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1. 发明申请

US20110180752A1 Process for Direct Liquification of Cellulosic Biomass 审中-公开
标题翻译：纤维素生物质直接液化工艺
公开(公告)号：US20110180752A1
公开(公告)日：2011-07-28
申请号：US13056602
申请日：2008-07-28
申请人： Zuolin Zhu , Meg M. Sun , Hongping Yie , Chungao Su
发明人： Zuolin Zhu , Meg M. Sun , Hongping Yie , Chungao Su
IPC分类号： C09K3/00
CPC分类号： C10L1/023 , C10G1/06 , C10G2300/1011 , Y02P30/20
摘要： The invention provides a process for direct liquification of cellulosic biomass, which may be used to liquefy all of the organics in cellulosic biomass, including all high molecular polymeric components such as carbohydrates and lignins, into small molecular organics in a short time under mild conditions. In other words, there is provided a technology capable of converting cellulosic biomass into oil. The resultant renewable high-quality oil may be converted into liquid fuels such as gasoline etc., or used as starting materials in chemical engineering industry. The technology for direct liquification of cellulosic biomass as disclosed in the invention is the first one-step process in the world for direct liquification of cellulosic biomass without black tar formation and gasification.
摘要翻译：本发明提供了一种直接液化纤维素生物质的方法，其可用于在温和条件下在短时间内将纤维素生物质中的所有有机物（包括所有高分子量聚合物组分如碳水化合物和木质素）液化成小分子有机物。换句话说，提供了能够将纤维素生物质转化为油的技术。所得到的可再生高品质油可以转化成液体燃料如汽油等，或用作化学工业的原料。如本发明所公开的用于直接液化纤维素生物质的技术是世界上直接液化纤维素生物质而没有黑焦油形成和气化的第一个一步法。

2. 发明申请

US20090196910A1 Sustained-Release Preparation of Statin Drugs 审中-公开
标题翻译：他汀类药物缓释制剂
公开(公告)号：US20090196910A1
公开(公告)日：2009-08-06
申请号：US11989086
申请日：2005-11-21
申请人： Hongping Yie , Zuolin Zhu , Meg M. Sun
发明人： Hongping Yie , Zuolin Zhu , Meg M. Sun
IPC分类号： A61K9/70 , A61K31/351 , A61L15/00
CPC分类号： A61K9/7061 , A61K9/0024 , A61K9/7084 , A61K31/00 , A61K31/22 , A61K31/351 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/47 , A61K31/505 , A61K47/10 , A61K47/32
摘要： A preparation of statins for prolonged release. The preparation is a transdermal therapeutic system or hypodermic implantation system. And they overcome the problem of low bioavailability and increase patient compliance. The statins in the invention contain all of statins and responding salts, hydroxyl ester derivatives at 4-position. The invention has many advantages: for example, reduce dosage frequency, remain stable and lasting blood concentration of medicine, further improve the curative effect, provide patients with a convenient and safety means of administration, and obtain an effective period of up to seven days to months by taking medicine once.
摘要翻译：他汀类药物的长期释放制剂。该制剂是透皮治疗系统或皮下注射系统。他们克服了生物利用度低的问题，并增加了患者的依从性。本发明中的他汀类药物含有所有的他汀类药物和应答盐，4-位羟基酯衍生物。本发明具有许多优点：例如，减少剂量频率，保持药物血药浓度保持稳定，进一步提高疗效，为患者提供方便，安全的治疗手段，并获得有效期达7天以上几个月服药一次。

3. 发明申请

US20100015115A1 COMPOUND PREPARATION FOR QUICKLY REDUCING OXIDATIVE STRESS AND PREPARATION OF THE SAME 失效
标题翻译：快速降低氧化应激的化合物制备及其制备
公开(公告)号：US20100015115A1
公开(公告)日：2010-01-21
申请号：US12441485
申请日：2007-04-23
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu , Wei Sun , Zhongquan Zhao , Jinyuan Wang , Feng Zheng
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu , Wei Sun , Zhongquan Zhao , Jinyuan Wang , Feng Zheng
IPC分类号： A61K38/43 , A61K33/32 , A61K33/04 , A61K33/00 , A61P39/00 , A61P39/06
CPC分类号： A61K36/538 , A61K31/01 , A61K31/05 , A61K31/07 , A61K31/122 , A61K31/198 , A61K31/355 , A61K31/375 , A61K31/525 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/30 , A61K33/32 , A61K36/19 , A61K36/35 , A61K36/634 , A61K38/06 , A61K45/06 , A61K2300/00
摘要： The present invention discloses a compound preparation for quickly reducing oxidative stress, which contains small molecules and mineral trace elements that can remove or help removing free radicals, can regulate the function of endocrine and circulatory digestive system, as well as other components that can rebuild inner harmony. The compound preparation is in solid dosage form, preferably effervescent tablet or effervescent granules. The preparative method of the compound preparation is also disclosed. Animal experiment and clinical trial show that the invention has strong effect in reducing oxidative stress and disease prevention.
摘要翻译：本发明公开了一种用于快速降低氧化应激的化合物，其含有可以去除或帮助去除自由基的小分子和矿物质微量元素，可以调节内分泌和循环消化系统的功能，以及可以重建内部的其他成分和谐。化合物制剂是固体剂型，优选泡腾片剂或泡腾颗粒剂。还公开了化合物制备的制备方法。动物实验和临床试验表明，本发明对减少氧化应激和预防疾病具有很强的疗效。

4. 发明授权

US08618341B2 Process of producing liquid fuel from cellulosic biomass 失效
标题翻译：从纤维素生物质生产液体燃料的工艺
公开(公告)号：US08618341B2
公开(公告)日：2013-12-31
申请号：US12534288
申请日：2009-08-03
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu
IPC分类号： C10G1/06 , C07C1/20 , C08H7/00
CPC分类号： C10L1/06 , B01J21/04 , B01J21/18 , B01J23/42 , B01J23/462 , C01B32/342 , C07C29/00 , C07C67/08 , C10G1/065 , C10G1/08 , C10G1/083 , C10G1/086 , C10L1/08 , Y02P30/20 , C07C31/26 , C07C31/18 , C07C69/21
摘要： A liquid fuel production process from cellulosic biomass comprises the following steps: (1) providing a mixture of cellulose and water; (2) subjecting the obtained mixture to hydrolysis and catalytic hydrogenation under the presence of acid to obtain mono-sugar alcohol and optional solid material lignin, or subjecting the obtained mixture to hydrolysis to obtain monosaccharide; (3) esterifying the obtained mono-sugar with C2-C5 organic acid to obtain a liquid fuel II, or subjecting the obtained mono-sugar alcohol or monosaccharide to dehydration/hydrogenation to obtain an organic liquid fuel I consisting of alkanes. This process avoids the loss of organic carbon atoms during fermentation, and the sugar derived from cellulosic biomass can be converted to organic carbon in the liquid fuel. The lignin produced by the process can be used for preparing aromatics.
摘要翻译：来自纤维素生物质的液体燃料生产方法包括以下步骤：（1）提供纤维素和水的混合物; （2）在酸存在下使所得混合物进行水解和催化氢化，得到单糖醇和任选的固体物质木质素，或将所得混合物水解得到单糖; （3）用C2-C5有机酸酯化所得单糖以获得液体燃料II，或将所得单糖醇或单糖进行脱水/氢化，得到由烷烃构成的有机液体燃料I。该方法避免了发酵期间有机碳原子的损失，并且来自纤维素生物质的糖可以转化为液体燃料中的有机碳。通过该方法生产的木质素可用于制备芳族化合物。

5. 发明申请

US20100186291A1 LIQUID FUEL PRODUCTION PROCESS FROM CELLULOSIC BIOMASS AND COAL 失效
标题翻译：来自细胞生物质和煤的液体燃料生产过程
公开(公告)号：US20100186291A1
公开(公告)日：2010-07-29
申请号：US12527357
申请日：2007-04-06
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu
IPC分类号： C10L1/182
CPC分类号： B01J27/051 , B01J27/0515 , B01J37/343 , C07C29/153 , C10G2/332 , C10G2/333 , C10G3/45 , C10G3/46 , C10G3/47 , C10G3/56 , C10G2300/1011 , C10G2300/1014 , C10G2300/1022 , C10J3/00 , C10J2300/0916 , C10J2300/093 , C10J2300/0956 , C10J2300/0973 , C10J2300/1659 , C10J2300/1665 , Y02E50/18 , Y02E50/32 , Y02P20/145 , Y02P20/52 , Y02P30/20 , C07C31/08 , C07C31/04
摘要： A liquid fuel production process from Cellulosic biomass and coal comprises providing a mixture of Cellulosic biomass and coal, subjecting the mixture to gasification to obtain synthesis gas and converting the synthesis gas to a liquid fuel under the presence of catalyst. The catalyst includes molybdenum sulfide, alkali metal compound and a component activating the C—H bond in alkanes product, wherein the alkali metal compound is selected from the group of salts of Li, Na, K, Rb and Cs, the component activating the C—H bond in alkanes product is selected from Mo, V, Os, Re, Ir, Pt, Pd, Co, Rh, Ni and their mixture. Additionally, co-gasification of Cellulosic biomass and coal can reduce the ash fusion temperature of coal.
摘要翻译：来自纤维素生物质和煤的液体燃料生产方法包括提供纤维素生物质和煤的混合物，使混合物气化以获得合成气并在催化剂存在下将合成气转化为液体燃料。催化剂包括硫化钼，碱金属化合物和在烷烃产物中活化C-H键的组分，其中碱金属化合物选自Li，Na，K，Rb和Cs的盐，其中C 烷烃产物中的-H键选自Mo，V，Os，Re，Ir，Pt，Pd，Co，Rh，Ni及其混合物。此外，纤维素生物质和煤的共气化可以降低煤的灰分熔化温度。

6. 发明申请

US20100105691A1 METFORMIN FOLATE AND PREPARATION OF THE SAME 失效
标题翻译：甲基纤维素及其制备
公开(公告)号：US20100105691A1
公开(公告)日：2010-04-29
申请号：US12515657
申请日：2007-05-11
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu
IPC分类号： A61K31/4985 , C07D475/00
CPC分类号： C07D475/08 , C07C279/26
摘要： The present invention discloses a novel biguanidine compound, i.e. folacin-metformin, and its manufacture with inorganic salt of metformin as raw material. Compared with metformin, the compound has the same clinic curative effect, such as lowering blood sugar, curing poly-cystic ovary syndrome (PCOS), losing weight and so on, without resulting in the increase of homocysteine concentration, even with a little decrease of homocysteine concentration in some cases.
摘要翻译：本发明公开了一种新型双胍化合物，即二十二甲酰二甲双胍，其二甲双胍的无机盐为原料。与二甲双胍相比，该化合物具有相同的临床疗效，如降血糖，多囊卵巢综合征（PCOS），体重减轻等，不会导致同型半胱氨酸浓度升高，即使有少量降低某些情况下高半胱氨酸浓度。

7. 发明授权

US08759596B2 Liquid fuel production process from cellulosic biomass and coal 失效
标题翻译：来自纤维素生物质和煤的液体燃料生产过程
公开(公告)号：US08759596B2
公开(公告)日：2014-06-24
申请号：US12527357
申请日：2007-04-06
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu
IPC分类号： C10L1/182
CPC分类号： B01J27/051 , B01J27/0515 , B01J37/343 , C07C29/153 , C10G2/332 , C10G2/333 , C10G3/45 , C10G3/46 , C10G3/47 , C10G3/56 , C10G2300/1011 , C10G2300/1014 , C10G2300/1022 , C10J3/00 , C10J2300/0916 , C10J2300/093 , C10J2300/0956 , C10J2300/0973 , C10J2300/1659 , C10J2300/1665 , Y02E50/18 , Y02E50/32 , Y02P20/145 , Y02P20/52 , Y02P30/20 , C07C31/08 , C07C31/04
摘要： A liquid fuel production process from Cellulosic biomass and coal comprises providing a mixture of Cellulosic biomass and coal, subjecting the mixture to gasification to obtain synthesis gas and converting the synthesis gas to a liquid fuel under the presence of catalyst. The catalyst includes molybdenum sulfide, alkali metal compound and a component activating the C—H bond in alkanes product, wherein the alkali metal compound is selected from the group of salts of Li, Na, K, Rb and Cs, the component activating the C—H bond in alkanes product is selected from Mo, V, Os, Re, Ir, Pt, Pd, Co, Rh, Ni and their mixture. Additionally, co-gasification of Cellulosic biomass and coal can reduce the ash fusion temperature of coal.
摘要翻译：来自纤维素生物质和煤的液体燃料生产方法包括提供纤维素生物质和煤的混合物，使混合物气化以获得合成气并在催化剂存在下将合成气转化为液体燃料。催化剂包括硫化钼，碱金属化合物和在烷烃产物中活化C-H键的组分，其中碱金属化合物选自Li，Na，K，Rb和Cs的盐，其中C 烷烃产物中的-H键选自Mo，V，Os，Re，Ir，Pt，Pd，Co，Rh，Ni及其混合物。此外，纤维素生物质和煤的共气化可以降低煤的灰分熔化温度。

8. 发明申请

US20090326286A1 PROCESS OF PRODUCING LIQUID FUEL FROM CELLULOSIC BIOMASS 失效
标题翻译：从细胞生物量生产液体燃料的方法
公开(公告)号：US20090326286A1
公开(公告)日：2009-12-31
申请号：US12534288
申请日：2009-08-03
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu
IPC分类号： C10G1/00 , C07G1/00
CPC分类号： C10L1/06 , B01J21/04 , B01J21/18 , B01J23/42 , B01J23/462 , C01B32/342 , C07C29/00 , C07C67/08 , C10G1/065 , C10G1/08 , C10G1/083 , C10G1/086 , C10L1/08 , Y02P30/20 , C07C31/26 , C07C31/18 , C07C69/21
摘要： A liquid fuel production process from cellulosic biomass comprises the following steps: (1) providing a mixture of cellulose and water; (2) subjecting the obtained mixture to hydrolysis and catalytic hydrogenation under the presence of acid to obtain mono-sugar alcohol and optional solid material lignin, or subjecting the obtained mixture to hydrolysis to obtain monosaccharide; (3) esterifying the obtained mono-sugar with C2-C5 organic acid to obtain a liquid fuel II, or subjecting the obtained mono-sugar alcohol or monosaccharide to dehydration/hydrogenation to obtain an organic liquid fuel I consisting of alkanes. This process avoids the loss of organic carbon atoms during fermentation, and the sugar derived from cellulosic biomass can be converted to organic carbon in the liquid fuel. The lignin produced by the process can be used for preparing aromatics.
摘要翻译：来自纤维素生物质的液体燃料生产方法包括以下步骤：（1）提供纤维素和水的混合物; （2）在酸存在下使所得混合物进行水解和催化氢化，得到单糖醇和任选的固体物质木质素，或将所得混合物水解得到单糖; （3）用C2-C5有机酸酯化所得单糖以获得液体燃料II，或将所得单糖醇或单糖进行脱水/氢化，得到由烷烃构成的有机液体燃料I。该方法避免了发酵期间有机碳原子的损失，并且来自纤维素生物质的糖可以转化为液体燃料中的有机碳。通过该方法生产的木质素可用于制备芳族化合物。

9. 发明授权

US08329710B2 Metformin folate and preparation of the same 失效
标题翻译：二甲双胍叶酸及其制备方法相同
公开(公告)号：US08329710B2
公开(公告)日：2012-12-11
申请号：US12515657
申请日：2007-05-11
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu
IPC分类号： A61K31/519
CPC分类号： C07D475/08 , C07C279/26
摘要： This disclosure is directed to compound having the formula (A) and a method of treatment using the compound. Compared with metformin, the disclosed compound has the same clinic curative effect, such as lowering blood sugar, curing poly-cystic ovary syndrome (PCOS), losing weight and so on, without resulting in the increase of homocysteine concentration, even with a little decrease of homocysteine concentration in some cases.
摘要翻译：本公开涉及具有式（A）的化合物和使用该化合物的方法。与二甲双胍相比，所公开的化合物具有降低血糖，治愈多囊卵巢综合征（PCOS），减轻体重等临床疗效，而不会导致高半胱氨酸浓度升高，甚至略有下降的同型半胱氨酸浓度。

10. 发明授权

US08124139B2 Compound preparation for quickly reducing oxidative stress and preparation of the same 失效
标题翻译：用于快速降低氧化应激的复方制剂及其制备
公开(公告)号：US08124139B2
公开(公告)日：2012-02-28
申请号：US12441485
申请日：2007-04-23
申请人： Hongping Yie , Meg M. Sun , Zuolin Zhu , Wei Sun , Zhongquan Zhao , Jinyuan Wang , Feng Zheng
发明人： Hongping Yie , Meg M. Sun , Zuolin Zhu , Wei Sun , Zhongquan Zhao , Jinyuan Wang , Feng Zheng
IPC分类号： A61K36/268 , A61K36/634 , A61K36/28 , A61K36/00
CPC分类号： A61K36/538 , A61K31/01 , A61K31/05 , A61K31/07 , A61K31/122 , A61K31/198 , A61K31/355 , A61K31/375 , A61K31/525 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/30 , A61K33/32 , A61K36/19 , A61K36/35 , A61K36/634 , A61K38/06 , A61K45/06 , A61K2300/00
摘要： The present invention discloses a compound preparation for quickly reducing oxidative stress, which contains small molecules and mineral trace elements that can remove or help removing free radicals, can regulate the function of endocrine and circulatory digestive system, as well as other components that can rebuild inner harmony. The compound preparation is in solid dosage form, preferably effervescent tablet or effervescent granules. The preparative method of the compound preparation is also disclosed. Animal experiment and clinical trial show that the invention has strong effect in reducing oxidative stress and disease prevention.
摘要翻译：本发明公开了一种用于快速降低氧化应激的化合物，其含有可以去除或帮助去除自由基的小分子和矿物质微量元素，可以调节内分泌和循环消化系统的功能，以及可以重建内部的其他成分和谐。化合物制剂是固体剂型，优选泡腾片剂或泡腾颗粒剂。还公开了化合物制备的制备方法。动物实验和临床试验表明，本发明对减少氧化应激和预防疾病具有很强的疗效。

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