test for blood coagulation factor deficiencies and for monitoring oral anti-coagulant therapy using coumadin. Thromboplastin reagents activate the extrinsic pathway of coagulation and are the basis for the Prothrombin Time (PT) test. This invention describes the use of barium sulfate and chaotropic agents, and nonionic detergents, for the extraction of sensitive thromboplastin reagents from tissue. Extraction with sodium thiocyanate alone also greatly enhances thromboplastin sensitivity. This invention should be useful for all thromboplastins and will improve their sensitivity for all PT-based tests and specific assays.
摘要翻译：凝血酶原时间（PT）用作凝血因子缺乏症的筛选试验，并用于使用香豆素监测口服抗凝血剂治疗。凝血酶原激活凝血因子的外在途径，是凝血酶原时间（PT）检测的基础。本发明描述了硫酸钡和离液剂以及非离子型洗涤剂用于从组织中提取敏感的凝血激酶原试剂。单独使用硫氰酸钠的提取也大大增强凝血活酶敏感性。本发明对于所有的凝血活酶都应该是有用的，并且将提高它们对所有基于PT的试验和特异性测定的敏感性。

6. 发明授权

US5242806A Method for conducting the cytotoxicity assays on tumor cells 失效
标题翻译：对肿瘤细胞进行细胞毒性测定的方法
公开(公告)号：US5242806A
公开(公告)日：1993-09-07
申请号：US884604
申请日：1992-05-15
申请人： Yu P. Yen-Maguire , Tom Cox , Fred Lewis
发明人： Yu P. Yen-Maguire , Tom Cox , Fred Lewis
IPC分类号： C12M1/20 , G01N33/50
CPC分类号： C12M23/12 , C12M25/14 , C12M41/46 , G01N33/5011 , G01N2800/52 , Y10S435/81
摘要： A method and apparatus for assaying the sensitivity of biopsied tumor cells to chemotherapeutic agents using a predetermined amount of chemotherapeutic agent in an easily deliverable form is disclosed and claimed.
摘要翻译：公开和要求保护的方法和装置，用于使用预定量的化学治疗剂以易于递送的形式测定活检肿瘤细胞对化学治疗剂的敏感性。

7. 发明授权

US5091206A Process for producing magnetically responsive polymer particles and application thereof 失效
标题翻译：用于生产磁响应聚合物颗粒的方法及其应用
公开(公告)号：US5091206A
公开(公告)日：1992-02-25
申请号：US337511
申请日：1989-05-30
申请人： Chao-Huei Wang , Dinesh O. Shah
发明人： Chao-Huei Wang , Dinesh O. Shah
IPC分类号： A61M1/36 , B01J8/00 , B01J20/28 , B03C1/01 , C08F257/02 , C08F285/00 , C12Q1/68 , G01N33/543 , G01N33/58 , H01F1/11
CPC分类号： B01J20/28004 , A61M1/3618 , B01J20/28009 , B01J20/28016 , B01J8/008 , B03C1/01 , C08F257/02 , C08F285/00 , C12Q1/6816 , C12Q1/6834 , G01N33/54326 , G01N33/5434 , G01N33/582 , G01N33/585 , H01F1/111 , G01N2446/10 , G01N2446/40 , G01N2446/84 , G01N2446/86
摘要： This invention provides a novel process of producing magnetically responsive polymer particles comprising polymeric core particles coated evenly with a layer of polymer containing magnetically responsive metal oxide. A wide variety of polymeric particles with sizes ranging from 1 to 100 microns can be used a core particles and transformed into magnetically responsive polymer particles. The surface of these magnetically responsive polymer particles can be coated further with another layer of functionalized polymer. These magnetically responsive polymer particles can be used for passive or covalent coupling of biological material such as antigens, antibodies, enzymes of DNA/RNA hybridization and used as solid phase for various types of immunoassays, DNA/RNA hybridization probes assays, affinity purification, cell separation and other medical, diagnostic, and industrial applications.
摘要翻译：本发明提供一种制备磁响应聚合物颗粒的新方法，其包括均匀地涂覆含有磁响应金属氧化物的聚合物层的聚合物芯颗粒。尺寸范围为1至100微米的多种聚合物颗粒可用于核心颗粒并转化为磁响应聚合物颗粒。这些磁响应聚合物颗粒的表面可以进一步被另一层官能化聚合物涂覆。这些磁响应聚合物颗粒可用于生物材料如抗原，抗体，DNA / RNA杂交的酶的被动或共价偶联，并用作各种类型的免疫测定的固相，DNA / RNA杂交探针测定，亲和纯化，细胞分离等医疗，诊断和工业应用。

8. 外观设计

USD321940S Sample cup for analyzer 失效
公开(公告)号：USD321940S
公开(公告)日：1991-11-26
申请号：US383136
申请日：1989-07-20
申请人： Michael D'Aquino , Manjeshwar S. Rao , Howard J. Kirchick
设计人： Michael D'Aquino , Manjeshwar S. Rao , Howard J. Kirchick

9. 发明授权

US5372784A Measurement of bacterial CO.sub.2 production in an isolated fluorophore by monitoring an absorbance regulated change of fluorescence 失效
标题翻译：通过监测荧光的吸光度调节变化来测量分离的荧光团中的细菌CO 2产生
公开(公告)号：US5372784A
公开(公告)日：1994-12-13
申请号：US212674
申请日：1994-03-11
申请人： Roger J. Morris , Shoshana Bascomb , Carolyn S. Olson , Jamie Bobolis , David Sherman
发明人： Roger J. Morris , Shoshana Bascomb , Carolyn S. Olson , Jamie Bobolis , David Sherman
IPC分类号： C12M1/34 , C12Q1/06 , G01N21/17 , G01N21/27 , G01N21/53 , G01N21/78 , G01N21/80 , G01N21/76
CPC分类号： G01N21/80 , C12Q1/06 , G01N21/17 , G01N21/272 , G01N21/78 , G01N21/534 , G01N2201/122 , Y10S435/808
摘要： A multi-layer blood culture sensor includes two matrices. The first matrix is a polymer that is permeable to carbon dioxide and water, but impermeable to protons. A pH sensitive absorbance based dye is encapsulated or isolated in the polymer. The second matrix is a polymer with a pH insensitive fluorescent dye encapsulated or isolated in the polymer. The matrices are spectrally coupled and are useful for the determination of microorganisms in a blood culture bottle.
摘要翻译：多层血培养传感器包括两个基质。第一种基质是可以渗透二氧化碳和水的聚合物，但对质子是不可渗透的。基于pH敏感的吸光度的染料被包封或分离在聚合物中。第二种基质是在聚合物中包封或分离的具有pH不敏感的荧光染料的聚合物。这些基质是光谱偶联的，并且可用于测定血液培养瓶中的微生物。

10. 发明授权

US5350564A Automated chemical analyzer with apparatus and method for conveying and temporary storage of sample tubes 失效
标题翻译：自动化学分析仪，用于输送和临时储存样品管的设备和方法
公开(公告)号：US5350564A
公开(公告)日：1994-09-27
申请号：US83733
申请日：1993-06-28
申请人： John C. Mazza , William A. Stark , Richard A. Scribner , Stephen L. Frye , Kempton H. Hardiman
发明人： John C. Mazza , William A. Stark , Richard A. Scribner , Stephen L. Frye , Kempton H. Hardiman
IPC分类号： B01L3/00 , B01L9/06 , B65G47/34 , G01N35/00 , G01N35/04 , G01N1/14
CPC分类号： B01L3/50855 , B01L9/06 , G01N35/04 , G01N2035/00752 , G01N2035/0406
摘要： An automated chemical analyzer includes an automated conveyor apparatus for receiving a variety of sizes of test tubes, cuvettes, and sample tubes in a standard carrier member receivable into the analyzer. The standard carrier members may be interlocked in ranks and placed side by side in file to replicate the size and handling convenience of conventional test tube racks. However, the conveyor apparatus also provides for receipt of the carriers either as individuals for stat handling, or in interlocked ranks, or as rank and file groups for routine handling. The interlocked ranks of carriers are automatically unlocked from one another and fed along with the carriers having stat samples therein to a recirculating endless loop conveyor device which conveys the samples to at least one chemical analysis module, as well as providing a storage capacity both for samples in testing, and those samples awaiting verification of test results. Carriers with samples on which testing is completed and verified are discharged from the endless loop conveyor device into an off-loading facility which again interlocks the carriers and presents them in rank and file groups for subsequent handling like conventional test tube racks.
摘要翻译：一种自动化学分析仪包括用于在可接收到分析器中的标准载体构件中接纳各种尺寸的试管，比色杯和样品管的自动输送装置。标准载体构件可以排列成并排放置，以复制常规试管架的尺寸和操作方便性。然而，传送装置还提供作为用于统计处理的个人或联锁队列的个体或作为用于日常处理的排名和文件组的承运人的接收。互锁的载体列彼此自动地解锁并与其中具有统计样本的载体一起馈送到循环无端环路传送装置，其将样品传送到至少一个化学分析模块，以及为样品提供存储容量在测试中，以及那些样品等待验证测试结果。具有完成和验证测试的样品的载体从无端环输送装置排放到卸载设备中，该卸载设备再次使载体互锁，并将其呈现在等级和文件组中，用于随后的处理，如常规试管架。

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