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1. 发明申请

US20120245367A1 Process for Producing Ester of Carboxylic Acid from Cellulosic Biomass 有权
标题翻译：从纤维素生物质生产羧酸酯的方法
公开(公告)号：US20120245367A1
公开(公告)日：2012-09-27
申请号：US13497286
申请日：2009-09-22
申请人： Zuolin Zhu , Meg M. Sun , Chungao Su , Hongping Ye
发明人： Zuolin Zhu , Meg M. Sun , Chungao Su , Hongping Ye
IPC分类号： C07C67/08
CPC分类号： C07C67/00 , C07C69/24 , C07C69/34 , C07C69/675 , C07C69/42 , C07C69/44
摘要： The invention discloses a technology for producing ester of carboxylic acid using cellulosic biomass as starting material. This technology comprises the following key steps: converting all of the organic polymers, including such high molecular-weight polymers as carbohydrate components and lignin, in cellulosic biomass into water soluble, small molecular organics completely in relatively short time under relatively mild conditions; separating the resultant water soluble compounds containing aromatic rings by adjusting the acidity/basicity of the reaction solution or by using adsorption resin; and converting the water soluble compounds containing aromatic rings into ester of carboxylic acid by hydrogenation and esterification in a corresponding alcohol solution.
摘要翻译：本发明公开了一种使用纤维素生物质作为原料生产羧酸酯的技术。该技术包括以下关键步骤：在相对温和的条件下，将所有有机聚合物（包括碳水化合物组分和木质素）中的高分子量聚合物在纤维素生物质中转化成水溶性小分子有机物; 通过调节反应溶液的酸度/碱度或使用吸附树脂分离所得到的含有芳环的水溶性化合物; 并通过在相应的醇溶液中氢化和酯化将含有芳环的水溶性化合物转化成羧酸的酯。

2. 发明申请

US20130123547A1 Simultaneous Hydrolysis Refine Method Of Cellulose Biomass 审中-公开
标题翻译：纤维素生物质的同时水解精制方法
公开(公告)号：US20130123547A1
公开(公告)日：2013-05-16
申请号：US13625644
申请日：2012-09-24
申请人： Zuolin Zhu , Meg M. Sun , Chungao Su , Hongping Ye
发明人： Zuolin Zhu , Meg M. Sun , Chungao Su , Hongping Ye
IPC分类号： C07C41/01 , C07C37/01
CPC分类号： C07C41/01 , A23V2002/00 , C07C37/01 , C08H8/00 , C13K1/02 , A23V2250/5108
摘要： A method of refining cellulosic biomass, including synchronous hydrolyzation of at least 85 wt % organic polymers, based on the total weight of the cellulosic biomass, in the cellulosic biomass into small molecular organic compounds. The synchronous hydrolyzation is catalytic hydrolyzation for which the catalyst used is a substance represented by L-M-S-H or L-M=S, wherein “M” represents metal, carbon or silicon, “S” represents a heteroatom, “L” represents one or more ligands, and “H” represents hydrogen.
摘要翻译：精炼纤维素生物质的方法，包括将纤维素生物质中的至少85重量％的有机聚合物基于纤维素生物质的总重量同步水解成小分子有机化合物。同步水解是催化水解，其中使用的催化剂是由LMSH或LM = S表示的物质，其中“M”表示金属，碳或硅，“S”表示杂原子，“L”表示一个或多个配体， “H”表示氢。

3. 发明申请

US20130092602A1 Continuous Reaction System Comprising Subcritical Or Supercritical Liquid As Solvent And Reactant As Solid 审中-公开
标题翻译：包含亚临界或超临界液体作为溶剂和反应物的连续反应体系
公开(公告)号：US20130092602A1
公开(公告)日：2013-04-18
申请号：US13625665
申请日：2012-09-24
申请人： Zuolin Zhu , Meg M. Sun , Chungao Su , Kangfu Gu , Hongmei Zhao , Xuemei Ma , Weiguo Yu , Daochuang Liu , Zuodong Zhu , Hongping Ye
发明人： Zuolin Zhu , Meg M. Sun , Chungao Su , Kangfu Gu , Hongmei Zhao , Xuemei Ma , Weiguo Yu , Daochuang Liu , Zuodong Zhu , Hongping Ye
IPC分类号： B01J19/00
CPC分类号： B01J19/002 , B01J3/008 , B01J2219/00033 , Y02P20/544
摘要： A continuous reaction system is provided, which specifically relates to a continuous reaction system comprising subcritical and/or supercritical liquid as solvents and a reactant as solid. The invention can effectively prevent cavitations in the reaction system effectively, and realize maximum conversion of the solid reactant material.
摘要翻译：提供了连续反应体系，其特别涉及包含作为溶剂的亚临界和/或超临界液体和作为固体的反应物的连续反应体系。本发明可有效地有效地防止反应体系中的空穴化，实现固体反应物料的最大转化。

4. 发明授权

US08859795B2 Process for producing ester of carboxylic acid from cellulosic biomass 有权
标题翻译：从纤维素生物质生产羧酸酯的方法
公开(公告)号：US08859795B2
公开(公告)日：2014-10-14
申请号：US13497286
申请日：2009-09-22
申请人： Zuolin Zhu , Meg M. Sun , Chungao Su , Hongping Ye
发明人： Zuolin Zhu , Meg M. Sun , Chungao Su , Hongping Ye
IPC分类号： C07C69/00 , C07C67/00
CPC分类号： C07C67/00 , C07C69/24 , C07C69/34 , C07C69/675 , C07C69/42 , C07C69/44
摘要： The invention discloses a technology for producing ester of carboxylic acid using cellulosic biomass as starting material. This technology comprises the following key steps: converting all of the organic polymers, including such high molecular-weight polymers as carbohydrate components and lignin, in cellulosic biomass into water soluble, small molecular organics completely in relatively short time under relatively mild conditions; separating the resultant water soluble compounds containing aromatic rings by adjusting the acidity/basicity of the reaction solution or by using adsorption resin; and converting the water soluble compounds containing aromatic rings into ester of carboxylic acid by hydrogenation and esterification in a corresponding alcohol solution.
摘要翻译：本发明公开了一种使用纤维素生物质作为原料生产羧酸酯的技术。该技术包括以下关键步骤：在相对温和的条件下，将所有有机聚合物（包括碳水化合物组分和木质素）中的高分子量聚合物在纤维素生物质中转化成水溶性小分子有机物; 通过调节反应溶液的酸度/碱度或使用吸附树脂分离所得到的含有芳环的水溶性化合物; 并通过在相应的醇溶液中氢化和酯化将含有芳环的水溶性化合物转化成羧酸的酯。

5. 发明申请

US20110180752A1 Process for Direct Liquification of Cellulosic Biomass 审中-公开
标题翻译：纤维素生物质直接液化工艺
公开(公告)号：US20110180752A1
公开(公告)日：2011-07-28
申请号：US13056602
申请日：2008-07-28
申请人： Zuolin Zhu , Meg M. Sun , Hongping Yie , Chungao Su
发明人： Zuolin Zhu , Meg M. Sun , Hongping Yie , Chungao Su
IPC分类号： C09K3/00
CPC分类号： C10L1/023 , C10G1/06 , C10G2300/1011 , Y02P30/20
摘要： The invention provides a process for direct liquification of cellulosic biomass, which may be used to liquefy all of the organics in cellulosic biomass, including all high molecular polymeric components such as carbohydrates and lignins, into small molecular organics in a short time under mild conditions. In other words, there is provided a technology capable of converting cellulosic biomass into oil. The resultant renewable high-quality oil may be converted into liquid fuels such as gasoline etc., or used as starting materials in chemical engineering industry. The technology for direct liquification of cellulosic biomass as disclosed in the invention is the first one-step process in the world for direct liquification of cellulosic biomass without black tar formation and gasification.
摘要翻译：本发明提供了一种直接液化纤维素生物质的方法，其可用于在温和条件下在短时间内将纤维素生物质中的所有有机物（包括所有高分子量聚合物组分如碳水化合物和木质素）液化成小分子有机物。换句话说，提供了能够将纤维素生物质转化为油的技术。所得到的可再生高品质油可以转化成液体燃料如汽油等，或用作化学工业的原料。如本发明所公开的用于直接液化纤维素生物质的技术是世界上直接液化纤维素生物质而没有黑焦油形成和气化的第一个一步法。

6. 发明申请

US20090043115A1 Process for Producing Simvastatin 审中-公开
标题翻译：辛伐他汀生产工艺
公开(公告)号：US20090043115A1
公开(公告)日：2009-02-12
申请号：US11576424
申请日：2005-09-26
申请人： Hongping Ye , Meg M. Sun , Zuolin Zhu
发明人： Hongping Ye , Meg M. Sun , Zuolin Zhu
IPC分类号： C07D309/30 , C07C69/76 , C07C63/33 , C07D319/06
CPC分类号： C07C69/732 , C07C59/46 , C07C67/03 , C07C2602/28 , C07D309/30 , C07D317/30
摘要： The present invention discloses a process for producing Simvastatin and intermediate thereof. The present invention uses inexpensive and easily available reagents, its condition is mild, and it leaves out the protective and deprotective steps, which are necessary in prior methods. Compared with prior art, the esterifying condition in 8-position is greatly simplified.
摘要翻译：本发明公开了一种辛伐他汀及其中间体的制备方法。本发明使用廉价且容易获得的试剂，其条件温和，并且留下了在现有方法中必需的保护和去保护步骤。与现有技术相比，8位酯化条件大大简化。

7. 发明申请

US20080160001A1 Antihypercholesterolemic Formulation with Less Side-Effects 审中-公开
标题翻译：抗高胆固醇血症配方，副作用少
公开(公告)号：US20080160001A1
公开(公告)日：2008-07-03
申请号：US11887306
申请日：2005-03-28
申请人： Hongping Ye , Zuolin Zhu , Meg M. Sun
发明人： Hongping Ye , Zuolin Zhu , Meg M. Sun
IPC分类号： A61K38/43 , A61K31/357 , A61K31/351
CPC分类号： A61K31/122 , A61K31/22 , A61K31/357 , A61K31/366 , A61K31/40
摘要： The present disclosure provides a combined medicament for reducing blood fat with safety and high efficiency, the active ingredients of which include an agent for lowering blood fat such as statins; an agent for protecting and repairing liver such as silymarin; an agent for protecting kidney, heart, blood vessel or muscle such as coenzyme Q10 and various excipients desired for producing medicaments. The present disclosure can safely and reliably lower the concentration of cholesterol in the blood; protect blood vessels of heart and brain and provide them with nutrition; protect and repair other relevant causes of disease which result in the increasing of blood fat; and lower, even eliminate the side effects of the damage of statins on muscle and liver.
摘要翻译：本公开提供了一种用于以安全性和高效率降低血脂的组合药物，其活性成分包括用于降低血脂的药剂，例如他汀类药物; 用于保护和修复肝脏的药剂如水飞蓟素; 用于保护肾脏，心脏，血管或肌肉的药剂，例如辅酶Q10和制备药物所需的各种赋形剂。本公开可以安全可靠地降低血液中胆固醇的浓度; 保护心脑血管，为他们提供营养; 保护和修复导致血脂升高的其他相关疾病原因; 降低，甚至消除他汀类药物对肌肉和肝脏的损伤的副作用。

8. 发明申请

US20090196910A1 Sustained-Release Preparation of Statin Drugs 审中-公开
标题翻译：他汀类药物缓释制剂
公开(公告)号：US20090196910A1
公开(公告)日：2009-08-06
申请号：US11989086
申请日：2005-11-21
申请人： Hongping Yie , Zuolin Zhu , Meg M. Sun
发明人： Hongping Yie , Zuolin Zhu , Meg M. Sun
IPC分类号： A61K9/70 , A61K31/351 , A61L15/00
CPC分类号： A61K9/7061 , A61K9/0024 , A61K9/7084 , A61K31/00 , A61K31/22 , A61K31/351 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/47 , A61K31/505 , A61K47/10 , A61K47/32
摘要： A preparation of statins for prolonged release. The preparation is a transdermal therapeutic system or hypodermic implantation system. And they overcome the problem of low bioavailability and increase patient compliance. The statins in the invention contain all of statins and responding salts, hydroxyl ester derivatives at 4-position. The invention has many advantages: for example, reduce dosage frequency, remain stable and lasting blood concentration of medicine, further improve the curative effect, provide patients with a convenient and safety means of administration, and obtain an effective period of up to seven days to months by taking medicine once.
摘要翻译：他汀类药物的长期释放制剂。该制剂是透皮治疗系统或皮下注射系统。他们克服了生物利用度低的问题，并增加了患者的依从性。本发明中的他汀类药物含有所有的他汀类药物和应答盐，4-位羟基酯衍生物。本发明具有许多优点：例如，减少剂量频率，保持药物血药浓度保持稳定，进一步提高疗效，为患者提供方便，安全的治疗手段，并获得有效期达7天以上几个月服药一次。

9. 发明申请

US20100015115A1 COMPOUND PREPARATION FOR QUICKLY REDUCING OXIDATIVE STRESS AND PREPARATION OF THE SAME 失效
标题翻译：快速降低氧化应激的化合物制备及其制备
公开(公告)号：US20100015115A1
公开(公告)日：2010-01-21
申请号：US12441485
申请日：2007-04-23
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu , Wei Sun , Zhongquan Zhao , Jinyuan Wang , Feng Zheng
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu , Wei Sun , Zhongquan Zhao , Jinyuan Wang , Feng Zheng
IPC分类号： A61K38/43 , A61K33/32 , A61K33/04 , A61K33/00 , A61P39/00 , A61P39/06
CPC分类号： A61K36/538 , A61K31/01 , A61K31/05 , A61K31/07 , A61K31/122 , A61K31/198 , A61K31/355 , A61K31/375 , A61K31/525 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/30 , A61K33/32 , A61K36/19 , A61K36/35 , A61K36/634 , A61K38/06 , A61K45/06 , A61K2300/00
摘要： The present invention discloses a compound preparation for quickly reducing oxidative stress, which contains small molecules and mineral trace elements that can remove or help removing free radicals, can regulate the function of endocrine and circulatory digestive system, as well as other components that can rebuild inner harmony. The compound preparation is in solid dosage form, preferably effervescent tablet or effervescent granules. The preparative method of the compound preparation is also disclosed. Animal experiment and clinical trial show that the invention has strong effect in reducing oxidative stress and disease prevention.
摘要翻译：本发明公开了一种用于快速降低氧化应激的化合物，其含有可以去除或帮助去除自由基的小分子和矿物质微量元素，可以调节内分泌和循环消化系统的功能，以及可以重建内部的其他成分和谐。化合物制剂是固体剂型，优选泡腾片剂或泡腾颗粒剂。还公开了化合物制备的制备方法。动物实验和临床试验表明，本发明对减少氧化应激和预防疾病具有很强的疗效。

10. 发明授权

US08618341B2 Process of producing liquid fuel from cellulosic biomass 失效
标题翻译：从纤维素生物质生产液体燃料的工艺
公开(公告)号：US08618341B2
公开(公告)日：2013-12-31
申请号：US12534288
申请日：2009-08-03
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu
IPC分类号： C10G1/06 , C07C1/20 , C08H7/00
CPC分类号： C10L1/06 , B01J21/04 , B01J21/18 , B01J23/42 , B01J23/462 , C01B32/342 , C07C29/00 , C07C67/08 , C10G1/065 , C10G1/08 , C10G1/083 , C10G1/086 , C10L1/08 , Y02P30/20 , C07C31/26 , C07C31/18 , C07C69/21
摘要： A liquid fuel production process from cellulosic biomass comprises the following steps: (1) providing a mixture of cellulose and water; (2) subjecting the obtained mixture to hydrolysis and catalytic hydrogenation under the presence of acid to obtain mono-sugar alcohol and optional solid material lignin, or subjecting the obtained mixture to hydrolysis to obtain monosaccharide; (3) esterifying the obtained mono-sugar with C2-C5 organic acid to obtain a liquid fuel II, or subjecting the obtained mono-sugar alcohol or monosaccharide to dehydration/hydrogenation to obtain an organic liquid fuel I consisting of alkanes. This process avoids the loss of organic carbon atoms during fermentation, and the sugar derived from cellulosic biomass can be converted to organic carbon in the liquid fuel. The lignin produced by the process can be used for preparing aromatics.
摘要翻译：来自纤维素生物质的液体燃料生产方法包括以下步骤：（1）提供纤维素和水的混合物; （2）在酸存在下使所得混合物进行水解和催化氢化，得到单糖醇和任选的固体物质木质素，或将所得混合物水解得到单糖; （3）用C2-C5有机酸酯化所得单糖以获得液体燃料II，或将所得单糖醇或单糖进行脱水/氢化，得到由烷烃构成的有机液体燃料I。该方法避免了发酵期间有机碳原子的损失，并且来自纤维素生物质的糖可以转化为液体燃料中的有机碳。通过该方法生产的木质素可用于制备芳族化合物。

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